17b14390fcf33ebdd3b237b15d30eb6d pmc_31540052.pdf 0bb507427e1c5359f5c9e9d842453ca3ba9249bf pmc_31540052.pdf dd1686650f67c144ac9014a74672721ce7e53c2e166df0e6b223a771ca776cfe pmc_31540052.pdf Title: Insight into the Antifungal Mechanism of Action of Human RNase N-terminus Derived Peptides Subject: Candida albicans is a polymorphic fungus responsible for mucosal and skin infections. Candida cells establish themselves into biofilm communities resistant to most currently available antifungal agents. An increase of severe infections ensuing in fungal septic shock in elderly or immunosuppressed patients, along with the emergence of drug-resistant strains, urge the need for the development of alternative antifungal agents. In the search for novel antifungal drugs our laboratory demonstrated that two human ribonucleases from the vertebrate-specific RNaseA superfamily, hRNase3 and hRNase7, display a high anticandidal activity. In a previous work, we proved that the N-terminal region of the RNases was sufficient to reproduce most of the parental protein bactericidal activity. Next, we explored their potency against a fungal pathogen. Here, we have tested the N-terminal derived peptides that correspond to the eight human canonical RNases (RN1-8) against planktonic cells and biofilms of C. albicans. RN3 and RN7 peptides displayed the most potent inhibitory effect with a mechanism of action characterized by cell-wall binding, membrane permeabilization and biofilm eradication activities. Both peptides are able to eradicate planktonic and sessile cells, and to alter their gene expression, reinforcing its role as a lead candidate to develop novel antifungal and antibiofilm therapies. Keywords: antimicrobial peptides; Candida albicans; biofilms; antifungal activity; RNaseA superfamily Author: Vivian A. Salazar, Javier Arranz-Trullén, Guillem Prats-Ejarque, Marc Torrent, David Andreu, David Pulido and Ester Boix Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat Sep 14 09:30:29 2019 CEST ModDate: Sat Sep 14 09:30:29 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 24 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3191143 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HWESHS+URWPalladioL-Ital Type 1 Custom yes yes no 150 0 GGMCIB+URWPalladioL-Bold Type 1 Custom yes yes no 151 0 CUAJJQ+Pxbsy Type 1 Builtin yes yes no 152 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 153 0 CVTYPJ+URWPalladioL-Roma Type 1 Custom yes yes no 154 0 OHKNFJ+VnURWPalladioL Type 1 Custom yes yes no 155 0 PUXWWS+Pxsy Type 1 Builtin yes yes no 156 0 QLMOVM+Rpxr Type 1 Builtin yes yes no 157 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 162 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 163 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 182 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 183 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 184 0 NXQZWG+EURM10 Type 1 Builtin yes yes no 231 0 MMEDJI+Courier-Bold Type 1C WinAnsi yes yes no 258 0 MMEDMI+Courier-BoldOblique Type 1C WinAnsi yes yes no 259 0 MMEDMJ+Courier Type 1C WinAnsi yes yes no 260 0 MMEEDK+Symbol Type 1C Custom yes yes yes 261 0 MMEDPK+CourierNew,BoldItalic TrueType WinAnsi yes yes no 262 0 MMEEDL+Arial,Bold CID TrueType Identity-H yes yes yes 263 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 264 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 265 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 266 0 MMECGP+TimesNewRoman CID TrueType Identity-H yes yes yes 267 0 MFIGJL+Rpxb Type 1 Builtin yes yes no 316 0 XIRVNA+EURB10 Type 1 Builtin yes yes no 317 0 MLKEUD+t1xtt Type 1 Builtin yes yes no 318 0 CIOIKG+Courier Type 1C WinAnsi yes yes no 323 0 CIOHCJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 324 0 CIOHCK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 325 0 CIOHCL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 326 0 CIOHCM+PalatinoLinotype CID TrueType Identity-H yes yes yes 327 0 CIOHCN+PalatinoLinotype TrueType WinAnsi yes yes no 328 0 CIOHFN+TimesNewRoman CID TrueType Identity-H yes yes yes 329 0 CIOIKG+Courier Type 1C WinAnsi yes yes no 359 0 CIOHCJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 360 0 CIOHCK+PalatinoLinotype,Bold CID TrueType Identity-H yes yes yes 361 0 CIOHCL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 362 0 CIOHCM+PalatinoLinotype CID TrueType Identity-H yes yes yes 363 0 CIOHCN+PalatinoLinotype TrueType WinAnsi yes yes no 364 0 CIOHFN+TimesNewRoman CID TrueType Identity-H yes yes yes 365 0 YICMPF+Rpcxr Type 1 Builtin yes yes no 414 0 YTIKJS+Rpcxi Type 1 Builtin yes yes no 437 0 KNZVOU+Rpxsc Type 1 Builtin yes yes no 450 0 MMDPHJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 457 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 458 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 459 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 460 0 MMDPHJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 495 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 496 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 497 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 498 0 MMECGP+TimesNewRoman CID TrueType Identity-H yes yes yes 499 0 MMEEDK+Symbol Type 1C Custom yes yes yes 537 0 MMDPHJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 538 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 539 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 540 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 541 0 MMECGP+TimesNewRoman CID TrueType Identity-H yes yes yes 542 0 MMDPHJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 579 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 580 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 581 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 582 0 MMECGP+TimesNewRoman CID TrueType Identity-H yes yes yes 583 0 MMEEDK+Symbol Type 1C Custom yes yes yes 616 0 MMDPHJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 617 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 618 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 619 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 620 0 MMECGP+TimesNewRoman CID TrueType Identity-H yes yes yes 621 0 MMEEDK+Symbol Type 1C Custom yes yes yes 682 0 MMDPHJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 683 0 MMDPIJ+PalatinoLinotype TrueType WinAnsi yes yes no 684 0 MMEAGG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 685 0 MMEAGI+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 686 0 MMECGP+TimesNewRoman CID TrueType Identity-H yes yes yes 687 0 YWGLGW+Rpxi Type 1 Builtin yes yes no 845 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-19 06:09:46 CET RepresentationInformation: pmc_31540052.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-03 03:39:36 CEST Size: 3191143 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 5 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐづばぴどつづびぜ〴ぜ〰いづびどでのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどてふのでちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづびぜ〴ぜ〰ぉびぜ〴ぜ〰げづぴちどのづつぜ〴ぜ〰ちぴぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎ〭ぴづひねどのふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぁのぴどてふのでちぬぜ〴ぜ〰きづっとちのどびねぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづ〭いづひどぶづつぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰げづぬどづびぜ〴ぜ〰はのぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぎふっぬづどっぜ〴ぜ〰ぁっどつびぜ〴ぜ〰あどのつどのでぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぴづのぴぜ〴ぜ〰ぁのぴどっちのつどつちぬぜ〴ぜ〰ぐづばぴどつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰あどはてどぬねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぐづばぴどつづびぜ〴ぜ〰いづびどでのぜ〴ぜ〰ちのつぜ〴ぜ〰ぐとべびどっはっとづねどっちぬぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどてふのでちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづびぜ〴ぜ〰ぉびぜ〴ぜ〰げづぴちどのづつぜ〴ぜ〰ちぴぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎ〭ぴづひねどのふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぁのぴどてふのでちぬぜ〴ぜ〰きづっとちのどびねぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづ〭いづひどぶづつぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰げづぬどづびぜ〴ぜ〰はのぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぎふっぬづどっぜ〴ぜ〰ぁっどつびぜ〴ぜ〰あどのつどのでぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぴづのぴぜ〴ぜ〰ぁのぴどっちのつどつちぬぜ〴ぜ〰ぐづばぴどつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰あどはてどぬねