4ffb8face22f0571d6329bb5c6bfc15b  pmc_31781168.pdf
75a351f5c1c54ede8da2c4bc82481354cb27bf70  pmc_31781168.pdf
54cc47e51b1cb2d0f8bad699d9b769cd21b2069e6352a96a13d44ecee888ca3e  pmc_31781168.pdf

Title:          Haplotype Analysis of the First A4V-SOD1 Spanish Family: Two Separate Founders or a Single Common Founder?
Subject:        Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isol
Keywords:       SOD1, A4V, p.A5V, amyotrophic lateral sclerosis, familial amyotrophic lateral sclerosis, ALS1,
founder effect
Author:         Cecilia Garcia
Creator:        Adobe InDesign CC 2015 (Windows)
Producer:       Adobe PDF Library 15.0
CreationDate:   Thu Nov  7 19:56:12 2019 CET
ModDate:        Fri Nov  8 01:56:03 2019 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 779.528 pts
Page rot:       0
File size:      1829545 bytes
Optimized:      no
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HelveticaNeueLTStd-Bd                Type 1C           Custom           yes no  yes   1259  0
HelveticaNeueLTStd-BdIt              Type 1C           WinAnsi          yes no  yes   1260  0
HelveticaNeueLTStd-LtIt              Type 1C           Custom           yes no  yes   1261  0
HelveticaNeueLTStd-MdIt              Type 1C           WinAnsi          yes no  yes   1275  0
HelveticaNeueLTStd-Lt                Type 1C           Custom           yes no  yes   1276  0
MinionProMTC-Regular                 Type 1C           Custom           yes no  yes   1283  0
MinionProMTC-Italic                  Type 1C           Custom           yes no  yes    120  0
MinionPro-Bold                       Type 1C           Custom           yes no  yes    115  0
HelveticaNeueLTStd-Md                Type 1C           WinAnsi          yes no  yes    110  0
EAUDDP+STIXGeneral                   Type 1C           WinAnsi          yes yes yes    150  0
EAUDDP+MinionPro-Regular             Type 1C           Custom           yes yes yes    181  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-08-10 12:16:46 CEST
 RepresentationInformation: pmc_31781168.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-03-09 03:41:29 CET
  Size: 1829545
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1351
   FreeObjects: 1213
   IncrementalUpdates: 3
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Haplotype Analysis of the First 
A4V-SOD1 Spanish Family: Two Separate Founders or a Single Common Founder?
      Children: 
       Item: 
        Title: Introduction
       Item: 
        Title: Material and Methods
        Children: 
         Item: 
          Title: Subjects
         Item: 
          Title: Genetic Studies
          Children: 
           Item: 
            Title: Selection of Single Nucleotide Polymorphisms for Analysis of the SOD1 Haplotype
           Item: 
            Title: Genotyping of Normal and Mutant p.A5V 
Alleles in SOD1
           Item: 
            Title: Genotyping of Single Nucleotide Polymorphisms and Microsatellite
           Item: 
            Title: Analysis of Data
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Clinical Characteristics of the p.A5V-SOD1 Pedigree
         Item: 
          Title: Genetic Results
         Item: 
          Title: Haplotype Analysis
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Redefining the p.A5V-SOD1 Phenotype. Reasons for the Disease’s Aggressive Course
         Item: 
          Title: Founder Effect
          Children: 
           Item: 
            Title: A Single Origin for All p.A5V-SOD1 
Families Worldwide
           Item: 
            Title: Several Origins (One for Asians, One for Americans, and Perhaps One or More for Europeans)
       Item: 
        Title: Data Availability Statement
       Item: 
        Title: Ethics Statement
       Item: 
        Title: Author Contributions
       Item: 
        Title: Funding
       Item: 
        Title: Acknowledgments
       Item: 
        Title: Supplementary Material
       Item: 
        Title: References
   Info: 
    Title: Haplotype Analysis of the First A4V-SOD1 Spanish Family: Two Separate Founders or a Single Common Founder?
