872d766a9c23bbb112626f86b472b1af pmc_31396074.pdf ce7577269ba67a95a7931f17efaf49ba165c8c98 pmc_31396074.pdf 4882b6f167c8778c4a8c14bef81115c59e035ba4d2841375ca5eab9216e4c83d pmc_31396074.pdf Title: Neuropsychiatric Symptoms as Predictors of Clinical Course in Neurodegeneration. A Longitudinal Study Subject: Background: To study the extent to which neuropsychiatric symptoms (NPS) influence the cognitive and functional decline in frontotemporal degeneration (FTD) and Alzheimer's disease (AD). Keywords: frontotemporal dementia, Alzheimer's disease, behavioral disturbances, depression, cohort studies, assessment of cognitive disorders/dementia Author: José Manuel Santacruz Escudero and Hernando Santamaría-García Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Wed Jul 24 13:52:53 2019 CEST ModDate: Wed Jul 24 13:49:34 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 928398 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KDIWWL+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 770 0 YQLHNJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 771 0 LVZFME+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 772 0 KSODRM+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 773 0 FWRVUP+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 774 0 FVXGPG+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 492 0 FNMZFV+MinionPro-Regular Type 1 Custom yes yes no 491 0 GNDJNH+MinionPro-It Type 1 Custom yes yes no 483 0 VSLMAD+MinionPro-Bold Type 1 Custom yes yes no 496 0 HNJOYJ+RMTMI Type 1 Builtin yes yes no 500 0 GDNWHS+MTSYN Type 1 Builtin yes yes no 501 0 NFYLJP+MinionPro-BoldIt Type 1 Custom yes yes no 505 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:33:16 CEST RepresentationInformation: pmc_31396074.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 04:03:27 CET Size: 928398 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 953 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Neuropsychiatric Symptoms as Predictors of Clinical Course in Neurodegeneration. A Longitudinal Study Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Participants Item: Title: Initial Clinical Considerations in AD and FTD Patients Children: Item: Title: AD Patients Item: Title: FTD Patients Item: Title: Assessment Milestones Item: Title: Cognitive Assessment Item: Title: Assessment of Instrumental Functionality Item: Title: Assessment of Physical Functionality Children: Item: Title: Assessment of Neuropsychiatric Symptoms (NPS) Item: Title: The Neuropsychiatric Inventory (NPI) Children: Item: Title: Data Analysis Item: Title: Analyses of Longitudinal Progression Measures and Predictive Factors Item: Title: Disease Progression Item: Title: Mediation Analyses Item: Title: RESULTS Children: Item: Title: First Stage of Assessment Item: Title: Second Stage of Assessment Item: Title: Progression Indexes Item: Title: Neuropsychiatric Symptoms and Progression in Cognitive and Functional Measures Children: Item: Title: AD Group Item: Title: FTD Group Item: Title: Regression Analyses According to the Subgroups of Disease Progression Children: Item: Title: AD Group Item: Title: FTD Group Item: Title: Mediation Analyses Children: Item: Title: AD Group Item: Title: FTD Group Item: Title: DISCUSSION Item: Title: CONCLUSION Item: Title: ETHICS STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: ACKNOWLEDGMENTS Item: Title: REFERENCES Info: Title: Neuropsychiatric Symptoms as Predictors of Clinical Course in Neurodegeneration. A Longitudinal Study Author: José Manuel Santacruz Escudero and Hernando Santamaría-García Subject: Background: To study the extent to which neuropsychiatric symptoms (NPS) influence the cognitive and functional decline in frontotemporal degeneration (FTD) and Alzheimer's disease (AD). Keywords: frontotemporal dementia, Alzheimer's disease, behavioral disturbances, depression, cohort studies, assessment of cognitive disorders/dementia Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Wed Jul 24 14:22:53 CEST 2019 ModDate: Wed Jul 24 14:19:34 CEST 2019 ID: 0xe8a65493a01be18af23edbf5482c0894, 0xf90351d38620d14f9e41eaafe93b2071 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VSLMAD+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 116 FontDescriptor: FontName: VSLMAD+MinionPro-Bold Flags: Symbolic FontBBox: -317, -358, 1684, 1024 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KDIWWL+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: KDIWWL+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -164, -212, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YQLHNJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: YQLHNJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -164, -216, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GNDJNH+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 237 FontDescriptor: FontName: GNDJNH+MinionPro-It Flags: Symbolic FontBBox: -199, -358, 1684, 1002 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LVZFME+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 2 LastChar: 242 FontDescriptor: FontName: LVZFME+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -163, -212, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HNJOYJ+RMTMI FontSubset: true FirstChar: 12 LastChar: 60 FontDescriptor: FontName: HNJOYJ+RMTMI Flags: Symbolic FontBBox: 0, -213, 987, 680 FontFile: true Font: BaseFont: KSODRM+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 237 FontDescriptor: FontName: KSODRM+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -163, -216, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GDNWHS+MTSYN FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: GDNWHS+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: FWRVUP+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 39 LastChar: 124 FontDescriptor: FontName: FWRVUP+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -164, -216, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: NFYLJP+MinionPro-BoldIt FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: NFYLJP+MinionPro-BoldIt Flags: Symbolic FontBBox: -228, -358, 1684, 1032 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FNMZFV+MinionPro-Regular FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: FNMZFV+MinionPro-Regular Flags: Symbolic FontBBox: -288, -358, 1684, 989 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FVXGPG+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: FVXGPG+HelveticaNeueLTStd-Md Flags: Symbolic FontBBox: -163, -219, 1066, 952 FontFile: true EncodingDictionary: Differences: true XMP: 2019-07-24T17:22:53+05:30 LaTeX with hyperref package 2019-07-24T17:19:34+05:30 2019-07-24T17:19:34+05:30 application/pdf Background: To study the extent to which neuropsychiatric symptoms (NPS) influence the cognitive and functional decline in frontotemporal degeneration (FTD) and Alzheimer's disease (AD). José Manuel Santacruz Escudero and Hernando Santamaría-García Neuropsychiatric Symptoms as Predictors of Clinical Course in Neurodegeneration. 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