86ed639303995fcca599b7811999de1e  227814.1.pdf
04b4ce66d69bcd7caeae177441835f976261f5da  227814.1.pdf
4d734cb30ea0845b435f633b302ab32713fb431818e7725b27045194c22288bc  227814.1.pdf

Title:          Bispecific T-cell engaging antibodies in B-cell precursor acute lymphoblastic leukemias: focus on blinatumomab
Subject:        Therapeutic Advances in Hematology 2020.11:2040620720919632
Keywords:       acute lymphoblastic leukemia,B-cell precursor,bispecific antibodies,blinatumomab,review
Author:         Jose-Maria Ribera, Eulalia Genescà, and Jordi Ribera
Creator:        Adobe InDesign CS5.5 (7.5)
Producer:       Adobe PDF Library 9.9; modified using iText 4.2.0 by 1T3XT
CreationDate:   Sat May  2 12:58:55 2020 CEST
ModDate:        Thu Feb 11 10:00:45 2021 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          15
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      475432 bytes
Optimized:      no
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
XCHVVE+DIN-Regular                   Type 1C           WinAnsi          yes yes yes     34  0
TWJXRM+DIN-Bold                      Type 1C           WinAnsi          yes yes yes     35  0
VZIJTI+DIN-RegularItalic             Type 1C           WinAnsi          yes yes yes     36  0
JHJPHG+DIN-BoldItalic                Type 1C           WinAnsi          yes yes yes     37  0
SXURDO+PlantinStd                    Type 1C           WinAnsi          yes yes yes     38  0
HEFDFK+TimesNewRomanPS-BoldMT        Type 1C           WinAnsi          yes yes yes     39  0
SCQYDO+DIN-RegularItalic             Type 1C           WinAnsi          yes yes yes    143  0
GAVXRM+PlantinStd-Italic             Type 1C           Custom           yes yes yes     45  0
BVITZW+MathematicalPiLTStd           Type 1C           Custom           yes yes yes     46  0
ZSJHXA+SymbolMT                      CID TrueType      Identity-H       yes yes yes     54  0
YOUBJC+HelveticaLTStd-Roman          Type 1C           WinAnsi          yes yes yes     76  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2021-03-03 02:21:26 CET
 RepresentationInformation: 227814.1.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2021-02-11 10:02:34 CET
  Size: 475432
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 200
      ImageHeight: 70
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1350
      ImageHeight: 913
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: ZSJHXA+SymbolMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: XCHVVE+DIN-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 242
      FontDescriptor: 
       FontName: XCHVVE+DIN-Regular
       Flags: Nonsymbolic
       FontBBox: -104, -226, 1115, 985
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TWJXRM+DIN-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 224
      FontDescriptor: 
       FontName: TWJXRM+DIN-Bold
       Flags: Nonsymbolic
       FontBBox: -115, -206, 1158, 1015
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: VZIJTI+DIN-RegularItalic
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: VZIJTI+DIN-RegularItalic
       Flags: Nonsymbolic
       FontBBox: -148, -225, 1066, 984
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: JHJPHG+DIN-BoldItalic
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: JHJPHG+DIN-BoldItalic
       Flags: Nonsymbolic
       FontBBox: -161, -203, 1107, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SXURDO+PlantinStd
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: SXURDO+PlantinStd
       Flags: Serif, Nonsymbolic
       FontBBox: -132, -250, 1052, 908
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HEFDFK+TimesNewRomanPS-BoldMT
      FontSubset: true
      FirstChar: 49
      LastChar: 57
      FontDescriptor: 
       FontName: HEFDFK+TimesNewRomanPS-BoldMT
       Flags: Serif, Nonsymbolic
       FontBBox: -557, -216, 2000, 891
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: YOUBJC+HelveticaLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: YOUBJC+HelveticaLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: GAVXRM+PlantinStd-Italic
      FontSubset: true
      FirstChar: 31
      LastChar: 121
      FontDescriptor: 
       FontName: GAVXRM+PlantinStd-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -148, -250, 1123, 920
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BVITZW+MathematicalPiLTStd
      FontSubset: true
      FirstChar: 27
      LastChar: 31
      FontDescriptor: 
       FontName: BVITZW+MathematicalPiLTStd
       Flags: Symbolic
       FontBBox: -30, -292, 1023, 981
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ZSJHXA+SymbolMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZSJHXA+SymbolMT
       Flags: Symbolic
       FontBBox: 0, -220, 1113, 1005
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1177/2040620720919632</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1177/2040620720919632</prism:doi><prism:url>https://doi.org/10.1177/2040620720919632</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2020-05-06</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>journals.sagepub.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1177/2040620720919632</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>journals.sagepub.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:CrossmarkMajorVersionDate>2020-05-06</pdfx:CrossmarkMajorVersionDate><pdfx:doi>10.1177/2040620720919632</pdfx:doi></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 491, 633, 558, 626
       Name: afe272cc-8aff-46d2-9ca4-f1d26ef26524
      Annotation: 
       Subtype: Link
       Rect: 491, 625, 527, 617
       Name: 9bfc7841-330d-48e3-a2e6-0d4ad06b58c9
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: f6caf7c9-1fb7-4eb7-8c80-1b7e9a30f63d
      Annotation: 
       Subtype: Link
       Rect: 491, 266, 561, 258
       Name: 9f4f4fd6-1342-42c9-8efc-ef66ab4d2cde
      Annotation: 
       Subtype: Link
       Rect: 25, 788, 89, 775
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: 7895064b-0a98-4199-b250-365eee7755e6
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: cc1327ac-2faf-4e5e-860a-d61c4f2e33fd
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: 0eaa52bd-4cdf-41df-b5fd-91020a84bd51
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: 50b62f69-d3cb-4462-a87f-aa5461defbc5
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: a8e01da0-81b0-4cf4-96fa-1aa913aad6ce
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: 00f7562d-8225-4dea-8a3a-95b488b1dbe7
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: 117a7618-7bbb-4667-a925-7132f427477f
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: 6bb264f5-b389-4a49-b3b8-04e2715b4816
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: 46006fee-ba03-480b-bea7-697e695a31de
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: 2e307155-e2c5-430d-bd9b-fe4792b9ec66
      Annotation: 
       Subtype: Link
       Rect: 383, 221, 481, 207
       Name: e24b8893-6a3d-48c6-8c55-99eaaf0cdfb6
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: ff6bb0bd-c96b-487d-a608-da2a81946876
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: 313aa3c4-f621-4969-a51b-51b71a5de9f7
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 50, 552, 42
       Name: 30ad7f89-c6bf-4966-a361-2365dafde703
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 136, 42
       Name: 55cdd474-a3e7-473f-8d39-530a49d4c2dd
      Annotation: 
       Subtype: Link
       Rect: 495, 556, 561, 548
       Name: d967f208-7eed-4bd0-8f85-4c2efa16ff7e
      Annotation: 
       Subtype: Link
       Rect: 495, 548, 522, 540
       Name: 9811ce7a-4b28-4631-a163-cf9da3a1be58
  Checksum: 5c57bfc9
   Type: CRC32
  Checksum: 86ed639303995fcca599b7811999de1e
   Type: MD5
  Checksum: 04b4ce66d69bcd7caeae177441835f976261f5da
   Type: SHA-1