30d720df70a9bda7fc3080c1b1c8a099 pmc_31462706.pdf 63b5b03659329a463eea49687e5f37e354acdc2c pmc_31462706.pdf 22a6c552077a9404435ed06384bee765ef320e0e9260c9818b320d761e3a18ab pmc_31462706.pdf Title: LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells Subject: Oncogene, doi:10.1038/s41388-019-0969-1 Keywords: Author: J. P. 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PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Generating an H3K4ox-specific antibody Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: H3K4ox maps to heterochromatin and controls chromatin accessibility in TNBC cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Chromatin structure alterations activate DDR in a LOXL2-dependent manner Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: LOXL2 KD activates DDR independently of DNA damage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Alterations in chromatin compaction activate the DDR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: LOXL2 reduction enhances chemosensitivity of TNBC cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Cell lines, transfections, and infections Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Antibodies and other reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Cell extracts, histone isolation, and PDX extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Recombinant LOXL2 purification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Oxidation reaction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Dot blot assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: ChIP experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: ATAC-seq and ATAC-qPCR experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: RNA-seq analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Differential expression analysis of transposable elements (TEs) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Replicate correlation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Analysis of ATAC peaks that overlap with H3K4ox peaks Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Integrated analysis of H3K4ox and ATAC peaks, and differentially expressed genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Inhibition of RNA synthesis, ATM kinase, and cell cycle analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Non-replicative cell experiment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Comet assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Rescue experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Immunofluorescence, image acquisition, and analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Metaphase spreads Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Cellular viability experiment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Cancer PDXs and treatments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Children: Item: Title: Compliance with ethical standards Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Info: Title: LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells Author: J. P. 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H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells J. P. Cebrià-Costa L. Pascual-Reguant A. Gonzalez-Perez G. Serra-Bardenys J. Querol M. Cosín G. Verde R. A. Cigliano W. Sanseverino S. Segura-Bayona A. Iturbide D. Andreu P. Nuciforo C. Bernado-Morales V. Rodilla J. Arribas J. Yelamos A. Garcia Herreros T. H. Stracker S. Peiró Springer US Oncogene, doi:10.1038/s41388-019-0969-1 10.1038/s41388-019-0969-1 http://dx.doi.org/10.1038/s41388-019-0969-1 journal Oncogene © 2019, The Author(s) 1476-5594 10.1038/s41388-019-0969-1 springer.com springerlink.com 2010-04-23 True 10.1038/s41388-019-0969-1 springer.com springerlink.com Springer 2019-12-14T14:25:46+05:30 2019-12-14T14:24:32+05:30 2019-12-14T14:25:46+05:30 True VoR uuid:65cf3717-4b5a-40fc-b29e-93e54ee19140 uuid:33d33cc8-b38d-4ca6-bac2-7077df1d439f default 1 converted uuid:70380588-9ef1-4292-bc9a-5d13246fbb12 converted to PDF/A-2b pdfToolbox 2019-12-14T14:25:46+05:30 2 B G. Verde http://orcid.org/0000-0003-4768-0165 W. Sanseverino http://orcid.org/0000-0003-3324-5912 S. Segura-Bayona http://orcid.org/0000-0001-7788-9889 D. Andreu http://orcid.org/0000-0002-6317-6666 P. Nuciforo http://orcid.org/0000-0003-1380-0990 T. H. Stracker http://orcid.org/0000-0002-8650-2081 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). 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