01c1866c03bc3653d83e43a5dd63d733 s41467-020-18151-y.pdf d311e621f807904cd15880e89f29ee188785fa99 s41467-020-18151-y.pdf c04efefb14bba24f5a9da183d2e984236acfc77e421f0a4cb0c9a0b19b8d9a93 s41467-020-18151-y.pdf Title: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples Subject: Nature Communications, doi:10.1038/s41467-020-18151-y Keywords: Author: Matthew H. Bailey Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Sep 11 18:35:25 2020 CEST ModDate: Tue Sep 15 12:12:16 2020 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2534040 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OCNGNF+AdvOTf23bb480+fb Type 1C Custom yes yes yes 403 0 OCNGNG+AdvTTda6f6cb8.B Type 1C WinAnsi yes yes no 69 0 OCNELM+AdvOTea1a7398 Type 1C WinAnsi yes yes no 71 0 OCNGLB+AdvTT2876772e+27 Type 1C Custom yes yes yes 789 0 OCNGLC+AdvOTea1a7398+fb Type 1C Custom yes yes yes 108 0 OCNGLD+AdvOTcb88df00 Type 1C WinAnsi yes yes no 74 0 Arial-BoldMT Type 1C WinAnsi yes no no 790 0 OCNGNE+AdvOTf23bb480 Type 1C WinAnsi yes yes no 405 0 OCNHAH+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 67 0 OCNHAI+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 68 0 OCNHAG+AdvOT125c650c Type 1C WinAnsi yes yes no 70 0 OCNHBL+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 72 0 OCNHBM+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 73 0 OCNHAJ+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 75 0 OCNHBK+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 76 0 OCNHLO+AdvOT9bd21c25.I Type 1C WinAnsi yes yes no 101 0 OCNHLP+AdvOTea1a7398+20 Type 1C WinAnsi yes yes no 102 0 OCNHLN+AdvTTab7e17fd+22 Type 1C Custom yes yes no 103 0 OCNHKL+Helvetica-Bold Type 1C WinAnsi yes yes no 104 0 OCNHKM+AdvOTcb88df00+fb Type 1C Custom yes yes yes 105 0 OCNHFL+Helvetica Type 1C Custom yes yes no 106 0 OCNHJL+Helvetica-Oblique Type 1C Custom yes yes no 107 0 OCNHNP+AdvTTab7e17fd Type 1C WinAnsi yes yes no 129 0 OCOFFO+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 381 0 OCOFFP+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 382 0 OCOFFN+AdvOT1ef757c0+01 Type 1C Custom yes yes no 383 0 OCOFJP+AdvOTf23bb480+20 Type 1C WinAnsi yes yes no 404 0 OCOFMP+AdvOTea1a7398+01 Type 1C Custom yes yes yes 420 0 OCOHEH+AdvOTf23bb480+01 Type 1C Custom yes yes yes 500 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-01-26 02:26:05 CET RepresentationInformation: s41467-020-18151-y.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-30 06:56:26 CET Size: 2534040 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR3' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR3' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR3' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 2016389 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR10' cannot be found Offset: 2016389 MIMEtype: application/pdf PDFMetadata: Objects: 914 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Data and workflow Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Landscape of mutational overlap between WGS and WES calls Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Variant allele fraction affects call-rates Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Association of variant allele fraction with recoverability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Exploring subclonality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Annotation differs by call-set Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Effects of software Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Effects on higher-level analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Landscape of private WES and WGS mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Variants present in only one public call-set Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Variants in GC-extreme intervals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Non-Coding/Flanking intersections with low coverage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: Human research participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Sample overlap Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Assessing cancer subtype selection preference Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Defining exonic regions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Coverage calculations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Overlapping mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Deduplication of variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Filtering optimization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Assessing mutations per megabase and cancer type