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁのぴどてふのでちぬぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづびぜ〴ぜ〰ぉびぜ〴ぜ〰げづぴちどのづつぜ〴ぜ〰ちぴぜ〴ぜ〰ぴとづぜ〴ぜ〰ぎ〭ぴづひねどのふびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぁのぴどてふのでちぬぜ〴ぜ〰きづっとちのどびねぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづ〭いづひどぶづつぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰げづぬどづびぜ〴ぜ〰はのぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぎふっぬづどっぜ〴ぜ〰ぁっどつびぜ〴ぜ〰あどのつどのでぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぴづのぴぜ〴ぜ〰ぁのぴどっちのつどつちぬぜ〴ぜ〰ぐづばぴどつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰あどはてどぬねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごとづぜ〴ぜ〰ぁのぴどてふのでちぬぜ〴ぜ〰きづっとちのどびねぜ〴ぜ〰はてぜ〴ぜ〰とげぎちびづ〭いづひどぶづつぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰げづぬどづびぜ〴ぜ〰はのぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰ぉのぴづひちっぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぎふっぬづどっぜ〴ぜ〰ぁっどつびぜ〴ぜ〰あどのつどのでぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぴづのぴぜ〴ぜ〰ぁのぴどっちのつどつちぬぜ〴ぜ〰ぐづばぴどつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰あどはてどぬねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぎふっぬづどっぜ〴ぜ〰ぁっどつびぜ〴ぜ〰あどのつどのでぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐはぴづのぴぜ〴ぜ〰ぁのぴどっちのつどつちぬぜ〴ぜ〰ぐづばぴどつづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰あどはてどぬねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅぶちぬふちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁっぴどぶどぴどづびぜ〴ぜ〰はてぜ〴ぜ〰げぎ〳ぜ〴ぜ〰ちのつぜ〴ぜ〰げぎ〷ぜ〴ぜ〰ぐづばぴどつづびぜ〴ぜ〰ちでちどのびぴぜ〴ぜ〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰あどはてどぬねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きはつふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぐひはてどぬづぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰しちぬぬぜ〴ぜ〰こべのぴとづびどびぜ〴ぜ〰ちのつぜ〴ぜ〰あどはてどぬねぜ〴ぜ〰うはひねちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぐぬちのにぴはのどっぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐづばぴどつづぜ〴ぜ〰こべのぴとづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぃはのつどぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰きどのどねふねぜ〴ぜ〰うふのでどっどつちぬぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぁででぬふぴどのちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぜ〵ぜ〰きぁぃぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Children: Item: Title: ぐづばぴどつづぜ〴ぜ〰こべのぴとづびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぃはのつどぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰きどのどねふねぜ〴ぜ〰うふのでどっどつちぬぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぁででぬふぴどのちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぜ〵ぜ〰きぁぃぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃ〮ぜ〴ぜ〰ちぬぢどっちのびぜ〴ぜ〰ぇひはぷぴとぜ〴ぜ〰ぃはのつどぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰きどのどねふねぜ〴ぜ〰うふのでどっどつちぬぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぁででぬふぴどのちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぜ〵ぜ〰きぁぃぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: きどのどねふねぜ〴ぜ〰うふのでどっどつちぬぜ〴ぜ〰ぃはのっづのぴひちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰きどのどねちぬぜ〴ぜ〰ぁででぬふぴどのちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぜ〵ぜ〰きぁぃぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: きどのどねちぬぜ〴ぜ〰ぁででぬふぴどのちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ぜ〵ぜ〰きぁぃぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㘩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰こふひぶどぶちぬぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㜩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰いづばはぬちひどぺちぴどはのぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㠩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰きづねぢひちのづぜ〴ぜ〰ぐづひねづちぢどぬどぺちぴどはのぜ〴ぜ〰ぁっぴどぶどぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㤩‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: ぃづぬぬぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㄰ Item: Title: いぎぁぜ〴ぜ〰あどのつどのでぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄱ Item: Title: ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄲ Item: Title: あどはてどぬねぜ〴ぜ〰ぇひはぷぴとぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄳ Item: Title: あどはてどぬねぜ〴ぜ〰ざどちぢどぬどぴべぜ〴ぜ〰ごづびぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄴ Item: Title: あどはてどぬねぜ〴ぜ〰きちびびぜ〴ぜ〰ぅひちつどっちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄵ Item: Title: ぃはのてはっちぬぜ〴ぜ〰きどっひはびっはばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄶ Item: Title: ぃべぴはぴはへどっどぴべぜ〴ぜ〰ぁびびちべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄷ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: KNZVOU+Rpxsc FontSubset: true FirstChar: 100 LastChar: 100 FontDescriptor: FontName: KNZVOU+Rpxsc Flags: Symbolic FontBBox: -37, -172, 852, 718 FontFile: true Font: BaseFont: NXQZWG+EURM10 FontSubset: true FirstChar: 11 LastChar: 22 FontDescriptor: FontName: NXQZWG+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: YWGLGW+Rpxi FontSubset: true FirstChar: 47 LastChar: 47 FontDescriptor: FontName: YWGLGW+Rpxi Flags: Symbolic FontBBox: -162, -280, 856, 733 FontFile: true Font: BaseFont: YTIKJS+Rpcxi FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: YTIKJS+Rpcxi Flags: Symbolic FontBBox: -223, -286, 1344, 973 FontFile: true Font: BaseFont: HWESHS+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: HWESHS+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GGMCIB+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 165 FontDescriptor: FontName: GGMCIB+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CUAJJQ+Pxbsy FontSubset: true FirstChar: 121 LastChar: 122 FontDescriptor: FontName: CUAJJQ+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: BTFGED+VnURWPalladioL-Bold FontSubset: true FirstChar: 178 LastChar: 178 FontDescriptor: FontName: BTFGED+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CVTYPJ+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: CVTYPJ+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OHKNFJ+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 226 FontDescriptor: FontName: OHKNFJ+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PUXWWS+Pxsy FontSubset: true FirstChar: 0 LastChar: 122 FontDescriptor: FontName: PUXWWS+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: MFIGJL+Rpxb FontSubset: true FirstChar: 47 LastChar: 47 FontDescriptor: FontName: MFIGJL+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: QLMOVM+Rpxr FontSubset: true FirstChar: 11 LastChar: 62 FontDescriptor: FontName: QLMOVM+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: XIRVNA+EURB10 FontSubset: true FirstChar: 22 LastChar: 22 FontDescriptor: FontName: XIRVNA+EURB10 Flags: Symbolic FontBBox: -30, -247, 1178, 723 FontFile: true Font: BaseFont: MLKEUD+t1xtt FontSubset: true FirstChar: 22 LastChar: 89 FontDescriptor: FontName: MLKEUD+t1xtt Flags: Symbolic FontBBox: -5, -183, 1501, 822 FontFile: true Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 221, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 467, 660, 478, 674 Annotation: Subtype: Link Rect: 466, 497, 518, 516 Annotation: Subtype: Link Rect: 419, 173, 426, 182 ActionDest: 859 Annotation: Subtype: Link Rect: 207, 92, 214, 101 ActionDest: 859 Annotation: Subtype: Link Rect: 215, 92, 222, 101 ActionDest: 859 Annotation: Subtype: Link Rect: 477, 78, 484, 87 ActionDest: 859 Annotation: Subtype: Link Rect: 484, 78, 491, 87 ActionDest: 900 Annotation: Subtype: Link Rect: 193, 38, 270, 50 Annotation: Subtype: Link Rect: 416, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 377, 729, 384, 738 ActionDest: 859 Annotation: Subtype: Link Rect: 397, 661, 404, 671 ActionDest: 900 Annotation: Subtype: Link Rect: 407, 661, 414, 671 ActionDest: 900 Annotation: Subtype: Link Rect: 177, 621, 184, 630 ActionDest: 900 Annotation: Subtype: Link Rect: 187, 621, 199, 630 ActionDest: 900 Annotation: Subtype: Link Rect: 126, 580, 138, 590 ActionDest: 900 Annotation: Subtype: Link Rect: 138, 580, 150, 590 ActionDest: 900 Annotation: Subtype: Link Rect: 503, 553, 515, 562 ActionDest: 900 Annotation: Subtype: Link Rect: 273, 513, 285, 522 ActionDest: 900 Annotation: Subtype: Link Rect: 331, 486, 343, 495 ActionDest: 900 Annotation: Subtype: Link Rect: 118, 459, 130, 468 ActionDest: 900 Annotation: Subtype: Link Rect: 131, 459, 142, 468 ActionDest: 900 Annotation: Subtype: Link Rect: 491, 445, 503, 454 ActionDest: 900 Annotation: Subtype: Link Rect: 503, 445, 515, 454 ActionDest: 900 Annotation: Subtype: Link Rect: 363, 418, 375, 427 ActionDest: 900 Annotation: Subtype: Link Rect: 280, 351, 292, 360 ActionDest: 900 