76b6f8a779cbf5f33570dd391e46d4ee pmc_31395819.pdf a29e9b79e344d94aa068aeafa03266c9f5c129c5 pmc_31395819.pdf 8086230129b92bc4c5c91527a9b1590e132d8acdefd2dc4d74cc86dc3db420b4 pmc_31395819.pdf Title: GRP94 Is Involved in the Lipid Phenotype of Brain Metastatic Cells Subject: Metabolic adaptation may happen in response to the pressure exerted by the microenvironment and is a key step in survival of metastatic cells. Brain metastasis occurs as a consequence of the systemic dissemination of tumor cells, a fact that correlates with poor prognosis and high morbidity due to the difficulty in identifying biomarkers that allow a more targeted therapy. Previously, we performed transcriptomic analysis of human breast cancer patient samples and evaluated the differential expression of genes in brain metastasis (BrM) compared to lung, bone and liver metastasis. Our network approach identified upregulation of glucose-regulated protein 94 (GRP94) as well as proteins related to synthesis of fatty acids (FA) in BrM. Here we report that BrM cells show an increase in FA content and decreased saturation with regard to parental cells measured by Raman spectroscopy that differentiate BrM from other metastases. Moreover, BrM cells exerted a high ability to oxidize FA and compensate hypoglycemic stress due to an overexpression of proteins involved in FA synthesis and degradation (SREBP-1, LXR, ACOT7). GRP94 ablation restored glucose dependence, down-regulated ACOT7 and SREBP-1 and decreased tumorigenicity in vivo. In conclusion, GRP94 is required for the metabolic stress survival of BrM cells, and it might act as a modulator of lipid metabolism to favor BrM progression. Keywords: GRP94; brain metastasis; endoplasmic reticulum stress; fatty acids Author: Naiara Santana-Codina, Anna Marcé-Grau, Laia Muixí, Claudia Nieva, Mónica Marro, David Sebastián, Juan Pablo Muñoz, Antonio Zorzano and Angels Sierra Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Fri Aug 9 07:57:58 2019 CEST ModDate: Fri Aug 9 07:57:58 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3340576 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UDSRPZ+URWPalladioL-Ital Type 1 Custom yes yes no 99 0 EAALOZ+URWPalladioL-Bold Type 1 Custom yes yes no 100 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 101 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 102 0 LKIBGH+URWPalladioL-Roma Type 1 Custom yes yes no 103 0 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437 0 CKLDNP+PalatinoLinotype TrueType WinAnsi yes yes no 438 0 CKLECA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 439 0 CKLECC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 440 0 CKLDMP+PalatinoLinotype CID TrueType Identity-H yes yes yes 490 0 CKLFCA+TimesNewRoman CID TrueType Identity-H yes yes yes 491 0 CKLDNP+PalatinoLinotype TrueType WinAnsi yes yes no 492 0 CKLECA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 493 0 CKLECC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 494 0 YICMPF+Rpcxr Type 1 Builtin yes yes no 560 0 LGZKLX+Rpxi Type 1 Builtin yes yes no 651 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:33:17 CEST RepresentationInformation: pmc_31395819.