This is the accepted version of the article: Mármol-Sánchez, Emilio; Luigi Sierra, Maria Gracia; Amills i Eras, Marcel. «Comparing the diversity of the casein genes in the Asian mouflon and domestic sheep». Animal Genetics, Vol. 51, Issue 3 (June 2020), p. 470-475. DOI 10.1111/age.12937 This version is available at https://ddd.uab.cat/record/224401 under the terms of the license Table S1. NCBI sample identifier, country of origin and productive purpose of the domestic sheep and mouflon individuals analysed in the current work. Production Species SRA Biosample Breed Sex Country Continent purpose Local Ovis aries ERR232488 ERS154776 F Morocco Africa Unknown populations Meat and Ovis aries ERR234302 ERS154782 Timahdite F Morocco Africa wool Ovis aries ERR234307 ERS154764 Sardi F Morocco Africa Meat Ovis aries ERR266271 ERS154746 Sardi M Morocco Africa Meat Local Ovis aries ERR277075 ERS154834 F Morocco Africa Unknown populations Local Ovis aries ERR283420 ERS154726 F Morocco Africa Unknown populations Local Ovis aries ERR283425 ERS154709 M Morocco Africa Unknown populations Meat and Ovis aries ERR283428 ERS154734 D'man M Morocco Africa mannure Local Ovis aries ERR296823 ERS154724 F Morocco Africa Unknown populations Local Ovis aries ERR299455 ERS154805 F Morocco Africa Unknown populations Meat, milk Ovis aries SRR501883 SRS335688 Castellana - Spain Europe and wool Border Meat and Ovis aries SRS2478867 SRS2478867 F UK Europe Leicester wool Merino Ovis aries SRS2478943 SRS2478943 M Spain Europe Wool Horned Dorset Ovis aries SRS2479022 SRS2479022 M UK Europe Meat Horned Border Meat and Ovis aries SRS2479095 SRS2479095 M UK Europe Leicester wool The Ovis aries SRS2479115 SRS2479115 Texel M Nether Europe Meat lands Meat, milk Ovis aries SRS335707 SRS335707 Castellana - Spain Europe and wool Meat and Ovis aries SRS335729 SRS335729 Cheviot - UK Europe wool Swiss White Switzer Ovis aries SRS335733 SRS335733 - Europe Meat Alpine land Ovis aries SRS335741 SRS335741 Ojalada - Spain Europe Meat South and Meat, milk Ovis aries SRS2184233 SRS2184233 Barag Sheep M Mongolia East Asia and wool South and Meat, milk Ovis aries SRS2184234 SRS2184234 Barag Sheep M Mongolia East Asia and wool Eastern South and Ovis aries SRS335677 SRS335677 - China Meat Tibetan East Asia Banglades South and Ovis aries SRS335686 SRS335686 Bangladeshi - Meat h East Asia Mutton, South and Ovis aries SRS335689 SRS335689 Changthangi - China wool, pelt, East Asia manure South and Ovis aries SRS335718 SRS335718 Garut - Indonesia Meat East Asia Meat and Ovis aries SRS335721 SRS335721 Norduz - Turkey West Asia milk Mutton, South and Ovis aries SRS335727 SRS335727 Changthangi - China wool, pelt, East Asia manure Indian South and Ovis aries SRS335736 SRS335736 - India Meat Garole East Asia Ovis aries ERX270550 ERS239054 Local - Iran West Asia Unknown Ovis aries ERX270551 ERS239053 Local - Iran West Asia Unknown Ovis aries ERX270553 ERS239057 Local - Iran West Asia Unknown Ovis aries ERX270554 ERS239047 Local - Iran West Asia Unknown Ovis aries ERX270555 ERS239052 Local - Iran West Asia Unknown Ovis aries ERX272603 ERS239055 Local M Iran West Asia Unknown Ovis aries ERX272605 ERS239056 Local M Iran West Asia Unknown Ovis aries ERX286344 ERS239049 Local F Iran West Asia Unknown Ovis aries ERX286349 ERS239046 Local F Iran West Asia Unknown Ovis aries ERX286361 ERS239050 Local F Iran West Asia Unknown Meat, milk Ovis aries SRS335723 SRS335723 Awassi - Turkey West Asia and wool Ovis Iran- ERS154526 ERS154526 Mouflon M West Asia Wild Orientalis Tabriz Ovis Iran- ERS154527 ERS154527 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS154528 ERS154528 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS154529 ERS154529 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS154530 ERS154530 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS154531 ERS154531 Mouflon M West Asia Wild orientalis Tabriz Ovis Iran- ERS154532 ERS154532 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS154533 ERS154533 Mouflon F West Asia Wild orientalis Tabriz Ovis Iran- ERS239022 ERS239022 Mouflon M West Asia Wild orientalis Tabriz Ovis Iran- ERS239058 ERS239058 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS239059 ERS239059 Mouflon M West Asia Wild orientalis Tehran Ovis Iran- ERS239060 ERS239060 Mouflon F West Asia Wild orientalis Tabriz Ovis Iran- ERS239061 ERS239061 Mouflon M West Asia Wild orientalis Tabriz Ovis Iran- ERS239062 ERS239062 Mouflon M West Asia Wild orientalis Tabriz Ovis Iran- ERS239063 ERS239063 Mouflon F West Asia Wild orientalis Tabriz Ovis Iran- ERS419580 ERS419580 Mouflon F West Asia Wild orientalis Tabriz Ovis Iran- ERS419581 ERS419581 Mouflon M West Asia Wild orientalis Tabriz Table S2. Number of individuals per breed with available whole-genome sequences. Country of Origin od Number of Continent Breed the Breed animals Africa Morocco Timahdite 1 Africa Morocco Sardi 2 Africa Morocco D'man 1 Africa Morocco Local populations 6 Europe Spain Castellana 2 Europe Spain Merino Horned 1 Europe UK Dorset Horned 1 Europe Netherlands Texel 1 Europe UK Cheviot 1 Europe Switzerland Swiss white alpine 1 Europe Spain Ojalada 1 Europe UK Border Leicester 2 South and East Mongolia Barag Sheep 2 Asia South and East China Eastern Tibetan 1 Asia South and East Bangladesh Bangladeshi 1 Asia South and