b9a2b5f77caed9e19432739a4c11c708 pmc_31652649.pdf ad59856f8a181d07e64131e9b0d6453e996e77a4 pmc_31652649.pdf efee77403334e1158df70e8d43f334d59447724c0ed38c1345e7fe2f415f7ba2 pmc_31652649.pdf Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Wed Oct 23 13:33:20 2019 CEST ModDate: Wed Oct 23 13:33:20 2019 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2888078 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 FUSPNT+Pxsy Type 1 Builtin yes yes no 15 0 DDMOHK+VnURWPalladioL Type 1 Custom yes yes no 19 0 SZRDEO+URWPalladioL-Ital Type 1 Custom yes yes no 23 0 SQNTRE+URWPalladioL-Bold Type 1 Custom yes yes no 28 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 32 0 ODNBCO+URWPalladioL-Roma Type 1 Custom yes yes no 36 0 FATHTC+Rpxr Type 1 Builtin yes yes no 40 0 OKGWPZ+EURM10 Type 1 Builtin yes yes no 44 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 48 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 56 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 78 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 82 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 86 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 99 0 OSGXHE+Rpxi Type 1 Builtin yes yes no 103 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 115 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 119 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 123 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 127 0 TimesNewRomanPSMT TrueType WinAnsi no no no 134 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 146 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 150 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 154 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 158 0 SymbolMT CID TrueType Identity-H yes no yes 165 0 TimesNewRomanPSMT TrueType WinAnsi no no no 173 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 186 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 190 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 194 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 198 0 TimesNewRomanPSMT TrueType WinAnsi no no no 205 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 217 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 221 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 225 0 SymbolMT CID TrueType Identity-H yes no yes 229 0 TimesNewRomanPSMT TrueType WinAnsi no no no 237 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 250 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 254 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 258 0 SymbolMT CID TrueType Identity-H yes no yes 262 0 TimesNewRomanPSMT TrueType WinAnsi no no no 270 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 283 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 287 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 291 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 295 0 SymbolMT CID TrueType Identity-H yes no yes 302 0 TimesNewRomanPSMT TrueType WinAnsi no no no 310 0 BCDEEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 323 0 BCDFEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 327 0 BCDGEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 331 0 BCDHEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 335 0 SymbolMT CID TrueType Identity-H yes no yes 342 0 TimesNewRomanPSMT TrueType WinAnsi no no no 350 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 374 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-19 06:09:11 CET RepresentationInformation: pmc_31652649.