b3c42e6583152ae072a4a7b8e34ebb8a 227771.pdf 3b81df60f766522e8ea51bcf8aaa70682ca8d372 227771.pdf fa872347f90df9ac8d705b5e3e17cfb2085a5f6295a61e81c5166faf997d0370 227771.pdf Title: MCT8 Deficiency: The Road to Therapies for a Rare Disease Subject: Allan-Herndon-Dudley syndrome is a rare disease caused by inactivating mutations in the SLC16A2 gene, which encodes the monocarboxylate transporter 8 (MCT8), a transmembrane transporter specific for thyroid hormones (T3 and T4). Keywords: thyroid hormones, brain, neurodevelopment, MCT8, DITPA, sobetirome, TRIAC Author: Carmen Grijota-Martínez and Ana Guadaño-Ferraz Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri Apr 24 16:16:04 2020 CEST ModDate: Fri Apr 24 16:16:52 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 744922 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ERRCGC+MinionPro-Regular Type 1 Custom yes yes no 28 0 JKQOFF+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 29 0 LAEJFE+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 30 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 35 0 TGACKC+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 36 0 NIXNIX+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 37 0 QHWLRN+MTGU Type 1 Builtin yes yes no 207 0 WQPJFW+MinionPro-It Type 1 Custom yes yes no 208 0 HBKCLK+MinionPro-Bold Type 1 Custom yes yes no 211 0 MBDJKA+MTSYN Type 1 Builtin yes yes no 262 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-03-22 02:52:23 CET RepresentationInformation: 227771.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-03-21 17:40:06 CET Size: 744922 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 583 FreeObjects: 44 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: MCT8 Deficiency: The Road to Therapies for a Rare Disease Children: Item: Title: Introduction Item: Title: Murine Models of the Disease Item: Title: Thyroid Hormone Replacement Therapies Item: Title: Treatment With Thyroid Hormone*-1pt Analogs Item: Title: Other Therapies for Mct8 Deficiency Item: Title: Conclusion Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: References Info: Title: MCT8 Deficiency: The Road to Therapies for a Rare Disease Author: Carmen Grijota-Martínez and Ana Guadaño-Ferraz Subject: Allan-Herndon-Dudley syndrome is a rare disease caused by inactivating mutations in the SLC16A2 gene, which encodes the monocarboxylate transporter 8 (MCT8), a transmembrane transporter specific for thyroid hormones (T3 and T4). 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