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CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods and analysis Children: Item: Title: Study design Children: Item: Title: Primary objectives Item: Title: Secondary objectives Item: Title: Patient reported outcome measurements Item: Title: Patient and public involvement Item: Title: Study population Children: Item: Title: Eligibility and enrolment Item: Title: Determination of sample size and dose-escalation procedure Item: Title: Study medication Item: Title: Trial intervention: tolDC administration Item: Title: Primary outcome measures Children: Item: Title: Safety Item: Title: Feasibility Item: Title: Secondary outcome measures Children: Item: Title: Clinical evaluation Item: Title: MRI acquisition 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