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Title:          Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells
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     Item: 
      Title: Dual lysosomal-„mitochondrial targeting by antihistamines to eradicate leukaemic cells
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       Item: 
        Title: 1. Introduction
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        Title: 2. Materials and methods
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         Item: 
          Title: 2.1. AML cell lines and cell cultures
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         Item: 
          Title: 2.2. Primary samples
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         Item: 
          Title: 2.3. Drugs and antibodies
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         Item: 
          Title: 2.4. Cytotoxicity assays
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         Item: 
          Title: 2.5. Proliferation assay
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         Item: 
          Title: 2.6. Clonogenicity assay
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       Item: 
        Title: Evidence before this study
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       Item: 
        Title: Added value of this study
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       Item: 
        Title: Implications of all the available evidence
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         Item: 
          Title: 2.7. In vivo studies
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         Item: 
          Title: 2.8. HRH1 immunofluorescence
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          Title: 2.9. Lysotracker
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          Title: 2.10. Lysosomal membrane permeabilization
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         Item: 
          Title: 2.11. Cyto-ID staining
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          Title: 2.12. LC3B immunoblotting
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          Title: 2.13. Mitochondrial reactive oxygen species (ROS)
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          Title: 2.14. Rhodamine 123 assay
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          Title: 2.15. CaspaseGlo assay
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          Title: 2.16. Annexin V staining
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          Title: 2.17. Flow cytometry
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          Title: 2.18. Statistics
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          Title: 2.19. Ethics approval
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          Title: 2.20. Availability of data and materials
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        Title: 3. Results
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          Title: 3.1. A group of antihistamines displayed antileukaemic effects
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          Title: 3.2. ANHA treatment selectively impaired the leukaemia regeneration capacity in vivo
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          Title: 3.3. ANHA antineoplastic effect was not mediated by HRH1
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          Title: 3.4. ANHAs perturbed lysosomes in AML cells
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          Title: 3.5. ANHAs damaged the mitochondrial compartment
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        Title: 4. Discussion
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        Title: Author contributions
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        Title: Declaration of Competing Interest
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        Title: Acknowledgements
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        Title: Appendix A. Supplementary data
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        Title: References
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  Checksum: 7d0e1d6f
   Type: CRC32
  Checksum: 3187b7309b9afa4b14d3c3ba8d0cfd35
   Type: MD5
  Checksum: 6103ace8d8900c8b09c6f245f6092605e949ea01
   Type: SHA-1