Annotation: Subtype: Link Rect: 295, 351, 307, 360 ActionDest: 900 Annotation: Subtype: Link Rect: 124, 177, 136, 186 ActionDest: 900 Annotation: Subtype: Link Rect: 139, 177, 151, 186 ActionDest: 900 Annotation: Subtype: Link Rect: 188, 174, 195, 186 ActionDest: 251 Annotation: Subtype: Link Rect: 239, 174, 246, 186 ActionDest: 313 Annotation: Subtype: Link Rect: 403, 96, 415, 105 ActionDest: 900 Annotation: Subtype: Link Rect: 415, 96, 427, 105 ActionDest: 900 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 139, 742, 151, 752 ActionDest: 900 Annotation: Subtype: Link Rect: 191, 740, 198, 752 ActionDest: 251 Annotation: Subtype: Link Rect: 134, 702, 146, 711 ActionDest: 900 Annotation: Subtype: Link Rect: 280, 688, 292, 698 ActionDest: 900 Annotation: Subtype: Link Rect: 292, 688, 304, 698 ActionDest: 929 Annotation: Subtype: Link Rect: 284, 672, 291, 684 ActionDest: 313 Annotation: Subtype: Link Rect: 365, 661, 377, 671 ActionDest: 929 Annotation: Subtype: Link Rect: 196, 648, 208, 657 ActionDest: 929 Annotation: Subtype: Link Rect: 240, 645, 247, 657 ActionDest: 313 Annotation: Subtype: Link Rect: 415, 634, 427, 644 ActionDest: 929 Annotation: Subtype: Link Rect: 99, 65, 410, 77 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 368, 311, 378, 319 ActionDest: 900 Annotation: Subtype: Link Rect: 378, 311, 388, 319 ActionDest: 929 Annotation: Subtype: Link Rect: 356, 301, 366, 309 ActionDest: 900 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 161, 710, 173, 719 ActionDest: 900 Annotation: Subtype: Link Rect: 169, 666, 176, 678 ActionDest: 410 Annotation: Subtype: Link Rect: 469, 655, 481, 665 ActionDest: 900 Annotation: Subtype: Link Rect: 197, 626, 204, 638 ActionDest: 313 Annotation: Subtype: Link Rect: 222, 626, 229, 638 ActionDest: 410 Annotation: Subtype: Link Rect: 283, 585, 290, 597 ActionDest: 313 Annotation: Subtype: Link Rect: 168, 574, 180, 584 ActionDest: 900 Annotation: Subtype: Link Rect: 437, 518, 444, 529 ActionDest: 313 Annotation: Subtype: Link Rect: 243, 213, 255, 222 ActionDest: 929 Annotation: Subtype: Link Rect: 375, 172, 387, 181 ActionDest: 929 Annotation: Subtype: Link Rect: 388, 172, 400, 181 ActionDest: 929 Annotation: Subtype: Link Rect: 445, 91, 457, 100 ActionDest: 900 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 443, 742, 455, 752 ActionDest: 900 Annotation: Subtype: Link Rect: 297, 688, 309, 698 ActionDest: 929 Annotation: Subtype: Link Rect: 309, 688, 321, 698 ActionDest: 929 Annotation: Subtype: Link Rect: 212, 675, 224, 684 ActionDest: 929 Annotation: Subtype: Link Rect: 226, 675, 238, 684 ActionDest: 929 Annotation: Subtype: Link Rect: 491, 605, 503, 614 ActionDest: 929 Annotation: Subtype: Link Rect: 503, 605, 515, 614 ActionDest: 929 Annotation: Subtype: Link Rect: 229, 548, 237, 560 ActionDest: 433 Annotation: Subtype: Link Rect: 377, 454, 384, 466 ActionDest: 433 Annotation: Subtype: Link Rect: 329, 402, 341, 412 ActionDest: 900 Annotation: Subtype: Link Rect: 134, 389, 146, 398 ActionDest: 929 Annotation: Subtype: Link Rect: 332, 375, 344, 385 ActionDest: 929 Annotation: Subtype: Link Rect: 345, 375, 357, 385 ActionDest: 929 Annotation: Subtype: Link Rect: 357, 375, 369, 385 ActionDest: 929 Annotation: Subtype: Link Rect: 332, 348, 344, 358 ActionDest: 900 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 253, 675, 265, 684 ActionDest: 929 Annotation: Subtype: Link Rect: 403, 661, 415, 671 ActionDest: 929 Annotation: Subtype: Link Rect: 416, 661, 428, 671 ActionDest: 929 Annotation: Subtype: Link Rect: 320, 618, 327, 630 ActionDest: 447 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 100, 729, 112, 738 ActionDest: 900 Annotation: Subtype: Link Rect: 415, 686, 422, 698 ActionDest: 487 Annotation: Subtype: Link Rect: 243, 300, 255, 309 ActionDest: 929 Annotation: Subtype: Link Rect: 278, 259, 290, 268 ActionDest: 929 Annotation: Subtype: Link Rect: 293, 259, 305, 268 ActionDest: 929 Annotation: Subtype: Link Rect: 352, 216, 359, 228 ActionDest: 530 Annotation: Subtype: Link Rect: 454, 162, 461, 174 ActionDest: 530 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 356, 197, 368, 207 ActionDest: 929 Annotation: Subtype: Link Rect: 503, 170, 515, 180 ActionDest: 929 Annotation: Subtype: Link Rect: 173, 87, 180, 99 ActionDest: 572 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 145, 740, 152, 752 ActionDest: 572 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 508, 672, 515, 684 ActionDest: 607 Annotation: Subtype: Link Rect: 424, 271, 431, 283 ActionDest: 675 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 108, 301, 115, 310 ActionDest: 859 Annotation: Subtype: Link Rect: 115, 301, 127, 310 ActionDest: 929 Annotation: Subtype: Link Rect: 306, 301, 318, 310 ActionDest: 900 Annotation: Subtype: Link Rect: 318, 300, 330, 310 ActionDest: 929 Annotation: Subtype: Link Rect: 331, 300, 343, 310 ActionDest: 954 Annotation: Subtype: Link Rect: 130, 246, 142, 256 ActionDest: 954 Annotation: Subtype: Link Rect: 439, 219, 450, 229 ActionDest: 900 Annotation: Subtype: Link Rect: 451, 219, 463, 229 ActionDest: 954 Annotation: Subtype: Link Rect: 464, 219, 475, 229 ActionDest: 954 Annotation: Subtype: Link Rect: 238, 192, 250, 202 ActionDest: 929 Annotation: Subtype: Link Rect: 251, 192, 263, 202 ActionDest: 954 Annotation: Subtype: Link Rect: 263, 192, 275, 202 ActionDest: 954 Annotation: Subtype: Link Rect: 169, 165, 181, 175 ActionDest: 900 Annotation: Subtype: Link Rect: 181, 165, 193, 175 ActionDest: 954 Annotation: Subtype: Link Rect: 194, 165, 206, 175 ActionDest: 954 Annotation: Subtype: Link Rect: 405, 152, 417, 161 ActionDest: 900 Annotation: Subtype: Link Rect: 418, 152, 430, 161 ActionDest: 900 Annotation: Subtype: Link Rect: 430, 152, 442, 161 ActionDest: 900 Annotation: Subtype: Link Rect: 443, 152, 455, 161 ActionDest: 900 Annotation: Subtype: Link Rect: 491, 111, 503, 121 ActionDest: 900 Annotation: Subtype: Link Rect: 504, 111, 516, 121 ActionDest: 929 Annotation: Subtype: Link Rect: 110, 95, 117, 107 ActionDest: 251 Annotation: Subtype: Link Rect: 301, 95, 308, 107 ActionDest: 251 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 118, 715, 130, 725 ActionDest: 900 Annotation: Subtype: Link Rect: 504, 715, 516, 725 ActionDest: 929 Annotation: Subtype: Link Rect: 430, 688, 442, 698 ActionDest: 900 Annotation: Subtype: Link Rect: 503, 661, 515, 671 ActionDest: 900 Annotation: Subtype: Link Rect: 263, 634, 275, 644 ActionDest: 900 Annotation: Subtype: Link Rect: 508, 551, 515, 562 ActionDest: 410 Annotation: Subtype: Link Rect: 126, 526, 138, 535 ActionDest: 900 Annotation: Subtype: Link Rect: 153, 513, 165, 522 ActionDest: 900 Annotation: Subtype: Link Rect: 165, 513, 177, 522 ActionDest: 900 Annotation: Subtype: Link Rect: 178, 513, 190, 522 ActionDest: 929 Annotation: Subtype: Link Rect: 190, 513, 202, 522 ActionDest: 954 Annotation: Subtype: Link Rect: 174, 472, 185, 481 ActionDest: 900 Annotation: Subtype: Link Rect: 341, 445, 353, 454 ActionDest: 954 Annotation: Subtype: Link Rect: 353, 445, 365, 454 ActionDest: 954 Annotation: Subtype: Link Rect: 384, 432, 396, 441 ActionDest: 900 Annotation: Subtype: Link Rect: 396, 432, 408, 441 ActionDest: 954 Annotation: Subtype: Link Rect: 409, 432, 420, 441 ActionDest: 954 Annotation: Subtype: Link Rect: 117, 405, 129, 414 ActionDest: 900 Annotation: Subtype: Link Rect: 130, 405, 142, 414 ActionDest: 954 Annotation: Subtype: Link Rect: 449, 378, 460, 387 ActionDest: 900 Annotation: Subtype: Link Rect: 461, 378, 473, 387 ActionDest: 954 Annotation: Subtype: Link Rect: 455, 364, 467, 373 ActionDest: 954 Annotation: Subtype: Link Rect: 182, 334, 189, 346 ActionDest: 447 Annotation: Subtype: Link Rect: 265, 280, 272, 292 ActionDest: 251 Annotation: Subtype: Link Rect: 194, 242, 206, 252 ActionDest: 954 Annotation: Subtype: Link Rect: 369, 229, 380, 238 ActionDest: 900 Annotation: Subtype: Link Rect: 393, 175, 405, 184 ActionDest: 954 Annotation: Subtype: Link Rect: 483, 134, 495, 144 ActionDest: 900 Annotation: Subtype: Link Rect: 299, 107, 311, 117 ActionDest: 954 Annotation: Subtype: Link Rect: 314, 107, 326, 117 ActionDest: 954 Annotation: Subtype: Link Rect: 508, 78, 515, 90 ActionDest: 313 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 316, 740, 323, 752 ActionDest: 487 Annotation: Subtype: Link Rect: 314, 