East Indonesia Garut 1 Asia South and East China Changthangi 2 Asia South and East India Indian Garole 1 Asia West Asia Iran Unknown 10 Saudi West Asia Arabia/Syria/Lebanon/ Awassi 1 Israel/Jordan West Asia Turkey Norduz 1 Table S3. Single nucleotide polymorphisms (SNPs) identified in domestic sheep populations from North Africa, West Asia, Europe and South and East Asia and in Iranian mouflon populations from Tehran and Tabriz. Position Aa MAF MAF Gene A1 A2 nt Substitution Presence* (bp) Substitution Sheep† Mouflon‡ 85089520 G T c.34G>T p.Val12Phe S 0.050 - 85089563 A T c.51+26A>T - B 0.125 0.029 85089636 C T c.51+99C>T - B 0.250 0.059 85089637 G A c.51+100G>A - M - 0.059 85089648 G A c.51+111G>A - M - 0.029 85089673 T A c.51+136T>A - M - 0.029 85089725 T C c.51+188T>C - B 0.100 0.029 85089735 G T c.51+198G>T - S 0.372 - 85089777 C T c.51+240C>T - B 0.050 0.088 85089940 T G c.51+403T>G - B 0.077 0 85089962 C T c.51+425C>T - B 0.141 0.382 85089985 A C c.51+448A>C - M - 0.029 85089990 C G c.51+453C>G - M - 0.029 85090100 G A c.51+563G>A - M - 0.029 85090116 G A c.51+579G>A - S 0.050 - 85090231 G C c.51+694G>C - M - 0.029 85090239 T A c.51+702T>A - B 0.075 0.029 CSN1S1 85090311 A T c.51+774A>T - M - 0.029 85090392 A C c.52-830A>C - M - 0.029 85090417 A G c.52-805A>G - M - 0.029 85090540 G A c.52-682G>A - S 0.050 - 85090565 G A c.52-657G>A - M - 0.029 85090591 T G c.52-631T>G - B 0.154 0.353 85090606 C A c.52-616C>A - S 0.111 - 85090627 A T c.52-595A>T - S 0.100 - 85090725 G T c.52-497G>T - M - 0.088 85090734 G A c.52-488G>A - M - 0.029 85091006 C T c.52-216C>T - B 0.224 0.177 85091074 G A c.52-148G>A - B 0.100 0.353 85091080 C T c.52-142C>T - M - 0.029 85091147 T C c.52-75T>C - M - 0.029 85091243 G A c.73G>A p.Gly25Arg M - 0.029 85091277 C T c.84+23C>T - B 0.118 0.353 85091300 A G c.84+46A>G - B 0.111 0.324 85091414 A C c.84+160A>C - S 0.050 - 85091466 A G c.84+212A>G - B 0.051 0 85091514 C A c.84+260C>A - M - 0.029 85091568 T C c.84+314T>C - M - 0.029 85091736 G A c.85-412G>A - S 0.050 - 85091742 T A c.85-406T>A - M - 0.029 85091788 G T c.85-360G>T - S 0.050 - 85091889 A G c.85-259A>G - S 0.050 - 85091924 G T c.85-224G>T - M - 0.029 85091968 C T c.85-180C>T - M - 0.029 85092039 A G c.85-109A>G - M - 0.029 85092091 A G c.85-57A>G - M - 0.088 85092186 G A c.123G>A p.Ala41Ala M - 0.029 85092207 T C c.123+21T>C - M - 0.029 85092276 C T c.123+90C>T - B 0.108 0 85092293 T C c.123+107T>C - M - 0.029 85092296 C T c.123+110C>T - M - 0.088 85092331 A G c.123+145A>G - M - 0.031 85092472 T C c.124-161T>C - B 0.103 0 85092477 C T c.124-156C>T - M - 0.029 85092529 C T c.124-104C>T - M - 0.031 85092586 C T c.124-47C>T - S 0.050 - 85092603 G T c.124-30G>T - M - 0.029 85092728 A G c.147+72A>G - M - 0.031 85092737 A T c.147+81A>T - B 0.090 0 85092819 C T c.147+163C>T - M - 0.029 85092878 T C c.148-203T>C - M - 0.029 85092922 A T c.148-159A>T - M - 0.029 85092936 G T c.148-145G>T - M - 0.029 85092941 C T c.148-140C>T - B 0.083 0.029 85092942 G A c.148-139G>A - M - 0.125 85092987 A G c.148-94A>G - M - 0.031 85093004 T C c.148-77T>C - B 0.203 0.281 85093043 C G c.148-38C>G - M - 0.029 85093046 T C c.148-35T>C - B 0.095 0.206 85093144 C T c.171+40C>T - M - 0.029 85093157 A T c.171+53A>T - M - 0.029 85093185 C A c.171+81C>A - B 0.090 0 85093200 A G c.171+96A>G - M - 0.029 85093228 A G c.171+124A>G - M - 0.029 85093259 G T c.171+155G>T - M - 0.029 85093266 G A c.171+162G>A - M - 0.125 85093287 A G c.171+183A>G - M - 0.031 85093331 T C c.171+227T>C - M - 0.029 85093360 C A c.171+256C>A - M - 0.029 85093375 T A c.171+271T>A - B 0.053 0 85093378 A T c.171+274A>T - B 0.067 0.029 85093411 A G c.172-301A>G - M - 0.029 85093482 T C c.172-230T>C - B 0.372 0.029 85093557 G A c.172-155G>A - M - 0.029 85093629 G A c.172-83G>A - M - 0.029 85093641 A C c.172-71A>C - M - 0.029 85093666 G T c.172-46G>T - M - 0.029 85093698 T C c.172-14T>C - M - 0.029 85093723 T C c.183T>C p.Ser61Ser M - 0.029 85093731 T C c.191T>C p.Ile64Thr M - 0.029 85093775 T G c.195+40T>G - M - 0.029 85093777 A G c.195+42A>G - M - 0.029 85093889 A C c.195+154A>C - M - 0.029 85093942 T C c.195+207T>C - M - 0.029 85093978 T C c.195+243T>C - M - 0.118 85093999 G C c.195+264G>C - M - 0.029 85094058 C G c.195+323C>G - M - 0.029 85094061 T C c.195+326T>C - M - 0.029 85094084 T A c.196-345T>A - M - 0.059 85094092 G A c.196-337G>A - M - 0.029 85094118 T C c.196-311T>C - M - 0.088 85094148 A G c.196-281A>G - M - 0.029 85094183 A G c.196-246A>G - M - 0.029 85094193 A G c.196-236A>G - M - 0.029 85094209 T C c.196-220T>C - M - 0.029 85094237 G A c.196-192G>A - M - 0.029 85094249 A C c.196-180A>C - M - 0.029 85094276 A G c.196-153A>G - B 0.066 0 85094280 G C c.196-149G>C - M - 0.029 85094297 T A c.196-132T>A - S 0.056 - 85094298 T A c.196-131T>A - B 0.039 0 85094313 G C c.196-116G>C - M - 0.029 85094317 T A c.196-112T>A - M - 0.029 85094318 C G c.196-111C>G - S 0.050 - 85094325 C T c.196-104C>T - M - 0.029 85094377 T C c.196-52T>C - M - 0.029 85094378 A T c.196-51A>T - B 0.050 0.353 85094390 G T c.196-39G>T - M - 0.088 85094394 T C c.196-35T>C - M - 0.029 85094448 C T c.215C>T p.Ala72Val M - 0.029 85094463 T C c.219+11T>C - B 0.067 0.029 85094465 T A c.219+13T>A - M - 0.029 85094490 T G c.219+38T>G - M - 0.029 85094497 C T c.219+45C>T - M - 0.029 85094511 C T c.219+59C>T - M - 0.029 85094530 G A c.219+78G>A - S 0.269 - 