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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 5131769 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 5131769 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 5131769 MIMEtype: application/pdf PDFMetadata: Objects: 766 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Computational algorithms predict Esp aggregation tendency Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: EspN expressed with the curli-dependent amyloid generator (C-DAG) system forms amyloid fibrils Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Recombinant EspN assembles into βnobreak-nobreaksheet-rich structures with amyloidogenic properties at acidic pH Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Heterologous expression of EspN induces multicellular behavior through the formation of fibrillar structures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Exogenous addition of rEspN to esp-negative bacteria induces cell-to-cell aggregation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Oligonucleotides, plasmids, bacterial strains, and culture conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: DNA manipulations and bacterial transformation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Generation of chimeric proteins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Construction of plasmids for Esp expression in C-DAG system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Multicellular behavior phenotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Protein expression and production of anti-Esp antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Immunoblot analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Formation of rEspN aggregates and reversion assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Th-T binding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: CR and ProteoStat binding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Far-UV CD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Static light scattering Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Bis-ANS binding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: ATR-FTIR spectroscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Microscopy analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: ADDITIONAL INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Info: Title: The biofilm-associated surface protein Esp of Enterococcus faecalis forms 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Garnett Iñigo Lasa Jaione Valle Springer US npj Biofilms and Microbiomes, doi:10.1038/s41522-020-0125-2 10.1038/s41522-020-0125-2 http://dx.doi.org/10.1038/s41522-020-0125-2 journal npj Biofilms and Microbiomes © 2020, The Author(s) 2055-5008 10.1038/s41522-020-0125-2 springer.com springerlink.com 2010-04-23 True 10.1038/s41522-020-0125-2 springer.com springerlink.com Springer 2020-03-23T14:25:07+01:00 2020-03-23T06:34:27+05:30 2020-03-23T14:25:07+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:10acbf0a-016f-4d7e-a680-08e7c4a914d0 uuid:807a611b-90d6-41e1-98c3-e445e062f1dc default 1 converted uuid:febe4807-1ea9-4970-bbae-b5143a7dd0c4 converted to PDF/A-2b pdfToolbox 2020-03-23T06:35:41+05:30 2 B Agustina Taglialegna http://orcid.org/0000-0003-4844-8720 Leticia Matilla-Cuenca http://orcid.org/0000-0003-1822-0151 Pedro Dorado-Morales http://orcid.org/0000-0001-5760-1999 Susanna Navarro http://orcid.org/0000-0001-8160-9536 Salvador Ventura http://orcid.org/0000-0002-9652-6351 Iñigo Lasa http://orcid.org/0000-0002-6625-9221 Jaione Valle http://orcid.org/0000-0003-3115-0207 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. 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