df8519ffa0e512250d479470bc24eb11 pdf_223691.pdf 634fa726bc44da13e68259fadda4424cb27fd790 pdf_223691.pdf e99a597cd5099e9bd3d5b344166bef90dc70a64983fbf6ff14e3fea8c71a5b18 pdf_223691.pdf Title: Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial Subject: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020. doi: 10.1080/21678421.2019.1632346 Keywords: Author: Mora Jesus S. Creator: Arbortext Advanced Print Publisher Producer: Adobe LiveCycle PDFG ES CreationDate: Fri Apr 23 12:46:59 2021 CEST ModDate: Fri Apr 23 12:46:59 2021 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 634.32 x 833.04 pts Page rot: 0 File size: 1143408 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EEFFCB+ArialUnicodeMS CID TrueType Identity-H yes yes yes 474 0 EEFFCC+OpenSans CID TrueType Identity-H yes yes yes 477 0 EEFFCA+OpenSans-Semibold CID TrueType Identity-H yes yes yes 480 0 NDIEMB+AdvOTa82ac8a1.B Type 1C WinAnsi yes yes no 260 0 NDIFIF+AdvT001 Type 1C Custom yes yes no 259 0 NDIEMC+AdvOT4b47d116 Type 1C WinAnsi yes yes no 262 0 NDIFDA+AdvP4C4E74 Type 1C Custom yes yes yes 267 0 NDIFDB+AdvOTb63a3543.I Type 1C WinAnsi yes yes no 274 0 NDIFEC+AdvOTb63a3543.I+20 Type 1C WinAnsi yes yes no 273 0 NDIFED+AdvP4C4E59 Type 1C Custom yes yes yes 269 0 NDIFEE+AdvPSMP13 Type 1C WinAnsi yes yes no 275 0 NDIFEF+AdvOT4b47d116+20 Type 1C WinAnsi yes yes no 257 0 NDIFEG+AdvP4C4E51 Type 1C WinAnsi yes yes no 255 0 NDIGDC+AdvP7DED Type 1C WinAnsi yes yes no 277 0 NDIHKJ+AdvPSMP11 Type 1C WinAnsi yes yes no 278 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-04-24 02:55:39 CEST RepresentationInformation: pdf_223691.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-04-23 12:56:09 CEST Size: 1143408 Format: PDF Version: 1.5 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF1' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF2' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF3' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF4' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF1' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF10' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF7' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF11' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF8' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF8' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF8' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF9' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF12' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF13' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF14' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lTF15' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0008' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0009' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0011' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0013' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0016' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0017' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0018' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0029' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0030' cannot be found Offset: 1133892 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bCIT0031' cannot be found Offset: 1133892 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: Study design and oversight Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Study measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Primary efficacy analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Secondary efficacy analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Subgroup analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Declaration of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 600 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im20 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 641 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im10 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 448 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im13 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 448 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im14 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 470 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im11 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 470 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im12 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 674 