b63597a80e20a95b881fce3043079e7e pmc_31357396.pdf cd3bee1488a869df1faa5e0e2a4ef46a4fca9883 pmc_31357396.pdf 3f85e510cf9e695832411dcc0a3c179245ca2157b9964549c16ddbab895aa102 pmc_31357396.pdf Title: Simultaneous Voltammetric Determination of Acetaminophen, Ascorbic Acid and Uric Acid by Use of Integrated Array of Screen-Printed Electrodes and Chemometric Tools Subject: In the present work, ternary mixtures of Acetaminophen, Ascorbic acid and Uric acid were resolved using the Electronic tongue (ET) principle and Cyclic voltammetry (CV) technique. The screen-printed integrated electrode array having differentiated response for the three oxidizable compounds was formed by Graphite, Prussian blue (PB), Cobalt (II) phthalocyanine (CoPc) and Copper oxide (II) (CuO) ink-modified carbon electrodes. A set of samples, ranging from 0 to 500 molL-1, was prepared, using a tilted (33) factorial design in order to build the quantitative response model. Subsequently, the model performance was evaluated with an external subset of samples defined randomly along the experimental domain. Partial Least Squares Regression (PLS) was employed to construct the quantitative model. Finally, the model successfully predicted the concentration of the three compounds with a normalized root mean square error (NRMSE) of 1.00 and 0.99 for the training and test subsets, respectively, and R2 0.762 for the obtained vs. expected comparison graphs. In this way, a screen-printed integrated electrode platform can be successfully used for voltammetric ET applications. Keywords: electronic tongue; modifiers; acetaminophen; ascorbic acid; uric acid; partial least squares regression Author: Dionisia Ortiz-Aguayo, Marta Bonet-San-Emeterio and Manel del Valle Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Jul 26 09:03:01 2019 CEST ModDate: Fri Jul 26 09:03:01 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4053797 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VSBOHP+URWPalladioL-Ital Type 1 Custom yes yes no 102 0 ONBTZY+URWPalladioL-Bold Type 1 Custom yes yes no 103 0 PBTADS+URWPalladioL-Roma Type 1 Custom yes yes no 104 0 EVENKJ+VnURWPalladioL Type 1 Custom yes yes no 105 0 FATHTC+Rpxr Type 1 Builtin yes yes no 106 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 107 0 RYNHBZ+Pxsy Type 1 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no 553 0 UEOHJE+Pxex Type 1 Builtin yes yes no 554 0 IJNMAH+PalatinoLinotype CID TrueType Identity-H yes yes yes 560 0 IJNMDH+PalatinoLinotype TrueType WinAnsi yes yes no 561 0 IJNMIH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 562 0 IJNMJI+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 563 0 IJNMJJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 564 0 IJNNAH+TimesNewRoman CID TrueType Identity-H yes yes yes 565 0 IJODFC+CambriaMath CID TrueType Identity-H yes yes yes 566 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 663 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-19 06:11:34 CET RepresentationInformation: pmc_31357396.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-03 03:40:51 CEST Size: 4053797 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとづねどっちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰げづちでづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはのどっぜ〴ぜ〰ごはのでふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きはつどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅぬづっぴひはつづぜ〴ぜ〰こふひてちっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰こっちののどのでぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぃとづねどっちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰げづちでづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはのどっぜ〴ぜ〰ごはのでふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きはつどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅぬづっぴひはつづぜ〴ぜ〰こふひてちっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰こっちののどのでぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅぬづっぴひはのどっぜ〴ぜ〰ごはのでふづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きはつどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅぬづっぴひはつづぜ〴ぜ〰こふひてちっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰こっちののどのでぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きはつどてどっちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅぬづっぴひはつづぜ〴ぜ〰こふひてちっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰こっちののどのでぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰こっちののどのでぜ〴ぜ〰ぅぬづっぴひはのぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こちねばぬづぜ〴ぜ〰ぐひづばちひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いちぴちぜ〴ぜ〰ぐひはっづびびどのでぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴ぜ〰ちのつぜ〴ぜ〰いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こふひてちっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ざはぬぴちねねづぴひどっぜ〴ぜ〰ぁひひちべぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きはつどてどづつぜ〴ぜ〰ぉのぴづでひちぴづつぜ〴ぜ〰こっひづづの〭ぐひどのぴづつぜ〴ぜ〰ぅぬづっぴひはつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Children: Item: Title: ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こふひてちっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ざはぬぴちねねづぴひどっぜ〴ぜ〰ぁひひちべぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きはつどてどづつぜ〴ぜ〰ぉのぴづでひちぴづつぜ〴ぜ〰こっひづづの〭ぐひどのぴづつぜ〴ぜ〰ぅぬづっぴひはつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Item: Title: ざはぬぴちねねづぴひどっぜ〴ぜ〰ぁひひちべぜ〴ぜ〰げづびばはのびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きはつどてどづつぜ〴ぜ〰ぉのぴづでひちぴづつぜ〴ぜ〰こっひづづの〭ぐひどのぴづつぜ〴ぜ〰ぅぬづっぴひはつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Item: Title: ぃとちひちっぴづひどぺちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰きはつどてどづつぜ〴ぜ〰ぉのぴづでひちぴづつぜ〴ぜ〰こっひづづの〭ぐひどのぴづつぜ〴ぜ〰ぅぬづっぴひはつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Children: Item: Title: ぃちぬどぢひちぴどはのぜ〴ぜ〰ぃふひぶづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸲ Item: Title: こぴちぢどぬどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰げづばひはつふっどぢどぬどぴべぜ〴ぜ〰こぴふつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰けふちぬどぴちぴどぶづぜ〴ぜ〰ぁのちぬべびどび〺ぜ〴ぜ〰ぐひどのっどばちぬぜ〴ぜ〰ぃはねばはのづのぴぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰ぜ〵ぜ〰ぐぃぁぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぁのちぬべびどび〺ぜ〴ぜ〰ぐちひぴどちぬぜ〴ぜ〰がづちびぴぜ〴ぜ〰こぱふちひづびぜ〴ぜ〰ぜ〵ぜ〰ぐがこぜ〵ㅜ〰ぜ〴ぜ〰げづでひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: けふちぬどぴちぴどぶづぜ〴ぜ〰ぁのちぬべびどび〺ぜ〴ぜ〰ぐひどのっどばちぬぜ〴ぜ〰ぃはねばはのづのぴぜ〴ぜ〰ぁのちぬべびどびぜ〴ぜ〰ぜ〵ぜ〰ぐぃぁぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰けふちのぴどぴちぴどぶづぜ〴ぜ〰ぁのちぬべびどび〺ぜ〴ぜ〰ぐちひぴどちぬぜ〴ぜ〰がづちびぴぜ〴ぜ〰こぱふちひづびぜ〴ぜ〰ぜ〵ぜ〰ぐがこぜ〵ㅜ〰ぜ〴ぜ〰げづでひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: けふちのぴどぴちぴどぶづぜ〴ぜ〰ぁのちぬべびどび〺ぜ〴ぜ〰ぐちひぴどちぬぜ〴ぜ〰がづちびぴぜ〴ぜ〰こぱふちひづびぜ〴ぜ〰ぜ〵ぜ〰ぐがこぜ〵ㅜ〰ぜ〴ぜ〰げづでひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: 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