23abfd5d9189d8563ffbd97d64311d3b pmc_31700058.pdf bef5846bf7f508486d8f17df77cc12bb13b0822a pmc_31700058.pdf 3b89c4986b8da2b359cf94ac2a4c23fcb869324ed2b7305a2813b0b929670a65 pmc_31700058.pdf Title: Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors Subject: Scientific Reports, doi:10.1038/s41598-019-52721-5 Keywords: Author: Anna Carnes-Vendrell Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Oct 31 15:12:05 2019 CET ModDate: Fri Nov 1 16:48:27 2019 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1333896 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JNEOKF+Corbel-Bold CID TrueType Identity-H yes yes yes 380 0 EuclidSymbol-Bold Type 1C Custom yes no yes 110 0 CVOYEL+Corbel-Bold2 Type 1C WinAnsi yes yes yes 65 0 MinionPro-Regular Type 1C Custom yes no yes 64 0 PEREGA+Corbel2 Type 1C WinAnsi yes yes yes 67 0 DJGJER+Corbel CID TrueType Identity-H yes yes yes 68 0 MyriadPro-It Type 1C WinAnsi yes no yes 69 0 YPRHHB+STIXGeneral-Regular Type 1C Custom yes yes yes 63 0 EuclidSymbol Type 1C Custom yes no yes 66 0 MinionPro-Bold Type 1C Custom yes no yes 92 0 MinionPro-BoldIt Type 1C WinAnsi yes no yes 111 0 MinionPro-It Type 1C Custom yes no yes 163 0 YAWVHB+TimesNewRomanPSMT Type 1C WinAnsi yes yes yes 233 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-08-10 12:21:39 CEST RepresentationInformation: pmc_31700058.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-03-02 03:51:07 CET Size: 1333896 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 5. Towfighi, A. et al. Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 47, 1–15 (2016). :29' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 8. Tang, W. K. et al. Location of infarcts and apathy in ischemic stroke. Cerebrovasc. Dis. 35, 566–71 (2013). :43' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 8. Tang, W. K. et al. Location of infarcts and apathy in ischemic stroke. Cerebrovasc. Dis. 35, 566–71 (2013). :58' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd:Figure 1. Flow-chart.:64' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: Table 2. Proportion of patients diagnosed with post-stroke depression, post-stroke apathy, or both.:66' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd:Figure 2. Evolution of post-stroke depression. Figure shows that there was a decrease in the level of depression, which is shown by the BDI-II and MADRS scales. In baseline PSD patients (blue line), both scores decreased at 12 months (the red li:67' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd:Figure 3. Evolution of post-stroke apathy. Figure shows how apathy remained stable during the first year post-stroke; the level of apathy measured by the AES-C score did not decrease (blue line). The red line indicates patients without post-stro:68' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: Table 2. Proportion of patients diagnosed with post-stroke depression, post-stroke apathy, or both.:69' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 9. Van Dalen, J. W., Van Charante, E. P. M., Nederkoorn, P. J., Van Gool, W. A. & Richard, E. Poststroke apathy. Stroke 44, 851–860 (2013). :76' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 41. Mihalov, J., Mikula, P., Budiš, J. & ValkoviŜ爀Ⰰ 倀⸀ 䘀爀漀渀琀愀氀 䌀漀爀琀椀挀愀氀 䄀琀爀漀瀀栀礀 愀猀 愀 倀爀攀搀椀挀琀漀爀 漀昀 倀漀猀琀猀琀爀漀欀攀 䄀瀀愀琀栀礀⸀⃾＀䨀⸀ 䜀攀爀椀愀琀爀⸀ 倀猀礀挀栀椀愀琀爀礀 一攀甀爀漀氀⻾＀⃾＀㈀㧾＀Ⰰ ㄀㜀ㄠጀ㄀㜀㘀 ㈀ ㄀㘀⻾＀㨀㜀㤩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㈶㤮㌰ㄠㄸ㘮㜶㌠㈷㐮㤱㜠ㄷ㐮㘲㉝⽈⽎⽁值㰯丠ㄵ㜠〠刾㸾㸊敮摯扪਱㐲‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_52721.indd: 9. Van Dalen, J. W., Van Charante, E. P. M., Nederkoorn, P. J., Van Gool, W. A. & Richard, E. Poststroke apathy. Stroke 44, 851–860 (2013). :80' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 9. Van Dalen, J. W., Van Charante, E. P. M., Nederkoorn, P. J., Van Gool, W. A. & Richard, E. Poststroke apathy. Stroke 44, 851–860 (2013). :80' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 42. Hackett, M. L., Yapa, C., Parag, V. & Anderson, C. S. Frequency of depression after stroke: a systematic review of observational studies. Stroke 36, 1330–40 (2005). :81' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 43. Hadidi, N., Treat-Jacobson, D. J. & Lindquist, R. Poststroke depression and functional outcome: a critical review of literature. Heart Lung 38, 151–62 (2009). :82' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 44. Snaphaan, L., Van Der Werf, S., Kanselaar, K. & De Leeuw, F. E. Post-stroke depressive symptoms are associated with post-stroke characteristics. Cerebrovasc. Dis. 28, 551–557 (2009). :83' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 42. Hackett, M. L., Yapa, C., Parag, V. & Anderson, C. S. Frequency of depression after stroke: a systematic review of observational studies. Stroke 36, 1330–40 (2005). :84' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 