19428dd1d3d9538b3dff4eb7a6aa1e31  227663.pdf
2989ea669a9de4c57cff052b86ca8c1cdd85b5e6  227663.pdf
2569dcd648cc4bccd2b29c4dfe1e226d90d62f37ac51e521bfc6e9d0049bc874  227663.pdf

Title:          Reduction and stabilization of bilirubin with obeticholic acid treatment in patients with primary biliary cholangitis
Subject:        Liver International 2020.40:1121-1129
Creator:        Adobe InDesign CC 2015 (Windows)
Producer:       Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT
CreationDate:   Fri Apr 24 18:28:49 2020 CEST
ModDate:        Mon Mar 21 13:23:38 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      512526 bytes
Optimized:      no
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
WCGJVQ+STIX-Regular                  Type 1C           Custom           yes yes yes     13  0
LBTVXM+Lato-Regular                  TrueType          WinAnsi          yes yes yes     17  0
LBTVXM+Lato-Regular                  CID TrueType      Identity-H       yes yes yes     14  0
WCGJVQ+Lato-Bold                     TrueType          WinAnsi          yes yes yes     18  0
BZVNNG+Lato-Italic                   TrueType          WinAnsi          yes yes yes     31  0
LBTVXM+Lato-Bold                     CID TrueType      Identity-H       yes yes yes     19  0
WCGJVQ+Lato-Semibold                 TrueType          WinAnsi          yes yes yes     15  0
WCGJVQ+Lato-Semibold                 CID TrueType      Identity-H       yes yes yes     16  0
RGNDIA+Lato-Regular-SC700            TrueType          WinAnsi          yes yes yes    136  0
RGNDIA+Lato-Regular-SC700            TrueType          WinAnsi          yes yes yes    142  0
WCGJVQ+SymbolMT                      Type 1C           Custom           yes yes no      47  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      48  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      49  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      50  0
GZERFW+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      51  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      52  0
WCGJVQ+SymbolMT                      Type 1C           Custom           yes yes no      66  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      67  0
GZERFW+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      68  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      69  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      70  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      71  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      72  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      81  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      82  0
GZERFW+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      83  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      84  0
WCGJVQ+SymbolMT                      Type 1C           Custom           yes yes no      85  0
WCGJVQ+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no      86  0
WCGJVQ+ArialMT                       Type 1C           WinAnsi          yes yes no      87  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-03-22 02:52:46 CET
 RepresentationInformation: 227663.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-03-21 13:24:52 CET
  Size: 512526
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseThumbs
    Language: en-US
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 414
      ImageHeight: 84
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: WCGJVQ+Lato-Semibold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: LBTVXM+Lato-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: LBTVXM+Lato-Regular
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: WCGJVQ+SymbolMT
      FontSubset: true
      FirstChar: 31
      LastChar: 181
      FontDescriptor: 
       FontName: WCGJVQ+SymbolMT
       Flags: Nonsymbolic
       FontBBox: 0, -220, 1113, 1005
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GZERFW+Helvetica-Bold
      FontSubset: true
      FirstChar: 40
      LastChar: 68
      FontDescriptor: 
       FontName: GZERFW+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: WCGJVQ+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WCGJVQ+SymbolMT
      FontSubset: true
      FirstChar: 31
      LastChar: 181
      FontDescriptor: 
       FontName: WCGJVQ+SymbolMT
       Flags: Nonsymbolic
       FontBBox: 0, -220, 1113, 1005
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GZERFW+Helvetica-Bold
      FontSubset: true
      FirstChar: 40
      LastChar: 68
      FontDescriptor: 
       FontName: GZERFW+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GZERFW+Helvetica-Bold