85094533 G C c.219+81G>C - M - 0.029 85094594 C T c.219+142C>T - M - 0.029 85094598 A G c.219+146A>G - M - 0.118 85094874 C T c.219+422C>T - S 0.067 - 85094876 C T c.219+424C>T - B 0.067 0.059 85095036 C T c.219+584C>T - B 0.067 0.059 85095255 C T c.220-671C>T - B 0.067 0.147 85095336 A C c.220-590A>C - M - 0.118 85095431 T C c.220-495T>C - S 0.111 - 85095600 G A c.220-326G>A - S 0.100 - 85095614 T C c.220-312T>C - B 0.145 0.324 85095648 G A c.220-278G>A - M - 0.029 85095664 T G c.220-262T>G - M - 0.118 85095758 A T c.220-168A>T - M - 0.088 85095774 C A c.220-152C>A - M - 0.177 85095964 C T c.252+6C>T - B 0.363 0.177 85096021 C T c.252+63C>T - M - 0.029 85096112 A C c.252+154A>C - M - 0.059 85096211 T C c.252+253T>C - B 0.071 0.029 85096282 C T c.252+324C>T - B 0.050 0.324 85096320 C T c.252+362C>T - M - 0.029 85096321 G A c.252+363G>A - S 0.100 - 85096390 G A c.253-319G>A - M - 0.118 85096397 C T c.253-312C>T - S 0.288 - 85096673 A G c.253-36A>G - M - 0.118 85096778 C A c.277-45C>A - B 0.053 0 85096807 T G c.277-16T>G - B 0.125 0.029 85096949 A G c.330+73A>G - M - 0.029 85096960 T C c.330+84T>C - M - 0.177 85096975 C T c.330+99C>T - B 0.397 0.353 85096987 C T c.330+111C>T - S 0.050 - 85097042 T C c.330+166T>C - M - 0.029 85097061 T G c.330+185T>G - M - 0.029 85097082 T C c.330+206T>C - B 0.375 0.059 85097138 G T c.330+262G>T - M - 0.029 85097187 C T c.330+311C>T - B 0.075 0.088 85097188 G A c.330+312G>A - M - 0.353 85097190 C T c.330+314C>T - M - 0.029 85097289 A G c.330+413A>G - M - 0.471 85097290 C A c.330+414C>A - B 0.192 0.412 85097394 A G c.330+518A>G - M - 0.029 85097611 T C c.331-580T>C - M - 0.088 85097743 A T c.331-448A>T - B 0.067 0.088 85097753 G A c.331-438G>A - B 0.067 0.088 85097769 C T c.331-422C>T - M - 0.059 85097796 T C c.331-395T>C - M - 0.059 85097893 G T c.331-298G>T - M - 0.029 85097997 A C c.331-194A>C - M - 0.147 85098007 A C c.331-184A>C - M - 0.147 85098139 C A c.331-52C>A - M - 0.059 85098331 C T c.372+99C>T - M - 0.029 85098357 G A c.372+125G>A - M - 0.059 85098411 A C c.372+179A>C - S 0.079 - 85098734 T A c.373-141T>A - M - 0.063 85098735 G A c.373-140G>A - M - 0.063 85098760 T A c.373-115T>A - M - 0.029 85098789 G A c.373-86G>A - B 0.056 0.088 85098805 A G c.373-70A>G - M - 0.029 85098887 A C c.385A>C p.Lys129Gln M - 0.147 85098951 A G c.396+53A>G - M - 0.059 85098984 T C c.396+86T>C - M - 0.059 85099015 G A c.396+117G>A - S 0.359 - 85099136 A G c.396+238A>G - B 0.474 0.382 85099166 A T c.396+268A>T - M - 0.324 85099191 A G c.396+293A>G - M - 0.029 85099228 G A c.396+330G>A - S 0.050 - 85099325 T G c.396+427T>G - S 0.150 - 85099413 T C c.396+515T>C - M - 0.088 85099466 A G c.396+568A>G - B 0.069 0.031 85099518 C T c.397-578C>T - S 0.050 - 85099664 T C c.397-432T>C - M - 0.031 85099722 T A c.397-374T>A - B 0.434 0.250 85099826 T A c.397-270T>A - B 0.500 0.125 85099867 T C c.397-229T>C - M - 0.294 85099884 C T c.397-212C>T - M - 0.059 85099917 T A c.397-179T>A - M - 0.059 85099985 T G c.397-111T>G - B 0.141 0.033 85099992 G T c.397-104G>T - M - 0.033 85100013 T G c.397-83T>G - S 0.125 - 85100107 T C c.408T>C p.His136His B 0.069 0.406 85100166 T C c.438+29T>C - M - 0.063 85100198 C G c.438+61C>G - M - 0.063 85100403 T C c.438+266T>C - M - 0.313 85100448 C A c.438+311C>A - M - 0.469 85100500 A G c.438+363A>G - M - 0.067 85100505 A G c.438+368A>G - S 0.050 - 85100525 C T c.438+388C>T - M - 0.313 85100541 C T c.438+404C>T - B 0.400 0.250 85100634 C G c.439-404C>G - M - 0.031 85100719 C T c.439-319C>T - B 0.438 0.250 85100727 T C c.439-311T>C - M - 0.031 85100748 T C c.439-290T>C - M - 0.059 85100809 C T c.439-229C>T - M - 0.059 85100847 C A c.439-191C>A - M - 0.029 85100850 A G c.439-188A>G - B 0.463 0.265 85101085 G T c.465+21G>T - B 0.475 0.125 85101182 C T c.465+118C>T - S 0.050 - 85101321 A G c.465+257A>G - B 0.075 0.063 85101325 A G c.465+261A>G - M - 0.063 85101353 G A c.465+289G>A - B 0.436 0.313 85101618 C T c.466-392C>T - B 0.052 0.188 85101636 A T c.466-374A>T - M - 0.094 85101647 C T c.466-363C>T - S 0.050 - 85101779 C T c.466-231C>T - B 0.069 0.067 85101820 A G c.466-190A>G - S 0.050 - 85101875 T A c.466-135T>A - S 0.050 - 85101883 T C c.466-127T>C - M - 0.067 85101891 A T c.466-119A>T - B 0.475 0.267 85101968 G T c.466-42G>T - M - 0.031 85102013 C T c.469C>T p.Leu157Leu B 0.052 0.094 85102070 G C c.489+37G>C - M - 0.033 85102103 G A c.489+70G>A - M - 0.100 85102281 A G c.489+248A>G - B 0.487 0.333 85102282 T G c.489+249T>G - B 0.461 0.133 85102297 C T c.489+264C>T - M - 0.031 85102426 A T c.489+393A>T - M - 0.029 85102550 C A c.490-279C>A - B 0.184 0.100 85102558 G A c.490-271G>A - S 0.367 - 85102580 A G c.490-249A>G - M - 0.344 85102582 T C c.490-247T>C - M - 0.344 85102707 A G c.490-122A>G - M - 0.033 85102787 T G c.490-42T>G - S 0.100 - 85184193 G A c.34G>A p.Val12Ile M - 0.059 CSN1S2 85184295 C T c.51+85C>T - B 0.180 0.206 85184324 T C c.51+114T>C - B 0.176 0.118 85184355 C T c.51+145C>T - S 0.050 - 85184418 A G c.51+208A>G - B 0.462 0.059 85184432 T A c.51+222T>A - S 0.050 - 85184452 G A c.51+242G>A - S 0.050 - 85184483 C T c.51+273C>T - S 0.050 - 85184498 C T c.51+288C>T - M - 0.118 85184549 C T c.51+339C>T - S 0.050 - 85184550 T G c.51+340T>G - S 0.075 - 85184552 C A c.51+342C>A - B 0.150 0.177 85184565 G A c.51+355G>A - B 0.175 0.177 85184566 G A c.51+356G>A - M - 0.059 85184591 C A c.51+381C>A - S 