43. Hadidi, N., Treat-Jacobson, D. J. & Lindquist, R. Poststroke depression and functional outcome: a critical review of literature. Heart Lung 38, 151–62 (2009). :85' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 44. Snaphaan, L., Van Der Werf, S., Kanselaar, K. & De Leeuw, F. E. Post-stroke depressive symptoms are associated with post-stroke characteristics. Cerebrovasc. Dis. 28, 551–557 (2009). :86' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 42. Hackett, M. L., Yapa, C., Parag, V. & Anderson, C. S. Frequency of depression after stroke: a systematic review of observational studies. Stroke 36, 1330–40 (2005). :87' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 45. Terroni, L. et al. Association among depression, cognitive impairment and executive dysfunction after stroke. Dement Neuropsychol 6, 152–157 (2012). :88' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 46. Provinciali, L. et al. Depression after first-ever ischemic stroke: The prognostic role of neuroanatomic subtypes in clinical practice. Cerebrovasc. Dis. 26, 592–599 (2008). :203' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 47. Provinciali, L. et al. Depression after first-ever ischemic stroke: The prognostic role of neuroanatomic subtypes in clinical practice. Cerebrovasc. Dis. 26, 592–599 (2008). :90' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 43. Hadidi, N., Treat-Jacobson, D. J. & Lindquist, R. Poststroke depression and functional outcome: a critical review of literature. Heart Lung 38, 151–62 (2009). :92' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 48. De Ryck, A. et al. Risk Factors for Poststroke Depression: Identification of Inconsistencies Based on a Systematic Review. J. Geriatr. Psychiatry Neurol. 27, 147–158 (2014). :93' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 49. Tang, W. K. et al. Cerebral microbleeds and depression in lacunar stroke. Stroke 42, 2443–2446 (2011). :95' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 41. Mihalov, J., Mikula, P., Budiš, J. & ValkoviŜ爀Ⰰ 倀⸀ 䘀爀漀渀琀愀氀 䌀漀爀琀椀挀愀氀 䄀琀爀漀瀀栀礀 愀猀 愀 倀爀攀搀椀挀琀漀爀 漀昀 倀漀猀琀猀琀爀漀欀攀 䄀瀀愀琀栀礀⸀⃾＀䨀⸀ 䜀攀爀椀愀琀爀⸀ 倀猀礀挀栀椀愀琀爀礀 一攀甀爀漀氀⻾＀⃾＀㈀㧾＀Ⰰ ㄀㜀ㄠጀ㄀㜀㘀 ㈀ ㄀㘀⻾＀㨀㤀㜩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛ㄸ㠮㌷㠠㌲〮㜶㌠ㄹ㌮㤹㐠㌰㠮㘲㉝⽈⽎⽁值㰯丠㈱〠〠刾㸾㸊敮摯扪਱㠳‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_52721.indd: 51. Lohner, V., Brookes, R. L., Hollocks, M. J., Morris, R. G. & Markus, S. Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease. PLoS One 12, e0176943 (2017). :98' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 9. Van Dalen, J. W., Van Charante, E. P. M., Nederkoorn, P. J., Van Gool, W. A. & Richard, E. Poststroke apathy. Stroke 44, 851–860 (2013). :101' cannot be found Offset: 996008 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_52721.indd: 51. Lohner, V., Brookes, R. L., Hollocks, M. J., Morris, R. G. & Markus, S. Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease. PLoS One 12, e0176943 (2017). :107' cannot be found Offset: 996008 MIMEtype: application/pdf PDFMetadata: Objects: 416 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Language: EN Outlines: Item: Title: Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors Children: Item: Title: Methods Children: Item: Title: Patients and study design. Item: Title: Neuroimaging evaluation. Item: Title: Depression and apathy assessment. Item: Title: Cognitive, functional and quality of life variables. Item: Title: Statistical analysis. Item: Title: Results Children: Item: Title: Sample characteristics. Item: Title: Neuroimaging data. Item: Title: Description and evolution of depression and post-stroke apathy. Item: Title: Variables related to post-stroke depression. Item: Title: Variables related to post-stroke apathy. Item: Title: Discussion Item: Title: Acknowledgements Item: Title: Figure 1 Flow-chart. Item: Title: Figure 2 Evolution of post-stroke depression. Item: Title: Figure 3 Evolution of post-stroke apathy. Item: Title: Table 1 Sociodemographic and clinical variables related to post-stroke depression and post-stroke apathy (baseline data). Item: Title: Table 2 Proportion of patients diagnosed with post-stroke depression, post-stroke apathy, or both. Item: Title: Table 3 Multivariate analysis for post-stroke depression after TIA and/or minor stroke. Item: Title: Table 4 Multivariate analysis for post-stroke apathy after TIA and/or minor stroke. Info: Title: Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors Author: Anna Carnes-Vendrell Subject: Scientific Reports, doi:10.1038/s41598-019-52721-5 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) CreationDate: Thu Oct 31 15:42:05 CET 2019 ModDate: Fri Nov 01 16:48:27 CET 2019 ID: 0xc175a0b44ceabb9995c6c05b454d7339, 0x4ea9ec3481ca988bfeeb9b44d4543638 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 804 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1300 