b472f4246ed4e798b325f0a4b6dc8986 pmc_31300657.pdf 1a3a877f952a6a706b45dc2eeab4a36814627cbb pmc_31300657.pdf c0be85bd43dce603448e849345652c984e05fe9a17131920488479d1288e48d0 pmc_31300657.pdf Title: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders Subject: Nature Communications, doi:10.1038/s41467-019-10910-w Keywords: Author: Vincenzo Salpietro Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Jul 5 14:42:48 2019 CEST ModDate: Mon Jul 8 18:33:06 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 3596199 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DKBLKN+AdvOTea1a7398 Type 1C WinAnsi yes yes no 76 0 DKBLKO+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 108 0 DKBLKP+AdvTTab7e17fd Type 1C WinAnsi yes yes no 78 0 DKBLLA+AdvOTea1a7398+fb Type 1C Custom yes yes yes 110 0 DKBLLB+AdvOTcb88df00 Type 1C WinAnsi yes yes no 80 0 Arial-BoldMT Type 1C WinAnsi yes no no 974 0 DKBMIA+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 75 0 DKBMGP+AdvOTf23bb480+fb Type 1C Custom yes yes yes 787 0 DKBMGO+AdvOTf23bb480 Type 1C WinAnsi yes yes no 754 0 DKBMLP+AdvOT125c650c Type 1C WinAnsi yes yes no 77 0 DKBMNA+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 79 0 DKBMND+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 81 0 DKBMNE+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 82 0 DKBMNB+AdvOT1ef757c0+20 Type 1C Custom yes yes yes 83 0 DKBMNC+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 84 0 DKBMPG+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 85 0 DKBMPH+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 86 0 DKBMOF+AdvTTab7e17fd+22 Type 1C Custom yes yes no 87 0 DKBMPF+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 88 0 DKCFAH+Helvetica Type 1C Custom yes yes no 109 0 DKCFCH+Helvetica-Bold Type 1C WinAnsi yes yes no 111 0 DKEELG+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 193 0 DKEELH+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 243 0 Helvetica2 Type 1C WinAnsi yes no no 244 0 Symbol Type 1C Custom yes no yes 245 0 DKEGEB+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 246 0 DKEKBK+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 271 0 DKEPMI+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 394 0 DKFABI+AdvOTe75a9404.I Type 1C WinAnsi yes yes no 485 0 DKFABH+AdvOTcb88df00+fb Type 1C Custom yes yes yes 486 0 DKFAKG+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 501 0 DKFANG+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 636 0 DKFEHB+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 753 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:35:53 CEST RepresentationInformation: pmc_31300657.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 04:09:43 CEST Size: 3596199 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR48' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR55' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR56' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR57' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR58' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR58' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR59' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR60' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR61' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR62' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR63' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR64' cannot be found Offset: 3379130 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR65' cannot be found Offset: 3379130 MIMEtype: application/pdf PDFMetadata: Objects: 1032 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: AMPA receptor GluA2’subunit defects are a cause of neurodevelopmental disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Identification of GRIA2 de-novo variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: GRIA2 is constrained and intolerant to loss-of-function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Phenotypic spectrum associated with GRIA2 de novo variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: AMPAR Molecular dynamic stimulations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Functional analyses of the identified GRIA2 variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Patients recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Genetic analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Functional characterization of the identified GRIA2 variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Molecular modeling and dynamic stimulations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: URLs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders Author: Vincenzo Salpietro Subject: Nature Communications, doi:10.1038/s41467-019-10910-w Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Fri Jul 05 15:12:48 CEST 2019 ModDate: Mon Jul 08 18:33:06 CEST 2019 ID: 0xc5c4596acaf64d47f3711c850b3e240e, 0x2fa1f9f19f016e2435a3801144216059 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1281 ImageHeight: 590 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 613 ImageHeight: 625 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1702 ImageHeight: 307 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1131 ImageHeight: 344 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1131 ImageHeight: 350 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1131 ImageHeight: 356 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1131 ImageHeight: 346 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1494 ImageHeight: 266 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1490 ImageHeight: 268 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1503 ImageHeight: 265 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1479 ImageHeight: 