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7f1c3c6a-ab97-11e9-0000-e11bf34aa00e uuid:3dcfbf6f-0867-4311-a926-36e2b21a783c application/pdf Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms Roger Colobran and Ricardo Pujol-Borrell Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. 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Subtype: Link Rect: 365, 238, 430, 245 Annotation: Subtype: Link Rect: 331, 209, 411, 217 Annotation: Subtype: Link Rect: 331, 179, 411, 188 Annotation: Subtype: Link Rect: 386, 153, 453, 160 Annotation: Subtype: Link Rect: 331, 115, 407, 123 Annotation: Subtype: Link Rect: 331, 77, 411, 85 Annotation: Subtype: Link Rect: 43, 28, 117, 36 Annotation: Subtype: Link Rect: 120, 28, 180, 36 Annotation: Subtype: Link Rect: 441, 28, 551, 37 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 70, 680, 138, 687 Annotation: Subtype: Link Rect: 70, 651, 142, 659 Annotation: Subtype: Link Rect: 129, 612, 195, 621 Annotation: Subtype: Link Rect: 122, 576, 187, 583 Annotation: Subtype: Link Rect: 70, 537, 169, 545 Annotation: Subtype: Link Rect: 108, 499, 205, 508 Annotation: Subtype: Link Rect: 70, 460, 137, 470 Annotation: Subtype: Link Rect: 198, 433, 254, 441 Annotation: Subtype: Link Rect: 178, 414, 275, 422 Annotation: Subtype: Link Rect: 169, 396, 254, 403 Annotation: Subtype: Link Rect: 178, 366, 241, 375 Annotation: Subtype: Link Rect: 70, 328, 151, 337 Annotation: Subtype: Link Rect: 70, 292, 120, 299 Annotation: Subtype: Link Rect: 70, 252, 150, 261 Annotation: Subtype: Link Rect: 292, 194, 56, 215 Annotation: Subtype: Link Rect: 70, 157, 136, 166 Annotation: Subtype: Link Rect: 70, 129, 147, 138 Annotation: Subtype: Link Rect: 70, 73, 170, 82 Annotation: Subtype: Link Rect: 426, 661, 489, 668 Annotation: Subtype: Link Rect: 331, 631, 418, 640 Annotation: Subtype: Link Rect: 444, 602, 514, 612 Annotation: Subtype: Link Rect: 331, 564, 419, 574 Annotation: Subtype: Link Rect: 368, 527, 434, 536 Annotation: Subtype: Link Rect: 331, 490, 380, 498 Annotation: Subtype: Link Rect: 474, 451, 537, 460 Annotation: Subtype: Link Rect: 467, 413, 551, 422 Annotation: Subtype: Link Rect: 365, 385, 434, 394 Annotation: Subtype: Link Rect: 331, 347, 415, 356 Annotation: Subtype: Link Rect: 476, 320, 522, 327 Annotation: Subtype: Link Rect: 457, 282, 536, 290 Annotation: Subtype: Link Rect: 331, 243, 419, 252 Annotation: Subtype: Link Rect: 331, 197, 386, 204 Annotation: Subtype: Link Rect: 405, 121, 431, 128 Annotation: Subtype: Link Rect: 431, 121, 463, 128 Annotation: Subtype: Link Rect: 463, 121, 499, 128 Annotation: Subtype: Link Rect: 499, 121, 522, 128 Annotation: Subtype: Link Rect: 522, 120, 549, 128 Annotation: Subtype: Link Rect: 43, 29, 117, 37 Annotation: Subtype: Link Rect: 120, 29, 180, 37 Annotation: Subtype: Link Rect: 441, 29, 551, 38 Checksum: a5e7212f Type: CRC32 Checksum: a80ec90ba49f2ab92165c6e319258fff Type: MD5 Checksum: d1840bfb6f4e25240ecfbaf11f537c1ef1966105 Type: SHA-1