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-08-03 03:39:09 CEST Size: 2888078 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 605 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Mice and Experimental Protocol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Systolic Cardiac Function by Transthoracic Echocardiography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Collagen Content and Cardiomyocyte Size Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Real Time-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Total Myocardial Homogenates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Gelatin Zymography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Cardiac Fibroblasts Isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Western Blot Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: AngII Treatment Induces a Similar Hypertrophic Response in Hearts from Cx43fl/fl and Cx43Cre-ER(T)/fl Mice Independently of Cx43 Levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: AngII Treatment Differentially Modulates Cardiac Fibrosis in Cx43Cre-ER(T)/fl Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Paradoxical Overexpression of mRNAs Coding for Proteins Involved in Collagen Turnover in Cx43-Deficient Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Enhanced Collagen Deposition in Response to AngII in Hearts from Partially Deficient Cx43Cre-ER(T)/fl Mice Correlates with Increased p38 MAPK Activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Normalization of Collagen Content in Hearts from Cx43Cre-ER(T)/fl Mice Injected with 4-OHT After AngII Treatment is Associated with Increased MMP-9 Activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Isolated Cardiac Fibroblasts from Highly Deficient Cx43Cre-ER(T)/fl Mice Have Altered Phenotype and Differentiation Capacity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Deletion of Cx43 in Cx43Cre-ER(T)/fl Mice Injected with 4-OHT is Associated with Enhanced Cardiac Expression of Inflammatory Markers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Info: Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Wed Oct 23 13:33:20 CEST 2019 ModDate: Wed Oct 23 13:33:20 CEST 2019 ID: 0xb424337eac46665a9ccec087313b3580, 0xb424337eac46665a9ccec087313b3580 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: LZDGTK+Rpxb FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: LZDGTK+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: MPUDFL+PazoMath FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: MPUDFL+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true Font: BaseFont: ODNBCO+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 186 FontDescriptor: FontName: ODNBCO+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OSGXHE+Rpxi FontSubset: true FirstChar: 11 LastChar: 60 FontDescriptor: FontName: OSGXHE+Rpxi Flags: Symbolic FontBBox: -162, -280, 856, 733 FontFile: true Font: BaseFont: FATHTC+Rpxr FontSubset: true FirstChar: 11 LastChar: 61 FontDescriptor: FontName: FATHTC+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: SSNIUI+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 189 FontDescriptor: FontName: SSNIUI+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: OKGWPZ+EURM10 FontSubset: true FirstChar: 11 LastChar: 28 FontDescriptor: FontName: OKGWPZ+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: FUSPNT+Pxsy FontSubset: true FirstChar: 0 LastChar: 121 FontDescriptor: FontName: FUSPNT+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: QTLELQ+Pxbsy FontSubset: true FirstChar: 121 LastChar: 121 FontDescriptor: FontName: QTLELQ+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: DDMOHK+VnURWPalladioL FontSubset: true FirstChar: 178 LastChar: 226 FontDescriptor: FontName: DDMOHK+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: VSHNAE+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: SZRDEO+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: SZRDEO+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: SQNTRE+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: SQNTRE+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 162, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 398, 640, 409, 654 Annotation: Subtype: Link Rect: 222, 613, 233, 626 Annotation: Subtype: Link Rect: 100, 113, 107, 122 ActionDest: 362 Annotation: Subtype: Link Rect: 429, 86, 436, 95 ActionDest: 362 Annotation: Subtype: Link Rect: 154, 38, 228, 50 Annotation: Subtype: Link Rect: 415, 38, 519, 50 Annotation: Subtype: Link Rect: 466, 462, 518, 481 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 473, 729, 480, 738 ActionDest: 362 Annotation: Subtype: Link Rect: 165, 702, 172, 711 ActionDest: 362 Annotation: Subtype: Link Rect: 169, 688, 176, 698 ActionDest: 362 Annotation: Subtype: Link Rect: 172, 661, 179, 671 ActionDest: 362 Annotation: Subtype: Link Rect: 180, 661, 187, 671 ActionDest: 362 Annotation: Subtype: Link Rect: 149, 634, 156, 644 ActionDest: 362 Annotation: Subtype: Link Rect: 163, 607, 170, 617 ActionDest: 362 Annotation: Subtype: Link Rect: 122, 594, 129, 603 ActionDest: 362 Annotation: Subtype: Link Rect: 461, 580, 468, 590 ActionDest: 365 Annotation: Subtype: Link Rect: 342, 540, 354, 549 ActionDest: 365 Annotation: Subtype: Link Rect: 485, 526, 497, 535 ActionDest: 365 Annotation: Subtype: Link Rect: 498, 526, 510, 535 ActionDest: 365 Annotation: Subtype: Link Rect: 496, 486, 503, 495 ActionDest: 362 Annotation: Subtype: Link Rect: 503, 486, 515, 495 ActionDest: 365 Annotation: Subtype: Link Rect: 442, 459, 454, 468 ActionDest: 365 Annotation: Subtype: Link Rect: 454, 459, 466, 468 ActionDest: 365 Annotation: Subtype: Link Rect: 229, 418, 241, 427 ActionDest: 365 Annotation: Subtype: Link Rect: 244, 418, 256, 427 ActionDest: 365 Annotation: Subtype: Link Rect: 115, 364, 127, 373 ActionDest: 365 Annotation: Subtype: Link Rect: 127, 364, 139, 373 ActionDest: 365 Annotation: Subtype: Link Rect: 311, 324, 323, 333 ActionDest: 365 Annotation: Subtype: Link Rect: 133, 310, 145, 319 ActionDest: 365 Annotation: Subtype: Link Rect: 418, 283, 430, 292 ActionDest: 365 Annotation: Subtype: Link Rect: 503, 242, 515, 252 ActionDest: 365 Annotation: Subtype: Link Rect: 338, 76, 350, 85 ActionDest: 365 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 118, 675, 125, 684 ActionDest: 362 Annotation: Subtype: Link Rect: 126, 675, 138, 684 ActionDest: 365 Annotation: Subtype: Link Rect: 138, 675, 150, 684 ActionDest: 365 Annotation: Subtype: Link Rect: 151, 675, 163, 684 ActionDest: 365 Annotation: Subtype: Link Rect: 253, 634, 265, 644 ActionDest: 365 Annotation: Subtype: Link Rect: 236, 607, 248, 617 ActionDest: 365 Annotation: Subtype: Link Rect: 248, 607, 260, 617 ActionDest: 365 Annotation: Subtype: Link Rect: 271, 580, 278, 590 ActionDest: 362 Annotation: Subtype: Link Rect: 278, 580, 290, 590 ActionDest: 365 Annotation: Subtype: Link Rect: 291, 580, 303, 590 ActionDest: 365 Annotation: Subtype: Link Rect: 182, 321, 194, 331 ActionDest: 365 Annotation: Subtype: Link Rect: 321, 265, 333, 274 ActionDest: 365 Annotation: Subtype: Link Rect: 353, 252, 365, 261 ActionDest: 365 Annotation: Subtype: Link Rect: 503, 182, 515, 191 ActionDest: 365 Annotation: Subtype: Link Rect: 422, 112, 433, 121 ActionDest: 365 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 337, 589, 349, 599 ActionDest: 368 Annotation: Subtype: Link Rect: 124, 493, 136, 502 ActionDest: 365 Annotation: Subtype: Link Rect: 130, 423, 142, 432 ActionDest: 365 Annotation: Subtype: Link Rect: 142, 423, 154, 432 ActionDest: 368 Annotation: Subtype: Link Rect: 362, 270, 369, 279 ActionDest: 362 Annotation: Subtype: Link Rect: 369, 270, 381, 279 ActionDest: 365 Annotation: Subtype: Link Rect: 382, 270, 394, 279 ActionDest: 365 Annotation: Subtype: Link Rect: 136, 185, 143, 197 ActionDest: 107 Annotation: Subtype: Link Rect: 108, 158, 115, 170 ActionDest: 107 Annotation: Subtype: Link Rect: 418, 158, 424, 170 ActionDest: 107 Annotation: Subtype: Link Rect: 310, 144, 317, 156 ActionDest: 107 Annotation: Subtype: Link Rect: 350, 77, 357, 89 ActionDest: 107 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 308, 201, 315, 213 ActionDest: 138 Annotation: Subtype: Link Rect: 110, 174, 117, 186 ActionDest: 138 Annotation: Subtype: Link Rect: 390, 160, 397, 174 ActionDest: 138 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 148, 290, 155, 303 ActionDest: 138 Annotation: Subtype: Link Rect: 398, 249, 404, 261 ActionDest: 