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im17 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 674 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im18 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 694 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im15 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 694 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im16 Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 265 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 600 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im19 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 1010 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im3 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3150 ImageHeight: 746 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 703 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im5 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 1010 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im4 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 512 ImageHeight: 346 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im7 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 703 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im6 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 641 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im9 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 512 ImageHeight: 346 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im8 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 600 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im20 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 641 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im10 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 448 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im13 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 448 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im14 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 470 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im11 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 470 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im12 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 674 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im17 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 674 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im18 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 694 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im15 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 694 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im16 Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 265 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 600 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im19 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 1010 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im3 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3150 ImageHeight: 746 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 703 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im5 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 1010 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im4 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 512 ImageHeight: 346 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im7 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 703 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im6 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 641 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im9 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 512 ImageHeight: 346 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im8 Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1400 ImageHeight: 1761 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: EEFFCA+OpenSans-Semibold Encoding: Identity-H ToUnicode: true Font: BaseFont: EEFFCB+ArialUnicodeMS Encoding: Identity-H ToUnicode: true Font: BaseFont: EEFFCC+OpenSans Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NDIFEF+AdvOT4b47d116+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: NDIFEF+AdvOT4b47d116+20 Flags: Nonsymbolic FontBBox: -132, -191, 1052, 706 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIFEC+AdvOTb63a3543.