ef47e8e577e1d6730d2d39846afe8abc  artifcellsnanomedbiotechnol_a2020v48np77-Final.pdf
c2f4a3983ea92fcbc5f0be0876aa5c94bcd3625c  artifcellsnanomedbiotechnol_a2020v48np77-Final.pdf
b04e56f7700cf6451016f7fe390bbf00ca81af9ac4fb52d8ae73d5f025f3aa64  artifcellsnanomedbiotechnol_a2020v48np77-Final.pdf

Producer:        iText 4.2.0 by 1T3XT
CreationDate:    Thu Jun 11 16:17:22 2020 CEST
ModDate:         Thu Jun 11 16:17:22 2020 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           8
Encrypted:       no
Page size:       634.32 x 833.04 pts
Page rot:        0
File size:       1320882 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EHIGAC+OpenSans                      CID TrueType      Identity-H       yes yes yes      9  0
EHIGAB+ArialUnicodeMS                CID TrueType      Identity-H       yes yes yes     10  0
EHIGAA+OpenSans-Semibold             CID TrueType      Identity-H       yes yes yes     11  0
EGNIPE+AdvOT5fcf1b24+20              Type 1C           WinAnsi          yes yes no     113  0
EGNIGF+AdvPSMP13                     Type 1C           WinAnsi          yes yes no     114  0
EGNIGG+AdvOTc20ddc96                 Type 1C           WinAnsi          yes yes no     115  0
EGNIMF+AdvT001                       Type 1C           Custom           yes yes no     116  0
EGNIDA+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no     117  0
EGNIDB+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     118  0
EGNIFB+AdvOT5fcf1b24                 Type 1C           WinAnsi          yes yes no     119  0
EGNIFC+AdvOT2bda31c3.B               Type 1C           WinAnsi          yes yes no     120  0
EGNIFD+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     121  0
EGNIGE+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     122  0
EGNJBF+AdvOTd0125be5.BI              Type 1C           WinAnsi          yes yes no     189  0
EGNJBI+AdvP4C4E74                    Type 1C           Custom           yes yes yes    190  0
EGNJBG+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     191  0
EGNJBH+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     192  0
EGNJGH+AdvPi1                        Type 1C           WinAnsi          yes yes no     215  0
EGNLDM+AdvOT5c7b8c86.I               Type 1C           WinAnsi          yes yes no     224  0
EGOACN+AdvOT46dcae81+01              Type 1C           MacRoman         yes yes no     259  0
EGNPOO+AdvP4C4E59                    Type 1C           Custom           yes yes yes    260  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:26:20 CEST
 RepresentationInformation: artifcellsnanomedbiotechnol_a2020v48np77-Final.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:39:15 CEST
  Size: 1320882
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: 1
      Children: 
       Item: 
        Title: Introduction
        Destination: 1
       Item: 
        Title: Material and methods
        Destination: 1
        Children: 
         Item: 
          Title: Mice
          Destination: 1
         Item: 
          Title: Peptides and liposomes
          Destination: 1
         Item: 
          Title: T1D prevention and assessment of islet leukocytic infiltration
          Destination: 1
         Item: 
          Title: Evaluation of the toxicity of PS-liposomes
          Destination: 1
         Item: 
          Title: Statistical analysis
          Destination: 1
       Item: 
        Title: Results
        Destination: 1
        Children: 
         Item: 
          Title: PS-liposomes encapsulating insulin, but not C-peptide, GAD65 or IA2 peptides decrease T1D incidence
          Destination: 1
         Item: 
          Title: PS-liposomes encapsulating insulin peptides reduce the severity of the autoimmune islet destruction
          Destination: 1
         Item: 
          Title: PS-liposomes treatment demonstrated optimal safety and tolerability in NOD mice
          Destination: 1
         Item: 
          Title: Discussion
          Destination: 1
       Item: 
        Title: Acknowledgements
        Destination: 1
       Item: 
        Title: Disclosure statement
        Destination: 1
       Item: 
        Title: References
        Destination: 1
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 600
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im20
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im10
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im13
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 448
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im14
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im11
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 470
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im12
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im17
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 674
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im18
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im15
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 694
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im16
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 200
      ImageHeight: 258
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Name: Im1
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 600
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im19
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im3
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 3150
      ImageHeight: 746
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im2
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 703
