c31c92a9c7f6ac081324fff6b13eb68e  227711.pdf
2f18cd39e2c503da53a327a69c6138c1e280c054  227711.pdf
c270d133edce9951b6f9ffe4e81a8639301c6de30bd60732602045b6895fb785  227711.pdf

Title:          The ACROSS study: Long-term efficacy of fingolimod in patients with relapsing–remitting multiple sclerosis
Subject:        Multiple Sclerosis Journal - Experimental, Translational and Clinical 2020.6:2055217320907951
Keywords:       Relapsing–remitting multiple sclerosis,fingolimod,oral therapy,long-term treatment,ambulatory assistance,disability progression
Author:         T Derfuss, J Sastre-Garriga, X Montalban, M Rodegher, J Wuerfel, L Gaetano, D Tomic, A Azmon, C Wolf, and L Kappos
Creator:        Arbortext Advanced Print Publisher 9.1.580/W Unicode
Producer:       Adobe LiveCycle PDF Generator; modified using iText 4.2.0 by 1T3XT
CreationDate:   Wed Mar  4 10:30:18 2020 CET
ModDate:        Mon Mar 21 17:26:43 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          10
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      710611 bytes
Optimized:      no
PDF version:    1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
CDCMKB+AdvP7D09                      Type 1C           WinAnsi          yes yes no      27  0
CDCMOB+AdvP42A1B7                    Type 1C           WinAnsi          yes yes no     139  0
CDCLJC+AdvP409AA8                    Type 1C           WinAnsi          yes yes no      15  0
CDCLJD+AdvP43600B                    Type 1C           WinAnsi          yes yes no      16  0
CDCMIO+AdvP3F3419                    Type 1C           WinAnsi          yes yes no     140  0
CDCMIP+AdvP40B4ED                    Type 1C           Custom           yes yes no      17  0
CDCMJA+AdvP4C4E74                    Type 1C           Custom           yes yes yes     18  0
CDCMKA+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no      19  0
CDCNBA+AdvPSMP13                     Type 1C           WinAnsi          yes yes no      14  0
CDCNDB+AdvTimes                      Type 1C           WinAnsi          yes yes no      23  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-03-22 02:52:27 CET
 RepresentationInformation: 227711.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-03-21 17:27:17 CET
  Size: 710611
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: table-fn1-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
     Item: 
      Title: table-fn2-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
     Item: 
      Title: table-fn3-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
     Item: 
      Title: table-fn4-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
     Item: 
      Title: table-fn5-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
     Item: 
      Title: table-fn6-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
     Item: 
      Title: table-fn7-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
     Item: 
      Title: table-fn8-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
     Item: 
      Title: table-fn9-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
     Item: 
      Title: table-fn10-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
     Item: 
      Title: table-fn11-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
     Item: 
      Title: table-fn12-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
     Item: 
      Title: table-fn13-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
     Item: 
      Title: table-fn14-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
     Item: 
      Title: table-fn15-2055217320907951
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 497
      ImageHeight: 388
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 497
      ImageHeight: 365
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: CDCLJD+AdvP43600B
      FontSubset: true
      FirstChar: 44
      LastChar: 150
      FontDescriptor: 
       FontName: CDCLJD+AdvP43600B
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -218, 1000, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCMIP+AdvP40B4ED
      FontSubset: true
      FirstChar: 30
      LastChar: 151
      FontDescriptor: 
       FontName: CDCMIP+AdvP40B4ED
       Flags: Serif, Nonsymbolic
       FontBBox: -156, -208, 1000, 718
