A                   500
                                                    #
                                                                                        B                                        Cells
                                                                    Soluble hFGF-2
                                            *   *       *                                                       80000            hFGF-2 ArtIBs Zn
                                                                hFGF-2 IBs
Proliferation (%)




                    400                                                                                                          GFP ArtIBs Zn




                                                                                          Cell survival (a.u)
                                                                                                                60000
                          *     *     *                                                                                          Soluble hFGF-2
                    300
                                                                Zn2+
                                                                                                                40000
                                                                Ca2+ hFGF-2 ArtIBs
                    200                                         Mn2+                                            20000
                                                                Zn2+
                    100                                         Ca2+ GFP ArtIBs
                                                                                                            - 20000
                                                                Mn2+
                     0                                                                                      - 40000        *

C
                                    0.1             1
                                Concentration (µg/ml)                                                                     Days
                              Cells                 GFP ArtIBs Zn                    hFGF-2 ArtIBs Zn                   Soluble hFGF-2