    Author: Cecilia Garcia
    Subject: Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isol
    Keywords: SOD1, A4V, p.A5V, amyotrophic lateral sclerosis, familial amyotrophic lateral sclerosis, ALS1,
founder effect
    Creator: Adobe InDesign CC 2015 (Windows)
    Producer: Adobe PDF Library 15.0
    CreationDate: Thu Nov 07 19:56:12 CET 2019
    ModDate: Fri Nov 08 01:56:03 CET 2019
   ID: 0xf15e082a174f3e4d8c3e53e00b9f7bc3, 0x77a224801f3760418a86f506d944cf92
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1476
      ImageHeight: 773
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1654
      ImageHeight: 744
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1772
      ImageHeight: 689
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MinionProMTC-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionProMTC-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EAUDDP+MinionPro-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: EAUDDP+MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EAUDDP+STIXGeneral
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: EAUDDP+STIXGeneral
       Flags: Serif, Nonsymbolic
       FontBBox: -178, -443, 2000, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionProMTC-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionProMTC-Italic
       Flags: Serif, Nonsymbolic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-MdIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-MdIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -218, 1125, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Bd
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -387, 1078, 975
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Lt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -295, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-BdIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-BdIt
       Flags: Nonsymbolic
       FontBBox: -166, -393, 1129, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-LtIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-LtIt
       Flags: Nonsymbolic
       FontBBox: -165, -303, 1099, 951
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Md
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Md
       Flags: Nonsymbolic
       FontBBox: -165, -221, 1066, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="3.1-701">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Haplotype Analysis of the First A4V-SOD1 Spanish Family: Two Separate Founders or a Single Common Founder?</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Bag>
               <rdf:li>Cecilia Garcia</rdf:li>
               <rdf:li>Jose Manuel Vidal-Taboada</rdf:li>
               <rdf:li>Enrique Syriani</rdf:li>
               <rdf:li>Maria Salvado</rdf:li>
               <rdf:li>Miguel Morales</rdf:li>
               <rdf:li>Josep Gamez</rdf:li>
            </rdf:Bag>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Despite the genetic heterogeneity reported in familial amyotrophic lateral sclerosis (ALS) (fALS), Cu/Zn superoxide-dismutase (SOD1) gene mutations are the second most common cause of the disease, accounting for around 20% of all families (ALS1) and isol</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>SOD1</rdf:li>
               <rdf:li>A4V</rdf:li>
               <rdf:li>p.A5V</rdf:li>
               <rdf:li>amyotrophic lateral sclerosis</rdf:li>
               <rdf:li>familial amyotrophic lateral sclerosis</rdf:li>
               <rdf:li>ALS1</rdf:li>
               <rdf:li>founder effect</rdf:li>
            </rdf:Bag>
         </dc:subject>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreateDate>2019-11-08T02:56:12+08:00</xap:CreateDate>
         <xap:MetadataDate>2019-11-08T08:56:03+08:00</xap:MetadataDate>
         <xap:ModifyDate>2019-11-08T08:56:03+08:00</xap:ModifyDate>
         <xap:CreatorTool>Adobe InDesign CC 2015 (Windows)</xap:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#">
         <xapMM:InstanceID>uuid:d0d4a6d8-f7fa-48f6-bd58-d745461619ec</xapMM:InstanceID>
         <xapMM:OriginalDocumentID>xmp.did:2aecd8bd-cbd3-4539-b083-9de383973cbe</xapMM:OriginalDocumentID>
         <xapMM:DocumentID>xmp.id:64218e8a-bbc7-f14d-a99a-7db227831d44</xapMM:DocumentID>
         <xapMM:RenditionClass>proof:pdf</xapMM:RenditionClass>
         <xapMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:473e0678-7b43-0749-aa22-771c4b127fca</stRef:instanceID>
            <stRef:documentID>xmp.did:5ba2f25d-b602-6942-b1ab-d5df1ddaea97</stRef:documentID>
            <stRef:originalDocumentID>xmp.did:2aecd8bd-cbd3-4539-b083-9de383973cbe</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xapMM:DerivedFrom>
         <xapMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign CC 2015 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2019-11-08T02:56:12+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xapMM:History>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Adobe PDF Library 15.0</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdf:Keywords>SOD1, A4V, p.A5V, amyotrophic lateral sclerosis, familial amyotrophic lateral sclerosis, ALS1,&#xD;&#xA;founder effect</pdf:Keywords>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 84, 421, 160, 410