274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1498 ImageHeight: 267 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1496 ImageHeight: 266 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 452 ImageHeight: 359 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 452 ImageHeight: 360 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 454 ImageHeight: 358 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 451 ImageHeight: 357 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 452 ImageHeight: 358 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 452 ImageHeight: 358 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 451 ImageHeight: 357 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 452 ImageHeight: 358 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 452 ImageHeight: 358 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 315 ImageHeight: 62 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 315 ImageHeight: 96 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1488 ImageHeight: 1325 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 487 ImageHeight: 749 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 315 ImageHeight: 226 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 259 ImageHeight: 17 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 562 ImageHeight: 626 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 910 ImageHeight: 249 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DKEELG+AdvOTea1a7398+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: DKEELG+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKEPMI+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKEPMI+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBMIA+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: DKBMIA+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBLKN+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: DKBLKN+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBMLP+AdvOT125c650c FontSubset: true FirstChar: 65 LastChar: 65 FontDescriptor: FontName: DKBMLP+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBLKP+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: DKBLKP+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBMNA+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: DKBMNA+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKEKBK+AdvOT8608a8d1+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKEKBK+AdvOT8608a8d1+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBLLB+AdvOTcb88df00 FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: DKBLLB+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBMND+AdvOT7d6df7ab.I FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: DKBMND+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBMNE+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: DKBMNE+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBMGP+AdvOTf23bb480+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKBMGP+AdvOTf23bb480+fb Flags: Symbolic FontBBox: 0, -197, 718, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBMNB+AdvOT1ef757c0+20 FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: DKBMNB+AdvOT1ef757c0+20 Flags: Symbolic FontBBox: -135, -187, 1010, 833 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBMNC+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKBMNC+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBMPG+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKBMPG+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBMPH+AdvOT45bf69de.BI FontSubset: true FirstChar: 50 LastChar: 82 FontDescriptor: FontName: DKBMPH+AdvOT45bf69de.BI Flags: Nonsymbolic FontBBox: -135, -250, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBMOF+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: DKBMOF+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DKBMPF+AdvOTb65e897d.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DKBMPF+AdvOTb65e897d.B Flags: Serif, Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKFABI+AdvOTe75a9404.I FontSubset: true FirstChar: 50 LastChar: 82 FontDescriptor: FontName: DKFABI+AdvOTe75a9404.I Flags: Nonsymbolic FontBBox: -83, -197, 1020, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKFABH+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKFABH+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKBLKO+AdvOT9bd21c25.I FontSubset: true FirstChar: 45 LastChar: 118 FontDescriptor: FontName: DKBLKO+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKCFAH+Helvetica FontSubset: true FirstChar: 32 LastChar: 209 FontDescriptor: FontName: DKCFAH+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: MacRomanEncoding Differences: true Font: BaseFont: DKBLLA+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DKBLLA+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKCFCH+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 105 FontDescriptor: FontName: DKCFCH+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKFEHB+AdvOTf23bb480+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: DKFEHB+AdvOTf23bb480+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKBMGO+AdvOTf23bb480 FontSubset: true FirstChar: 35 LastChar: 250 FontDescriptor: FontName: DKBMGO+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DKEELH+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKEELH+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Helvetica2 FirstChar: 32 LastChar: 151 FontDescriptor: FontName: Helvetica2 Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Symbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKFAKG+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKFAKG+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKEGEB+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DKEGEB+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DKFANG+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DKFANG+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41467-019-10910-w AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders Vincenzo Salpietro Christine L. Dixon Hui Guo Oscar D. Bello Jana Vandrovcova Stephanie Efthymiou Reza Maroofian Gali Heimer Lydie Burglen Stephanie Valence Erin Torti Moritz Hacke Julia Rankin Huma Tariq Estelle Colin Vincent Procaccio Pasquale Striano Kshitij Mankad Andreas Lieb Sharon Chen Laura Pisani Conceicao Bettencourt Roope Männikkö Andreea Manole Alfredo Brusco Enrico Grosso Giovanni Battista Ferrero Judith Armstrong-Moron Sophie Gueden Omer Bar-Yosef Michal Tzadok Kristin G. Monaghan Teresa Santiago-Sim Richard E. Person Megan T. Cho Rebecca Willaert Yongjin Yoo Jong-Hee Chae Yingting Quan Huidan Wu Tianyun Wang Raphael A. Bernier Kun Xia Alyssa Blesson Mahim Jain Mohammad M. Motazacker Bregje Jaeger Amy L. Schneider Katja Boysen Alison M. Muir Candace T. Myers Ralitza H. Gavrilova Lauren Gunderson Laura Schultz-Rogers Eric W. Klee David Dyment Matthew Osmond Mara Parellada Cloe Llorente Javier Gonzalez-Peñas Angel Carracedo Arie Haeringen Claudia Ruivenkamp Caroline Nava Delphine Heron Rosaria Nardello Michele Iacomino Carlo Minetti Aldo Skabar Antonella Fabretto Michael G. Hanna Enrico Bugiardini Isabel Hostettler Benjamin O’Callaghan Alaa Khan Andrea Cortese Emer O’Connor Wai Y. Yau Thomas Bourinaris Rauan Kaiyrzhanov Viorica Chelban Monika Madej Maria C. Diana Maria S. Vari Marina Pedemonte Claudio Bruno Ganna Balagura Marcello Scala Chiara Fiorillo Lino Nobili Nancy T. Malintan Maria N. Zanetti Shyam S. Krishnakumar Gabriele Lignani James E. C. Jepson Paolo Broda Simona Baldassari Pia Rossi Floriana Fruscione Francesca Madia Monica Traverso Patrizia De-Marco Belen Pérez-Dueñas Francina Munell Yamna Kriouile Mohamed El-Khorassani Blagovesta Karashova Daniela Avdjieva Hadil Kathom Radka Tincheva Lionel Van-Maldergem Wolfgang Nachbauer Sylvia Boesch Antonella Gagliano Elisabetta Amadori Jatinder S. Goraya Tipu Sultan Salman Kirmani Shahnaz Ibrahim Farida Jan Jun Mine Selina Banu Pierangelo Veggiotti Gian V. Zuccotti Michel D. Ferrari Arn M. J. Van Den Maagdenberg Alberto Verrotti Gian L. Marseglia Salvatore Savasta Miguel A. Soler Carmela Scuderi Eugenia Borgione Roberto Chimenz Eloisa Gitto Valeria Dipasquale Alessia Sallemi Monica Fusco Caterina Cuppari Maria C. Cutrupi Martino Ruggieri Armando Cama Valeria Capra Niccolò E. Mencacci Richard Boles Neerja Gupta Madhulika Kabra Savvas Papacostas Eleni Zamba-Papanicolaou Efthymios Dardiotis Shazia Maqbool Nuzhat Rana Osama Atawneh Shen Y. Lim Farooq Shaikh George Koutsis Marianthi Breza Domenico A. Coviello Yves A. Dauvilliers Issam AlKhawaja Mariam AlKhawaja Fuad Al-Mutairi Tanya Stojkovic Veronica Ferrucci Massimo Zollo Fowzan S. Alkuraya Maria Kinali Hamed Sherifa Hanene Benrhouma Ilhem B. Y. Turki Meriem Tazir Makram Obeid Sophia Bakhtadze Nebal W. Saadi Maha S. Zaki Chahnez C. Triki Fabio Benfenati Stefano Gustincich Majdi Kara Vincenzo Belcastro Nicola Specchio Giuseppe Capovilla Ehsan G. Karimiani Ahmed M. Salih Njideka U. Okubadejo Oluwadamilola O. Ojo Olajumoke O. Oshinaike Olapeju Oguntunde Kolawole Wahab Abiodun H. Bello Sanni Abubakar Yahaya Obiabo Ernest Nwazor Oluchi Ekenze Uduak Williams Alagoma Iyagba Lolade Taiwo Morenikeji Komolafe Konstantin Senkevich Chingiz Shashkin Nazira Zharkynbekova Kairgali Koneyev Ganieva Manizha Maksud Isrofilov Ulviyya Guliyeva Kamran Salayev Samson Khachatryan Salvatore Rossi Gabriella Silvestri Nourelhoda Haridy Luca A. Ramenghi Georgia Xiromerisiou Emanuele David Mhammed Aguennouz Liana Fidani Cleanthe Spanaki Arianna Tucci Miquel Raspall-Chaure Michael Chez Anne Tsai Emily Fassi Marwan Shinawi John N. Constantino Rita De Zorzi Sara Fortuna Fernando Kok Boris Keren Dominique Bonneau Murim Choi Bruria Benzeev Federico Zara Heather C. Mefford Ingrid E. Scheffer Jill Clayton-Smith Alfons Macaya James E. Rothman Evan E. Eichler Dimitri M. Kullmann Henry Houlden Springer US Nature Communications, doi:10.1038/s41467-019-10910-w 10.1038/s41467-019-10910-w http://dx.doi.org/10.1038/s41467-019-10910-w journal Nature Communications © 2019, The Author(s) 2041-1723 10.1038/s41467-019-10910-w springer.com springerlink.com 2010-04-23 True 10.1038/s41467-019-10910-w springer.com springerlink.com Springer 2019-07-08T18:33:06+02:00 2019-07-05T18:12:48+05:30 2019-07-08T18:33:06+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:29ca71bc-a407-45d8-a739-790a9717b54c uuid:0ff28c89-246a-4ed2-b772-ff57b6c24d3c default 1 converted uuid:0e1b4efc-0d99-48d3-a3ff-70da9886bfc1 converted to PDF/A-2b pdfToolbox 2019-07-05T18:13:30+05:30 2 B Oscar D. Bello http://orcid.org/0000-0001-5701-8365 Stephanie Efthymiou http://orcid.org/0000-0003-4900-9877 Lydie Burglen http://orcid.org/0000-0002-1119-6809 Stephanie Valence http://orcid.org/0000-0003-4530-4537 Erin Torti http://orcid.org/0000-0001-5790-1051 Andreas Lieb http://orcid.org/0000-0001-9567-649X Conceicao Bettencourt http://orcid.org/0000-0001-9090-7690 Roope Männikkö http://orcid.org/0000-0002-8727-9184 Alfredo Brusco http://orcid.org/0000-0002-8318-7231 Amy L. Schneider http://orcid.org/0000-0001-5260-7187 Alison M. Muir http://orcid.org/0000-0002-9420-085X Laura Schultz-Rogers http://orcid.org/0000-0002-7222-9985 Sara Fortuna http://orcid.org/0000-0002-8059-6064 Murim Choi http://orcid.org/0000-0002-9195-1455 Evan E. Eichler http://orcid.org/0000-0002-8246-4014 Dimitri M. Kullmann http://orcid.org/0000-0001-6696-3545 Henry Houlden http://orcid.org/0000-0002-2866-7777 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 312, 53, 382, 61 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 