A                              2500
                                                                                                            25nM
                                                                                                                              2500
                                                                                                                                                                                25nM
                                      2h                                                                                               24 h
                                                                                                                              2000
Intracellular protein (a.u.)


                               2000
                                                                                                            100nM                                                               100nM
                               1500                                                                                           1500
                                                                                                            1000nM                                                              1000nM
                               1000                                                                                           1000

                                500                                                                                           500                                         *
                                                                                                        *
                                  0                                                              * *                             0                                  * *
                                        T22-GFP-H6    T22-GFP-H6(LOOP)  H6-GFP-T22                               GFP-H6
                                      T22-GFP-H6   T22-GFP-H6(LOOP)    H6-GFP-T22                               GFP-H6                 T22-GFP-H6 T22-GFP-H6(LOOP) H6-GFP-T22    GFP-H6
                               -500                                             1,2
                                                                                                                     AMD -           AMD +
                                                                                1.01                                                                              0.86
                                                                                           *                *             *               *
                                                               protein (a.u.)




                                                                                                                                                                  0,86
                                                                       (a.u)




B                                                                               0.8
                                                                                0,8
                                                  Intracellularprotein




                                                                                0.6
                                                                                0,6
                                                 Intracellular




                                                                                0,4
                                                                                0.4
                                                                                                                               *                    0,21
                                                                                                                                                    0.21
                                                                                                        0.24
                                                                                                        0,24
                                                                                0,2
                                                                                0.2                                                     0.15
                                                                                                                                        0,15
                                                                                          0.02
                                                                                          0,02                        0.03
                                                                                                                      0,03
                                                                                  0
                                                                                       25 nM
                                                                                        25nM       1000 nM
                                                                                                   1000nM           25 nM
                                                                                                                    25nM             1000 nM
                                                                                                                                     1000nM      25 nM
                                                                                                                                                 25nM        1000 nM
                                                                                                                                                             1000nM
                                                                                           T22-GFP-H6               T22-GFP-H6 (LOOP)                H6-GFP-T22