      Annotation: 
       Subtype: Link
       Rect: 72, 292, 158, 283
      Annotation: 
       Subtype: Link
       Rect: 75, 73, 158, 64
      Annotation: 
       Subtype: Link
       Rect: 175, 648, 491, 619
      Annotation: 
       Subtype: Link
       Rect: 175, 625, 494, 596
      Annotation: 
       Subtype: Link
       Rect: 175, 602, 484, 573
      Annotation: 
       Subtype: Link
       Rect: 175, 579, 367, 550
      Annotation: 
       Subtype: Link
       Rect: 175, 541, 233, 531
      Annotation: 
       Subtype: Link
       Rect: 255, 541, 370, 531
      Annotation: 
       Subtype: Link
       Rect: 392, 541, 455, 531
      Annotation: 
       Subtype: Link
       Rect: 468, 541, 528, 531
      Annotation: 
       Subtype: Link
       Rect: 175, 530, 239, 518
      Annotation: 
       Subtype: Link
       Rect: 268, 530, 326, 518
      Annotation: 
       Subtype: Link
       Rect: 282, 98, 401, 86
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 405, 98, 506, 86
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 510, 98, 549, 86
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 175, 87, 193, 74
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 198, 87, 282, 74
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 287, 87, 361, 74
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 365, 87, 435, 74
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 440, 87, 503, 74
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 507, 87, 549, 74
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 175, 75, 215, 63
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 219, 75, 326, 63
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 330, 75, 410, 63
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 414, 75, 480, 63
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 484, 75, 544, 63
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 43, 755, 135, 719
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
      Annotation: 
       Subtype: Link
       Rect: 453, 745, 551, 736
      Annotation: 
       Subtype: Link
       Rect: 466, 728, 549, 720
      Annotation: 
       Subtype: Link
       Rect: 453, 737, 551, 728
      Annotation: 
       Subtype: Link
       Rect: 519, 708, 551, 676
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 558, 140, 546
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 147, 558, 214, 546
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 221, 558, 283, 546
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 121, 420, 211, 408
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 219, 420, 286, 408
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 409, 108, 396
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 263, 351, 288, 339
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 340, 63, 327
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 68, 340, 138, 327
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 143, 340, 194, 327
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 199, 340, 265, 327
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 270, 340, 288, 327
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 45, 329, 90, 316
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 180, 124, 214, 111
       ActionDest: 6
      Annotation: 
       Subtype: Link
       Rect: 48, 83, 288, 73
      Annotation: 
       Subtype: Link
       Rect: 45, 73, 73, 63
      Annotation: 
       Subtype: Link
       Rect: 360, 685, 456, 672
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 166, 456, 238, 443
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 200, 410, 268, 397
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 218, 399, 283, 386
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 82, 376, 177, 363
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 136, 283, 231, 270
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 55, 87, 152, 74
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 127, 76, 214, 63
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 373, 399, 487, 386
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 415, 330, 494, 317
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 502, 330, 549, 317
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 305, 318, 324, 305
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 470, 249, 549, 236
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 305, 238, 409, 225
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 398, 76, 491, 63
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 684, 148, 670
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 155, 649, 183, 636
       ActionDest: 19
      Annotation: 
       Subtype: Link
       Rect: 48, 615, 148, 601
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 309, 684, 409, 670
