f70d0b6176f53ce791590763be81b165 molecules_a2020v25n15p3449.pdf f6331bf82982306cbd288b31b6470495b8a45346 molecules_a2020v25n15p3449.pdf d18fc16647f838512a97d37972227e8c9dc92049f89191a04b6c00a95720e9f7 molecules_a2020v25n15p3449.pdf Title: Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy Subject: Conventional cancer chemotherapy presents notable drug side effects due to non-selective action of the chemotherapeutics to normal cells. Nanoparticles decorated with receptor-specific ligands on the surface have shown an important role in improving site-selective binding, retention, and drug delivery to the cancer cells. This review summarizes the recent reported achievements using nanostructured coordination polymers (NCPs) with active targeting properties for cancer treatment in vitro and in vivo. Despite the controversy surrounding the effectivity of active targeting nanoparticles, several studies suggest that active targeting nanoparticles notably increase the selectivity and the cytotoxic effect in tumoral cells over the conventional anticancer drugs and non-targeted nanoparticle platform, which enhances drug efficacy and safety. In most cases, the nanocarriers have been endowed with remarkable capabilities such as stimuli-responsive properties, targeting abilities, or the possibility to be monitored by imaging techniques. Unfortunately, the lack of preclinical studies impedes the evaluation of these unique and promising findings for the translation of NCPs into clinical trials. Keywords: coordination polymers; nanomedicine; cancer therapy; drug delivery; EPR (Enhanced Permeability and Retention effect); tumor-targeting Author: Fernando Novio Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Jul 29 11:46:14 2020 CEST ModDate: Wed Jul 29 11:46:14 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2024610 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- STRCQE+URWPalladioL-Ital Type 1 Custom yes yes no 71 0 WIBEJD+URWPalladioL-Bold Type 1 Custom yes yes no 72 0 TLBJUK+URWPalladioL-Roma Type 1 Custom yes yes no 73 0 IBTYZX+VnURWPalladioL Type 1 Custom yes yes no 74 0 SVVJCD+Rpxr Type 1 Builtin yes yes no 75 0 PUSVWS+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 80 0 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いづびどでのぜ〴ぜ〰はてぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰ぎちのは〭うはひねふぬちぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐぬちぴどのふね〭あちびづつぜ〴ぜ〰ぎぃぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぎぃぐびぜ〴ぜ〰ぉのっぬふつどのでぜ〴ぜ〰ぎはの〭きづぴちぬぜ〴ぜ〰ぃとづねはぴとづひちばづふぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ごちひでづぴどのでぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰てはひぜ〴ぜ〰ぐとはぴはつべのちねどっぜ〴ぜ〰ごとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぅへばぬはひづつぜ〴ぜ〰ぁばばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぐぬちぴどのふね〭あちびづつぜ〴ぜ〰ぎぃぐびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぎぃぐびぜ〴ぜ〰ぉのっぬふつどのでぜ〴ぜ〰ぎはの〭きづぴちぬぜ〴ぜ〰ぃとづねはぴとづひちばづふぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ごちひでづぴどのでぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰てはひぜ〴ぜ〰ぐとはぴはつべのちねどっぜ〴ぜ〰ごとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぅへばぬはひづつぜ〴ぜ〰ぁばばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぎぃぐびぜ〴ぜ〰ぉのっぬふつどのでぜ〴ぜ〰ぎはの〭きづぴちぬぜ〴ぜ〰ぃとづねはぴとづひちばづふぴどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ごちひでづぴどのでぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰てはひぜ〴ぜ〰ぐとはぴはつべのちねどっぜ〴ぜ〰ごとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぅへばぬはひづつぜ〴ぜ〰ぁばばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いづぶづぬはばねづのぴぜ〴ぜ〰はてぜ〴ぜ〰ごちひでづぴどのでぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰てはひぜ〴ぜ〰ぐとはぴはつべのちねどっぜ〴ぜ〰ごとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぅへばぬはひづつぜ〴ぜ〰ぁばばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: くぴとづひぜ〴ぜ〰ぅへばぬはひづつぜ〴ぜ〰ぁばばぬどっちぴどはのびぜ〴ぜ〰はてぜ〴ぜ〰ぎぃぐびぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはのっぬふびどはのびぜ〴ぜ〰ちのつぜ〴ぜ〰うふぴふひづぜ〴ぜ〰ぐづひびばづっぴどぶづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: FVVFRK+Pxsy FontSubset: true FirstChar: 6 LastChar: 48 FontDescriptor: FontName: FVVFRK+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: 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