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: NDIFEC+AdvOTb63a3543.I+20 Flags: Nonsymbolic FontBBox: -148, -188, 1083, 700 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIFDB+AdvOTb63a3543.I FontSubset: true FirstChar: 40 LastChar: 122 FontDescriptor: FontName: NDIFDB+AdvOTb63a3543.I Flags: Serif, Nonsymbolic FontBBox: -145, -250, 1123, 920 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIFEE+AdvPSMP13 FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: NDIFEE+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIFIF+AdvT001 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NDIFIF+AdvT001 Flags: Symbolic FontBBox: -197, -260, 1000, 937 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: NDIEMB+AdvOTa82ac8a1.B FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: NDIEMB+AdvOTa82ac8a1.B Flags: Serif, Nonsymbolic FontBBox: -60, -250, 1015, 934 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIGDC+AdvP7DED FontSubset: true FirstChar: 53 LastChar: 53 FontDescriptor: FontName: NDIGDC+AdvP7DED Flags: Nonsymbolic FontBBox: -20, -229, 927, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIEMC+AdvOT4b47d116 FontSubset: true FirstChar: 35 LastChar: 218 FontDescriptor: FontName: NDIEMC+AdvOT4b47d116 Flags: Serif, Nonsymbolic FontBBox: -35, -250, 999, 908 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIHKJ+AdvPSMP11 FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: NDIHKJ+AdvPSMP11 Flags: Nonsymbolic FontBBox: 0, -302, 989, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NDIFDA+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 188 FontDescriptor: FontName: NDIFDA+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NDIFED+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 126 FontDescriptor: FontName: NDIFED+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NDIFEG+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: NDIFEG+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: EEFFCB+ArialUnicodeMS CIDSystemInfo: Registry: Adobe Registry: UCS Supplement: 0 FontDescriptor: FontName: EEFFCB+ArialUnicodeMS Flags: FixedPitch, Nonsymbolic FontBBox: -1011, -329, 2260, 1078 FontFile2: true Font: BaseFont: EEFFCC+OpenSans CIDSystemInfo: Registry: Adobe Registry: UCS Supplement: 0 FontDescriptor: FontName: EEFFCC+OpenSans Flags: FixedPitch, Nonsymbolic FontBBox: -549, -270, 1204, 1047 FontFile2: true Font: BaseFont: EEFFCA+OpenSans-Semibold CIDSystemInfo: Registry: Adobe Registry: UCS Supplement: 0 FontDescriptor: FontName: EEFFCA+OpenSans-Semibold Flags: FixedPitch, Nonsymbolic FontBBox: -583, -282, 1261, 1048 FontFile2: true XMP: Adobe LiveCycle PDFG ES 2021-04-23T12:46:59+02:00 Arbortext Advanced Print Publisher 2021-04-23T12:46:59+02:00 2021-04-23T12:46:59+02:00 uuid:8addd02c-2a8d-4824-a074-0375b52bef83 uuid:69d16802-7be8-406e-9858-019207eeefd9 Journal Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2167-8421 2167-9223 21 1-2 5-14 5 14 10.1080/21678421.2019.1632346 https://doi.org/10.1080/21678421.2019.1632346 application/pdf 10.1080/21678421.2019.1632346 en-US Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial Taylor & Francis Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020. doi: 10.1080/21678421.2019.1632346 Mora Jesus S. Genge Angela Chio Adriano Estol Conrado J. Chaverri Delia Hernández Maria Marín Saúl Mascias Javier Rodriguez Gabriel E. Povedano Monica Paipa Andrés Dominguez Raul Gamez Josep Salvado Maria Lunetta Christian Ballario Carlos Riva Nilo Mandrioli Jessica Moussy Alain Kinet Jean-Pierre Auclair Christian Dubreuil Patrice Arnold Vincent Mansfield Colin D. Hermine Olivier Clinical trials therapy tyrosine kinase inhibitor masitinib VoR 10.1080/21678421.2019.1632346 2019-07-07 True www.tandfonline.com 10.1080/21678421.2019.1632346 2019-07-07 True www.tandfonline.com Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 365, 688, 518, 696 Annotation: Subtype: Link Rect: 145, 370, 296, 379 Annotation: Subtype: Link Rect: 202, 349, 427, 359 Annotation: Subtype: Link Rect: 106, 246, 122, 255 Annotation: Subtype: Link Rect: 131, 250, 269, 259 Annotation: Subtype: Link Rect: 106, 165, 124, 174 Annotation: Subtype: Link Rect: 131, 164, 286, 173 Annotation: Subtype: Link Rect: 106, 75, 122, 84 Annotation: Subtype: Link Rect: 131, 79, 230, 88 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 156, 42, 477, 51 Annotation: Subtype: Link Rect: 106, 794, 125, 803 Annotation: Subtype: Link Rect: 131, 801, 232, 810 Annotation: Subtype: Link Rect: 106, 754, 124, 763 Annotation: Subtype: Link Rect: 131, 758, 297, 767 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 152, 593, 156, 604 Destination: 4 Annotation: Subtype: Link Rect: 259, 593, 263, 604 