0.050 - 85184593 C A c.51+383C>A - S 0.050 - 85184607 A G c.51+397A>G - B 0.263 0.265 85184657 C A c.51+447C>A - B 0.275 0.265 85184662 T A,G c.51+452T>A - B 0.283 0.233 85184677 G A c.51+467G>A - M - 0.088 85184687 A G c.51+477A>G - M - 0.029 85184689 G T c.51+479G>T - B 0.288 0.235 85184787 T C c.51+577T>C - B 0.225 0.265 85184788 T C c.51+578T>C - B 0.317 0.324 85184795 A G c.51+585A>G - M - 0.059 85184811 C T c.51+601C>T - M - 0.324 85184855 G A c.51+645G>A - B 0.050 0.059 85184872 A G c.51+662A>G - B 0.463 0.471 85184884 G C c.51+674G>C - B 0.200 0.206 85184935 C T c.51+725C>T - B 0.050 0.059 85184945 T C c.51+735T>C - B 0.050 0.059 85184948 G T c.51+738G>T - B 0.450 0.118 85185100 G A c.51+890G>A - B 0.425 0.235 85185118 C T c.51+908C>T - S 0.125 - 85185122 G A c.51+912G>A - S 0.083 - 85185123 C A c.51+913C>A - S 0.083 - 85185182 C T c.52-859C>T - M - 0.059 85185186 T C c.52-855T>C - B 0.413 0.471 85185202 A T c.52-839A>T - M - 0.029 85185203 A G c.52-838A>G - B 0.267 0.382 85185206 C A c.52-835C>A - S 0.083 - 85185228 G T c.52-813G>T - M - 0.118 85185332 T A c.52-709T>A - S 0.050 - 85185378 T C c.52-663T>C - B 0.167 0.441 85185417 A G c.52-624A>G - M - 0.118 85185552 T C c.52-489T>C - M - 0.029 85185569 T G c.52-472T>G - M - 0.029 85185641 G A c.52-400G>A - S 0.075 - 85185686 A G c.52-355A>G - B 0.205 0.206 85185690 T C c.52-351T>C - B 0.231 0.059 85185728 C T c.52-313C>T - M - 0.059 85185734 T C c.52-307T>C - B 0.224 0.382 85185735 A C c.52-306A>C - B 0.224 0.206 85185749 G A c.52-292G>A - M - 0.029 85185755 A C c.52-286A>C - M - 0.029 85185825 T C c.52-216T>C - B 0.375 0.382 85185877 T G c.52-164T>G - S 0.050 - 85185950 G A c.52-91G>A - M - 0.118 85186016 A G c.52-25A>G - B 0.282 0.353 85186160 A G c.78+93A>G - B 0.163 0.118 85186169 A G c.78+102A>G - B 0.375 0.118 85186215 A G c.78+148A>G - M - 0.059 85186218 T G c.78+151T>G - B 0.359 0.118 85186382 G C c.78+315G>C - S 0.111 - 85186396 G A c.78+329G>A - M - 0.029 85186427 C A c.78+360C>A - S 0.050 - 85186428 A G c.78+361A>G - B 0.154 0.406 85186430 C T c.78+363C>T - B 0.213 0.219 85186466 G A c.79-385G>A - M - 0.063 85186531 G A c.79-320G>A - B 0.205 0.406 85186564 A C c.79-287A>C - B 0.133 0.059 85186582 A G c.79-269A>G - B 0.231 0.471 85186706 G A c.79-145G>A - B 0.125 0.059 85186789 A G c.79-62A>G - M - 0.029 85186812 G A c.79-39G>A - B 0.154 0.438 85186902 T C c.102+28T>C - B 0.132 0.059 85187019 C T c.144+15C>T - S 0.075 - 85187172 C T c.144+168C>T - B 0.197 0.188 85187249 T C c.145-140T>C - B 0.180 0.200 85187326 C G c.145-63C>G - B 0.194 0.206 85187329 C A c.145-60C>A - M - 0.029 85187339 A T c.145-50A>T - S 0.079 - 85187340 T C c.145-49T>C - M - 0.029 85187352 G A c.145-37G>A - B 0.216 0.177 85187376 T A c.145-13T>A - M - 0.029 85187436 T A c.171+21T>A - B 0.132 0.059 85187437 A G c.171+22A>G - B 0.500 0.118 85187471 G C c.171+56G>C - B 0.203 0.188 85187479 C T c.171+64C>T - B 0.392 0.177 85187712 A G c.171+297A>G - B 0.200 0.147 85187732 A G c.171+317A>G - B 0.171 0.188 85187752 C G c.171+337C>G - B 0.050 0.059 85187761 T G c.171+346T>G - M - 0.029 85187813 A G c.171+398A>G - B 0.141 0.059 85187843 C T c.172-370C>T - S 0.050 - 85187915 T C c.172-298T>C - S 0.275 - 85187997 T C c.172-216T>C - B 0.213 0.188 85188009 C A c.172-204C>A - M - 0.029 85188038 C T c.172-175C>T - B 0.300 0.265 85188219 G A c.178G>A p.Val60Ile S 0.050 - 85188228 G T c.187G>T p.Ala63Ser S 0.050 - 85188321 A G c.198+82A>G - S 0.275 - 85188341 A T c.198+102A>T - B 0.410 0.265 85188404 A C c.198+165A>C - B 0.207 0.029 85188447 G A c.198+208G>A - B 0.487 0.118 85188557 G T c.199-123G>T - B 0.449 0.412 85188723 C T c.225+17C>T - B 0.269 0.471 85188731 T C c.225+25T>C - B 0.263 0.471 85188822 C T c.225+116C>T - B 0.100 0.353 85188831 T G c.225+125T>G - B 0.188 0.118 85188933 G T c.225+227G>T - B 0.450 0.147 85189014 G C c.225+308G>C - M - 0.118 85189027 G A c.225+321G>A - B 0.400 0.471 85189040 G A c.225+334G>A - M - 0.118 85189081 C T c.225+375C>T - B 0.188 0.088 85189082 T C c.225+376T>C - B 0.475 0.088 85189116 C G c.225+410C>G - S 0.050 - 85189155 A G c.225+449A>G - M - 0.029 85189233 C T c.226-470C>T - M - 0.265 85189341 T C c.226-362T>C - B 0.217 0.088 85189347 C T c.226-356C>T - B 0.413 0.500 85189405 G A c.226-298G>A - S 0 - 85189459 T G c.226-244T>G - S 0.250 - 85189501 C T c.226-202C>T - S 0.050 - 85189514 A G c.226-189A>G - S 0.050 - 85189589 T C c.226-114T>C - B 0.425 0.500 85189595 G T c.226-108G>T - S 0.050 - 85189601 G T c.226-102G>T - S 0.050 - 85189633 C T c.226-70C>T - M - 0.118 85189680 A T c.226-23A>T - M - 0.029 85189688 T C c.226-15T>C - B 0.400 0.500 85189771 C T c.249+45C>T - B 0.487 0.118 85189841 G T c.268G>T p.Asp90Tyr B 0.488 0.118 85189843 C T c.270C>T p.Asp90Asp B 0.050 0.412 85189864 A C c.291A>C p.Ala97Ala B 0.463 0.500 85189890 A T c.294+23A>T - B 0.488 0.500 85189978 C T c.294+111C>T - S 0.075 - 85189988 C G c.294+121C>G - S 0.167 - 85190019 C T c.295-110C>T - B 0.461 0.500 85190074 C T c.295-55C>T - M - 0.059 85190109 G C c.295-20G>C - S 0.050 - 85190117 C G c.295-12C>G - M - 0.088 85190123 A C c.295-6A>C - B 0.392 0.412 85190124 T G c.295-5T>G - B 0.125 0.088 85190178 T C c.344T>C p.Leu115Pro B 0.050 0.177 85190187 G A c.353G>A p.Gly118Asp S 0.050 - 85190188 C T c.354C>T p.Gly118Gly B 0.050 0.118 85190192 A G c.358A>G p.Ile120Val B 0.447 0.059 85190241 C T c.407C>T p.Thr136Ile