ImageHeight: 811 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1650 ImageHeight: 639 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: DJGJER+Corbel Encoding: Identity-H ToUnicode: true Font: BaseFont: JNEOKF+Corbel-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CVOYEL+Corbel-Bold2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: CVOYEL+Corbel-Bold2 Flags: Nonsymbolic FontBBox: -556, -239, 1155, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EuclidSymbol FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol Flags: Symbolic FontBBox: -166, -253, 1090, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PEREGA+Corbel2 FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: PEREGA+Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: YAWVHB+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 120 FontDescriptor: FontName: YAWVHB+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: EuclidSymbol-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EuclidSymbol-Bold Flags: Symbolic FontBBox: -186, -308, 1101, 960 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YPRHHB+STIXGeneral-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: YPRHHB+STIXGeneral-Regular Flags: Serif, Symbolic FontBBox: -995, -455, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-BoldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-BoldIt Flags: Serif, Nonsymbolic, Italic FontBBox: -230, -360, 1684, 1032 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: DJGJER+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DJGJER+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: JNEOKF+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JNEOKF+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: application/pdf doi:10.1038/s41598-019-52721-5 Springer US Scientific Reports, doi:10.1038/s41598-019-52721-5 Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors Anna Carnes-Vendrell Joan Deus Jessica Molina-Seguin Josep Pifarramp#x000E9; Francisco Purroy 10.1038/s41598-019-52721-5 http://dx.doi.org/10.1038/s41598-019-52721-5 journal Scientific Reports © 2019, The Author(s) 2045-2322 10.1038/s41598-019-52721-5 Springer 2019-11-01T16:48:27+01:00 2019-10-31T19:42:05+05:30 2019-11-01T16:48:27+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version) VoR uuid:3143666d-87e3-4e5f-8eed-8dd3038e952c uuid:e1e786e8-0096-4263-acee-9eff661644cb default 1 converted uuid:4215ce7c-949e-4c3a-919d-78adcb18bcea converted to PDF/A-2b pdfToolbox 2019-10-31T19:42:43+05:30 2 B http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. 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PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 227, 496, 236, 484 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 545, 258, 548, 246 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 549, 258, 552, 246 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 375, 238, 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Destination: 225 Annotation: Subtype: Link Rect: 546, 138, 552, 126 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 192, 88, 197, 76 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 199, 88, 204, 76 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 468, 78, 474, 66 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 530, 58, 533, 46 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 534, 58, 540, 46 Flags: Print AppearanceDictionary: true Destination: 225 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 374, 463, 380, 451 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 520, 463, 526, 451 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 501, 413, 507, 401 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 509, 413, 515, 401 Flags: Print AppearanceDictionary: true Destination: 225 Annotation: Subtype: Link Rect: 226, 193, 230, 181 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 179, 133, 184, 121 Flags: Print AppearanceDictionary: true Destination: 94 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 458, 157, 463, 145 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 487, 117, 492, 105 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 509, 117, 513, 105 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 209, 65, 213, 53 Flags: Print AppearanceDictionary: true Destination: 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8 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 223, 25, 370, 16 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 361, 331, 520, 318 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 349, 302, 441, 289 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 192, 504, 180 Flags: Print AppearanceDictionary: true Thumb: true Checksum: fd973cda Type: CRC32 Checksum: 23abfd5d9189d8563ffbd97d64311d3b Type: MD5 Checksum: bef5846bf7f508486d8f17df77cc12bb13b0822a Type: SHA-1