a962d5bf0b3bf30ccd6939080bcda0ca cells_a2020v9n9p2131.pdf 991f20e2f31315952c64c13f3a549c0be7085ee6 cells_a2020v9n9p2131.pdf 1bf3471ffceb9ef25e1d584a15d16a9624646c30b200ebf40f1bcabe0a773e8a cells_a2020v9n9p2131.pdf Title: Schwann Cell Role in Selectivity of Nerve Regeneration Subject: Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating axons respond to their environment and direct their growth is essential to improve the functional outcome of patients with nerve lesions. Schwann cells (SCs) play a crucial role in the regeneration process, but little is known about their contribution to specific reinnervation. Here, we review the mechanisms by which SCs can differentially influence the regeneration of motor and sensory axons. Mature SCs express modality-specific phenotypes that have been associated with the promotion of selective regeneration. These include molecular markers, such as L2/HNK-1 carbohydrate, which is differentially expressed in motor and sensory SCs, or the neurotrophic profile after denervation, which differs remarkably between SC modalities. Other important factors include several molecules implicated in axon-SC interaction. This cell–cell communication through adhesion (e.g., polysialic acid) and inhibitory molecules (e.g., MAG) contributes to guiding growing axons to their targets. As many of these factors can be modulated, further research will allow the design of new strategies to improve functional recovery after peripheral nerve injuries. Keywords: axon; Schwann cell; regeneration; axon-glia interactions; peripheral nerve injury; reinnervation accuracy; preferential motor reinnervation; motor; sensory Author: Sara Bolívar, Xavier Navarro and Esther Udina Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sun Sep 20 10:53:41 2020 CEST ModDate: Sun Sep 20 10:53:41 2020 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1461011 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IWRNUY+URWPalladioL-Ital Type 1 Custom yes yes no 92 0 DBZSTQ+URWPalladioL-Bold Type 1 Custom yes yes no 93 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 94 0 IMDJSN+URWPalladioL-Roma Type 1 Custom yes yes no 95 0 DQPZUJ+VnURWPalladioL Type 1 Custom yes yes no 96 0 MHAHCD+Rpxr Type 1 Builtin yes yes no 97 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 102 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 119 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 120 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 121 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 152 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 153 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 154 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 155 0 Times New Roman TrueType WinAnsi no no no 156 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 295 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 296 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 297 0 Times New Roman TrueType WinAnsi no no no 298 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 329 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 330 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 331 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 332 0 Times New Roman TrueType WinAnsi no no no 333 0 ABCDEE+Palatino Linotype,BoldItalic TrueType WinAnsi yes yes no 334 0 NYXXMW+Pxsy Type 1 Builtin yes yes no 418 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 703 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:24:55 CEST RepresentationInformation: cells_a2020v9n9p2131.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:39:33 CEST Size: 1461011 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: 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Annotation: Subtype: Link Rect: 143, 547, 179, 557 Annotation: Subtype: Link Rect: 76, 505, 166, 536 Annotation: Subtype: Link Rect: 234, 499, 407, 510 Checksum: aa9a18f2 Type: CRC32 Checksum: a962d5bf0b3bf30ccd6939080bcda0ca Type: MD5 Checksum: 991f20e2f31315952c64c13f3a549c0be7085ee6 Type: SHA-1 Checksum: 1bf3471ffceb9ef25e1d584a15d16a9624646c30b200ebf40f1bcabe0a773e8a Type: SHA-256