M - 0.118 85190344 T C c.417+93T>C - B 0.474 0.063 85190367 C T c.417+116C>T - B 0.125 0.088 85190397 A G c.417+146A>G - S 0.050 - 85190431 A G c.417+180A>G - M - 0.029 85190466 A G c.417+215A>G - B 0.117 0.324 85190555 A G c.418-218A>G - M - 0.059 85190559 G A c.418-214G>A - B 0.488 0.118 85190576 C G c.418-197C>G - B 0.488 0.059 85190583 A G c.418-190A>G - M - 0.118 85190599 G A c.418-174G>A - B 0.488 0.059 85190639 A C c.418-134A>C - B 0.488 0.059 85190699 C T c.418-74C>T - M - 0.059 85190700 A G c.418-73A>G - B 0.375 0.206 85190705 G A c.418-68G>A - S 0.188 - 85190717 G A c.418-56G>A - S 0.050 - 85190765 T G c.418-8T>G - B 0.474 0.059 85190839 G A c.444+40G>A - M - 0.118 85190917 A G c.444+118A>G - B 0.475 0.177 85190941 A G c.444+142A>G - M - 0.059 85190942 T C c.444+143T>C - M - 0.324 85190985 G A c.444+186G>A - M - 0.088 85191000 T C c.444+201T>C - M - 0.265 85191115 T G c.444+316T>G - B 0.397 0.324 85191178 T C c.444+379T>C - B 0.475 0.059 85191179 G A c.444+380G>A - B 0.375 0.324 85191213 T C c.444+414T>C - B 0.125 0.118 85191248 C A,T c.444+449C>A - M - 0.133 85191249 A G c.444+450A>G - B 0.150 0.147 85191316 A G c.445-460A>G - B 0.363 0.324 85191319 A G c.445-457A>G - M - 0.118 85191374 G A c.445-402G>A - B 0.363 0.324 85191377 A C c.445-399A>C - B 0.488 0.300 85191407 C T c.445-369C>T - S 0.075 - 85191408 A G c.445-368A>G - S 0.075 - 85191412 G C c.445-364G>C - M - 0.118 85191430 A G c.445-346A>G - B 0.200 0.147 85191533 G A c.445-243G>A - M - 0.029 85191580 T G c.445-196T>G - S 0.050 - 85191622 G A c.445-154G>A - B 0.363 0.265 85191772 C T c.445-4C>T - B 0.132 0.147 85191773 G A c.445-3G>A - B 0.180 0.233 85191900 G A c.471+98G>A - B 0.487 0.059 85191935 C A c.471+133C>A - M - 0.118 85191937 G C c.471+135G>C - B 0.405 0.324 85191956 C T c.471+154C>T - M - 0.118 85191962 A G c.471+160A>G - M - 0.118 85191997 C T c.471+195C>T - B 0.388 0.235 85192039 C T c.471+237C>T - B 0.385 0.324 85192123 G A c.471+321G>A - B 0.421 0.324 85192173 C T c.471+371C>T - S 0.050 - 85192192 C T c.471+390C>T - M - 0.029 85192193 T C c.471+391T>C - M - 0.147 85192221 T A c.471+419T>A - B 0.117 0.088 85192408 G A c.471+606G>A - B 0.385 0.324 85192451 A G c.471+649A>G - M - 0.029 85192635 G A c.471+833G>A - B 0.125 0.118 85192639 A T c.471+837A>T - B 0.413 0.324 85192790 C T c.472-709C>T - B 0.475 0.059 85192805 G A c.472-694G>A - S 0.050 - 85192826 C A c.472-673C>A - B 0.500 0.059 85192837 T C c.472-662T>C - B 0.487 0.177 85192840 T A c.472-659T>A - B 0.125 0.059 85192853 G A c.472-646G>A - B 0.200 0.088 85192904 A G c.472-595A>G - S 0.275 - 85192932 T A c.472-567T>A - B 0.125 0.059 85192971 A C c.472-528A>C - B 0.388 0.265 85192972 G A c.472-527G>A - B 0.388 0.265 85192977 C T c.472-522C>T - M - 0.118 85192988 C T c.472-511C>T - M - 0.059 85192998 A T c.472-501A>T - S 0.075 - 85193026 T C c.472-473T>C - B 0.200 0.059 85193036 A G c.472-463A>G - B 0.487 0.177 85193068 G A c.472-431G>A - S 0.050 - 85193123 C T c.472-376C>T - B 0.488 0.059 85193139 A C c.472-360A>C - B 0.475 0.177 85193186 G C c.472-313G>C - B 0.372 0.353 85193197 C T c.472-302C>T - M - 0.029 85193245 T C c.472-254T>C - S 0.050 - 85193248 G A c.472-251G>A - B 0.400 0.353 85193293 T C c.472-206T>C - M - 0.029 85193310 C T c.472-189C>T - B 0.474 0.059 85193388 C A c.472-111C>A - B 0.500 0.059 85193436 T C c.472-63T>C - S 0.050 - 85193438 T C c.472-61T>C - B 0.145 0 85193443 A G c.472-56A>G - M - 0.029 85193455 A G c.472-44A>G - B 0.405 0.265 85193481 A T c.472-18A>T - S 0.444 - 85193514 T G c.487T>G p.Phe163Val M - 0.059 85193587 T C c.496-26T>C - M - 0.029 85193604 C T c.496-9C>T - B 0.375 0.441 85193644 G A c.527G>A p.Arg176His B 0.238 0.059 85193790 T G c.540+133T>G - M - 0.118 85193812 A G c.540+155A>G - B 0.487 0.500 85193837 C T c.540+180C>T - S 0.050 - 85193862 C T c.540+205C>T - S 0.050 - 85193882 A C c.540+225A>C - B 0.180 0.088 85194005 G A c.540+348G>A - M - 0.294 85194044 T G c.540+387T>G - B 0.270 0.344 85194089 T C c.541-375T>C - S 0.063 - 85194102 G T c.541-362G>T - M - 0.088 85194144 G A c.541-320G>A - B 0.338 0.235 85194162 C T c.541-302C>T - M - 0.059 85194163 G T c.541-301G>T - B 0.075 0.029 85194251 A G c.541-213A>G - B 0.308 0.438 85194568 C T,G c.645C>G p.Asn215Lys M - 0.063 85194597 T A c.660+14T>A - M - 0.313 85194618 A G c.660+35A>G - B 0.205 0.324 85194697 T C c.660+114T>C - B 0.218 0.324 85194811 A G c.660+228A>G - S 0.275 - 85194905 A G c.660+322A>G - B 0.158 0 85194980 T C c.661-365T>C - S 0.079 - 85195006 A G c.661-339A>G - M - 0.059 85195033 T C c.661-312T>C - M - 0.029 85195142 T A c.661-203T>A - M - 0.059 85195214 A G c.661-131A>G - B 0.474 0.059 85195225 C T c.661-120C>T - B 0.218 0.324 85195226 G A c.661-119G>A - S 0.125 - 85195250 A T c.661-95A>T - M - 0.029 85195305 A G c.661-40A>G - M - 0.029 85116838 T C c.679A>G p.Thr227Ala M - 0.029 85117013 C T c.667-163G>A - B 0.163 0.500 85117090 G C c.666+172C>G - M - 0.088 85117091 A G c.666+171T>C - S 0.050 - 85117166 A G c.666+96T>C - M - 0.118 85117168 C A c.666+94G>T - B 0.100 0.118 85117207 A G c.666+55T>C - B 0.163 0.500 85117294 G T c.634C>A p.Leu212Ile B 0.175 0.500 85117313 C A c.615G>T p.Leu205Leu M - 0.029 85117333 T C c.595A>G p.Met199Val S 0.117 - 85117756 G A c.175-3C>T - B 0.103 0.118 85117808 T C c.175-55A>G - B 0.163 0.471 85118048 G C c.175-295C>G - B 0.163 0.471 85118121 G A c.175-368C>T - B 0.117 0.382 85118191 G A c.175-438C>T - B 0.125 0.088 85118306 T C c.175-553A>G - M - 0.029 85118469 A T c.174+611T>A - M - 0.088 CSN2 85118557 T A c.174+523A>T - B 0.100 0.118 85118559 A T c.174+521T>A - B 0.100 0.118 85118572 T C c.174+508A>G - M - 0.029 85118618 T C c.174+462A>G - M - 0.029 85118680 T C c.174+400A>G - B 0.163 0.471 85118691 G T c.174+389C>A - M - 0.177 85118716 A G c.174+364T>C - S 0.050 - 85118759 T C c.174+321A>G - B 0.150 0.500 85118765 C T c.174+315G>A - M - 0.118 85118794 T C c.174+286A>G - M - 0.177 85118921 T G c.174+159A>C - B 0.103 0.118 85118931 C T c.174+149G>A - B 0.167 0.471 85118966 T C c.174+114A>G - B 0.103 0.118 85119048 T C c.174+32A>G - M - 0.029 85119140 G C c.130-16C>G - B 0.342 0.353 85119174 C T c.129+41G>A - M - 0.029 85119178 G A c.129+37C>T - B 0.150 0.471 85119194 G A c.129+21C>T - M - 0.029 85119270 G A c.106-32C>T - S 0.050 - 85119288 T C c.106-50A>G - M - 0.088 85119299 G A c.106-61C>T - B 0.368 0.324 85119353 A T c.106-115T>A - B 0.163 0.500 85119387 A G c.106-149T>C - M - 0.029 85119403 C A c.106-165G>T - B 0.167 0.469 85119452 A C c.106-214T>G - B 0.167 0.500 85119551 A G c.106-313T>C - M - 0.029 85119695 A T c.106-457T>A - B 0.150 0.500 85119731 A T c.106-493T>A - B 0.163 0.500 85119761 T C c.106-523A>G - B 0.163 0.500 85119835 G C c.106-597C>G - B 0.117 0.382 85119861 G A c.106-623C>T - S 0.050 - 85119872 T C c.106-634A>G - B 0.086 0.118 85119877 A G c.106-639T>C - B 0.154 0.441 85119897 A G c.106-659T>C - B 0.115 0.412 85119946 G A c.106-708C>T - S 0.133 - 85120010 T C c.106-772A>G - S 0.155 - 85120029 A G c.106-791T>C - S 0.150 - 85120048 A C c.106-810T>G - B 0.086 0.029 85120061 A G c.106-823T>C - S 0.138 - 85120081 T C c.106-843A>G - M - 0.029 85120102 T A,G c.106-864A>T - S 0.056 - 85120135 A C c.106-897T>G - S 0.050 - 85120137 C T c.106-899G>A - S 0.103 - 85120161 G T c.106-923C>A - S 0.086 - 85120206 C T c.106-968G>A - M - 0.029 85120226 G C c.106-988C>G - S 0.100 - 85120232 T C c.106-994A>G - S 0.050 - 85120240 C G c.106-1002G>C - B 0.100 0.029 85120245 T G c.106-1007A>C - M - 0.031 85120260 T A c.106-1022A>T - B 0.125 0.219 85120264 T C c.106-1026A>G - S 0.125 - 85120267 T A c.106-1029A>T - S 0.125 - 85120270 G A c.106-1032C>T - S 0.117 - 85120271 A G c.106-1033T>C - B 0.125 0.219 85120292 C T c.106-1054G>A - B 0.438 0.094 85120297 C G c.106-1059G>C - M - 0.063 85120329 A G c.106-1091T>C - S 0.075 - 85120336 G A c.106-1098C>T - B 0.163 0.324 85120343 T A c.106-1105A>T - S 0.100 - 85120350 T C c.106-1112A>G - B 0.100 0.118 85120373 C T c.106-1135G>A - B 0.100 0.500 85120427 G C c.106-1189C>G - B 0.167 0.500 85120428 G A c.106-1190C>T - S 0.103 - 85120457 T C c.106-1219A>G - B 0.163 0.500 85120461 C T c.106-1223G>A - B 0.308 0.353 85120474 C T c.106-1236G>A - B 0.163 0.471 85120521 C T c.105+1204G>A - B 0.100 0.118 85120548 C T c.105+1177G>A - M - 0.059 85120557 G C c.105+1168C>G - B 0.163 0.500 85120574 A G c.105+1151T>C - M - 0.029 85120595 T G c.105+1130A>C - B 0.117 0.382 85120598 C A c.105+1127G>T - B 0.163 0.471 85120600 T A c.105+1125A>T - M - 0.029 85120619 G A c.105+1106C>T - B 0.163 0.500 85120693 G A c.105+1032C>T - B 0.183 0.441 85120708 T C c.105+1017A>G - B 0.150 0.441 85120730 A G c.105+995T>C - B 0.138 0.412 85120785 G A c.105+940C>T - M - 0.029 85120837 C T c.105+888G>A - B 0.150 0.500 85120838 A G c.105+887T>C - B 0.150 0.500 85120845 T A c.105+880A>T - B 0.150 0.500 85120846 A C c.105+879T>G - B 0.150 0.500 85120895 A C c.105+830T>G - B 0.163 0.500 85120924 A G c.105+801T>C - S 0.133 - 85121058 A T c.105+667T>A - B 0.163 0.500 85121065 G A c.105+660C>T - M - 0.029 85121072 T C c.105+653A>G - B 0.163 0.500 85121095 A T c.105+630T>A - B 0.163 0.500 85121128 T C c.105+597A>G - B 0.150 0.471 85121169 G A c.105+556C>T - B 0.163 0.471 85121240 G A c.105+485C>T - B 0.150 0.471 85121271 G A c.105+454C>T - B 0.150 0.471 85121328 G T c.105+397C>A - B 0.163 0.471 85121374 A G c.105+351T>C - B 0.333 0.417 85121379 T G c.105+346A>C - B 0.143 0.364 85121386 C T c.105+339G>A - M - 0.029 85121399 A G c.105+326T>C - B 0.125 0.364 85121426 C A,* c.105+299G>T - S 0.019 - 85121446 T C c.105+279A>G - B 0.100 0.308 85121658 A G c.105+67T>C - M - 0.029 85121679 G A c.105+46C>T - B 0.163 0.471 85121798 A G c.79-47T>C - B 0.175 0.471 85121812 G A c.78+52C>T - M - 0.059 85121917 C A c.52-27G>T - B 0.154 0.471 85121918 G T c.52-28C>A - B 0.154 0.471 85121923 C T c.52-33G>A - B 0.158 0.471 85121965 A G c.52-75T>C - B 0.100 0.059 85122020 C T c.52-130G>A - B 0.154 0.471 85122023 T C c.52-133A>G - B 0.154 0.471 85122036 T C c.52-146A>G - B 0.154 0.500 85122048 A G c.52-158T>C - B 0.500 0.029 85122230 C T c.52-340G>A - B 0.163 0.471 85122265 G A c.51+357C>T - B 0.163 0.471 85122287 T A c.51+335A>T - B 0.100 0.059 85122288 G T c.51+334C>A - B 0.100 0.059 85122296 A G c.51+326T>C - B 0.138 0.500 85122298 G A c.51+324C>T - B 0.100 0.088 85122312 G A c.51+310C>T - B 0.163 0.471 85122315 C A c.51+307G>T - B 0.088 0.471 85122341 G A c.51+281C>T - M - 0.029 85122356 T G c.51+266A>C - B 0.163 0.471 85122401 A T c.51+221T>A - B 0.163 0.471 85122499 G C c.51+123C>G - M - 0.029 85122502 T C c.51+120A>G - B 0.100 0.118 85122679 C T c.-7G>A - B 0.163 0.471 85122721 C G c.-49G>C - B 0.150 0.469 85122723 C A c.-51G>T - B 0.100 0.063 85122762 C A c.-90G>T - B 0.154 0.471 85122769 C A c.