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 440, 626, 472, 613
       ActionDest: 6
      Annotation: 
       Subtype: Link
       Rect: 79, 331, 136, 322
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 176, 331, 227, 322
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 720, 82, 707
       ActionDest: 19
      Annotation: 
       Subtype: Link
       Rect: 90, 697, 124, 684
       ActionDest: 19
      Annotation: 
       Subtype: Link
       Rect: 48, 662, 80, 649
       ActionDest: 19
      Annotation: 
       Subtype: Link
       Rect: 98, 662, 125, 649
       ActionDest: 19
      Annotation: 
       Subtype: Link
       Rect: 248, 651, 281, 638
       ActionDest: 6
      Annotation: 
       Subtype: Link
       Rect: 157, 628, 269, 615
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 178, 570, 283, 557
       ActionDest: 61
      Annotation: 
       Subtype: Link
       Rect: 83, 478, 110, 465
       ActionDest: 19
      Annotation: 
       Subtype: Link
       Rect: 236, 432, 272, 419
       ActionDest: 38
      Annotation: 
       Subtype: Link
       Rect: 72, 352, 106, 339
       ActionDest: 38
      Annotation: 
       Subtype: Link
       Rect: 376, 522, 448, 509
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 506, 476, 549, 463
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 305, 465, 345, 452
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 349, 465, 415, 452
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 419, 465, 483, 452
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 488, 465, 547, 452
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 305, 453, 377, 440
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 382, 453, 448, 440
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 439, 384, 497, 371
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 489, 350, 549, 337
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 719, 63, 707
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 67, 719, 126, 707
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 95, 616, 172, 603
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 249, 420, 288, 408
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 409, 85, 396
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 90, 409, 152, 396
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 156, 409, 235, 396
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 239, 409, 288, 396
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 397, 63, 385
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 67, 397, 194, 385
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 116, 328, 186, 316
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 260, 283, 288, 270
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 271, 86, 258
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 91, 271, 156, 258
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 161, 271, 238, 258
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 243, 271, 288, 258
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 45, 259, 91, 247
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 97, 259, 188, 247
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 195, 259, 286, 247
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 45, 248, 117, 235
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 385, 708, 453, 695
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 457, 708, 521, 695
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 309, 650, 355, 638
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 359, 650, 409, 638
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 477, 467, 510, 454
       ActionDest: 38
      Annotation: 
       Subtype: Link
       Rect: 478, 305, 547, 292
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 305, 293, 354, 281
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 360, 293, 436, 281
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 442, 293, 495, 281
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 501, 293, 549, 281
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 305, 282, 324, 269
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 500, 156, 547, 143
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 305, 144, 378, 132
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 384, 144, 451, 132
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 457, 144, 525, 132
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 236, 719, 288, 707
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 45, 708, 63, 695
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 67, 708, 108, 695
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 48, 604, 153, 592
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 159, 604, 233, 592
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 136, 478, 220, 465
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 113, 432, 182, 419
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 120, 386, 164, 373
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 169, 386, 239, 373