446, 53, 512, 61 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 71, 684, 75, 691 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 78, 684, 82, 691 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 128, 663, 132, 670 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 135, 663, 143, 670 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 248, 652, 255, 660 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 652, 266, 660 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 621, 187, 629 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 189, 621, 196, 629 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 600, 289, 608 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 67, 569, 71, 576 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 73, 569, 80, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 82, 569, 89, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 90, 569, 98, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 165, 527, 172, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 174, 527, 181, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 127, 495, 134, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 196, 471, 286, 481 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 191, 454, 194, 461 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 67, 401, 74, 409 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 78, 401, 85, 409 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 349, 289, 357 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 79, 126, 266, 135 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 427, 701, 431, 711 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 509, 612, 551, 622 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 602, 371, 611 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 391, 584, 398, 592 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 406, 529, 530, 538 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 480, 518, 484, 528 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 377, 354, 384, 362 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 375, 286, 383, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 479, 252, 484, 261 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 152, 171, 156, 181 Flags: Print AppearanceDictionary: true Destination: 116 Annotation: Subtype: Link Rect: 511, 318, 516, 327 Flags: Print AppearanceDictionary: true Destination: 144 Annotation: Subtype: Link Rect: 541, 318, 546, 327 Flags: Print AppearanceDictionary: true Destination: 162 Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 251, 189, 256, 198 Flags: Print AppearanceDictionary: true Destination: 198 Annotation: Subtype: Link Rect: 224, 56, 231, 64 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 233, 56, 240, 64 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 487, 189, 491, 198 Flags: Print AppearanceDictionary: true Destination: 198 Annotation: Subtype: Link Rect: 326, 136, 330, 146 Flags: Print AppearanceDictionary: true Destination: 198 Annotation: Subtype: Link Rect: 364, 53, 369, 62 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 175, 235, 179, 245 Flags: Print AppearanceDictionary: true Destination: 257 Annotation: Subtype: Link Rect: 149, 172, 154, 182 Flags: Print AppearanceDictionary: true Destination: 288 Annotation: Subtype: Link Rect: 285, 131, 289, 140 Flags: Print AppearanceDictionary: true Destination: 288 Annotation: Subtype: Link Rect: 152, 92, 159, 100 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 183, 89, 187, 98 Flags: Print AppearanceDictionary: true Destination: 288 Annotation: Subtype: Link Rect: 467, 49, 474, 56 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 476, 49, 483, 56 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 485, 49, 492, 56 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 136, 275, 141, 284 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 81, 236, 89, 244 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 90, 236, 98, 244 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 187, 226, 194, 234 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 195, 227, 202 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 169, 48, 176, 56 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 524, 631, 531, 639 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 534, 537, 538, 545 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 542, 537, 549, 545 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 482, 495, 489, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 424, 454, 427, 461 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 479, 433, 486, 440 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 422, 443, 430 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 322, 359, 329, 367 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 355, 328, 362, 336 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 364, 328, 371, 336 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 321, 244, 325, 252 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 323, 157, 328, 167 Flags: Print AppearanceDictionary: true Destination: 162 Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 509, 72, 514, 80 Flags: Print AppearanceDictionary: true Destination: 162 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 364, 600, 371, 608 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 542, 590, 549, 597 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 542, 527, 549, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 499, 495, 506, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 524, 192, 531, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 150, 511, 158 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 515, 150, 522, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 524, 150, 531, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 533, 150, 540, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 542, 150, 549, 158 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 519, 119, 522, 126 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 524, 119, 531, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 533, 119, 540, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 542, 119, 549, 126 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 275, 569, 282, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 284, 569, 291, 576 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 548, 135, 555 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 139, 548, 146, 555 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 260, 331, 264, 338 Flags: Print AppearanceDictionary: true Destination: 91 Annotation: Subtype: Link Rect: 131, 266, 137, 272 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 253, 266, 259, 272 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 260, 266, 266, 272 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 109, 249, 114, 255 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 116, 249, 121, 255 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 129, 232, 134, 238 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 178, 246, 186 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 261, 170, 283, 177 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 161, 96, 169 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 122, 242, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 88, 231, 94 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 325, 537, 328, 543 Flags: Print AppearanceDictionary: true Destination: 495 Annotation: Subtype: Link Rect: 392, 503, 397, 509 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 344, 460, 350, 466 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 400, 460, 406, 466 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 544, 393, 550, 399 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 326, 359, 332, 365 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 330, 299, 335, 305 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 337, 299, 342, 305 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 338, 274, 344, 280 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 347, 274, 353, 280 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 55, 691, 61, 697 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 574, 447, 580 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 405, 565, 410, 571 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 454, 554, 536, 562 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 345, 515, 351, 521 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 541, 489, 547, 495 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 505, 464, 510, 470 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 450, 447, 456, 453 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 491, 430, 497, 436 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 332, 410, 379, 418 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 424, 347, 548, 355 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 339, 357, 346 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 407, 339, 499, 346 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 324, 330, 433, 338 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 477, 314, 551, 321 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 305, 332, 313 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 468, 305, 547, 313 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 297, 330, 304 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 493, 297, 529, 304 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 288, 347, 296 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 450, 288, 538, 296 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 280, 326, 287 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 499, 280, 550, 287 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 348, 271, 439, 279 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 516, 271, 551, 279 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 263, 409, 270 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 514, 263, 533, 270 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 254, 356, 262 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 439, 254, 511, 262 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 246, 551, 253 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 237, 315, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 376, 237, 477, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 525, 237, 547, 245 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 229, 383, 236 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 229, 551, 236 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 220, 371, 228 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 422, 220, 481, 228 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 334, 134, 463, 141 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 463, 545, 551, 552 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 537, 340, 544 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 484, 538, 491 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 475, 371, 482 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 304, 551, 311 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 295, 346, 302 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 199, 414, 210 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 199, 414, 210 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 421, 199, 423, 210 