edb88622ac1e69a930f0b280be8f806e pmc_31306552.pdf f64bab9e7f3a71342c086e59d8a0c9a6aca1b1c1 pmc_31306552.pdf 999830f13e2222a09a0750b7c0ce18f920426fd5f6bf62c6102c666268380543 pmc_31306552.pdf Title: Vitamin D differentially regulates colon stem cells in patient‐derived normal and tumor organoids Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Mon Jan 6 12:51:33 2020 CET ModDate: Mon Jan 6 12:51:33 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 20894686 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EPFMPL+AdvPSUnv Type 1C Custom yes yes no 277 0 EPFNDD+AdvPSSym Type 1C Custom yes yes yes 300 0 EPFNDE+AdvPSUnv-LO Type 1C WinAnsi yes yes no 301 0 EPFMPM+AdvPS-UVBL Type 1C MacRoman yes yes no 280 0 EPFMPN+AdvP4C4E59 Type 1C Custom yes yes yes 281 0 EPFNBN+AdvPSUnv-L Type 1C Custom yes yes no 282 0 EPFNBO+AdvPSUnv-B Type 1C MacRoman yes yes no 292 0 EPFNCP+AdvTimes Type 1C MacRoman yes yes no 293 0 EPFNDA+AdvPSMP13 Type 1C WinAnsi yes yes no 294 0 EPFNDB+AdvTimes-i Type 1C WinAnsi yes yes no 295 0 EPFNDC+AdvTTec369687 Type 1C WinAnsi yes yes no 296 0 EPGDKL+AdvP4C4E74 Type 1C Custom yes yes yes 192 0 EPGDLL+AdvTTec369687+20 Type 1C WinAnsi yes yes no 197 0 EPHMKJ+AdvTimes-b Type 1C WinAnsi yes yes no 200 0 EPIDBP+AdvTimes-bi Type 1C WinAnsi yes yes no 203 0 EPIDDP+AdvPSUnv-BO Type 1C WinAnsi yes yes no 151 0 EPIDLN+AdvTT689d5d16.B+20 Type 1C WinAnsi yes yes no 185 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:35:40 CEST RepresentationInformation: pmc_31306552.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:07:44 CET Size: 20894686 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0003' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0007' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0009' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0010' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0009' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0012' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0013' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0014' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0015' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0003' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0003' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0003' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0004' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0004' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0004' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0016' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0018' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0014' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0005' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0019' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0009' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0012' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0023' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0015' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0024' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0026' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0022' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0007' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0027' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0007' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0028' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0007' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0007' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0029' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0031' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0032' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0021' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0034' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0022' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0036' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0037' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0038' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0039' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0015' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0023' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0007' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0010' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0010' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0040' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0004' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0041' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0042' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0043' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0044' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0045' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0046' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0048' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0049' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0050' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0052' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0012' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-bib-0022' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0002' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0004' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0006' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0001' cannot be found Offset: 20887082 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lfebs14998-fig-0004' cannot be found Offset: 20887082 MIMEtype: application/pdf Profile: Linearized PDF, ISO PDF/A-1, Level B PDFMetadata: Objects: 316 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Info: Title: Vitamin D differentially regulates colon stem cells in patient‐derived normal and tumor organoids Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Mon Jan 06 13:21:33 CET 2020 ModDate: Mon Jan 06 13:21:33 CET 2020 ID: 0x1c0d4b49f7fed88c1f23cbdc082a8388, 0x3562e0bc54084257b2b73b39d839801e Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1933 ImageHeight: 2261 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1905 ImageHeight: 2571 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1940 ImageHeight: 2214 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1898 ImageHeight: 1763 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1901 ImageHeight: 2576 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1711 ImageHeight: 2579 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1861 ImageHeight: 2666 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: EPGDKL+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 48 FontDescriptor: FontName: EPGDKL+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EPFNBO+AdvPSUnv-B FontSubset: true FirstChar: 44 LastChar: 222 FontDescriptor: FontName: EPFNBO+AdvPSUnv-B Flags: Nonsymbolic FontBBox: -145, -218, 1000, 770 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EPFNCP+AdvTimes FontSubset: true FirstChar: 35 LastChar: 245 FontDescriptor: FontName: EPFNCP+AdvTimes Flags: Serif, Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EPGDLL+AdvTTec369687+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: EPGDLL+AdvTTec369687+20 Flags: Nonsymbolic FontBBox: -208, -208, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFNDA+AdvPSMP13 FontSubset: true FirstChar: 97 LastChar: 108 FontDescriptor: FontName: EPFNDA+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFNDB+AdvTimes-i FontSubset: true FirstChar: 41 LastChar: 121 FontDescriptor: FontName: EPFNDB+AdvTimes-i Flags: Nonsymbolic FontBBox: -253, -211, 1078, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFNDC+AdvTTec369687 FontSubset: true FirstChar: 43 LastChar: 176 FontDescriptor: FontName: EPFNDC+AdvTTec369687 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPHMKJ+AdvTimes-b FontSubset: true FirstChar: 44 LastChar: 120 FontDescriptor: FontName: EPHMKJ+AdvTimes-b Flags: Nonsymbolic FontBBox: -168, -210, 1002, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPIDBP+AdvTimes-bi FontSubset: true FirstChar: 103 LastChar: 103 FontDescriptor: FontName: EPIDBP+AdvTimes-bi Flags: Nonsymbolic FontBBox: -276, -210, 1076, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFNDD+AdvPSSym FontSubset: true FirstChar: 2 LastChar: 170 FontDescriptor: FontName: EPFNDD+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EPFNDE+AdvPSUnv-LO FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: EPFNDE+AdvPSUnv-LO Flags: Nonsymbolic FontBBox: -145, -187, 1135, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFMPL+AdvPSUnv FontSubset: true FirstChar: 25 LastChar: 146 FontDescriptor: FontName: EPFMPL+AdvPSUnv Flags: Nonsymbolic FontBBox: -156, -229, 1000, 791 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EPIDDP+AdvPSUnv-BO FontSubset: true FirstChar: 105 LastChar: 117 FontDescriptor: FontName: EPIDDP+AdvPSUnv-BO Flags: Nonsymbolic FontBBox: -145, -218, 1135, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFMPM+AdvPS-UVBL FontSubset: true FirstChar: 45 LastChar: 223 FontDescriptor: FontName: EPFMPM+AdvPS-UVBL Flags: Nonsymbolic FontBBox: -145, -208, 1000, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: EPFMPN+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: EPFMPN+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EPIDLN+AdvTT689d5d16.