ab63f7deb57817ac9715b9475236078c  pmc_31296923.pdf
8274071dd0c4fc66b6bdf4ca70873d1af1ad97e3  pmc_31296923.pdf
a49a80d72adf5521727398e30214c47c29435de500bd9e093571b638f13bc1da  pmc_31296923.pdf

Title:          Association of post-operative CEA with survival and oxaliplatin benefit in patients with stage II colon cancer: a post hoc analysis of the MOSAIC trial
Subject:        British Journal of Cancer, doi:10.1038/s41416-019-0521-7
Keywords:       
Author:         Edouard Auclin
Creator:        Springer
CreationDate:   Wed Jul 31 07:48:52 2019 CEST
ModDate:        Wed Jul 31 07:49:52 2019 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      772822 bytes
Optimized:      yes
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
KMJLHI+AdvTT5afe5d37.B               Type 1C           WinAnsi          yes yes no     234  0
KMJNND+AdvOT46dcae81+22              Type 1C           Custom           yes yes yes    251  0
KMJNNE+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     252  0
KMJNNF+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no     261  0
KMJNPF+AdvOTfe809cc4                 Type 1C           WinAnsi          yes yes no     264  0
KMJOEE+AdvMyriad_R                   Type 1C           WinAnsi          yes yes no     269  0
KMJNKM+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no     254  0
KMJNKN+AdvOTa20b42a7                 Type 1C           WinAnsi          yes yes no     255  0
KMJNLN+AdvOTa20b42a7+fb              Type 1C           Custom           yes yes yes    256  0
KMJNLO+AdvTT6780a46b                 Type 1C           WinAnsi          yes yes no     257  0
KMJNLP+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     258  0
KMJNMA+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     259  0
KMJNNB+AdvOT46dcae81+fb              Type 1C           Custom           yes yes yes    237  0
KMJNNC+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     243  0
KMJOIE+AdvOT919a0533.B               Type 1C           WinAnsi          yes yes no      84  0
KMJOIF+AdvTT6780a46b+22              Type 1C           Custom           yes yes yes     86  0
KMJOJG+AdvTT6780a46b+fb              Type 1C           Custom           yes yes yes     92  0
KMJOJH+AdvTT6780a46b+20              Type 1C           WinAnsi          yes yes no      89  0
KMJOKH+AdvOT7d2ebc01                 Type 1C           WinAnsi          yes yes no      93  0
KMKBFI+Helvetica                     Type 1C           WinAnsi          yes yes no     119  0
KMKBJH+Helvetica-Bold                Type 1C           WinAnsi          yes yes no     111  0
Helvetica-Oblique                    Type 1C           WinAnsi          yes no  no     108  0
KMKEEJ+Symbol                        Type 1C           Custom           yes yes yes    107  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  no     106  0
KMKEHK+AdvTTab7e17fd+22              Type 1C           Custom           yes yes no     123  0
KMKJOJ+AdvOT3b30f6db.B+20            Type 1C           WinAnsi          yes yes no     137  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-04-28 02:26:37 CEST
 RepresentationInformation: pmc_31296923.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-07-13 03:40:02 CEST
  Size: 772822
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web_521_' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web_521_' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web_521_' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web_521_' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found
   Offset: 739006
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found
   Offset: 739006
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 325
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Association of post-operative CEA with survival and oxaliplatin benefit in patients with stage II colon cancer: a’post’hoc ana氀礀猀椀猀 漀昀 琀栀攀 䴀伀匀䄀䤀䌀 琀爀椀愀氩㸾൥湤潢樍㌰㠠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀ㄩ⽆‰⽎數琠㌱㠠〠刯偡牥湴″〷‰⁒⽔楴汥⣾＀䈀愀挀欀最爀漀甀渀搩㸾൥湤潢樍㌰㤠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䴀ㄩ⽆‰⽐慲敮琠㌰㜠〠刯偲敶″㄰‰⁒⽔楴汥⣾＀䄀䌀䬀一伀圀䰀䔀䐀䜀䴀䔀一吀匩㸾൥湤潢樍㌱〠〠潢樍㰼⽃嬰⸰‰⸰‰⸰崯䍯畮琠〯䑥獴⣾＀䄀㠩⽆‰⽎數琠㌰㤠〠刯偡牥湴″〷‰⁒⽐牥瘠㌱ㄠ〠刯呩瑬攨Competing interests
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
      Children: 
       Item: 
        Title: Background
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
        Children: 
         Item: 
          Title: Population
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: Definition of high-risk stage II CC
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
        Children: 
         Item: 
          Title: Characteristics of patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: Post-operative CEA and survival
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: Independent prognostic value of post-operative CEA
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: Predictive value of post-operative CEA
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: Conclusion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: Author contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: Competing interests
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
   Info: 
    Title: Association of post-operative CEA with survival and oxaliplatin benefit in patients with stage II colon cancer: a post hoc analysis of the MOSAIC trial
    Author: Edouard Auclin
    Subject: British Journal of Cancer, doi:10.1038/s41416-019-0521-7
    Keywords: 
    Creator: Springer
    CreationDate: Wed Jul 31 08:18:52 CEST 2019
    ModDate: Wed Jul 31 08:19:52 CEST 2019
   ID: 0xb0197b7a1753acdf4b3848b3344a02ee, 0x65c555c591951a44ac6a6260ddb0fa0d
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 96
      ImageHeight: 82
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 632
      ImageHeight: 608