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-16 03:43:23 CET Size: 3340576 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰あひちどのぜ〴ぜ〰きづぴちびぴちぴどっぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぉのっひづちびづぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぜ〵ぜ〰ごうぁぜ〵ㅜ〰ぜ〴ぜ〰ちのつぜ〴ぜ〰いづっひづちびづぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰さのびちぴふひちぴづつぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぜ〵ぜ〰ごさうぁぜ〵ㅜ〰ぜ〴ぜ〰ぃはのぴづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うぁぜ〴ぜ〰ぉねばはひぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰きどぴはっとはのつひどちぜ〴ぜ〰ぉねばちどひびぜ〴ぜ〰あひきぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ちてぴづひぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴひづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぇげぐ〹〴ぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ごふねはひぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴぜ〴ぜ〰きはつふぬちぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がどばはでづのどっぜ〴ぜ〰ぐとづのはぴべばづぜ〴ぜ〰はてぜ〴ぜ〰あひちどのぜ〴ぜ〰きづぴちびぴちぴどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: あひちどのぜ〴ぜ〰きづぴちびぴちぴどっぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぉのっひづちびづぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぜ〵ぜ〰ごうぁぜ〵ㅜ〰ぜ〴ぜ〰ちのつぜ〴ぜ〰いづっひづちびづぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰さのびちぴふひちぴづつぜ〴ぜ〰うちぴぴべぜ〴ぜ〰ぁっどつぜ〴ぜ〰ぜ〵ぜ〰ごさうぁぜ〵ㅜ〰ぜ〴ぜ〰ぃはのぴづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うぁぜ〴ぜ〰ぉねばはひぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰きどぴはっとはのつひどちぜ〴ぜ〰ぉねばちどひびぜ〴ぜ〰あひきぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ちてぴづひぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴひづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぇげぐ〹〴ぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ごふねはひぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴぜ〴ぜ〰きはつふぬちぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がどばはでづのどっぜ〴ぜ〰ぐとづのはぴべばづぜ〴ぜ〰はてぜ〴ぜ〰あひちどのぜ〴ぜ〰きづぴちびぴちぴどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのとどぢどぴどはのぜ〴ぜ〰はてぜ〴ぜ〰うぁぜ〴ぜ〰ぉねばはひぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰きどぴはっとはのつひどちぜ〴ぜ〰ぉねばちどひびぜ〴ぜ〰あひきぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ちてぴづひぜ〴ぜ〰きづぴちぢはぬどっぜ〴ぜ〰こぴひづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぇげぐ〹〴ぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ごふねはひぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴぜ〴ぜ〰きはつふぬちぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がどばはでづのどっぜ〴ぜ〰ぐとづのはぴべばづぜ〴ぜ〰はてぜ〴ぜ〰あひちどのぜ〴ぜ〰きづぴちびぴちぴどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぇげぐ〹〴ぜ〴ぜ〰ぉびぜ〴ぜ〰げづぱふどひづつぜ〴ぜ〰てはひぜ〴ぜ〰ごふねはひぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ちのつぜ〴ぜ〰ぉぴぜ〴ぜ〰きはつふぬちぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がどばはでづのどっぜ〴ぜ〰ぐとづのはぴべばづぜ〴ぜ〰はてぜ〴ぜ〰あひちどのぜ〴ぜ〰きづぴちびぴちぴどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰うぬふはひづびっづのぴぜ〴ぜ〰こぴちどのどのでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぢぬづぜ〴ぜ〰ぇげぐ〹〴ぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰かのはっにつはぷのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Children: Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ごひづちぴねづのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰うぬふはひづびっづのぴぜ〴ぜ〰こぴちどのどのでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぢぬづぜ〴ぜ〰ぇげぐ〹〴ぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰かのはっにつはぷのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰うぬふはひづびっづのぴぜ〴ぜ〰こぴちどのどのでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぢぬづぜ〴ぜ〰ぇげぐ〹〴ぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰かのはっにつはぷのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: うぬふはひづびっづのぴぜ〴ぜ〰こぴちどのどのでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぢぬづぜ〴ぜ〰ぇげぐ〹〴ぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰かのはっにつはぷのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: こぴちぢぬづぜ〴ぜ〰ぇげぐ〹〴ぜ〴ぜ〰ぐひはぴづどのぜ〴ぜ〰かのはっにつはぷのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぐひはぴづどのぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぐひはぴづどのぜ〴ぜ〰ぅへばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: 〱〴ぃ〭ぐちねどぴちぴづぜ〴ぜ〰くへどつちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: ぁのどねちぬぜ〴ぜ〰きはつづぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: げちねちのぜ〴ぜ〰こばづっぴひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: UDSRPZ+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: UDSRPZ+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 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