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: EPIDLN+AdvTT689d5d16.B+20 Flags: Nonsymbolic FontBBox: -208, -208, 1177, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: EPFNBN+AdvPSUnv-L FontSubset: true FirstChar: 25 LastChar: 150 FontDescriptor: FontName: EPFNBN+AdvPSUnv-L Flags: Nonsymbolic FontBBox: -145, -187, 1000, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2020-01-06T18:26:58+05:30 2020-01-06T18:26:58+05:30 2020-01-06T18:26:58+05:30 Acrobat Distiller 10.1.7 (Windows) 10.1111/febs.14998 10.1111/(ISSN)1742-4658 3 VoR 10.1111/febs.14998 application/pdf Vitamin D differentially regulates colon stem cells in patient‐derived normal and tumor organoids uuid:5fb226ae-620a-4879-8969-c24b4c2b9010 uuid:60abd0d4-011b-443d-a658-c41beb8b4b39 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 134, 594, 136, 604 Annotation: Subtype: Link Rect: 134, 594, 136, 604 Annotation: Subtype: Link Rect: 136, 594, 144, 605 Annotation: Subtype: Link Rect: 81, 257, 147, 265 Annotation: Subtype: Link Rect: 53, 247, 135, 254 Annotation: Subtype: Link Rect: 209, 34, 373, 41 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 189, 620, 199, 629 Destination: null Annotation: Subtype: Link Rect: 104, 548, 122, 558 Destination: null Annotation: Subtype: Link Rect: 197, 500, 222, 510 Destination: null Annotation: Subtype: Link Rect: 69, 452, 86, 462 Destination: null Annotation: Subtype: Link Rect: 102, 417, 112, 426 Destination: null Annotation: Subtype: Link Rect: 115, 369, 133, 378 Destination: null Annotation: Subtype: Link Rect: 240, 309, 250, 318 Destination: null Annotation: Subtype: Link Rect: 124, 273, 151, 283 Destination: null Annotation: Subtype: Link Rect: 436, 511, 446, 520 Destination: null Annotation: Subtype: Link Rect: 463, 439, 468, 449 Destination: null Annotation: Subtype: Link Rect: 337, 379, 342, 389 Destination: null Annotation: Subtype: Link Rect: 493, 344, 507, 353 Destination: null Annotation: Subtype: Link Rect: 477, 128, 481, 138 Destination: null Annotation: Subtype: Link Rect: 501, 116, 506, 126 Destination: null Annotation: Subtype: Link Rect: 383, 81, 388, 90 Destination: null Thumb: true Page: Label: 3 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 186, 666, 200, 676 Destination: null Annotation: Subtype: Link Rect: 189, 642, 194, 652 Destination: null Annotation: Subtype: Link Rect: 198, 607, 203, 616 Destination: null Annotation: Subtype: Link Rect: 281, 595, 296, 604 Destination: null Annotation: Subtype: Link Rect: 92, 583, 97, 592 Destination: null Annotation: Subtype: Link Rect: 252, 511, 257, 520 Destination: null Annotation: Subtype: Link Rect: 166, 379, 180, 389 Destination: null Annotation: Subtype: Link Rect: 158, 248, 162, 257 Destination: null Annotation: Subtype: Link Rect: 337, 678, 342, 688 Destination: null Annotation: Subtype: Link Rect: 382, 642, 387, 652 Destination: null Annotation: Subtype: Link Rect: 504, 619, 521, 628 Destination: null Annotation: Subtype: Link Rect: 470, 571, 475, 580 Destination: null Annotation: Subtype: Link Rect: 494, 535, 499, 544 Destination: null Annotation: Subtype: Link Rect: 337, 487, 342, 496 Destination: null Annotation: Subtype: Link Rect: 374, 260, 401, 269 Destination: null Annotation: Subtype: Link Rect: 345, 248, 360, 257 Destination: null Thumb: true Page: Label: 5 Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 104, 140, 109, 150 Destination: null Annotation: Subtype: Link Rect: 460, 140, 464, 150 Destination: null Annotation: Subtype: Link Rect: 479, 140, 522, 150 Annotation: Subtype: Link Rect: 299, 128, 313, 138 Destination: null Thumb: true Page: Label: 8 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 112, 512, 117, 522 Destination: null Annotation: Subtype: Link Rect: 212, 512, 260, 522 Annotation: Subtype: Link Rect: 76, 465, 81, 474 Destination: null Annotation: Subtype: Link Rect: 248, 441, 252, 450 Destination: null Annotation: Subtype: Link Rect: 242, 405, 247, 414 Destination: null Annotation: Subtype: Link Rect: 235, 381, 239, 390 Destination: null Annotation: Subtype: Link Rect: 182, 321, 209, 331 Destination: null Annotation: Subtype: Link Rect: 441, 489, 446, 498 Destination: null Annotation: Subtype: Link Rect: 462, 489, 508, 498 Destination: null Annotation: Subtype: Link Rect: 394, 453, 399, 462 Destination: null Annotation: Subtype: Link