138 Annotation: Subtype: Link Rect: 502, 222, 509, 236 ActionDest: 138 Annotation: Subtype: Link Rect: 454, 208, 461, 222 ActionDest: 138 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 481, 682, 488, 696 ActionDest: 178 Annotation: Subtype: Link Rect: 191, 614, 198, 626 ActionDest: 138 Annotation: Subtype: Link Rect: 151, 191, 158, 203 ActionDest: 178 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 129, 742, 141, 752 ActionDest: 368 Annotation: Subtype: Link Rect: 141, 742, 153, 752 ActionDest: 368 Annotation: Subtype: Link Rect: 209, 645, 216, 657 ActionDest: 209 Annotation: Subtype: Link Rect: 233, 632, 241, 645 ActionDest: 209 Annotation: Subtype: Link Rect: 205, 618, 212, 630 ActionDest: 138 Annotation: Subtype: Link Rect: 507, 94, 514, 106 ActionDest: 209 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 146, 726, 153, 738 ActionDest: 209 Annotation: Subtype: Link Rect: 313, 549, 320, 561 ActionDest: 242 Annotation: Subtype: Link Rect: 503, 99, 510, 111 ActionDest: 275 Annotation: Subtype: Link Rect: 109, 72, 116, 84 ActionDest: 275 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 446, 225, 453, 237 ActionDest: 315 Annotation: Subtype: Link Rect: 276, 157, 282, 169 ActionDest: 315 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 203, 224, 215, 234 ActionDest: 365 Annotation: Subtype: Link Rect: 215, 224, 227, 234 ActionDest: 368 Annotation: Subtype: Link Rect: 228, 224, 240, 234 ActionDest: 368 Annotation: Subtype: Link Rect: 240, 224, 252, 234 ActionDest: 368 Annotation: Subtype: Link Rect: 132, 184, 144, 193 ActionDest: 368 Annotation: Subtype: Link Rect: 145, 184, 157, 193 ActionDest: 368 Annotation: Subtype: Link Rect: 157, 184, 169, 193 ActionDest: 368 Annotation: Subtype: Link Rect: 503, 130, 515, 139 ActionDest: 368 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 209, 729, 221, 738 ActionDest: 368 Annotation: Subtype: Link Rect: 503, 675, 515, 684 ActionDest: 365 Annotation: Subtype: Link Rect: 118, 621, 130, 630 ActionDest: 365 Annotation: Subtype: Link Rect: 131, 621, 143, 630 ActionDest: 368 Annotation: Subtype: Link Rect: 145, 621, 157, 630 ActionDest: 368 Annotation: Subtype: Link Rect: 503, 607, 515, 617 ActionDest: 368 Annotation: Subtype: Link Rect: 158, 567, 170, 576 ActionDest: 368 Annotation: Subtype: Link Rect: 245, 540, 257, 549 ActionDest: 365 Annotation: Subtype: Link Rect: 380, 513, 392, 522 ActionDest: 365 Annotation: Subtype: Link Rect: 241, 499, 253, 508 ActionDest: 365 Annotation: Subtype: Link Rect: 254, 499, 266, 508 ActionDest: 365 Annotation: Subtype: Link Rect: 408, 499, 420, 508 ActionDest: 365 Annotation: Subtype: Link Rect: 421, 499, 433, 508 ActionDest: 365 Annotation: Subtype: Link Rect: 140, 405, 152, 414 ActionDest: 368 Annotation: Subtype: Link Rect: 388, 378, 400, 387 ActionDest: 365 Annotation: Subtype: Link Rect: 339, 351, 351, 360 ActionDest: 365 Annotation: Subtype: Link Rect: 394, 175, 406, 184 ActionDest: 368 Annotation: Subtype: Link Rect: 406, 175, 418, 184 ActionDest: 368 Annotation: Subtype: Link Rect: 117, 81, 129, 90 ActionDest: 365 Annotation: Subtype: Link Rect: 129, 80, 141, 90 ActionDest: 365 Annotation: Subtype: Link Rect: 142, 80, 154, 90 ActionDest: 365 Annotation: Subtype: Link Rect: 154, 80, 166, 90 ActionDest: 368 Annotation: Subtype: Link Rect: 169, 80, 181, 90 ActionDest: 368 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 240, 513, 252, 522 ActionDest: 365 Annotation: Subtype: Link Rect: 224, 486, 236, 495 ActionDest: 368 Annotation: Subtype: Link Rect: 372, 445, 384, 454 ActionDest: 368 Annotation: Subtype: Link Rect: 141, 378, 153, 387 ActionDest: 368 Annotation: Subtype: Link Rect: 153, 378, 165, 387 ActionDest: 368 Annotation: Subtype: Link Rect: 475, 351, 487, 360 ActionDest: 368 Annotation: Subtype: Link Rect: 160, 337, 172, 346 ActionDest: 371 Annotation: Subtype: Link Rect: 393, 337, 400, 346 ActionDest: 362 Annotation: Subtype: Link Rect: 221, 310, 233, 319 ActionDest: 371 Annotation: Subtype: Link Rect: 