4cbff7a023d772d9fbccf3f6bae603a8 pmc_31530855.pdf 6c45131f2aec581b115ff900e428a03411d86624 pmc_31530855.pdf ee8b152acbc7f9068d632880ab07abba2708c1d0d000622ea1ef90e76ad65042 pmc_31530855.pdf Title: Estimating dyskinesia severity in Parkinson’s disease by using a waist-worn sensor: concurrent validity study Subject: Scientific Reports, doi:10.1038/s41598-019-49798-3 Keywords: Author: Alejandro Rodramp#x000ED;guez-Molinero Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Sep 10 08:11:05 2019 CEST ModDate: Wed Sep 11 10:42:15 2019 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1361322 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UIDQUE+Corbel-Bold CID TrueType Identity-H yes yes yes 53 0 PQAKXO+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 208 0 MinionPro-It Type 1C Custom yes no yes 108 0 EuclidSymbol-Bold Type 1C Custom yes no yes 209 0 YUIMSP+Corbel-Bold2 Type 1C WinAnsi yes yes yes 55 0 MinionPro-Regular Type 1C Custom yes no yes 54 0 PFHEUP+Corbel2 Type 1C WinAnsi yes yes yes 57 0 INKBIC+Corbel CID TrueType Identity-H yes yes yes 58 0 MyriadPro-It Type 1C WinAnsi yes no yes 59 0 PFHEUP+Corbel2 Type 1C WinAnsi yes yes yes 153 0 EuclidSymbol Type 1C Custom yes no yes 56 0 MinionPro-Bold Type 1C Custom yes no yes 86 0 SRCDNI+STIXGeneral-Regular Type 1C Custom yes yes yes 109 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:28:12 CEST RepresentationInformation: pmc_31530855.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 03:57:55 CET Size: 1361322 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_49798.indd:Figure 1. Schematic representation of the signal treatment and the statistical analysis process.:39' cannot be found Offset: 831885 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_49798.indd:Figure 2. Correlation of total Unified Dyskinesia Rating Scale score with sensor output.:42' cannot be found Offset: 831885 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_49798.indd:Figure 3. Correlation of lower-limb Unified Dyskinesia Rating Scale scores with sensor output.:43' cannot be found Offset: 831885 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_49798.indd: Table 2. Spearman’s correlation between the dyskinesia algorithm and the Unified Dyskinesia Rating Scale. Bold type: statistically significant finding.:44' cannot be found Offset: 831885 MIMEtype: application/pdf PDFMetadata: Objects: 273 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Estimating dyskinesia severity in Parkinson’s disease by using a waist-worn sensor: concurrent validity study Children: Item: Title: Methods Item: Title: Results Item: Title: Discussion Item: Title: Acknowledgements Item: Title: Figure 1 Schematic representation of the signal treatment and the statistical analysis process. Item: Title: Figure 2 Correlation of total Unified Dyskinesia Rating Scale score with sensor output. Item: Title: Figure 3 Correlation of lower-limb Unified Dyskinesia Rating Scale scores with sensor output. Item: Title: Table 1 Demographic and health data of the participants. Item: Title: Table 2 Spearman’s correlation between the dyskinesia algorithm and the Unified Dyskinesia Rating Scale. Info: Title: Estimating dyskinesia severity in Parkinson’s disease by using a waist-worn sensor: concurrent validity study Author: Alejandro Rodramp#x000ED;guez-Molinero Subject: Scientific Reports, doi:10.1038/s41598-019-49798-3 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Tue Sep 10 08:41:05 CEST 2019 ModDate: Wed Sep 11 10:42:15 CEST 2019 ID: 0xde937de9b001d93a95787d41f9f4cc90, 0xe5f66ba0630a7757cf476b938ec3e134 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1902 ImageHeight: 529 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 721 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1000 ImageHeight: 856 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: UIDQUE+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: INKBIC+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: PQAKXO+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: PQAKXO+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1101, 960 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YUIMSP+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: YUIMSP+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PFHEUP+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: PFHEUP+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SRCDNI+STIXGeneral-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: SRCDNI+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: UIDQUE+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UIDQUE+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true Font: BaseFont: INKBIC+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: INKBIC+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-019-49798-3 Springer US Scientific Reports, doi:10.1038/s41598-019-49798-3 Estimating dyskinesia severity in Parkinson’s disease by using a waist-worn sensor: concurrent validity study Alejandro Rodramp#x000ED;guez-Molinero Carlos Pamp#x000E9;rez-Lamp#x000F3;pez Albert Samamp#x000E0; Daniel Rodramp#x000ED;guez-Martamp#x000ED;n Sheila Alcaine Berta Mestre Paola Quispe Benedetta Giuliani Gabriel Vainstein Patrick Browne Dean Sweeney Leo R. Quinlan J. Manuel Moreno Arostegui amp#x000C0;ngels Bayes Hadas Lewy Alberto Costa Roberta Annicchiarico Timothy Counihan Gearamp#x000F2;id amp#x000D2;. Laighin Joan Cabestany 10.1038/s41598-019-49798-3 http://dx.doi.org/10.1038/s41598-019-49798-3 journal Scientific Reports © 2019, The Author(s) 2045-2322 10.1038/s41598-019-49798-3 Springer 2019-09-11T10:42:15+02:00 2019-09-10T11:41:05+05:30 2019-09-11T10:42:15+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:c7ce1f6d-0f12-4ef2-bf07-3d182af6e259 uuid:e9c01150-85be-44a1-91e0-29d503d2f27e default 1 converted uuid:a17fe498-ceab-4ef9-9cd1-7c6f8d04b737 converted to PDF/A-2b pdfToolbox 2019-09-10T11:41:50+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 285, 508, 294, 496 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 218, 472, 227, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 223, 448, 232, 436 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 217, 211, 219, 199 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 471, 191, 474, 179 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 350, 161, 353, 149 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 383, 53, 496, 43 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 427, 724, 430, 712 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 498, 644, 501, 632 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 238, 624, 241, 612 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 369, 594, 372, 582 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 373, 594, 376, 582 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 428, 594, 431, 582 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 549, 594, 552, 582 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 312, 574, 318, 562 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 487, 474, 493, 462 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 229, 434, 235, 422 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 227, 384, 233, 372 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 512, 374, 518, 362 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 519, 374, 525, 362 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 354, 354, 357, 342 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 290, 344, 296, 332 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 200, 154, 206, 142 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 457, 154, 463, 142 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 363, 144, 368, 132 Flags: Print AppearanceDictionary: true Destination: 126 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 482, 456, 487, 444 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 177, 396, 182, 384 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 268, 266, 273, 254 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 247, 186, 253, 174 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 463, 124, 467, 112 Flags: Print AppearanceDictionary: true Destination: 89 Annotation: Subtype: Link Rect: 481, 64, 486, 52 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 503, 64, 507, 52 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 245, 54, 249, 42 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 447, 225, 452, 213 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 382, 215, 388, 203 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 209, 135, 215, 123 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 447, 85, 452, 73 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 426, 55, 431, 43 Flags: Print AppearanceDictionary: true Destination: 126 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 258, 304, 264, 292 Flags: Print AppearanceDictionary: true Destination: 126 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 565, 504, 553 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 0a3499a2 Type: CRC32 Checksum: 4cbff7a023d772d9fbccf3f6bae603a8 Type: MD5 Checksum: 6c45131f2aec581b115ff900e428a03411d86624 Type: SHA-1