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Title:          Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion
Subject:        EBioMedicine, 48 (2019) 605-618. doi:10.1016/j.ebiom.2019.09.019
Keywords:       GRK2; AKT; Ischemia-reperfusion; Cardioprotection; Pin1; Proteasome; Calpains
Author:         Petronila Penela
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      Title: Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion
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        Title: Evidence before this study
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       Item: 
        Title: Added value of this study
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        Title: Implications
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       Item: 
        Title: 1 Introduction
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        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 Experimental protocol of ischemia/reperfusion in rats
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          Title: 2.2 Experimental protocol of ischemia/reperfusion in pigs
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          Title: 2.3 Myocardial tissue processing
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          Title: 2.4 Western blot and dot blot analysis
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          Title: 2.5 Determination of Pin1 acetylation
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          Title: 2.6 Cell culture and transfection and protein degradation assays
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          Title: 2.7 Quantification of cell death
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          Title: 3.1 GRK2 is degraded in ischemia and reperfusion conditions by different mechanisms
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          Title: 3.2 AKT degradation takes place in early I/R resulting in decreased overall activity of this pathway
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          Title: 3.3 Combined use of proteasome and calpain inhibitors prevents GRK2/Pin1/AKT degradation and attenuates I/R myocardial injury
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        Title: 4 Discussion
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       Item: 
        Title: Funding
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        Title: Author contributions
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        Title: Acknowledgements and funding sources
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        Title: Declaration of Competing Interest
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        Title: Appendix A Supplementary data
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        Title: References
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   Type: CRC32
  Checksum: 9d8846449fa8b31ee8457f0119349c8c
   Type: MD5
  Checksum: 078dbe4ee764d2a43f9ea605277cadff1a353329
   Type: SHA-1