Destination: 4 Annotation: Subtype: Link Rect: 360, 593, 365, 604 Destination: 4 Annotation: Subtype: Link Rect: 500, 593, 504, 604 Destination: 4 Annotation: Subtype: Link Rect: 166, 580, 171, 591 Destination: 4 Annotation: Subtype: Link Rect: 296, 580, 300, 591 Destination: 4 Annotation: Subtype: Link Rect: 382, 580, 387, 591 Destination: 4 Annotation: Subtype: Link Rect: 489, 580, 494, 591 Destination: 4 Annotation: Subtype: Link Rect: 206, 567, 211, 578 Destination: 4 Annotation: Subtype: Link Rect: 338, 567, 343, 578 Destination: 4 Annotation: Subtype: Link Rect: 435, 567, 440, 578 Destination: 4 Annotation: Subtype: Link Rect: 141, 554, 146, 565 Destination: 4 Annotation: Subtype: Link Rect: 233, 554, 238, 565 Destination: 4 Annotation: Subtype: Link Rect: 357, 554, 362, 565 Destination: 4 Annotation: Subtype: Link Rect: 496, 554, 501, 565 Destination: 4 Annotation: Subtype: Link Rect: 176, 541, 185, 552 Destination: 4 Annotation: Subtype: Link Rect: 253, 541, 262, 552 Destination: 4 Annotation: Subtype: Link Rect: 388, 541, 397, 552 Destination: 4 Annotation: Subtype: Link Rect: 494, 541, 504, 552 Destination: 4 Annotation: Subtype: Link Rect: 181, 528, 191, 539 Destination: 4 Annotation: Subtype: Link Rect: 193, 528, 202, 539 Destination: 4 Annotation: Subtype: Link Rect: 332, 528, 341, 539 Destination: 4 Annotation: Subtype: Link Rect: 344, 528, 353, 539 Destination: 4 Annotation: Subtype: Link Rect: 477, 528, 486, 539 Destination: 4 Annotation: Subtype: Link Rect: 489, 528, 498, 539 Destination: 4 Annotation: Subtype: Link Rect: 175, 515, 184, 526 Destination: 4 Annotation: Subtype: Link Rect: 319, 515, 328, 526 Destination: 4 Annotation: Subtype: Link Rect: 444, 515, 453, 526 Destination: 4 Annotation: Subtype: Link Rect: 455, 515, 464, 526 Destination: 4 Annotation: Subtype: Link Rect: 301, 502, 307, 513 Destination: 4 Annotation: Subtype: Link Rect: 478, 728, 541, 740 Annotation: Subtype: Link Rect: 369, 593, 379, 603 Annotation: Subtype: Link Rect: 242, 554, 252, 564 Annotation: Subtype: Link Rect: 309, 87, 381, 95 Annotation: Subtype: Link Rect: 233, 76, 246, 83 Annotation: Subtype: Link Rect: 522, 42, 541, 49 Annotation: Subtype: Link Rect: 65, 33, 199, 40 Annotation: Subtype: Link Rect: 84, 15, 189, 22 Annotation: Subtype: Link Rect: 439, 749, 541, 773 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 123, 491, 129, 501 Destination: 44 Annotation: Subtype: Link Rect: 132, 491, 137, 501 Destination: 44 Annotation: Subtype: Link Rect: 209, 467, 214, 477 Destination: 44 Annotation: Subtype: Link Rect: 228, 430, 233, 440 Destination: 44 Annotation: Subtype: Link Rect: 236, 430, 242, 440 Destination: 44 Annotation: Subtype: Link Rect: 228, 346, 234, 356 Destination: 44 Annotation: Subtype: Link Rect: 237, 346, 242, 356 Destination: 44 Annotation: Subtype: Link Rect: 166, 262, 182, 272 Destination: 44 Annotation: Subtype: Link Rect: 122, 39, 149, 49 Destination: 44 Annotation: Subtype: Link Rect: 420, 545, 515, 555 Annotation: Subtype: Link Rect: 430, 304, 457, 314 Destination: 44 Annotation: Subtype: Link Rect: 315, 63, 440, 73 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 140, 732, 151, 742 Destination: 44 Annotation: Subtype: Link Rect: 108, 671, 119, 681 Destination: 44 Annotation: Subtype: Link Rect: 69, 532, 80, 542 Destination: 44 Annotation: Subtype: Link Rect: 83, 532, 94, 542 Destination: 44 Annotation: Subtype: Link Rect: 65, 173, 236, 183 Annotation: Subtype: Link Rect: 164, 75, 175, 85 Destination: 44 Annotation: Subtype: Link Rect: 203, 39, 213, 49 Destination: 51 Annotation: Subtype: Link Rect: 216, 39, 227, 49 Destination: 51 Annotation: Subtype: Link Rect: 445, 461, 481, 471 Destination: 28 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 343, 704, 346, 712 Destination: null Annotation: Subtype: Link Rect: 519, 704, 523, 712 Destination: null Annotation: Subtype: Link Rect: 116, 553, 119, 561 Destination: null Annotation: Subtype: Link Rect: 124, 513, 128, 521 Destination: null Annotation: Subtype: Link Rect: 73, 473, 76, 481 Destination: null Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 223, 568, 262, 579 Destination: 34 Annotation: Subtype: Link Rect: 225, 495, 291, 505 Annotation: Subtype: Link Rect: 65, 483, 161, 493 Annotation: Subtype: Link Rect: 251, 422, 287, 432 Destination: 34 Annotation: Subtype: Link Rect: 230, 373, 268, 383 Destination: 28 Annotation: Subtype: Link Rect: 65, 361, 172, 371 Annotation: Subtype: Link Rect: 214, 270, 260, 280 Destination: 