-97G>T - B 0.158 0.471 85309593 A G c.42A>G p.Leu14Leu B 0.050 0.147 85309623 T C c.57+15T>C - S 0.100 - 85309654 C T c.57+46C>T - B 0.128 0.147 85309805 C G c.57+197C>G - B 0.167 0.147 85310101 G T c.57+493G>T - S 0.050 - 85310112 C T c.57+504C>T - B 0.372 0.324 85310116 A G c.57+508A>G - M - 0.059 85310125 C T c.57+517C>T - M - 0.059 85310141 C T c.57+533C>T - B 0.385 0.294 CSN3 85310217 C T c.57+609C>T - B 0.359 0.206 85310258 T C c.57+650T>C - B 0.197 0.294 85310343 G A c.57+735G>A - S 0.056 - 85310384 G T c.57+776G>T - B 0.200 0.029 85310452 A T c.57+844A>T - S 0.233 - 85310455 T A c.57+847T>A - B 0.225 0.088 85310473 C A c.57+865C>A - B 0.138 0.147 85310499 T G c.57+891T>G - B 0.133 0.235 85310507 G A c.57+899G>A - M - 0.147 85310848 C T c.57+1240C>T - M - 0.029 85310868 G C c.57+1260G>C - B 0.125 0.147 85310922 T G c.57+1314T>G - B 0.325 0.147 85310946 G A c.57+1338G>A - B 0.138 0.147 85310988 A G,* c.57+1380A>G - S 0.273 - 85311018 G A c.57+1410G>A - S 0.050 - 85311134 A G c.57+1526A>G - B 0.154 0 85311362 T C c.57+1754T>C - B 0.138 0 85311385 T C c.57+1777T>C - B 0.138 0.147 85311408 G A c.57+1800G>A - B 0.175 0.147 85311464 G A c.57+1856G>A - S 0.100 - 85311465 C T c.57+1857C>T - S 0.050 - 85311477 A C c.57+1869A>C - S 0.100 - 85311487 T A c.57+1879T>A - S 0.050 - 85311488 C T c.57+1880C>T - S 0.050 - 85311508 T C c.57+1900T>C - S 0.163 - 85311515 G T c.57+1907G>T - B 0.175 0.088 85311524 T G c.57+1916T>G - B 0.188 0.118 85311544 T G c.57+1936T>G - S 0.150 - 85311547 C A c.57+1939C>A - S 0.100 - 85311548 A T c.57+1940A>T - S 0.050 - 85311550 A T,C c.57+1942A>C - S 0.079 - 85311553 T C c.57+1945T>C - S 0.050 - 85311565 G A c.57+1957G>A - S 0.050 - 85311566 A C c.57+1958A>C - S 0.050 - 85311580 C A c.57+1972C>A - B 0.213 0.324 85311585 G A c.57+1977G>A - S 0.050 - 85311588 G A c.57+1980G>A - S 0.050 - 85311664 G C,A c.57+2056G>A - S 0.026 - 85311666 T A c.57+2058T>A - S 0.050 - 85311708 A C c.57+2100A>C - S 0.150 - 85311711 C G c.57+2103C>G - S 0.050 - 85311712 C A c.57+2104C>A - S 0.050 - 85311730 A G c.57+2122A>G - B 0.375 0.353 85311815 T C c.57+2207T>C - B 0.225 0.206 85311926 C T c.58-2315C>T - B 0.013 0.029 85311929 G C c.58-2312G>C - B 0.200 0.029 85311990 G C c.58-2251G>C - M - 0.029 85312140 A C c.58-2101A>C - B 0.200 0.324 85312182 T C c.58-2059T>C - B 0.050 0.029 85312230 G A c.58-2011G>A - B 0.244 0.206 85312285 A G c.58-1956A>G - S 0.218 - 85312314 T C c.58-1927T>C - M - 0.059 85312318 T A c.58-1923T>A - S 0.050 - 85312414 G A c.58-1827G>A - B 0.133 0.206 85312436 A G c.58-1805A>G - B 0.158 0.147 85312467 G A c.58-1774G>A - B 0.150 0.177 85312571 C G c.58-1670C>G - B 0.141 0.147 85312764 T C c.58-1477T>C - M - 0.059 85312811 C A c.58-1430C>A - S 0.269 - 85312812 C A c.58-1429C>A - B 0.487 0.471 85313047 G A c.58-1194G>A - M - 0.029 85313055 G A c.58-1186G>A - B 0.175 0.324 85313119 A G c.58-1122A>G - B 0.050 0.059 85313121 T C c.58-1120T>C - B 0.050 0.059 85313178 A G c.58-1063A>G - B 0.141 0.118 85313463 T C c.58-778T>C - B 0.050 0.059 85313715 T A c.58-526T>A - B 0.013 0.029 85313865 T C c.58-376T>C - B 0.145 0.147 85314041 G A c.58-200G>A - B 0.066 0.088 85314053 T C c.58-188T>C - S 0.050 - 85314123 C A c.58-118C>A - M - 0.029 85314152 A C c.58-89A>C - B 0.083 0.088 85314571 G A c.90+298G>A - B 0.141 0.147 85314642 C T c.90+369C>T - S 0.192 - 85314727 G T c.90+454G>T - M - 0.029 85314739 T C c.90+466T>C - B 0.231 0.324 85314831 T A c.90+558T>A - B 0.172 0.147 85314859 A T c.90+586A>T - M - 0.059 85314865 C T c.90+592C>T - B 0.173 0.147 85314975 T C c.90+702T>C - B 0.080 0.133 85315042 A T c.90+769A>T - S 0.100 - 85315043 T G c.90+770T>G - S 0.050 - 85315064 T C c.90+791T>C - B 0.460 0.267 85315199 G C c.90+926G>C - B 0.177 0 85315343 T G c.91-1003T>G - B 0.200 0.177 85315411 C A c.91-935C>A - S 0.167 - 85315637 C T c.91-709C>T - M - 0.177 85315758 G A c.91-588G>A - B 0.176 0 85315838 G A c.91-508G>A - S 0.056 - 85315845 A G c.91-501A>G - S 0.056 - 85315859 T C c.91-487T>C - B 0.200 0.206 85315882 A G c.91-464A>G - M - 0.059 85315916 C T c.91-430C>T - B 0.194 0.406 85315918 C T c.91-428C>T - M - 0.235 85315949 G C c.91-397G>C - M - 0.029 85315979 T C c.91-367T>C - S 0.050 - 85315983 A G c.91-363A>G - B 0.175 0.206 85316130 T G c.91-216T>G - B 0.288 0.147 85316304 C G c.91-42C>G - S 0.218 - 85316328 A T c.91-18A>T - S 0.050 - 85316423 C T c.168C>T p.Tyr56Tyr B 0.141 0 85316562 G A c.307G>A p.Ala103Thr M - 0.147 85316665 A G c.410A>G p.Lys137Arg M - 0.029 *Presence, S= Sheep, M= Mouflon, B= Both; †MAF Sheep, minor allele frequency in domestic sheep; ‡MAF Mouflon, minor allele frequency in mouflon. Table S4. Classification and number of SNPs mapping to the casein genes in domestic sheep populations from North Africa, West Asia, Europe and South and East Asia. # SNPs Splice # SNPs # SNPs South # SNPs Gene Exon Intron Upstream Downstream 5'UTR 3'UTR North Total site West Asia and East Asia Europe Africa CSN1S1 4 90 1 0 0 0 0 64 67 63 74 95 CSN1S2 10 182 4 0 0 0 0 185 143 122 159 196 CSN2 2 107 1 0 0 5 0 97 102 83 108 115 CSN3 2 93 0 0 0 0 0 64 61 62 73 95 Table S5. Classification and number of SNPs mapping to the casein genes in mouflons. Gene Exon Intron Splice site Upstream Downstream 5'UTR 3'UTR Mouflon Tabriz Mouflon Tehran Total CSN1S1 8 205 2 0 0 0 0 201 40 215 CSN1S2 11 197 5 0 0 0 0 195 103 213 CSN2 3 114 1 0 0 5 0 122 79 123 CSN3 4 69 