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 411, 199, 423, 210 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 423, 199, 424, 210 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 183, 138, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 183, 138, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 145, 183, 147, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 183, 147, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 147, 183, 148, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 374, 183, 375, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 374, 183, 375, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 381, 183, 383, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 371, 183, 383, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 383, 183, 385, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 480, 183, 481, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 480, 183, 481, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 183, 490, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 183, 490, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 490, 183, 491, 194 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 167, 87, 178 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 86, 167, 87, 178 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 93, 167, 96, 178 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 84, 167, 96, 178 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 96, 167, 97, 178 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 279, 151, 280, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 279, 151, 280, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 286, 151, 289, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 277, 151, 289, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 289, 151, 290, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 147, 135, 148, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 147, 135, 148, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 154, 135, 157, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 145, 135, 157, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 157, 135, 158, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 249, 135, 250, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 249, 135, 250, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 256, 135, 259, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 135, 259, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 259, 135, 260, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 423, 135, 424, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 423, 135, 424, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 431, 135, 433, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 421, 135, 433, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 433, 135, 434, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 124, 55, 125, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 124, 55, 125, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 131, 55, 134, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 122, 55, 134, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 134, 55, 135, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 296, 55, 297, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 296, 55, 297, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 55, 306, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 294, 55, 306, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 55, 307, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 238, 722, 239, 733 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 238, 722, 239, 733 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 245, 722, 248, 733 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 236, 722, 248, 733 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 248, 722, 249, 733 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 642, 442, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 642, 442, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 448, 642, 451, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 438, 642, 451, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 451, 642, 452, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 282, 626, 283, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 282, 626, 283, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 290, 626, 292, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 280, 626, 292, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 292, 626, 293, 637 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 594, 111, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 110, 594, 111, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 117, 594, 120, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 108, 594, 120, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 594, 121, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 594, 238, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 594, 238, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 244, 594, 247, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 235, 594, 247, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 594, 248, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 594, 339, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 594, 339, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 345, 594, 347, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 335, 594, 347, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 347, 594, 349, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 372, 23, 487, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 07a4aa74 Type: CRC32 Checksum: b472f4246ed4e798b325f0a4b6dc8986 Type: MD5 Checksum: 1a3a877f952a6a706b45dc2eeab4a36814627cbb Type: SHA-1