38 Annotation: Subtype: Link Rect: 65, 258, 179, 268 Annotation: Subtype: Link Rect: 65, 197, 291, 207 Annotation: Subtype: Link Rect: 65, 185, 107, 195 Annotation: Subtype: Link Rect: 418, 732, 541, 742 Annotation: Subtype: Link Rect: 315, 720, 357, 730 Annotation: Subtype: Link Rect: 412, 569, 521, 579 Annotation: Subtype: Link Rect: 352, 509, 389, 519 Destination: 38 Annotation: Subtype: Link Rect: 417, 509, 534, 519 Annotation: Subtype: Link Rect: 367, 364, 479, 374 Annotation: Subtype: Link Rect: 319, 153, 485, 163 Annotation: Subtype: Link Rect: 364, 87, 401, 97 Destination: 38 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 69, 88, 115, 98 Destination: 38 Annotation: Subtype: Link Rect: 351, 163, 386, 173 Destination: 41 Annotation: Subtype: Link Rect: 523, 76, 534, 86 Destination: 51 Annotation: Subtype: Link Rect: 166, 202, 270, 210 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 110, 76, 250, 86 Annotation: Subtype: Link Rect: 176, 39, 203, 49 Destination: 44 Annotation: Subtype: Link Rect: 449, 186, 460, 196 Destination: 51 Annotation: Subtype: Link Rect: 217, 704, 221, 712 Destination: null Annotation: Subtype: Link Rect: 65, 689, 68, 697 Destination: null Annotation: Subtype: Link Rect: 536, 679, 539, 687 Destination: null Annotation: Subtype: Link Rect: 65, 659, 69, 667 Destination: null Annotation: Subtype: Link Rect: 65, 629, 69, 637 Destination: null Annotation: Subtype: Link Rect: 65, 599, 70, 607 Destination: null Annotation: Subtype: Link Rect: 70, 599, 73, 607 Destination: null Annotation: Subtype: Link Rect: 188, 488, 322, 496 Annotation: Subtype: Link Rect: 108, 420, 111, 428 Destination: null Annotation: Subtype: Link Rect: 136, 355, 139, 363 Destination: null Annotation: Subtype: Link Rect: 211, 345, 214, 353 Destination: null Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 87, 267, 260, 277 Annotation: Subtype: Link Rect: 111, 123, 284, 133 Annotation: Subtype: Link Rect: 469, 147, 480, 157 Destination: 44 Annotation: Subtype: Link Rect: 483, 147, 510, 157 Destination: 51 Annotation: Subtype: Link Rect: 466, 724, 469, 732 Destination: null Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 228, 708, 239, 718 Destination: 44 Annotation: Subtype: Link Rect: 158, 562, 264, 572 Annotation: Subtype: Link Rect: 70, 213, 74, 221 Destination: 22 Annotation: Subtype: Link Rect: 70, 172, 74, 180 Destination: 22 Annotation: Subtype: Link Rect: 70, 141, 74, 149 Destination: 22 Annotation: Subtype: Link Rect: 70, 89, 74, 97 Destination: 22 Annotation: Subtype: Link Rect: 70, 48, 74, 56 Destination: 22 Annotation: Subtype: Link Rect: 319, 714, 324, 722 Destination: 22 Annotation: Subtype: Link Rect: 319, 684, 324, 692 Destination: 22 Annotation: Subtype: Link Rect: 319, 633, 324, 641 Destination: null Annotation: Subtype: Link Rect: 319, 593, 324, 601 Destination: null Annotation: Subtype: Link Rect: 315, 552, 324, 560 Destination: 22 Annotation: Subtype: Link Rect: 315, 512, 324, 520 Destination: null Annotation: Subtype: Link Rect: 315, 482, 324, 490 Destination: 38 Annotation: Subtype: Link Rect: 315, 441, 324, 449 Destination: null Annotation: Subtype: Link Rect: 315, 401, 324, 409 Destination: 44 Annotation: Subtype: Link Rect: 315, 360, 324, 368 Destination: 22 Annotation: Subtype: Link Rect: 315, 330, 324, 338 Destination: null Annotation: Subtype: Link Rect: 315, 290, 324, 298 Destination: null Annotation: Subtype: Link Rect: 315, 259, 324, 268 Destination: null Annotation: Subtype: Link Rect: 315, 229, 324, 237 Destination: 25 Annotation: Subtype: Link Rect: 315, 189, 324, 197 Destination: 25 Annotation: Subtype: Link Rect: 315, 148, 324, 156 Destination: 25 Annotation: Subtype: Link Rect: 315, 78, 324, 86 Destination: 25 Annotation: Subtype: Link Rect: 315, 37, 324, 45 Destination: 25 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 65, 714, 74, 722 Destination: 25 Annotation: Subtype: Link Rect: 65, 664, 74, 672 Destination: 25 Annotation: Subtype: Link Rect: 65, 614, 74, 622 Destination: 34 Annotation: Subtype: Link Rect: 65, 574, 74, 582 Destination: 38 Annotation: Subtype: Link Rect: 315, 714, 324, 722 Destination: 41 Annotation: Subtype: Link Rect: 315, 674, 324, 682 Destination: null Annotation: Subtype: Link Rect: 315, 634, 324, 642 Destination: null Annotation: Subtype: Link Rect: 315, 594, 324, 602 Destination: null Checksum: 99b06035 Type: CRC32 Checksum: df8519ffa0e512250d479470bc24eb11 Type: MD5 Checksum: 634fa726bc44da13e68259fadda4424cb27fd790 Type: SHA-1