605, 321, 617 ActionDest: 607 Annotation: Subtype: Link Rect: 161, 580, 173, 590 ActionDest: 954 Annotation: Subtype: Link Rect: 274, 567, 286, 576 ActionDest: 954 Annotation: Subtype: Link Rect: 407, 537, 414, 549 ActionDest: 607 Annotation: Subtype: Link Rect: 217, 526, 229, 535 ActionDest: 954 Annotation: Subtype: Link Rect: 108, 486, 120, 495 ActionDest: 954 Annotation: Subtype: Link Rect: 120, 486, 132, 495 ActionDest: 954 Annotation: Subtype: Link Rect: 109, 418, 116, 427 ActionDest: 900 Annotation: Subtype: Link Rect: 117, 418, 129, 427 ActionDest: 929 Annotation: Subtype: Link Rect: 129, 418, 141, 427 ActionDest: 954 Annotation: Subtype: Link Rect: 223, 364, 235, 373 ActionDest: 929 Annotation: Subtype: Link Rect: 235, 364, 247, 373 ActionDest: 929 Annotation: Subtype: Link Rect: 423, 364, 435, 373 ActionDest: 929 Annotation: Subtype: Link Rect: 436, 364, 448, 373 ActionDest: 980 Annotation: Subtype: Link Rect: 302, 324, 314, 333 ActionDest: 980 Annotation: Subtype: Link Rect: 488, 297, 500, 306 ActionDest: 980 Annotation: Subtype: Link Rect: 503, 297, 515, 306 ActionDest: 980 Annotation: Subtype: Link Rect: 289, 270, 301, 279 ActionDest: 980 Annotation: Subtype: Link Rect: 304, 270, 316, 279 ActionDest: 980 Annotation: Subtype: Link Rect: 503, 256, 515, 265 ActionDest: 980 Annotation: Subtype: Link Rect: 170, 226, 177, 238 ActionDest: 530 Annotation: Subtype: Link Rect: 150, 172, 157, 184 ActionDest: 572 Annotation: Subtype: Link Rect: 110, 105, 117, 117 ActionDest: 675 Annotation: Subtype: Link Rect: 95, 80, 107, 90 ActionDest: 980 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 140, 661, 152, 671 ActionDest: 980 Annotation: Subtype: Link Rect: 349, 648, 361, 657 ActionDest: 980 Annotation: Subtype: Link Rect: 109, 607, 121, 617 ActionDest: 980 Annotation: Subtype: Link Rect: 124, 607, 136, 617 ActionDest: 980 Annotation: Subtype: Link Rect: 340, 460, 352, 470 ActionDest: 900 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 412, 532, 424, 541 ActionDest: 954 Annotation: Subtype: Link Rect: 125, 271, 137, 280 ActionDest: 929 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 406, 709, 418, 719 ActionDest: 929 Annotation: Subtype: Link Rect: 115, 189, 127, 199 ActionDest: 980 Annotation: Subtype: Link Rect: 128, 189, 140, 199 ActionDest: 980 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 370, 221, 382, 230 ActionDest: 980 Annotation: Subtype: Link Rect: 383, 221, 395, 230 ActionDest: 980 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 490, 559, 502, 568 ActionDest: 980 Annotation: Subtype: Link Rect: 503, 559, 515, 568 ActionDest: 980 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 359, 548, 519, 559 Annotation: Subtype: Link Rect: 75, 539, 106, 548 Annotation: Subtype: Link Rect: 159, 160, 196, 170 Annotation: Subtype: Link Rect: 202, 160, 238, 170 Annotation: Subtype: Link Rect: 233, 133, 271, 144 Annotation: Subtype: Link Rect: 277, 133, 313, 144 Annotation: Subtype: Link Rect: 100, 95, 137, 105 Annotation: Subtype: Link Rect: 143, 95, 179, 105 Annotation: Subtype: Link Rect: 426, 69, 463, 80 Annotation: Subtype: Link Rect: 470, 69, 506, 80 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 141, 728, 178, 738 Annotation: Subtype: Link Rect: 478, 714, 516, 725 Annotation: Subtype: Link Rect: 100, 702, 136, 712 Annotation: Subtype: Link Rect: 478, 688, 516, 699 Annotation: Subtype: Link Rect: 100, 676, 136, 686 Annotation: Subtype: Link Rect: 360, 650, 397, 661 Annotation: Subtype: Link Rect: 272, 624, 309, 635 Annotation: Subtype: Link Rect: 100, 599, 137, 609 Annotation: Subtype: Link Rect: 172, 573, 210, 583 Annotation: Subtype: Link Rect: 216, 573, 252, 583 Annotation: Subtype: Link Rect: 392, 546, 430, 557 Annotation: Subtype: Link Rect: 436, 546, 472, 557 Annotation: Subtype: Link Rect: 345, 521, 382, 531 Annotation: Subtype: Link Rect: 389, 521, 425, 531 Annotation: Subtype: Link Rect: 419, 495, 457, 506 Annotation: Subtype: Link Rect: 463, 495, 499, 506 Annotation: Subtype: Link Rect: 227, 457, 265, 467 Annotation: Subtype: Link Rect: 271, 457, 307, 467 Annotation: Subtype: Link Rect: 478, 430, 516, 441 Annotation: Subtype: Link