458, 310, 470, 319 ActionDest: 371 Annotation: Subtype: Link Rect: 175, 297, 187, 306 ActionDest: 371 Annotation: Subtype: Link Rect: 382, 283, 394, 292 ActionDest: 371 Annotation: Subtype: Link Rect: 424, 256, 436, 265 ActionDest: 371 Annotation: Subtype: Link Rect: 142, 161, 154, 171 ActionDest: 368 Annotation: Subtype: Link Rect: 154, 161, 166, 171 ActionDest: 368 Annotation: Subtype: Link Rect: 127, 121, 139, 130 ActionDest: 368 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 109, 742, 121, 752 ActionDest: 368 Annotation: Subtype: Link Rect: 333, 536, 518, 547 Annotation: Subtype: Link Rect: 154, 274, 191, 284 Annotation: Subtype: Link Rect: 198, 274, 234, 284 Annotation: Subtype: Link Rect: 463, 260, 500, 271 Annotation: Subtype: Link Rect: 182, 234, 219, 245 Annotation: Subtype: Link Rect: 225, 234, 262, 245 Annotation: Subtype: Link Rect: 238, 209, 274, 219 Annotation: Subtype: Link Rect: 310, 183, 348, 194 Annotation: Subtype: Link Rect: 436, 171, 473, 181 Annotation: Subtype: Link Rect: 480, 131, 516, 142 Annotation: Subtype: Link Rect: 246, 92, 284, 103 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 426, 727, 464, 738 Annotation: Subtype: Link Rect: 411, 688, 449, 699 Annotation: Subtype: Link Rect: 100, 638, 137, 648 Annotation: Subtype: Link Rect: 143, 638, 179, 648 Annotation: Subtype: Link Rect: 209, 586, 247, 596 Annotation: Subtype: Link Rect: 253, 586, 289, 596 Annotation: Subtype: Link Rect: 344, 546, 382, 557 Annotation: Subtype: Link Rect: 388, 546, 424, 557 Annotation: Subtype: Link Rect: 415, 521, 452, 531 Annotation: Subtype: Link Rect: 438, 482, 476, 493 Annotation: Subtype: Link Rect: 191, 444, 229, 454 Annotation: Subtype: Link Rect: 241, 404, 279, 415 Annotation: Subtype: Link Rect: 403, 378, 441, 389 Annotation: Subtype: Link Rect: 216, 341, 253, 351 Annotation: Subtype: Link Rect: 159, 302, 196, 312 Annotation: Subtype: Link Rect: 401, 262, 439, 273 Annotation: Subtype: Link Rect: 445, 262, 481, 273 Annotation: Subtype: Link Rect: 252, 224, 290, 234 Annotation: Subtype: Link Rect: 296, 224, 332, 234 Annotation: Subtype: Link Rect: 401, 186, 438, 196 Annotation: Subtype: Link Rect: 444, 186, 480, 196 Annotation: Subtype: Link Rect: 427, 146, 464, 157 Annotation: Subtype: Link Rect: 154, 108, 191, 118 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 100, 702, 137, 712 Annotation: Subtype: Link Rect: 388, 663, 426, 673 Annotation: Subtype: Link Rect: 381, 637, 419, 648 Annotation: Subtype: Link Rect: 275, 533, 313, 544 Annotation: Subtype: Link Rect: 319, 533, 355, 544 Annotation: Subtype: Link Rect: 127, 508, 165, 519 Annotation: Subtype: Link Rect: 171, 508, 207, 519 Annotation: Subtype: Link Rect: 100, 470, 137, 480 Annotation: Subtype: Link Rect: 143, 470, 179, 480 Annotation: Subtype: Link Rect: 217, 430, 255, 441 Annotation: Subtype: Link Rect: 237, 392, 274, 402 Annotation: Subtype: Link Rect: 320, 366, 357, 376 Annotation: Subtype: Link Rect: 163, 328, 201, 338 Annotation: Subtype: Link Rect: 177, 289, 214, 299 Annotation: Subtype: Link Rect: 189, 250, 226, 260 Annotation: Subtype: Link Rect: 186, 199, 223, 209 Annotation: Subtype: Link Rect: 240, 173, 276, 183 Annotation: Subtype: Link Rect: 150, 147, 187, 157 Annotation: Subtype: Link Rect: 193, 147, 230, 157 Annotation: Subtype: Link Rect: 408, 120, 445, 131 Annotation: Subtype: Link Rect: 285, 82, 323, 92 Annotation: Subtype: Link Rect: 329, 82, 365, 92 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 278, 727, 316, 738 Annotation: Subtype: Link Rect: 322, 727, 358, 738 Annotation: Subtype: Link Rect: 218, 701, 255, 712 Annotation: Subtype: Link Rect: 244, 675, 281, 686 Annotation: Subtype: Link Rect: 172, 638, 210, 648 Annotation: Subtype: Link Rect: 100, 599, 137, 609 Annotation: Subtype: Link Rect: 76, 557, 166, 588 Annotation: Subtype: Link Rect: 234, 551, 407, 562 Checksum: 6c7f2db1 Type: CRC32 Checksum: b9a2b5f77caed9e19432739a4c11c708 Type: MD5 Checksum: ad59856f8a181d07e64131e9b0d6453e996e77a4 Type: SHA-1