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Title:          Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells
Subject:        Oncogene, doi:10.1038/s41388-019-1053-6
Keywords:       
Author:         Mónica López-Guerra
Creator:        Springer
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      Title: Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells
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        Title: Introduction
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        Title: Results
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          Title: DLL4 is a potent stimulator of Notch signaling and proliferation in NOTCH1-mutated CLL
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          Title: DLL4 is expressed in the CLL lymph node
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          Title: The anti-NOTCH1 antibody OMP-52M51 inhibits DLL4-induced Notch activation in CLL
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          Title: OMP-52M51 inhibits DLL4-induced CLL proliferation
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          Title: DLL4’stimulation of NOTCH1-mutated CLL cells induces CXCR4 expression and migration that can be inhibited by OMP-52M51
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          Title: DLL4 increases angiogenic factors in NOTCH1-mutated CLL that can be blocked by OMP-52M51
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        Title: Discussion
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        Title: Materials and methods
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          Title: Isolation and culture of cells
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          Title: Notch ligand stimulation and cell treatment
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          Title: Protein analysis
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          Title: Quantitative real-time PCR
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          Title: Immunohistochemistry and confocal microscopy
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         Item: 
          Title: CFSE-based proliferation assay
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          Title: CXCR4’staining
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          Title: Chemotaxis assay
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          Title: HUVEC tube formation assay
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          Title: Statistical analyses
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          Title: Compliance with ethical standards
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        Title: ACKNOWLEDGMENTS
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    Title: Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells
    Author: Mónica López-Guerra
    Subject: Oncogene, doi:10.1038/s41388-019-1053-6
    Keywords: 
    Creator: Springer
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