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 632
      ImageHeight: 610
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 781
      ImageHeight: 729
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 781
      ImageHeight: 729
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 472
      ImageHeight: 414
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 443
      ImageHeight: 427
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 468
      ImageHeight: 409
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 442
      ImageHeight: 428
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 468
      ImageHeight: 410
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 473
      ImageHeight: 413
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 426
      ImageHeight: 409
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 460
      ImageHeight: 402
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 426
      ImageHeight: 410
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 457
      ImageHeight: 399
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: KMJNLN+AdvOTa20b42a7+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: KMJNLN+AdvOTa20b42a7+fb
       Flags: Symbolic
       FontBBox: 0, 0, 531, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KMJNLO+AdvTT6780a46b
      FontSubset: true
      FirstChar: 37
      LastChar: 233
      FontDescriptor: 
       FontName: KMJNLO+AdvTT6780a46b
       Flags: Nonsymbolic
       FontBBox: -41, -250, 875, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNLP+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: KMJNLP+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNMA+AdvOT46dcae81
      FontSubset: true
      FirstChar: 37
      LastChar: 244
      FontDescriptor: 
       FontName: KMJNMA+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNNF+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 43
      LastChar: 61
      FontDescriptor: 
       FontName: KMJNNF+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNPF+AdvOTfe809cc4
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: KMJNPF+AdvOTfe809cc4
       Flags: Nonsymbolic
       FontBBox: -20, -281, 937, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMKJOJ+AdvOT3b30f6db.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: KMKJOJ+AdvOT3b30f6db.B+20
       Flags: Nonsymbolic
       FontBBox: -10, -197, 1250, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJOEE+AdvMyriad_R
      FontSubset: true
      FirstChar: 40
      LastChar: 120
      FontDescriptor: 
       FontName: KMJOEE+AdvMyriad_R
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJOIE+AdvOT919a0533.B
      FontSubset: true
      FirstChar: 46
      LastChar: 108
      FontDescriptor: 
       FontName: KMJOIE+AdvOT919a0533.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 656, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJOIF+AdvTT6780a46b+22
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: KMJOIF+AdvTT6780a46b+22
       Flags: Symbolic
       FontBBox: 0, -250, 875, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KMJOJH+AdvTT6780a46b+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: KMJOJH+AdvTT6780a46b+20
       Flags: Nonsymbolic
       FontBBox: 0, -114, 1156, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJOJG+AdvTT6780a46b+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: KMJOJG+AdvTT6780a46b+fb
       Flags: Symbolic
       FontBBox: 9, 0, 875, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KMJOKH+AdvOT7d2ebc01
      FontSubset: true
      FirstChar: 49
      LastChar: 55
      FontDescriptor: 
       FontName: KMJOKH+AdvOT7d2ebc01
       Flags: Nonsymbolic
       FontBBox: -31, -208, 958, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJLHI+AdvTT5afe5d37.B
      FontSubset: true
      FirstChar: 65
      LastChar: 84
      FontDescriptor: 
       FontName: KMJLHI+AdvTT5afe5d37.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 895, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMKEEJ+Symbol
      FontSubset: true
      FirstChar: 1
      LastChar: 62
      FontDescriptor: 
       FontName: KMKEEJ+Symbol
       Flags: Symbolic
       FontBBox: -180, -293, 1090, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: Helvetica-Oblique
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Helvetica-Oblique
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNNB+AdvOT46dcae81+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: KMJNNB+AdvOT46dcae81+fb
       Flags: Symbolic
       FontBBox: 0, 0, 739, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KMKBJH+Helvetica-Bold
      FontSubset: true
      FirstChar: 97
      LastChar: 101
      FontDescriptor: 
       FontName: KMKBJH+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNNC+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: KMJNNC+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1125, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMKBFI+Helvetica
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: KMKBFI+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNND+AdvOT46dcae81+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: KMJNND+AdvOT46dcae81+22
       Flags: Symbolic
       FontBBox: 0, -145, 687, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: KMKEHK+AdvTTab7e17fd+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: KMKEHK+AdvTTab7e17fd+22
       Flags: Nonsymbolic
       FontBBox: -156, -218, 937, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: KMJNNE+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 45
      LastChar: 120
      FontDescriptor: 
       FontName: KMJNNE+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNKM+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 67
      LastChar: 121
      FontDescriptor: 
