2d2425b1436af35b6c6b184f304fe5e8 pmc_31650016.pdf 1d251d9460c3c86ec5e156fa5dc59d7c1c45e306 pmc_31650016.pdf 8aee649b4a080f3f7203a6e281f5a807137546cf97e14a87638ff463c07e2b3a pmc_31650016.pdf Title: The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders Subject: Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (2019) 597-609. doi:10.1016/j.trci.2019.09.005 Author: Daniel Alcolea Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 28th December 2019 ModDate: Sat Dec 28 06:26:17 2019 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 576 x 773.972 pts Page rot: 0 File size: 611293 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FKKONJ+AdvPSA88A Type 1C MacRoman yes yes no 1609 0 FKKONK+AdvP4C4E59 Type 1C Custom yes yes yes 1614 0 FKKONL+AdvPSA88C Type 1C Custom yes yes no 1619 0 FKKOOL+AdvPSA88B Type 1C WinAnsi yes yes no 1622 0 FKKOOM+AdvPS586B Type 1C WinAnsi yes yes no 1624 0 FKKOPN+AdvPSSym Type 1C Custom yes yes no 1629 0 FKKPIK+Calibri Type 1C Custom yes yes yes 1176 0 FKKPIL+ArialMT Type 1C WinAnsi yes yes no 1182 0 FKKPIM+Calibri-Bold Type 1C WinAnsi yes yes no 1185 0 FKKPJN+AdvP4C4E74 Type 1C Custom yes yes no 1188 0 FKKPJO+AdvPS480274 Type 1C WinAnsi yes yes no 1193 0 FKKPKP+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1197 0 FKKPPO+Arial-BoldMT Type 1C WinAnsi yes yes no 1204 0 FKLAAO+Helvetica-Bold Type 1C WinAnsi yes yes no 1202 0 FKLABP+AdvPS44A44B Type 1C WinAnsi yes yes no 1208 0 FKLAFP+AdvOTd877c31c+03 Type 1C Custom yes yes yes 1219 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:23:07 CEST RepresentationInformation: pmc_31650016.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 03:53:05 CET Size: 611293 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Improperly formed date Offset: 581956 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib82' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib75' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib78' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib85' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib86' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib87' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib25' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib41' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 559275 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: 1. Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 2. Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 2.1. The SPIN cohort: General protocol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.2. Cognitively normal volunteers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.3. Ethical aspects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.4. Neuropsychological evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.5. Cerebrospinal fluid Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.6. Blood and DNA extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.7. Structural, diffusion, and functional MRI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.8. Nuclear medicine imaging: 18FDG PET, amyloid PET, Tau PET Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.9. Sleep evaluation and real-world evidence data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.10. Neuropathology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.11. Data integration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.12. The Down-Alzheimer Barcelona Neuroimaging Initiative: DABNI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders Author: Daniel Alcolea Subject: Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (2019) 597-609. doi:10.1016/j.trci.2019.09.005 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) ID: 0xe7e57233c39c42248d44f04130644565, 0x9feb7d372fb0ed4d85b15fc4ee4a5f54 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 276 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Fonts: Type1: Font: BaseFont: FKKPIM+Calibri-Bold FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: FKKPIM+Calibri-Bold Flags: Nonsymbolic FontBBox: -519, -349, 1263, 1039 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKLAFP+AdvOTd877c31c+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FKLAFP+AdvOTd877c31c+03 Flags: Symbolic FontBBox: 24, -10, 407, 460 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FKKPJN+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: FKKPJN+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FKKONJ+AdvPSA88A FontSubset: true FirstChar: 38 LastChar: 252 FontDescriptor: FontName: FKKONJ+AdvPSA88A Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: FKKPJO+AdvPS480274 FontSubset: true FirstChar: 45 LastChar: 66 FontDescriptor: FontName: FKKPJO+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKPKP+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 98 FontDescriptor: FontName: FKKPKP+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKONK+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 160 FontDescriptor: FontName: FKKONK+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FKLAAO+Helvetica-Bold FontSubset: true FirstChar: 65 LastChar: 66 FontDescriptor: FontName: FKLAAO+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKONL+AdvPSA88C FontSubset: true FirstChar: 25 LastChar: 150 FontDescriptor: FontName: FKKONL+AdvPSA88C Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1010, 781 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FKKPPO+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 186 FontDescriptor: FontName: FKKPPO+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKOOL+AdvPSA88B FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: FKKOOL+AdvPSA88B Flags: Serif, Nonsymbolic FontBBox: -166, -208, 1000, 781 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKOOM+AdvPS586B FontSubset: true FirstChar: 49 LastChar: 53 FontDescriptor: FontName: FKKOOM+AdvPS586B Flags: Nonsymbolic FontBBox: -20, -229, 1010, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKPIK+Calibri FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: FKKPIK+Calibri Flags: Symbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FKLABP+AdvPS44A44B FontSubset: true FirstChar: 33 LastChar: 33 FontDescriptor: FontName: FKLABP+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FKKOPN+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FKKOPN+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: FKKPIL+ArialMT FontSubset: true FirstChar: 32 LastChar: 149 FontDescriptor: FontName: FKKPIL+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.trci.2019.09.005 The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders Daniel Alcolea Jordi Clarimón María Carmona-Iragui Ignacio Illán-Gala Estrella Morenas-Rodríguez Isabel Barroeta Roser Ribosa-Nogué Isabel Sala M. Belén Sánchez-Saudinós Laura Videla Andrea Subirana Bessy Benejam Sílvia Valldeneu Susana Fernández Teresa Estellés Miren Altuna Miguel Santos-Santos Lídia García-Losada Alexandre Bejanin Jordi Pegueroles Víctor Montal Eduard Vilaplana Olivia Belbin Oriol Dols-Icardo Sònia Sirisi Marta Querol-Vilaseca Laura Cervera-Carles Laia Muñoz Raúl Núñez Soraya Torres M. Valle Camacho Ignasi Carrió Sandra Giménez Constance Delaby Ricard Rojas-Garcia Janina Turon-Sans Javier Pagonabarraga Amanda Jiménez Rafael Blesa Juan Fortea Alberto Lleó Biomarkers Neuroimaging Alzheimer's disease Frontontemporal dementia Dementia with Lewy bodies Neurodegeneration Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (2019) 597-609. doi:10.1016/j.trci.2019.09.005 Elsevier Inc. journal Alzheimer's & Dementia: Translational Research & Clinical Interventions © 2019 The Authors. 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