3342b998993cffd32d8f0a3134c2b751 intjoumolsci_a2020v21n21p8236.pdf 619b258d084831f50f583da7e0f69d1286ea818c intjoumolsci_a2020v21n21p8236.pdf 8750ba160526b45e44357499fa8d90a0d6a614c142975174657552d3458cd2d0 intjoumolsci_a2020v21n21p8236.pdf Title: Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability Subject: Atherosclerosis is responsible for 20% of ischemic strokes, and the plaques from the internal carotid artery the most frequently involved. Lipoproteins play a key role in carotid atherosclerosis since lipid accumulation contributes to plaque progression and chronic inflammation, both factors leading to plaque vulnerability. Carotid revascularization to prevent future vascular events is reasonable in some patients with high-grade carotid stenosis. However, the degree of stenosis alone is not sufficient to decide upon the best clinical management in some situations. In this context, it is essential to further characterize plaque vulnerability, according to specific characteristics (lipid-rich core, fibrous cap thinning, intraplaque hemorrhage). Although these features can be partly detected by imaging techniques, identifying carotid plaque vulnerability is still challenging. Therefore, the study of circulating biomarkers could provide adjunctive criteria to predict the risk of atherothrombotic stroke. In this regard, several molecules have been found altered, but reliable biomarkers have not been clearly established yet. The current review discusses the concept of vulnerable carotid plaque, and collects existing information about putative circulating biomarkers, being particularly focused on lipid-related and inflammatory molecules. Keywords: carotid atherosclerosis; ischemic stroke; atherothrombotic stroke; biomarkers; lipoproteins; lipids; inflammation; plaque vulnerability Author: Núria Puig, Elena Jiménez-Xarrié, Pol Camps-Renom and Sonia Benitez Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Nov 5 09:48:12 2020 CET ModDate: Thu Nov 5 09:53:57 2020 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 26 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1394148 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PLOLAK+VnURWPalladioL Type 1 Custom yes yes no 10 0 QJYHBJ+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 HUEXTX+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 EUUJTW+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 QLMOVM+Rpxr Type 1 Builtin yes yes no 28 0 MQFYIK+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 40 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 83 0 CIDFont+F1 CID TrueType Identity-H yes no yes 89 0 PNEDFF+PalatinoLinotype TrueType WinAnsi yes yes no 111 0 PNEDOD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 114 0 PNEDPF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 117 0 PNEFDO+TimesNewRoman CID TrueType Identity-H yes yes yes 120 0 PNEDFF+PalatinoLinotype TrueType WinAnsi yes yes no 137 0 PNEDOD+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 140 0 PNEDPF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 143 0 PNEFDO+TimesNewRoman CID TrueType Identity-H yes yes yes 146 0 FQVKWM+Pxsy Type 1 Builtin yes yes no 156 0 MFIGJL+Rpxb Type 1 Builtin yes yes no 160 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 223 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:24:35 CEST RepresentationInformation: intjoumolsci_a2020v21n21p8236.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:39:38 CEST Size: 1394148 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 819 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Atherosclerosis and Plaque Vulnerability Destination: section.2 Item: Title: Carotid Plaque Vulnerability and Ischemic Stroke Destination: section.3 Item: Title: Search for Circulating Biomarkers in Atherothrombotic Ischemic Stroke Destination: section.4 Item: Title: Lipid-Related and Lipoproteins Biomarkers Destination: section.5 Children: Item: Title: Lipids and Lipoproteins Destination: subsection.5.1 Item: Title: Lipoprotein Components Destination: subsection.5.2 Item: Title: Modified LDL Destination: subsection.5.3 Item: Title: Inflammatory Biomarkers Destination: section.6 Children: Item: Title: Cytokines Destination: subsection.6.1 Item: Title: Enzymes, Adhesion Molecules and Cell Receptors Destination: subsection.6.2 Item: Title: Adipokines Destination: subsection.6.3 Item: Title: Other Stroke Biomarkers Destination: section.7 Item: Title: Novel Therapies Destination: section.8 Item: Title: Plasma Biomarkers in the Clinical Practice and Future Directions Destination: section.9 Item: Title: Conclusions Destination: section.10 Item: Title: References Destination: section.10 Info: Title: Search for Reliable Circulating Biomarkers to Predict Carotid Plaque Vulnerability Author: Núria Puig, Elena Jiménez-Xarrié, Pol Camps-Renom and Sonia Benitez Subject: Atherosclerosis is responsible for 20% of ischemic strokes, and the plaques from the internal carotid artery the most frequently involved. Lipoproteins play a key role in carotid atherosclerosis since lipid accumulation contributes to plaque progression and chronic inflammation, both factors leading to plaque vulnerability. Carotid revascularization to prevent future vascular events is reasonable in some patients with high-grade carotid stenosis. However, the degree of stenosis alone is not sufficient to decide upon the best clinical management in some situations. In this context, it is essential to further characterize plaque vulnerability, according to specific characteristics (lipid-rich core, fibrous cap thinning, intraplaque hemorrhage). Although these features can be partly detected by imaging techniques, identifying carotid plaque vulnerability is still challenging. Therefore, the study of circulating biomarkers could provide adjunctive criteria to predict the risk of atherothrombotic stroke. In this regard, several molecules have been found altered, but reliable biomarkers have not been clearly established yet. The current review discusses the concept of vulnerable carotid plaque, and collects existing information about putative circulating biomarkers, being particularly focused on lipid-related and inflammatory molecules. 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