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im5
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 1010
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im4
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im7
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 703
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im6
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 600
      ImageHeight: 641
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Name: Im9
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 512
      ImageHeight: 346
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
     Name: Im8
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 700
      ImageHeight: 393
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 900
      ImageHeight: 572
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 750
      ImageHeight: 601
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: EHIGAC+OpenSans
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EHIGAB+ArialUnicodeMS
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: EHIGAA+OpenSans-Semibold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: EGNJBH+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: EGNJBH+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNLDM+AdvOT5c7b8c86.I
      FontSubset: true
      FirstChar: 73
      LastChar: 118
      FontDescriptor: 
       FontName: EGNLDM+AdvOT5c7b8c86.I
       Flags: Nonsymbolic
       FontBBox: -111, -250, 834, 870
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGOACN+AdvOT46dcae81+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: EGOACN+AdvOT46dcae81+01
       Flags: Nonsymbolic
       FontBBox: -46, -227, 857, 873
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: EGNPOO+AdvP4C4E59
      FontSubset: true
      FirstChar: 2
      LastChar: 126
      FontDescriptor: 
       FontName: EGNPOO+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGNIPE+AdvOT5fcf1b24+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: EGNIPE+AdvOT5fcf1b24+20
       Flags: Nonsymbolic
       FontBBox: -128, -205, 1059, 861
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIGF+AdvPSMP13
      FontSubset: true
      FirstChar: 98
      LastChar: 108
      FontDescriptor: 
       FontName: EGNIGF+AdvPSMP13
       Flags: Nonsymbolic
       FontBBox: 0, -302, 958, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIGG+AdvOTc20ddc96
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: EGNIGG+AdvOTc20ddc96
       Flags: Nonsymbolic
       FontBBox: -39, -250, 796, 886
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIMF+AdvT001
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EGNIMF+AdvT001
       Flags: Symbolic
       FontBBox: -197, -260, 1000, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: EGNIDA+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: EGNIDA+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -42, -250, 858, 889
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIDB+AdvOT46dcae81
      FontSubset: true
      FirstChar: 37
      LastChar: 177
      FontDescriptor: 
       FontName: EGNIDB+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -46, -250, 838, 879
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIFB+AdvOT5fcf1b24
      FontSubset: true
      FirstChar: 37
      LastChar: 184
      FontDescriptor: 
       FontName: EGNIFB+AdvOT5fcf1b24
       Flags: Nonsymbolic
       FontBBox: -40, -250, 777, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNJGH+AdvPi1
      FontSubset: true
      FirstChar: 109
      LastChar: 109
      FontDescriptor: 
       FontName: EGNJGH+AdvPi1
       Flags: Nonsymbolic
       FontBBox: 13, -323, 958, 824
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIFC+AdvOT2bda31c3.B
      FontSubset: true
      FirstChar: 65
      LastChar: 89
      FontDescriptor: 
       FontName: EGNIFC+AdvOT2bda31c3.B
       Flags: Nonsymbolic
       FontBBox: -44, -250, 892, 905
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIFD+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: EGNIFD+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: -9, -205, 1126, 868
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNIGE+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 65
      LastChar: 119
      FontDescriptor: 
       FontName: EGNIGE+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -39, -250, 875, 897
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNJBF+AdvOTd0125be5.BI
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: EGNJBF+AdvOTd0125be5.BI
       Flags: Nonsymbolic
       FontBBox: -95, -250, 930, 889
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EGNJBI+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 188
      FontDescriptor: 
       FontName: EGNJBI+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EGNJBG+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 97
      LastChar: 117
      FontDescriptor: 
       FontName: EGNJBG+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -112, -250, 894, 873
       FontFile3: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: EHIGAC+OpenSans
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EHIGAC+OpenSans
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -549, -270, 1204, 1047
       FontFile2: true
     Font: 
      BaseFont: EHIGAB+ArialUnicodeMS
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EHIGAB+ArialUnicodeMS
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -1011, -329, 2260, 1078
       FontFile2: true