0 0 0 0 0 73 28 73 Table S6. Description and frequencies of the missense variants identified in each sheep and mouflon population. South Mouflon Mouflon Study Nucleotide and West North- Associated Gene SNP Effect* Europe from from reporting the substitution East Asia Africa allele Tabriz Tehran allele Asia p.Val12Phe rs593739642 c.34G>T 0 0 0 0.05 0 0 DEL Oar_3.1:6:85091243:G>A c.73G>A p.Gly25Arg 0 0 0 0 0.05 0 CSN1S1 Oar_3.1:6:85093731:T>C c.191T>C p.Ile64Thr 0 0 0 0 0.05 0 Oar_3.1:6:85094448:C>T c.215C>T p.Ala72Val 0 0 0 0 0.05 0 Oar_3.1:6:85098887:A>C c.385A>C p.Lys129Gln 0 0 0 0 0.05 0.29 Oar_3.1:6:85184193:G>A c.34G>A p.Val12Ile 0 0 0 0 0.11 0 Giambra & rs588453493 c.178G>A P.Val60Ile 0 0 0.05 0.05 0 0 C Erhardt, (2012) Giambra & rs596411552 c.187G>T p.Ala63Ser 0 0 0.05 0.05 0 C Erhardt, (2012) Giambra & p.Asp90Tyr rs430397133 c.268G>T 0.75 0.2 0.67 0.35 0.22 0 B Erhardt, CSN1S2 DEL (2012) rs591309828 c.344T>C p.Leu115Pro 0 0 0.05 0.05 0.11 0.286 Giambra & rs424657035 C.358A>G p.Ile120Val 0.83 0.4 0.67 0.4 0.11 0 B Erhardt, (2012) Oar_3.1:6:85190241:C>T c.407C>T c.407C>T 0 0 0 0 0 0.29 Oar_3.1:6:85193514:T>C c.487T>G p.Phe163Val 0 0 0 0 0.11 0 Giambra & rs399378277 c.527G>A p.Arg176His 0 0.35 0.25 0.3 0.11 0 G Erhardt, (2012) Oar_3.1:6:85116838:A>G c.679A>G p.Thr227Ala 0 0 0 0 0.05 0 rs416941267 c.634C>A p.Leu212Ile 0.06 0.3 0.16 0.15 0.61 0 Giambra & Erhardt, (2012), CSN2 Bastos et al., rs430298704 c.595A>G p.Met199Val 0 0.15 0.5 0.1 0 0 G (2001), Corral et al., (2010) and Suárez-Vega et al., (2017) rs420470202 c.307G>A p.Ala103Thr 0 0 0 0 0.28 0 CSN3 p.Lys137Arg Oar_3.1:6:85316665:A>G c.410A>G 0 0 0 0 0.05 0 DEL *DEL, mutation predicted by SIFT to be deleterious (SIFT score lower than 0.05). Table S7. Nucleotide diversity estimates (π) ± Standard Error in two Iranian mouflon populations and in 4 domestic sheep populations from North Africa, West Asia, Europe and South and East Asia by using the per-site and per-window (1,000 bp) analyses implemented in VCFtools. Genomic Mouflon Mouflon from Mouflon from Tehran Domestic Sheep European Sheep Nor-African West Asian Sheep South and East region Tabriz Sheep Asian Sheep Nucleotide Per-site Window Per-site Window Per-site Window Per-site Window Per- Window Per- Window Per- Window Per- Window diversity site site site site Whole 0.24± 0.0038 0.25± 0.0042± 0.16 ± 0.0029± 0.28 ± 0.003± - - - - - - - - Genome 2.4x10-5 2.2x10-06 2.6x10-5 1.8x10-06 8.7x10-5 3.45x10-06 3.2x10-5 1.69x10-06 Casein 0.23 0.0034 ± 0.25± 0.0036± 0.17±0.009 0.0026± 0.27± 0.0025± 0.31± 0.0037± 0.3± 0.0036± 0.28± 0.0026± 0.25± 0.0018± cluster ±0.007 0.00036 0.006 0.0003 0.0003 0.006 0.0003 0.0068 0.00037 0.0066 0.00036 0.0075 0.00031 0.0069 0.0002 CSN1S1 0.14 0.0021± 0.17± 0.0025 ± 0.071± 0.0011± 0.22± 0.0011±0.0001 - - - - - - - - ±0.009 0.00018 0.009 2x10-5 0.011 0.0002 0.015 CSN1S2 0.25 ± 0.0044 ± 0.19± 0.0044± 0.21± 0.015 0.0036± 0.32± 0.0041±0.0004 - - - - - - - - 0.010 0.00044 0.01 0.0004 0.0004 0.011 CSN2 0.34 ± 0.0059 ± 0.36± 0.0061± 0.28± 0.020 0.0057± 0.24± 0.0037±0.0008 - - - - - - - - 0.017 0.0013 0.015 0.0013 0.001 0.007 CSN3 0.22 ± 0.002 ± 0.25± 0.0022± 0.13± 0.04 0.0013± 0.234± 0.0019±0.0005 - - - - - - - - 0.016 0.00038 0.017 0.0003 0.0003 0.012 Fig. S1. Number of SNPs discovered in (A) sheep and (B) Iranian mouflon by using whole-genome sequence data sets with varying sizes. Individuals comprised in the reduced data sets (N < 40 in sheep and N < 17 in mouflon) were chosen at random. Fig. S2. Histogram showing the proportion of the total SNP dataset (y-axis) belonging to each one of the minimum allele frequency intervals defined in the x-axis. In total, we have considered 58,626,591 SNPs detected in sheep and Iranian mouflons. It can be seen that 50% of these SNPs display frequencies below 0.10. Fig. S3. Cross-validation error values for each K- value obtained in the Admixture analysis based on a dataset of 55,352,935 autosomal SNPs. Fig. S4. Principal component analysis (PCA) based on 774 SNPs mapping to the casein genes and comprising two Iranian mouflon populations as well as four domestic sheep populations from North Africa, West Asia, Europe and South and East Asia. B Admixture analysis (K=2-10) encompassing the same number of markers and populations defined in A. Fig. S5. Cross-validation error values for each K- value obtained in the Admixture analysis based on 774 SNPs mapping to the casein genes. Fig. S6. Principal component analysis of domestic sheep and Iranian mouflon populations based on (A) 248 SNPs mapping to the CSN1S1 gene; (B) 268 SNPs mapping to the CSN1S2 gene; (C) 146 SNPs mapping to the CSN2 gene; and (D) 112 SNPs mapping to the CSN3 gene. Fig. S7. Neighbor-joining tree of sheep from North Africa, West Asia, Europe and South and East Asia and Iranian mouflons (Tabriz and Tehran) based on 774 SNPs mapping to the casein genes. Fig. S8. Number of reconstructed casein haplotypes and proportion of haplotypes corresponding to each frequency interval in (A) domestic sheep and (B) mouflon populations. It can be seen that the vast majority of casein haplotypes have very low frequencies. Fig. S9. Venn diagrams depicting the sharing of casein SNPs between domestic sheep populations from North-Africa, West Asia, Europe and South and East Asia, and two Iranian mouflon populations (Tabriz and Tehran).