Rect: 100, 418, 136, 428 Annotation: Subtype: Link Rect: 226, 391, 264, 402 Annotation: Subtype: Link Rect: 370, 366, 408, 376 Annotation: Subtype: Link Rect: 181, 315, 219, 325 Annotation: Subtype: Link Rect: 439, 275, 477, 286 Annotation: Subtype: Link Rect: 168, 237, 205, 247 Annotation: Subtype: Link Rect: 211, 237, 247, 247 Annotation: Subtype: Link Rect: 246, 211, 283, 222 Annotation: Subtype: Link Rect: 290, 211, 326, 222 Annotation: Subtype: Link Rect: 100, 173, 137, 183 Annotation: Subtype: Link Rect: 143, 173, 179, 183 Annotation: Subtype: Link Rect: 154, 134, 192, 144 Annotation: Subtype: Link Rect: 198, 134, 234, 144 Annotation: Subtype: Link Rect: 236, 95, 273, 105 Annotation: Subtype: Link Rect: 280, 95, 316, 105 Annotation: Subtype: Link Rect: 163, 69, 201, 80 Annotation: Subtype: Link Rect: 207, 69, 243, 80 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 159, 728, 196, 738 Annotation: Subtype: Link Rect: 207, 702, 245, 712 Annotation: Subtype: Link Rect: 100, 663, 137, 673 Annotation: Subtype: Link Rect: 419, 637, 457, 648 Annotation: Subtype: Link Rect: 167, 599, 205, 609 Annotation: Subtype: Link Rect: 163, 560, 200, 570 Annotation: Subtype: Link Rect: 480, 533, 516, 544 Annotation: Subtype: Link Rect: 315, 495, 352, 506 Annotation: Subtype: Link Rect: 474, 456, 511, 467 Annotation: Subtype: Link Rect: 434, 430, 472, 441 Annotation: Subtype: Link Rect: 100, 405, 137, 415 Annotation: Subtype: Link Rect: 222, 366, 259, 376 Annotation: Subtype: Link Rect: 251, 328, 288, 338 Annotation: Subtype: Link Rect: 479, 301, 516, 312 Annotation: Subtype: Link Rect: 145, 250, 183, 260 Annotation: Subtype: Link Rect: 394, 224, 431, 234 Annotation: Subtype: Link Rect: 100, 186, 137, 196 Annotation: Subtype: Link Rect: 253, 146, 291, 157 Annotation: Subtype: Link Rect: 150, 121, 187, 131 Annotation: Subtype: Link Rect: 287, 94, 324, 105 Annotation: Subtype: Link Rect: 427, 69, 464, 80 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 286, 727, 323, 738 Annotation: Subtype: Link Rect: 159, 689, 196, 699 Annotation: Subtype: Link Rect: 386, 650, 424, 661 Annotation: Subtype: Link Rect: 338, 611, 376, 622 Annotation: Subtype: Link Rect: 290, 585, 327, 596 Annotation: Subtype: Link Rect: 439, 559, 477, 570 Annotation: Subtype: Link Rect: 184, 534, 221, 544 Annotation: Subtype: Link Rect: 159, 508, 196, 519 Annotation: Subtype: Link Rect: 303, 469, 341, 480 Annotation: Subtype: Link Rect: 300, 430, 337, 441 Annotation: Subtype: Link Rect: 260, 391, 298, 402 Annotation: Subtype: Link Rect: 231, 366, 268, 376 Annotation: Subtype: Link Rect: 158, 328, 196, 338 Annotation: Subtype: Link Rect: 186, 289, 223, 299 Annotation: Subtype: Link Rect: 450, 249, 487, 260 Annotation: Subtype: Link Rect: 343, 211, 380, 222 Annotation: Subtype: Link Rect: 281, 185, 318, 196 Annotation: Subtype: Link Rect: 392, 159, 429, 170 Annotation: Subtype: Link Rect: 100, 121, 137, 131 Annotation: Subtype: Link Rect: 408, 94, 445, 105 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 293, 727, 331, 738 Annotation: Subtype: Link Rect: 163, 689, 200, 699 Annotation: Subtype: Link Rect: 250, 663, 288, 673 Annotation: Subtype: Link Rect: 420, 637, 457, 648 Annotation: Subtype: Link Rect: 342, 611, 379, 622 Annotation: Subtype: Link Rect: 202, 573, 239, 583 Annotation: Subtype: Link Rect: 100, 534, 137, 544 Annotation: Subtype: Link Rect: 300, 495, 337, 506 Annotation: Subtype: Link Rect: 172, 457, 210, 467 Annotation: Subtype: Link Rect: 221, 431, 258, 441 Annotation: Subtype: Link Rect: 177, 392, 214, 402 Annotation: Subtype: Link Rect: 246, 353, 283, 364 Annotation: Subtype: Link Rect: 428, 327, 465, 338 Annotation: Subtype: Link Rect: 233, 289, 271, 299 Annotation: Subtype: Link Rect: 420, 262, 458, 273 Annotation: Subtype: Link Rect: 313, 224, 350, 234 Annotation: Subtype: Link Rect: 340, 198, 377, 209 Annotation: Subtype: Link Rect: 362, 172, 400, 183 Annotation: Subtype: Link Rect: 76, 130, 166, 161 Annotation: Subtype: Link Rect: 234, 124, 407, 135 Checksum: 180c5c46 Type: CRC32 Checksum: 17b14390fcf33ebdd3b237b15d30eb6d Type: MD5 Checksum: 0bb507427e1c5359f5c9e9d842453ca3ba9249bf Type: SHA-1