     Font: 
      BaseFont: EHIGAA+OpenSans-Semibold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: UCS
       Supplement: 0
      FontDescriptor: 
       FontName: EHIGAA+OpenSans-Semibold
       Flags: FixedPitch, Nonsymbolic
       FontBBox: -583, -282, 1261, 1048
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="XMP toolkit 3.0.1-30, framework 1.6" xmlns:x="adobe:ns:meta/"><rdf:RDF xmlns:iX="http://ns.adobe.com/iX/1.0/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/"><pdf:Producer>iText 4.2.0 by 1T3XT</pdf:Producer><pdf:Keywords></pdf:Keywords></rdf:Description><rdf:Description rdf:about="" xmlns:photoshop="http://ns.adobe.com/photoshop/1.0/"></rdf:Description><rdf:Description rdf:about="" xmlns:tiff="http://ns.adobe.com/tiff/1.0/"></rdf:Description><rdf:Description rdf:about="" xmlns:xap="http://ns.adobe.com/xap/1.0/"><xap:CreateDate>2019-12-17T17:06:53+05:30</xap:CreateDate><xap:CreatorTool>Arbortext Advanced Print Publisher</xap:CreatorTool><xap:ModifyDate>2020-06-11T07:17:22-07:00</xap:ModifyDate><xap:MetadataDate>2020-06-11T07:17:22-07:00</xap:MetadataDate></rdf:Description><rdf:Description rdf:about="" xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/"><xapMM:DocumentID>uuid:8addd02c-2a8d-4824-a074-0375b52bef83</xapMM:DocumentID><xapMM:InstanceID>uuid:9735c38c-787b-4f5b-aca7-e8422204bc96</xapMM:InstanceID></rdf:Description><rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"><prism:aggregationType>Journal</prism:aggregationType><prism:publicationName>Artificial Cells, Nanomedicine, and Biotechnology</prism:publicationName><prism:copyright>© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor &amp; Francis Group</prism:copyright><prism:issn>2169-1401</prism:issn><prism:eissn>2169-141X</prism:eissn><prism:volume>48</prism:volume><prism:number>1</prism:number><prism:issueName></prism:issueName><prism:coverDate></prism:coverDate><prism:pageRange>77-83</prism:pageRange><prism:startingPage>77</prism:startingPage><prism:endingPage>83</prism:endingPage><prism:doi>10.1080/21691401.2019.1699812</prism:doi><prism:url>https://doi.org/10.1080/21691401.2019.1699812</prism:url></rdf:Description><rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>10.1080/21691401.2019.1699812</dc:identifier><dc:language>en-US</dc:language><dc:title><rdf:Alt><rdf:li xml:lang="x-default">Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes</rdf:li></rdf:Alt></dc:title><dc:publisher><rdf:Bag><rdf:li>Taylor &amp; Francis</rdf:li></rdf:Bag></dc:publisher><dc:description><rdf:Alt><rdf:li xml:lang="x-default">Artificial Cells, Nanomedicine, and Biotechnology, 2019. doi: 10.1080/21691401.2019.1699812</rdf:li></rdf:Alt></dc:description><dc:creator><rdf:Seq><rdf:li>Villalba Adrian</rdf:li><rdf:li>Rodriguez-Fernandez Silvia</rdf:li><rdf:li>Ampudia Rosa-Maria</rdf:li><rdf:li>Cano-Sarabia Mary</rdf:li><rdf:li>Perna-Barrull David</rdf:li><rdf:li>Bertran-Cobo Cesc</rdf:li><rdf:li>Ehrenberg Clara</rdf:li><rdf:li>Maspoch Daniel</rdf:li><rdf:li>Vives-Pi Marta</rdf:li></rdf:Seq></dc:creator><dc:subject><rdf:Bag><rdf:li>Nanovesicles</rdf:li><rdf:li>immunotherapy</rdf:li><rdf:li>autoimmunity</rdf:li></rdf:Bag></dc:subject></rdf:Description><rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/"><jav:journal_article_version>VoR</jav:journal_article_version></rdf:Description><rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2019-12-18</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>www.tandfonline.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1080/21691401.2019.1699812</crossmark:DOI></rdf:Description><rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>www.tandfonline.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:CrossmarkMajorVersionDate>2019-12-18</pdfx:CrossmarkMajorVersionDate><pdfx:doi>10.1080/21691401.2019.1699812</pdfx:doi></rdf:Description></rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 42, 478, 51
      Annotation: 
       Subtype: Link
       Rect: 365, 688, 521, 696
      Annotation: 
       Subtype: Link
       Rect: 97, 448, 247, 457
      Annotation: 
       Subtype: Link
       Rect: 202, 428, 427, 438
      Annotation: 
       Subtype: Link
       Rect: 326, 367, 342, 376
      Annotation: 
       Subtype: Link
       Rect: 351, 371, 489, 380
      Annotation: 
       Subtype: Link
       Rect: 326, 329, 343, 338
      Annotation: 
       Subtype: Link
       Rect: 351, 328, 506, 337
      Annotation: 
       Subtype: Link
       Rect: 326, 282, 341, 291
      Annotation: 
       Subtype: Link
       Rect: 351, 285, 450, 294
      Annotation: 
       Subtype: Link
       Rect: 106, 236, 125, 245
      Annotation: 
       Subtype: Link
       Rect: 131, 243, 232, 252
      Annotation: 
       Subtype: Link
       Rect: 326, 239, 343, 248
      Annotation: 
       Subtype: Link
       Rect: 351, 243, 511, 252
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 633, 116, 644
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 242, 633, 245, 644
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 343, 633, 347, 644
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 437, 633, 441, 644
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 533, 633, 536, 644
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 130, 621, 134, 632
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 225, 621, 229, 632
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 306, 621, 310, 632
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 312, 621, 316, 632
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 403, 621, 407, 632
