94577a017ff3b9ba623a677e47b9fb01 nutrients_a2020v12n8p2200.pdf a6cd8660ec47895d937c439b63492f09c6f6da7f nutrients_a2020v12n8p2200.pdf d953bc4933ac0aec115e5df3596fd72b24d5346902210263fd20435b77f51b20 nutrients_a2020v12n8p2200.pdf Title: Modulation of the Gut Microbiota by Olive Oil Phenolic Compounds: Implications for Lipid Metabolism, Immune System, and Obesity Subject: There is extensive information of the beneficial effects of virgin olive oil (VOO), especially on cardiovascular diseases. Some VOO healthy properties have been attributed to their phenolic-compounds (PCs). The aim of this review is to present updated data on the effects of olive oil (OO) PCs on the gut microbiota, lipid metabolism, immune system, and obesity, as well as on the crosstalk among them. We summarize experiments and clinical trials which assessed the specific effects of the olive oil phenolic-compounds (OOPCs) without the synergy with OO-fats. Several studies have demonstrated that OOPC consumption increases Bacteroidetes and/or reduces the Firmicutes/Bacteroidetes ratio, which have both been related to atheroprotection. OOPCs also increase certain beneficial bacteria and gut-bacteria diversity which can be therapeutic for lipid-immune disorders and obesity. Furthermore, some of the mechanisms implicated in the crosstalk between OOPCs and these disorders include antimicrobial-activity, cholesterol microbial metabolism, and metabolites produced by bacteria. Specifically, OOPCs modulate short-chain fatty-acids produced by gut-microbiota, which can affect cholesterol metabolism and the immune system, and may play a role in weight gain through promoting satiety. Since data in humans are scarce, there is a necessity for more clinical trials designed to assess the specific role of the OOPCs in this crosstalk. Keywords: gut microbiota; immune system; lipids; obesity; olive oil; phenolic compounds Author: Marta Farràs, Laura Martinez-Gili, Kevin Portune, Sara Arranz, Gary Frost, Mireia Tondo and Francisco Blanco-Vaca Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Jul 23 17:42:18 2020 CEST ModDate: Thu Jul 23 17:42:18 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 28 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 666982 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ZQOBKK+URWPalladioL-Ital Type 1 Custom yes yes no 76 0 JYXERS+URWPalladioL-Bold Type 1 Custom yes yes no 77 0 WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes no 78 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 79 0 EAHZXE+URWPalladioL-Roma Type 1 Custom yes yes no 80 0 SWRFCF+VnURWPalladioL Type 1 Custom yes yes no 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きづぴちぢはぬどびねぜ〴ぜ〰はてぜ〴ぜ〰くくぐぃびぜ〴ぜ〰ぢべぜ〴ぜ〰ぇふぴぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぐひはばづひぴどづびぜ〴ぜ〰はてぜ〴ぜ〰くくぐぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぴちぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰くくぐぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぁのぴどねどっひはぢどちぬぜ〴ぜ〰ぐひはばづひぴどづびぜ〴ぜ〰はてぜ〴ぜ〰くくぐぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰きどっひはぢどはぴちぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰くくぐぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きどっひはぢどはぴちぜ〴ぜ〰ぃはねばはびどぴどはのぜ〴ぜ〰きはつふぬちぴどはのぜ〴ぜ〰ぢべぜ〴ぜ〰くくぐぃぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰くぬどぶづぜ〴ぜ〰くどぬぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰はのぜ〴ぜ〰がどばどつぜ〴ぜ〰きづぴちぢはぬどびねぜ〴ぜ〰ちのつぜ〴ぜ〰ぇふぴぜ〴ぜ〰きどっひはぢどはぴちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰くぬどぶづぜ〴ぜ〰くどぬぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰はのぜ〴ぜ〰ぇふぴぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰こべびぴづねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰くぬどぶづぜ〴ぜ〰くどぬぜ〴ぜ〰ぐとづのはぬどっぜ〴ぜ〰ぃはねばはふのつびぜ〴ぜ〰はのぜ〴ぜ〰ぇふぴぜ〴ぜ〰きどっひはぢどはぴちぜ〴ぜ〰ちのつぜ〴ぜ〰くぢづびどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰ぁびびはっどちぴづつぜ〴ぜ〰きはひぢどつどぴどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸷ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳捨敭攮捡灴楯渮㘩‾㸊⡜㌷㙜㌷㝜〰げづてづひづのっづび Item: Title: げづてづひづのっづび Filters: 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Link Rect: 168, 379, 205, 389 Annotation: Subtype: Link Rect: 76, 337, 166, 368 Annotation: Subtype: Link Rect: 234, 332, 407, 343 Checksum: 2b75b6ae Type: CRC32 Checksum: 94577a017ff3b9ba623a677e47b9fb01 Type: MD5 Checksum: a6cd8660ec47895d937c439b63492f09c6f6da7f Type: SHA-1