      FontSubset: true
      FirstChar: 40
      LastChar: 68
      FontDescriptor: 
       FontName: GZERFW+Helvetica-Bold
       Flags: Nonsymbolic
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+SymbolMT
      FontSubset: true
      FirstChar: 31
      LastChar: 181
      FontDescriptor: 
       FontName: WCGJVQ+SymbolMT
       Flags: Nonsymbolic
       FontBBox: 0, -220, 1113, 1005
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: WCGJVQ+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: WCGJVQ+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1018
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WCGJVQ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 111
      FontDescriptor: 
       FontName: WCGJVQ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
    TrueType: 
     Font: 
      BaseFont: LBTVXM+Lato-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: LBTVXM+Lato-Regular
       Flags: Nonsymbolic
       FontBBox: -546, -268, 1342, 1079
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WCGJVQ+Lato-Bold
      FontSubset: true
      FirstChar: 51
      LastChar: 124
      FontDescriptor: 
       FontName: WCGJVQ+Lato-Bold
       Flags: Nonsymbolic
       FontBBox: -603, -285, 1344, 1100
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BZVNNG+Lato-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 233
      FontDescriptor: 
       FontName: BZVNNG+Lato-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -501, -268, 1290, 1077
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WCGJVQ+Lato-Semibold
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: WCGJVQ+Lato-Semibold
       Flags: Nonsymbolic
       FontBBox: -576, -277, 1344, 1090
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: LBTVXM+Lato-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: LBTVXM+Lato-Regular
       Flags: Symbolic
       FontBBox: -546, -268, 1342, 1079
       FontFile2: true
     Font: 
      BaseFont: WCGJVQ+Lato-Semibold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WCGJVQ+Lato-Semibold
       Flags: Symbolic
       FontBBox: -576, -277, 1344, 1090
       FontFile2: true
     Font: 
      BaseFont: LBTVXM+Lato-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: LBTVXM+Lato-Bold
       Flags: Symbolic
       FontBBox: -603, -285, 1344, 1100
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1111/liv.14429</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1111/liv.14429</prism:doi><prism:url>https://doi.org/10.1111/liv.14429</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2020-03-24</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>onlinelibrary.wiley.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1111/liv.14429</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>onlinelibrary.wiley.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:doi>10.1111/liv.14429</pdfx:doi><pdfx:CrossmarkMajorVersionDate>2020-03-24</pdfx:CrossmarkMajorVersionDate></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 1121
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 412, 38, 516, 28
      Annotation: 
       Subtype: Link
       Rect: 110, 610, 110, 593
      Annotation: 
       Subtype: Link
       Rect: 115, 610, 130, 595
      Annotation: 
       Subtype: Link
       Rect: 460, 610, 475, 595
      Annotation: 
       Subtype: Link
       Rect: 210, 78, 307, 68
      Annotation: 
       Subtype: Link
       Rect: 65, 306, 110, 297
      Annotation: 
       Subtype: Link
       Rect: 519, 782, 595, 767
    Page: 
     Label: 1122
     Sequence: 2
    Page: 
     Label: 1123
     Sequence: 3
    Page: 
     Label: 1124
     Sequence: 4
    Page: 
     Label: 1125
     Sequence: 5
    Page: 
     Label: 1126
     Sequence: 6
    Page: 
     Label: 1127
     Sequence: 7
    Page: 
     Label: 1128
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 349, 167, 364, 152
      Annotation: 
       Subtype: Link
       Rect: 364, 165, 512, 152
      Annotation: 
       Subtype: Link
       Rect: 361, 154, 377, 139
      Annotation: 
       Subtype: Link
       Rect: 377, 152, 524, 139
    Page: 
     Label: 1129
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 344, 431, 512, 421
      Annotation: 
       Subtype: Link
       Rect: 522, 400, 548, 390
      Annotation: 
       Subtype: Link
       Rect: 323, 389, 466, 379
      Annotation: 
       Subtype: Link
       Rect: 406, 114, 526, 103
  Checksum: a53fabde
   Type: CRC32
  Checksum: 19428dd1d3d9538b3dff4eb7a6aa1e31
   Type: MD5
  Checksum: 2989ea669a9de4c57cff052b86ca8c1cdd85b5e6
   Type: SHA-1