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 408, 621, 413, 632
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 244, 274, 249, 283
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 238, 249, 243, 259
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 96, 151, 100, 160
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 197, 126, 202, 135
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 365, 306, 369, 315
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 371, 306, 376, 315
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 468, 258, 473, 267
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 501, 222, 506, 231
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 509, 173, 514, 183
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 429, 161, 434, 171
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 460, 149, 469, 159
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 501, 702, 564, 714
      Annotation: 
       Subtype: Link
       Rect: 137, 621, 147, 631
      Annotation: 
       Subtype: Link
       Rect: 236, 55, 386, 63
      Annotation: 
       Subtype: Link
       Rect: 348, 36, 469, 43
      Annotation: 
       Subtype: Link
       Rect: 462, 725, 564, 749
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 72, 255, 76, 264
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 50, 243, 84, 252
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 443, 718, 453, 727
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 495, 157, 505, 166
       Destination: 1
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 50, 484, 150, 493
      Annotation: 
       Subtype: Link
       Rect: 157, 181, 187, 190
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 50, 144, 81, 153
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 140, 107, 176, 117
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 261, 46, 295, 55
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 368, 307, 402, 316
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 314, 96, 362, 105
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 418, 34, 470, 43
       Destination: 1
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 46, 191, 55
      Annotation: 
       Subtype: Link
       Rect: 420, 82, 451, 92
       Destination: 1
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 730, 252, 739
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 285, 705, 295, 714
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 278, 517, 283, 526
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 285, 517, 295, 526
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 385, 632, 395, 641
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 486, 595, 496, 605
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 314, 558, 338, 568
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 437, 509, 447, 519
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 414, 485, 424, 494
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 492, 460, 516, 470
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 343, 411, 348, 421
       Destination: 1
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 125, 537, 130, 546
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 103, 512, 112, 522
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 262, 476, 272, 486
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 274, 476, 284, 486
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 495, 336, 503
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 465, 336, 473
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 445, 336, 453
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 405, 336, 413
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 385, 336, 393
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 355, 336, 363
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 325, 336, 333
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 295, 336, 303
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 265, 336, 273
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 245, 336, 253
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 215, 336, 223
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 175, 336, 183
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 134, 336, 142
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 114, 336, 122
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 74, 336, 82
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 54, 336, 62
       Destination: 1
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 47, 731, 72, 739
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 47, 701, 72, 709
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 47, 671, 72, 679
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 47, 651, 72, 659
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 47, 591, 72, 599
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 731, 336, 739
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 311, 688, 336, 696
       Destination: External
      Annotation: 
       Subtype: Link
       Rect: 311, 657, 336, 665
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 625, 336, 633
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 311, 593, 336, 601
       Destination: 1
  Checksum: 48315144
   Type: CRC32
  Checksum: ef47e8e577e1d6730d2d39846afe8abc
   Type: MD5
  Checksum: c2f4a3983ea92fcbc5f0be0876aa5c94bcd3625c
   Type: SHA-1
  Checksum: b04e56f7700cf6451016f7fe390bbf00ca81af9ac4fb52d8ae73d5f025f3aa64
   Type: SHA-256