ebf47809329acc383d6a7c4bf1d86907 intjoumolsci_a2020v21n18p6568.pdf 6a0c7f163437647e5f89ad6d6405749b362a59a0 intjoumolsci_a2020v21n18p6568.pdf ce95982a865272031bdc5f8ec01be492e25b5d1a4de4129f2d49f495f0df041e intjoumolsci_a2020v21n18p6568.pdf Title: Relevance of Porcine Stroke Models to Bridge the Gap from Pre-Clinical Findings to Clinical Implementation Subject: In the search of animal stroke models providing translational advantages for biomedical research, pigs are large mammals with interesting brain characteristics and wide social acceptance. Compared to rodents, pigs have human-like highly gyrencephalic brains. In addition, increasingly through phylogeny, animals have more sophisticated white matter connectivity; thus, ratios of white-to-gray matter in humans and pigs are higher than in rodents. Swine models provide the opportunity to study the effect of stroke with emphasis on white matter damage and neuroanatomical changes in connectivity, and their pathophysiological correlate. In addition, the subarachnoid space surrounding the swine brain resembles that of humans. This allows the accumulation of blood and clots in subarachnoid hemorrhage models mimicking the clinical condition. The clot accumulation has been reported to mediate pathological mechanisms known to contribute to infarct progression and final damage in stroke patients. Importantly, swine allows trustworthy tracking of brain damage evolution using the same non-invasive multimodal imaging sequences used in the clinical practice. Moreover, several models of comorbidities and pathologies usually found in stroke patients have recently been established in swine. We review here ischemic and hemorrhagic stroke models reported so far in pigs. The advantages and limitations of each model are also discussed. Keywords: stroke; animal models; pig; swine; gyrencephalic brain; white matter damage; connectivity; translational research Author: Marc Melià-Sorolla, Carlos Castaño, Núria DeGregorio-Rocasolano, Luis Rodríguez-Esparragoza, Antoni Dávalos, Octavi Martí-Sistac and Teresa Gasull Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Sep 8 12:38:18 2020 CEST ModDate: Tue Sep 8 12:38:28 2020 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 30 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 881901 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OHKNFJ+VnURWPalladioL Type 1 Custom yes yes no 1389 0 DIMMNX+URWPalladioL-Ital Type 1 Custom yes yes no 1393 0 RGDFJL+URWPalladioL-Bold Type 1 Custom yes yes no 1396 0 HGOXGM+URWPalladioL-Roma Type 1 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QDCWHF+EURM10 Type 1 Builtin yes yes no 919 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 921 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:24:50 CEST RepresentationInformation: intjoumolsci_a2020v21n18p6568.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:39:33 CEST Size: 881901 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Item: Title: Pig Brain to Model Human Stroke Pathophysiology Item: Title: Importance of White Matter Injury in Stroke Item: Title: Interventions to Induce Ischemic Strokes in Pigs Children: Item: Title: Electrocoagulation Item: Title: Microvascular Clip Item: Title: Endovascular Embolization Item: Title: Photothrombosis Item: Title: Endothelin-1 Injection Item: Title: Interventions to Induce Hemorrhagic Strokes in Pigs Children: Item: Title: Autologous Blood Injection in Meningeal Spaces Item: Title: Intracerebral Autologous Blood Injection Item: Title: Intracerebral Collagenase Injection Item: Title: Sonographic Blood-Brain Barrier Disruption Item: Title: Neurological Function Assessment in Pigs Item: Title: Evaluation of Stroke Damage in Swine by Neuroimaging Item: Title: Conclusions and Future Perspectives Item: Title: References Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: DIMMNX+URWPalladioL-Ital FontSubset: true FirstChar: 39 LastChar: 150 FontDescriptor: FontName: DIMMNX+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: 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acceptance. Compared to rodents, pigs have human-like highly gyrencephalic brains. In addition, increasingly through phylogeny, animals have more sophisticated white matter connectivity; thus, ratios of white-to-gray matter in humans and pigs are higher than in rodents. Swine models provide the opportunity to study the effect of stroke with emphasis on white matter damage and neuroanatomical changes in connectivity, and their pathophysiological correlate. In addition, the subarachnoid space surrounding the swine brain resembles that of humans. This allows the accumulation of blood and clots in subarachnoid hemorrhage models mimicking the clinical condition. The clot accumulation has been reported to mediate pathological mechanisms known to contribute to infarct progression and final damage in stroke patients. Importantly, swine allows trustworthy tracking of brain damage evolution using the same non-invasive multimodal imaging sequences used in the clinical practice. Moreover, several models of comorbidities and pathologies usually found in stroke patients have recently been established in swine. We review here ischemic and hemorrhagic stroke models reported so far in pigs. The advantages and limitations of each model are also discussed. 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