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 244, 386, 288, 373
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 45, 374, 63, 362
       ActionDest: 79
      Annotation: 
       Subtype: Link
       Rect: 122, 121, 192, 109
       ActionDest: 70
      Annotation: 
       Subtype: Link
       Rect: 378, 583, 536, 570
      Annotation: 
       Subtype: Link
       Rect: 305, 110, 549, 97
      Annotation: 
       Subtype: Link
       Rect: 305, 98, 414, 86
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 679, 183, 669
      Annotation: 
       Subtype: Link
       Rect: 186, 641, 256, 631
      Annotation: 
       Subtype: Link
       Rect: 55, 603, 149, 593
      Annotation: 
       Subtype: Link
       Rect: 127, 574, 208, 564
      Annotation: 
       Subtype: Link
       Rect: 118, 536, 198, 526
      Annotation: 
       Subtype: Link
       Rect: 55, 413, 142, 403
      Annotation: 
       Subtype: Link
       Rect: 55, 384, 135, 374
      Annotation: 
       Subtype: Link
       Rect: 254, 365, 288, 355
      Annotation: 
       Subtype: Link
       Rect: 55, 356, 131, 346
      Annotation: 
       Subtype: Link
       Rect: 169, 327, 250, 317
      Annotation: 
       Subtype: Link
       Rect: 198, 299, 268, 289
      Annotation: 
       Subtype: Link
       Rect: 259, 270, 288, 260
      Annotation: 
       Subtype: Link
       Rect: 55, 261, 111, 251
      Annotation: 
       Subtype: Link
       Rect: 127, 242, 203, 232
      Annotation: 
       Subtype: Link
       Rect: 126, 204, 223, 194
      Annotation: 
       Subtype: Link
       Rect: 127, 175, 224, 165
      Annotation: 
       Subtype: Link
       Rect: 263, 147, 288, 137
      Annotation: 
       Subtype: Link
       Rect: 55, 137, 99, 127
      Annotation: 
       Subtype: Link
       Rect: 209, 109, 283, 99
      Annotation: 
       Subtype: Link
       Rect: 440, 708, 527, 697
      Annotation: 
       Subtype: Link
       Rect: 468, 679, 525, 669
      Annotation: 
       Subtype: Link
       Rect: 350, 641, 428, 631
      Annotation: 
       Subtype: Link
       Rect: 523, 603, 549, 593
      Annotation: 
       Subtype: Link
       Rect: 315, 593, 387, 583
      Annotation: 
       Subtype: Link
       Rect: 315, 555, 388, 545
      Annotation: 
       Subtype: Link
       Rect: 315, 527, 390, 517
      Annotation: 
       Subtype: Link
       Rect: 328, 498, 394, 488
      Annotation: 
       Subtype: Link
       Rect: 520, 470, 549, 460
      Annotation: 
       Subtype: Link
       Rect: 315, 460, 398, 450
      Annotation: 
       Subtype: Link
       Rect: 350, 422, 410, 412
      Annotation: 
       Subtype: Link
       Rect: 353, 394, 408, 384
      Annotation: 
       Subtype: Link
       Rect: 354, 365, 451, 355
      Annotation: 
       Subtype: Link
       Rect: 523, 337, 549, 327
      Annotation: 
       Subtype: Link
       Rect: 315, 327, 382, 317
      Annotation: 
       Subtype: Link
       Rect: 315, 289, 399, 279
      Annotation: 
       Subtype: Link
       Rect: 523, 252, 549, 241
      Annotation: 
       Subtype: Link
       Rect: 315, 242, 349, 232
      Annotation: 
       Subtype: Link
       Rect: 373, 213, 451, 203
      Annotation: 
       Subtype: Link
       Rect: 523, 185, 549, 175
      Annotation: 
       Subtype: Link
       Rect: 315, 175, 355, 165
      Annotation: 
       Subtype: Link
       Rect: 479, 157, 529, 146
      Annotation: 
       Subtype: Link
       Rect: 385, 119, 448, 108
      Annotation: 
       Subtype: Link
       Rect: 343, 90, 445, 80
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 114, 700, 226, 690
      Annotation: 
       Subtype: Link
       Rect: 180, 672, 238, 661
      Annotation: 
       Subtype: Link
       Rect: 55, 633, 131, 623
      Annotation: 
       Subtype: Link
       Rect: 119, 596, 189, 585
      Annotation: 
       Subtype: Link
       Rect: 97, 548, 180, 538
      Annotation: 
       Subtype: Link
       Rect: 104, 510, 179, 500
      Annotation: 
       Subtype: Link
       Rect: 181, 472, 279, 462
      Annotation: 
       Subtype: Link
       Rect: 179, 453, 242, 443
      Annotation: 
       Subtype: Link
       Rect: 315, 700, 375, 690
      Annotation: 
       Subtype: Link
       Rect: 315, 671, 413, 661
      Annotation: 
       Subtype: Link
       Rect: 458, 643, 521, 633
      Annotation: 
       Subtype: Link
       Rect: 413, 605, 500, 595
      Annotation: 
       Subtype: Link
       Rect: 523, 577, 549, 566
      Annotation: 
       Subtype: Link
       Rect: 315, 567, 348, 557
      Annotation: 
       Subtype: Link
       Rect: 493, 501, 549, 490
      Annotation: 
       Subtype: Link
       Rect: 305, 491, 389, 481
      Annotation: 
       Subtype: Link
       Rect: 45, 38, 104, 29
      Annotation: 
       Subtype: Link
       Rect: 112, 38, 168, 29
      Annotation: 
       Subtype: Link
       Rect: 418, 39, 551, 30
  Checksum: 9f9edccb
   Type: CRC32
  Checksum: 4ffb8face22f0571d6329bb5c6bfc15b
   Type: MD5
  Checksum: 75a351f5c1c54ede8da2c4bc82481354cb27bf70
   Type: SHA-1