       FontName: KMJNKM+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: KMJNKN+AdvOTa20b42a7
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: KMJNKN+AdvOTa20b42a7
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -239, 979, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41416-019-0521-7</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Association of post-operative CEA with survival and oxaliplatin benefit in patients with stage II colon cancer: a post hoc analysis of the MOSAIC trial</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Edouard Auclin</rdf:li>
               <rdf:li>Thierry André</rdf:li>
               <rdf:li>Julien Taieb</rdf:li>
               <rdf:li>Maria Banzi</rdf:li>
               <rdf:li>Jean-Luc Van Laethem</rdf:li>
               <rdf:li>Josep Tabernero</rdf:li>
               <rdf:li>Tamas Hickish</rdf:li>
               <rdf:li>Aimery Gramont</rdf:li>
               <rdf:li>Dewi Vernerey</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag/>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">British Journal of Cancer, doi:10.1038/s41416-019-0521-7</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41416-019-0521-7</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41416-019-0521-7</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>British Journal of Cancer</prism:publicationName>
         <prism:copyright>© 2019, The Author(s), under exclusive licence to Cancer Research UK</prism:copyright>
         <prism:issn>1532-1827</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41416-019-0521-7</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41416-019-0521-7</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2019-07-31T11:19:52+05:30</xmp:ModifyDate>
         <xmp:CreateDate>2019-07-31T11:18:52+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2019-07-31T11:19:52+05:30</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords/>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xmpMM:DocumentID>uuid:4e3418c2-23e7-48bb-889b-268cec694d0a</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:53ea513b-4eaf-40b3-a13e-87e298b398a0</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:52bd6947-a608-46ed-b494-50a5d850f4cf</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-07-31T11:19:52+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 312
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 533, 704, 535, 736
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 533, 709, 553, 740
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 553, 695, 559, 705
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 553, 695, 559, 705
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 76, 328, 79, 337
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 81, 328, 85, 337
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 200, 298, 204, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 171, 239, 174, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 250, 209, 253, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 255, 209, 258, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 498, 289, 502, 297
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 486, 239, 489, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 476, 749, 548, 757
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 144, 80, 225, 87
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 313
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 257, 697, 260, 706
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 166, 358, 169, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 143, 205, 234, 214
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 147, 75, 152, 84
       Flags: Print
       AppearanceDictionary: true
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 483, 85, 488, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
     Thumb: true
    Page: 
     Label: 314
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 138, 215, 142, 224
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 151, 165, 155, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 554, 105, 559, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 9
     Thumb: true
    Page: 
     Label: 315
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 62, 85, 67, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 52, 55, 57, 64
       Flags: Print
       AppearanceDictionary: true
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 545, 120, 549, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 29
     Thumb: true
    Page: 
     Label: 316
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 314, 111, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 152, 314, 157, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 268, 304, 273, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 158, 139, 161, 148
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 222, 109, 226, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 361, 328, 368, 337
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 384, 269, 391, 278
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 385, 209, 392, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 396, 209, 402, 218
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 505, 179, 512, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 554, 393, 559, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
     Thumb: true
    Page: 
     Label: 317
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 214, 270, 283, 277
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 35, 261, 91, 268
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 04f97df2
   Type: CRC32
  Checksum: ab63f7deb57817ac9715b9475236078c
   Type: MD5
  Checksum: 8274071dd0c4fc66b6bdf4ca70873d1af1ad97e3
   Type: SHA-1