0b263497ec580b78899cfa4e1bed25e0 jouclimed_a2020v9n9p2726.pdf 3f68dd76c3d8f08dfb21398e83ceeb662f3b405e jouclimed_a2020v9n9p2726.pdf 06de6fb21308b315a7d590b7bc15bdf7315cb219248482905b22a951ee4f606e jouclimed_a2020v9n9p2726.pdf Title: Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment: Results of the MOPEAD Study in Spain Subject: Introduction: Although the Diabetes Specific Dementia Risk Score (DSDRS) was proposed for predicting risk of dementia at 10 years, its usefulness as a screening tool is unknown. For this purpose, the European consortium MOPEAD included the DSDRS within the specific strategy for screening of cognitive impairment in type 2 diabetes (T2D) patients attended in a third-level hospital. Material and Methods: T2D patients > 65 years, without known cognitive impairment, attended in a third-level hospital, were evaluated. As per MOPEAD protocol, patients with MMSE 27 or DSDRS 7 were referred to the memory clinic for complete neuropsychological assessment. Results: 112 T2D patients were recruited. A total of 82 fulfilled the criteria for referral to the memory unit (43 of them declined referral: 48.8% for associated comorbidities, 37.2% lack of interest, 13.95% lack of social support). At the Fundació ACE’s Memory Clinic, 34 cases (87.2%) of mild cognitive impairment (MCI) and 3 cases (7.7%) of dementia were diagnosed. The predictive value of DSDRS 7 as a screening tool of cognitive impairment was AUROC = 0.739, p 0.024, CI 95% (0.609–0.825). Conclusions: We found a high prevalence of unknown cognitive impairment in TD2 patients who attended a third-level hospital. The DSDRS was found to be a useful screening tool. The presence of associated comorbidities was the main factor of declining referral. Keywords: type 2 diabetes; mild cognitive impairment; Alzheimer’s disease Author: Angel Michael Ortiz Zuñiga, Rafael Simó, Octavio Rodriguez-Gómez, Cristina Hernández, Adrian Rodrigo, Laura Jamilis, Laura Campo, Montserrat Alegret, Merce Boada and Andreea Ciudin Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Aug 24 12:40:40 2020 CEST ModDate: Mon Aug 24 12:40:40 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 677223 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WRYCYM+URWPalladioL-Ital Type 1 Custom yes yes no 53 0 YXGVHR+URWPalladioL-Bold Type 1 Custom yes yes no 54 0 ENXZUH+VnURWPalladioL-Bold Type 1 Custom yes yes no 55 0 OHYGQJ+URWPalladioL-Roma Type 1 Custom yes yes no 56 0 KORLVE+VnURWPalladioL Type 1 Custom 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