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: CDCMJA+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: CDCMJA+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CDCMKA+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: CDCMKA+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCNDB+AdvTimes
      FontSubset: true
      FirstChar: 37
      LastChar: 37
      FontDescriptor: 
       FontName: CDCNDB+AdvTimes
       Flags: Nonsymbolic
       FontBBox: -217, -212, 1005, 766
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCMKB+AdvP7D09
      FontSubset: true
      FirstChar: 37
      LastChar: 37
      FontDescriptor: 
       FontName: CDCMKB+AdvP7D09
       Flags: Nonsymbolic
       FontBBox: -156, -218, 1041, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCMOB+AdvP42A1B7
      FontSubset: true
      FirstChar: 33
      LastChar: 33
      FontDescriptor: 
       FontName: CDCMOB+AdvP42A1B7
       Flags: Nonsymbolic
       FontBBox: -62, -343, 1239, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCMIO+AdvP3F3419
      FontSubset: true
      FirstChar: 58
      LastChar: 121
      FontDescriptor: 
       FontName: CDCMIO+AdvP3F3419
       Flags: Nonsymbolic
       FontBBox: -166, -208, 1000, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCNBA+AdvPSMP13
      FontSubset: true
      FirstChar: 98
      LastChar: 98
      FontDescriptor: 
       FontName: CDCNBA+AdvPSMP13
       Flags: Nonsymbolic
       FontBBox: 0, -302, 958, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CDCLJC+AdvP409AA8
      FontSubset: true
      FirstChar: 44
      LastChar: 151
      FontDescriptor: 
       FontName: CDCLJC+AdvP409AA8
       Flags: Serif, Nonsymbolic
       FontBBox: -187, -208, 989, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1177/2055217320907951</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1177/2055217320907951</prism:doi><prism:url>https://doi.org/10.1177/2055217320907951</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2020-03-30</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>journals.sagepub.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1177/2055217320907951</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>journals.sagepub.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:CrossmarkMajorVersionDate>2020-03-30</pdfx:CrossmarkMajorVersionDate><pdfx:doi>10.1177/2055217320907951</pdfx:doi></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 86, 591, 95, 601
      Annotation: 
       Subtype: Link
       Rect: 173, 591, 183, 601
      Annotation: 
       Subtype: Link
       Rect: 403, 591, 413, 601
      Annotation: 
       Subtype: Link
       Rect: 122, 579, 132, 589
      Annotation: 
       Subtype: Link
       Rect: 198, 579, 208, 589
      Annotation: 
       Subtype: Link
       Rect: 493, 635, 532, 641
      Annotation: 
       Subtype: Link
       Rect: 493, 627, 545, 633
      Annotation: 
       Subtype: Link
       Rect: 493, 595, 552, 601
      Annotation: 
       Subtype: Link
       Rect: 493, 587, 524, 593
      Annotation: 
       Subtype: Link
       Rect: 493, 126, 559, 133
      Annotation: 
       Subtype: Link
       Rect: 25, 788, 89, 775
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 343, 623, 428, 633
    Page: 
     Label: 3
    Page: 
     Label: 4
    Page: 
     Label: 5
    Page: 
     Label: 6
    Page: 
     Label: 7
    Page: 
     Label: 8
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 308, 121, 318, 130
      Annotation: 
       Subtype: Link
       Rect: 321, 120, 462, 129
      Annotation: 
       Subtype: Link
       Rect: 341, 110, 350, 119
      Annotation: 
       Subtype: Link
       Rect: 358, 109, 481, 118
      Annotation: 
       Subtype: Link
       Rect: 269, 98, 287, 107
      Annotation: 
       Subtype: Link
       Rect: 310, 88, 320, 97
      Annotation: 
       Subtype: Link
       Rect: 323, 87, 464, 96
      Annotation: 
       Subtype: Link
       Rect: 299, 77, 309, 86
      Annotation: 
       Subtype: Link
       Rect: 312, 76, 453, 85
      Annotation: 
       Subtype: Link
       Rect: 308, 66, 317, 75
      Annotation: 
       Subtype: Link
       Rect: 320, 65, 462, 74
    Page: 
     Label: 10
  Checksum: 7a5c32f2
   Type: CRC32
  Checksum: c31c92a9c7f6ac081324fff6b13eb68e
   Type: MD5
  Checksum: 2f18cd39e2c503da53a327a69c6138c1e280c054
   Type: SHA-1