ecd3514e89a6d8c253fd135858e9e1c9  pmc_31703718.pdf
330f14bb5136b3a0ad799954d973f613cb8a5b08  pmc_31703718.pdf
3561ab7d3fc829804fde47f5aa8548bf02601acd2b0a73d606481f3ac57b97ae  pmc_31703718.pdf

Title:          Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain
Subject:        Parasites & Vectors, https://doi.org/10.1186/s13071-019-3783-2
Keywords:       Toxoplasma gondii,Chronic infection,Reproductive impairment,DEGs,RNA-seq
Author:         Yu-Xiang Zheng 
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
CreationDate:   Tue Nov  5 07:47:31 2019 CET
ModDate:        Fri Nov  8 08:51:14 2019 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1648214 bytes
Optimized:      no
PDF version:    1.6

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     42  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     38  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     41  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     39  0
MyriadPro-LightIt                    Type 1C           Custom           yes no  yes     57  0
ANKIXX+MTSY                          Type 1C           Custom           yes yes yes     44  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     43  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes     37  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     40  0
VCPIKI+OpenSans                      Type 1C           WinAnsi          yes yes no     236  0
VCPIKI+STIXMath-Regular              Type 1C           Custom           yes yes yes    161  0
QXASXS+OregonLDOBookSinistral        Type 1C           WinAnsi          yes yes no     185  0
QXASXS+OpenSans-Light                Type 1C           Custom           yes yes no     179  0
QXASXS+OpenSans-Bold                 Type 1C           WinAnsi          yes yes no     182  0
QXASXS+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     175  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-08-10 12:21:32 CEST
 RepresentationInformation: pmc_31703718.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-07-06 04:06:52 CEST
  Size: 1648214
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 340
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusions: 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study population and experiment set-up
         Item: 
          Title: Transcriptome sequencing, data analysis and verification
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Pre-experiment
         Item: 
          Title: Identification of infection in mice
         Item: 
          Title: Quality analysis of RNA
         Item: 
          Title: Sequencing data preprocessing
         Item: 
          Title: Analysis of gene expression
         Item: 
          Title: Analysis of DEGs
         Item: 
          Title: Bioinformatics analysis for the DEGs
         Item: 
          Title: Verification results by qPCR analyzing and western blotting
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Glycolytic pathway and sperm motility
         Item: 
          Title: Mitochondrial damage and apoptosis
         Item: 
          Title: Testis-specific genes in the epididymis
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain
    Author: Yu-Xiang Zheng 
    Subject: Parasites & Vectors, https://doi.org/10.1186/s13071-019-3783-2
    Keywords: Toxoplasma gondii,Chronic infection,Reproductive impairment,DEGs,RNA-seq
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
    CreationDate: Tue Nov 05 08:17:31 CET 2019
    ModDate: Fri Nov 08 08:51:14 CET 2019
   ID: 0xd33f9680bc24b67a06afd19a35556cd9, 0x00e06ad1261ae77aee80046197ad78a7
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 39
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 81
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 74
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 898
      ImageHeight: 752
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 896
      ImageHeight: 1499
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1593
      ImageHeight: 685
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1961
      ImageHeight: 1098
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1595
      ImageHeight: 917
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 591
      ImageHeight: 760
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: VCPIKI+STIXMath-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: VCPIKI+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VCPIKI+OpenSans
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: VCPIKI+OpenSans
       Flags: Nonsymbolic
       FontBBox: -550, -271, 1204, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ANKIXX+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: ANKIXX+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2019-11-05T12:17:31+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2019-11-08T08:51:14+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2019-11-08T08:51:14+01:00</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)</pdf:Producer>
         <pdf:Keywords>Toxoplasma gondii,Chronic infection,Reproductive impairment,DEGs,RNA-seq</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s13071-019-3783-2</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Parasites &amp; Vectors, https://doi.org/10.1186/s13071-019-3783-2</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Toxoplasma gondii</rdf:li>
               <rdf:li>Chronic infection</rdf:li>
               <rdf:li>Reproductive impairment</rdf:li>
               <rdf:li>DEGs</rdf:li>
               <rdf:li>RNA-seq</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Transcriptomic analysis of reproductive damage in the epididymis of male Kunming mice induced by chronic infection of Toxoplasma gondii PRU strain</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Yu-Xiang Zheng </rdf:li>
               <rdf:li>Xiu-Xiang Zhang </rdf:li>
               <rdf:li>Jorge A. Hernandez </rdf:li>
               <rdf:li>Yasser S. Mahmmod </rdf:li>
               <rdf:li>Wan-Yi Huang </rdf:li>
               <rdf:li>Gui-Feng Li </rdf:li>
               <rdf:li>Ya-Pei Wang </rdf:li>
               <rdf:li>Xue Zhou </rdf:li>
               <rdf:li>Xiu-Ming Li </rdf:li>
               <rdf:li>Zi-Guo Yuan </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s13071-019-3783-2</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s13071-019-3783-2</prism:url>
         <prism:doi>10.1186/s13071-019-3783-2</prism:doi>
         <prism:issn>1756-3305</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Parasites &amp; Vectors</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13071-019-3783-2</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:6bcfa73c-3493-4bc2-b44d-8227d7339032</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:fe5b3f70-7084-4e79-8c73-fff45ba08376</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:b08aeed8-8659-4956-a391-ca2acc45f3c3</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2019-11-05T12:18:34+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 182, 80, 307, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 241, 204, 246, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 253, 204, 258, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 527, 217, 533, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 237, 680, 242, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 105, 668, 110, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 217, 632, 222, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 279, 584, 284, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 121, 536, 126, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 130, 536, 136, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 107, 500, 117, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 213, 464, 223, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 59, 368, 69, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 277, 368, 287, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 260, 356, 270, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 342, 355, 347, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 345, 331, 350, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 118, 560, 123, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 72, 404, 76, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 333, 596, 338, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 352, 440, 357, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 45
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 207, 693, 212, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 280, 621, 285, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 176, 585, 181, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 200, 585, 205, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 443, 460, 448, 448
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 430, 340, 435, 328
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 326, 304, 331, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 373, 232, 378, 220
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 442, 220, 447, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 104
      Annotation: 
       Subtype: Link
       Rect: 470, 136, 474, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 121
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 185, 285, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 110, 101, 120, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 126, 101, 136, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 456, 233, 466, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 253, 143, 263, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 86, 119, 96, 107
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 327, 155, 337, 143
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 342, 131, 352, 119
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 279, 151, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 278, 183, 288, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 56, 171, 66, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 446, 279, 456, 267
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 388, 219, 398, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 502, 219, 511, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 516, 219, 526, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 473, 159, 483, 147
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 332, 111, 342, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 74, 407, 84, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 167, 275, 177, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 179, 167, 189, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 275, 143, 285, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 468, 705, 478, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 475, 693, 485, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 470, 621, 480, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 156
      Annotation: 
       Subtype: Link
       Rect: 359, 573, 369, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 447, 93, 457, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 518, 243, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 228, 446, 238, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 226, 398, 236, 386
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 218, 326, 223, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 189, 266, 199, 254
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 233, 218, 244, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 249, 218, 259, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 479, 468, 513, 459
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 458, 400, 450
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Thumb: true
  Checksum: 80f062e1
   Type: CRC32
  Checksum: ecd3514e89a6d8c253fd135858e9e1c9
   Type: MD5
  Checksum: 330f14bb5136b3a0ad799954d973f613cb8a5b08
   Type: SHA-1