Rect: 463, 357, 468, 367 Destination: null Annotation: Subtype: Link Rect: 439, 321, 453, 331 Destination: null Annotation: Subtype: Link Rect: 365, 297, 369, 307 Destination: null Annotation: Subtype: Link Rect: 375, 202, 380, 211 Destination: null Annotation: Subtype: Link Rect: 508, 166, 513, 175 Destination: null Annotation: Subtype: Link Rect: 417, 118, 432, 127 Destination: null Annotation: Subtype: Link Rect: 405, 82, 410, 92 Destination: null Thumb: true Page: Label: 10 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 245, 590, 260, 600 Destination: null Annotation: Subtype: Link Rect: 162, 566, 167, 576 Destination: null Annotation: Subtype: Link Rect: 253, 554, 280, 564 Destination: null Annotation: Subtype: Link Rect: 78, 327, 125, 337 Annotation: Subtype: Link Rect: 181, 279, 196, 289 Destination: null Annotation: Subtype: Link Rect: 265, 244, 280, 253 Destination: null Annotation: Subtype: Link Rect: 365, 590, 369, 600 Destination: null Annotation: Subtype: Link Rect: 475, 590, 489, 600 Destination: null Annotation: Subtype: Link Rect: 299, 507, 348, 516 Annotation: Subtype: Link Rect: 424, 459, 428, 468 Destination: null Annotation: Subtype: Link Rect: 387, 399, 402, 408 Destination: null Annotation: Subtype: Link Rect: 486, 303, 491, 313 Destination: null Annotation: Subtype: Link Rect: 321, 255, 326, 265 Destination: null Annotation: Subtype: Link Rect: 376, 112, 405, 122 Destination: null Thumb: true Page: Label: 12 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 149, 501, 176, 511 Destination: null Annotation: Subtype: Link Rect: 152, 406, 169, 415 Destination: null Annotation: Subtype: Link Rect: 378, 573, 393, 583 Destination: null Annotation: Subtype: Link Rect: 479, 513, 506, 523 Destination: null Annotation: Subtype: Link Rect: 342, 453, 369, 463 Destination: null Annotation: Subtype: Link Rect: 340, 418, 367, 427 Destination: null Annotation: Subtype: Link Rect: 411, 370, 426, 379 Destination: null Annotation: Subtype: Link Rect: 510, 358, 525, 367 Destination: null Annotation: Subtype: Link Rect: 424, 310, 439, 320 Destination: null Annotation: Subtype: Link Rect: 475, 202, 489, 212 Destination: null Annotation: Subtype: Link Rect: 508, 95, 522, 104 Destination: null Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 96, 678, 111, 688 Destination: null Annotation: Subtype: Link Rect: 190, 654, 200, 664 Destination: null Annotation: Subtype: Link Rect: 148, 523, 163, 532 Destination: null Annotation: Subtype: Link Rect: 277, 451, 282, 461 Destination: null Annotation: Subtype: Link Rect: 150, 362, 230, 371 Annotation: Subtype: Link Rect: 69, 177, 94, 185 Destination: null Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 92, 661, 117, 670 Destination: null Annotation: Subtype: Link Rect: 357, 180, 371, 189 Destination: null Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 333, 611, 337, 620 Destination: null Annotation: Subtype: Link Rect: 370, 611, 375, 620 Destination: null Annotation: Subtype: Link Rect: 358, 313, 371, 322 Destination: null Annotation: Subtype: Link Rect: 437, 267, 451, 276 Destination: null Annotation: Subtype: Link Rect: 473, 244, 486, 253 Destination: null Annotation: Subtype: Link Rect: 314, 199, 328, 207 Destination: null Annotation: Subtype: Link Rect: 507, 199, 521, 207 Destination: null Annotation: Subtype: Link Rect: 504, 153, 529, 161 Destination: null Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 407, 669, 420, 677 Destination: null Annotation: Subtype: Link Rect: 391, 657, 404, 666 Destination: null Annotation: Subtype: Link Rect: 329, 531, 354, 540 Destination: null Annotation: Subtype: Link Rect: 499, 483, 512, 492 Destination: null Annotation: Subtype: Link Rect: 355, 403, 369, 412 Destination: null Annotation: Subtype: Link Rect: 369, 357, 382, 366 Destination: null Annotation: Subtype: Link Rect: 436, 222, 440, 231 Destination: null Annotation: Subtype: Link Rect: 460, 222, 464, 231 Destination: null Annotation: Subtype: Link Rect: 497, 222, 501, 231 Destination: null Annotation: Subtype: Link Rect: 347, 188, 352, 197 Destination: null Annotation: Subtype: Link Rect: 404, 153, 408, 162 Destination: null Thumb: true Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 190, 244, 238, 253 Annotation: Subtype: Link Rect: 69, 232, 117, 241 Annotation: Subtype: Link Rect: 188, 232, 236, 241 Thumb: true Page: Label: 19 Thumb: true Page: Label: 20 Thumb: true Checksum: fabced01 Type: CRC32 Checksum: edb88622ac1e69a930f0b280be8f806e Type: MD5 Checksum: f64bab9e7f3a71342c086e59d8a0c9a6aca1b1c1 Type: SHA-1