175d023089b11f16fd4645750c27d6f2 pmc_31658748.pdf 25663d84adaddd7172ef12aec87373b42e8e4229 pmc_31658748.pdf 51e0bbaca47398c27bcf623b8189ec6641cd712572fde0d2c9064df6695fa979 pmc_31658748.pdf Title: Myxomatosis and Rabbit Haemorrhagic Disease: A 30-Year Study of the Occurrence on Commercial Farms in Spain Subject: In this retrospective study, we describe the relative occurrence of clinical myxomatosis, and rabbit haemorrhagic disease (RHD), on 1714 commercial farms visited in Spain, between 1988 and 2018. We determined the annual prevalence based on 817 visits to 394 farms affected by myxomatosis. Myxomatosis was more prevalent from August to March, being lowest in June (3%) and highest in September (8.9%). With regard to RHD, we assessed 253 visits to 156 affected farms. We analyzed mean annual and monthly incidence. Two important RHD epidemics occurred; the first in 1988–1989 due to RHDV GI.1 (also known as RHDV), and the second from 2011 to 2013 due to RHDV GI.2 (RHDV2 or RHDVb). These epidemics occurred at times when effective vaccination had not been carried out. Relative monthly incidence in 2011–2018 was higher from April to August (p < 0.001). The results we obtained from 1404 necropsies on 102 farms did not clearly relate serosanguinous nasal discharge in rabbits with disease caused by GI.2 infection. We also assessed vaccination schedules used on 200 doe farms visited from the end of 2014 to 2018; 95.5% vaccinated against myxomatosis and 97.5% against RHD. Both diseases remain prevalent; however, effective vaccination has produced a steady decline in myxomatosis and RHDV GI.1 and GI.2 on-farm detection. The maintenance of high hygienic standards will be needed to continue and improve this control. However, further studies are required to investigate the causes of sustained virus presence and vaccine breaks. Keywords: animal welfare; disease prevention; myxomatosis prevalence; rabbit haemorrhagic disease incidence Author: Joan M. Rosell, L. Fernando de la Fuente, Francisco Parra, Kevin P. Dalton, J. Ignacio Badiola Sáiz, Ana Pérez de Rozas, Juan J. Badiola Díez, Daniel Fernández de Luco, Jordi Casal, Natàlia Majó, Jordina Casas, Ricard Garriga and Xosé M. 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IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰うちひねびぜ〴ぜ〰ざどびどぴづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ざづぴづひどのちひべぜ〴ぜ〰ざどびどぴびぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くの〭うちひねぜ〴ぜ〰いどちでのはびぴどっぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰うちひねびぜ〴ぜ〰ざどびどぴづつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ざづぴづひどのちひべぜ〴ぜ〰ざどびどぴびぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くの〭うちひねぜ〴ぜ〰いどちでのはびぴどっぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ざづぴづひどのちひべぜ〴ぜ〰ざどびどぴびぜ〴ぜ〰ぴはぜ〴ぜ〰ぴとづぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くの〭うちひねぜ〴ぜ〰いどちでのはびぴどっぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くの〭うちひねぜ〴ぜ〰いどちでのはびぴどっぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ざどびどぴづつぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ざどびどぴびぜ〴ぜ〰ぴはぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつどづつぜ〴ぜ〰げどびにぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Children: Item: Title: ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ざどびどぴづつぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ざどびどぴびぜ〴ぜ〰ぴはぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつどづつぜ〴ぜ〰げどびにぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Item: Title: ざどびどぴびぜ〴ぜ〰ぴはぜ〴ぜ〰うちひねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつどづつぜ〴ぜ〰げどびにぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Item: Title: いどちでのはびどのでぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰いどちでのはびどのでぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつどづつぜ〴ぜ〰げどびにぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Item: Title: いどちでのはびどのでぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつどづつぜ〴ぜ〰げどびにぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Item: Title: ぁのちぬべびどびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつどづつぜ〴ぜ〰げどびにぜ〴ぜ〰うちっぴはひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Item: Title: げづぬちぴどぶづぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸱ Children: Item: Title: ぁののふちぬぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸶⸲ Item: Title: きはのぴとぬべぜ〴ぜ〰ぐひづぶちぬづのっづぜ〴ぜ〰はてぜ〴ぜ〰きべへはねちぴはびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㜩‾㸊⡜㌷㙜㌷㝜〰げづぬちぴどぶづぜ〴ぜ〰ぉのっどつづのっづぜ〴ぜ〰はてぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸷⸱ Item: Title: げづぬちぴどぶづぜ〴ぜ〰ぉのっどつづのっづぜ〴ぜ〰はてぜ〴ぜ〰げちぢぢどぴぜ〴ぜ〰えちづねはひひとちでどっぜ〴ぜ〰いどびづちびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸷⸱ Children: Item: Title: ぁののふちぬぜ〴ぜ〰ぉのっどつづのっづぜ〴ぜ〰はてぜ〴ぜ〰げえいぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸷⸲ Item: Title: きはのぴとぬべぜ〴ぜ〰ぉのっどつづのっづぜ〴ぜ〰はてぜ〴ぜ〰げえいぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: TGMEOR+Rpcxr FontSubset: true FirstChar: 169 LastChar: 174 FontDescriptor: FontName: TGMEOR+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: FMXQFV+Rpxb FontSubset: true FirstChar: 62 LastChar: 62 FontDescriptor: FontName: FMXQFV+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: OVNEXW+EURM10 FontSubset: true FirstChar: 22 LastChar: 22 FontDescriptor: FontName: OVNEXW+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: GBLQZB+Rpxi FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: 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