concordance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Simulation of sequencing noise and recoverability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Integrating clonality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Fraction of private variation explained Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: MAFit: online comparison and visualization tool Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Controlled access files Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Assessment of impact on mutation signature analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Code availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Additional information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Info: Title: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples Author: Matthew H. Bailey Subject: Nature Communications, doi:10.1038/s41467-020-18151-y Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Sep 11 19:05:25 CEST 2020 ModDate: Tue Sep 15 12:12:16 CEST 2020 ID: 0xa266849cb330ac18cdf68f9402f89019, 0x75ff0762e2cabc5948e4dca4dea6053f Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1919 ImageHeight: 557 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 366 ImageHeight: 572 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1303 ImageHeight: 549 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: OCNHNP+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: OCNHNP+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHAH+AdvOT1ef757c0 FontSubset: true FirstChar: 33 LastChar: 215 FontDescriptor: FontName: OCNHAH+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHAI+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: OCNHAI+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNGNG+AdvTTda6f6cb8.B FontSubset: true FirstChar: 48 LastChar: 57 FontDescriptor: FontName: OCNGNG+AdvTTda6f6cb8.B Flags: Nonsymbolic FontBBox: -72, -218, 895, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHAG+AdvOT125c650c FontSubset: true FirstChar: 67 LastChar: 67 FontDescriptor: FontName: OCNHAG+AdvOT125c650c Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNELM+AdvOTea1a7398 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: OCNELM+AdvOTea1a7398 Flags: Nonsymbolic FontBBox: -31, -197, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHBL+AdvOTb65e897d.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OCNHBL+AdvOTb65e897d.B+fb Flags: Symbolic FontBBox: 0, -10, 843, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCNHBM+AdvOT7d6df7ab.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: OCNHBM+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNGLD+AdvOTcb88df00 FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: OCNGLD+AdvOTcb88df00 Flags: Nonsymbolic FontBBox: -41, -197, 968, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHAJ+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OCNHAJ+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCNHBK+AdvOTb65e897d.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: OCNHBK+AdvOTb65e897d.B Flags: Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNGNF+AdvOTf23bb480+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OCNGNF+AdvOTf23bb480+fb Flags: Symbolic FontBBox: 0, -197, 718, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCOFJP+AdvOTf23bb480+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: OCOFJP+AdvOTf23bb480+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNGNE+AdvOTf23bb480 FontSubset: true FirstChar: 40 LastChar: 252 FontDescriptor: FontName: OCNGNE+AdvOTf23bb480 Flags: Nonsymbolic FontBBox: -31, -197, 968, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNGLB+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OCNGLB+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Arial-BoldMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCOFMP+AdvOTea1a7398+01 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OCOFMP+AdvOTea1a7398+01 Flags: Symbolic FontBBox: -10, -260, 979, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCNHLO+AdvOT9bd21c25.I FontSubset: true FirstChar: 67 LastChar: 121 FontDescriptor: FontName: OCNHLO+AdvOT9bd21c25.I Flags: Nonsymbolic FontBBox: -83, -197, 1010, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHLP+AdvOTea1a7398+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: OCNHLP+AdvOTea1a7398+20 Flags: Nonsymbolic FontBBox: -93, -197, 843, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHLN+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: OCNHLN+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OCNHKL+Helvetica-Bold FontSubset: true FirstChar: 97 LastChar: 103 FontDescriptor: FontName: OCNHKL+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCNHKM+AdvOTcb88df00+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OCNHKM+AdvOTcb88df00+fb Flags: Symbolic FontBBox: 0, -197, 895, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCNHFL+Helvetica FontSubset: true FirstChar: 21 LastChar: 215 FontDescriptor: FontName: OCNHFL+Helvetica Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OCNHJL+Helvetica-Oblique FontSubset: true FirstChar: 21 LastChar: 119 FontDescriptor: FontName: OCNHJL+Helvetica-Oblique Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OCNGLC+AdvOTea1a7398+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: OCNGLC+AdvOTea1a7398+fb Flags: Symbolic FontBBox: 0, -197, 750, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCOHEH+AdvOTf23bb480+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OCOHEH+AdvOTf23bb480+01 Flags: Symbolic FontBBox: -10, -250, 968, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCOFFO+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: OCOFFO+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OCOFFP+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: OCOFFP+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OCOFFN+AdvOT1ef757c0+01 FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: OCOFFN+AdvOT1ef757c0+01 Flags: Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: application/pdf doi:10.1038/s41467-020-18151-y Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples Matthew H. Bailey William U. Meyerson Lewis Jonathan Dursi Liang-Bo Wang Guanlan Dong Wen-Wei Liang Amila Weerasinghe Shantao Li Sean Kelso Rehan Akbani Pavana Anur Matthew H. Bailey Alex Buchanan Kami Chiotti Kyle Covington Allison Creason Li Ding Kyle Ellrott Yu Fan Steven Foltz Gad Getz Walker Hale David Haussler Julian M. Hess Carolyn M. Hutter Cyriac Kandoth Katayoon Kasaian Melpomeni Kasapi Dave Larson Ignaty Leshchiner John Letaw Singer Ma Michael D. McLellan Yifei Men Gordon B. Mills Beifang Niu Myron Peto Amie Radenbaugh Sheila M. Reynolds Gordon Saksena Heidi Sofia Chip Stewart Adam J. Struck Joshua M. Stuart Wenyi Wang John N. Weinstein David A. Wheeler Christopher K. Wong Liu Xi Kai Ye Matthew H. Bailey Beifang Niu Matthias Bieg Paul C. Boutros Ivo Buchhalter Adam P. Butler Ken Chen Zechen Chong Li Ding Oliver Drechsel Lewis Jonathan Dursi Roland Eils Kyle Ellrott Shadrielle M. G. Espiritu Yu Fan Robert S. Fulton Shengjie Gao Josep L. l. Gelpi Mark B. Gerstein Gad Getz Santiago Gonzalez Ivo G. Gut Faraz Hach Michael C. Heinold Julian M. Hess Jonathan Hinton Taobo Hu Vincent Huang Yi Huang Barbara Hutter David R. Jones Jongsun Jung Natalie Jäger Hyung-Lae Kim Kortine Kleinheinz Sushant Kumar Yogesh Kumar Christopher M. Lalansingh Ignaty Leshchiner Ivica Letunic Dimitri Livitz Eric Z. Ma Yosef E. Maruvka R. Jay Mashl Michael D. McLellan Andrew Menzies Ana Milovanovic Morten Muhlig Nielsen Stephan Ossowski Nagarajan Paramasivam Jakob Skou Pedersen Marc D. Perry Montserrat Puiggròs Keiran M. Raine Esther Rheinbay Romina Royo S. Cenk Sahinalp Gordon Saksena Iman Sarrafi Matthias Schlesner Jared T. Simpson Lucy Stebbings Chip Stewart Miranda D. Stobbe Jon W. Teague Grace Tiao David Torrents Jeremiah A. Wala Jiayin Wang Wenyi Wang Sebastian M. Waszak Joachim Weischenfeldt Michael C. Wendl Johannes Werner Zhenggang Wu Hong Xue Sergei Yakneen Takafumi N. Yamaguchi Kai Ye Venkata D. Yellapantula Christina K. Yung Junjun Zhang Gordon Saksena Kyle Ellrott Michael C. Wendl David A. Wheeler Gad Getz Jared T. Simpson Mark B. Gerstein Li Ding Lauri A. Aaltonen Federico Abascal Adam Abeshouse Hiroyuki Aburatani David J. Adams Nishant Agrawal Keun Soo Ahn Sung-Min Ahn Hiroshi Aikata Rehan Akbani Kadir C. Akdemir Hikmat Al-Ahmadie Sultan T. Al-Sedairy Fatima Al-Shahrour Malik Alawi Monique Albert Kenneth Aldape Ludmil B. Alexandrov Adrian Ally Kathryn Alsop Eva G. Alvarez Fernanda Amary Samirkumar B. Amin Brice Aminou Ole Ammerpohl Matthew J. Anderson Yeng Ang Davide Antonello Pavana Anur Samuel Aparicio Elizabeth L. Appelbaum Yasuhito Arai Axel Aretz Koji Arihiro Shun-ichi Ariizumi Joshua Armenia Laurent Arnould Sylvia Asa Yassen Assenov Gurnit Atwal Sietse Aukema J. Todd Auman Miriam R. Aure Philip Awadalla Marta Aymerich Gary D. Bader Adrian Baez-Ortega Matthew H. Bailey Peter J. Bailey Miruna Balasundaram Saianand Balu Pratiti Bandopadhayay Rosamonde E. Banks Stefano Barbi Andrew P. Barbour Jonathan Barenboim Jill Barnholtz-Sloan Hugh Barr Elisabet Barrera John Bartlett Javier Bartolome Claudio Bassi Oliver F. Bathe Daniel Baumhoer Prashant Bavi Stephen B. Baylin Wojciech Bazant Duncan Beardsmore Timothy A. Beck Sam Behjati Andreas Behren Beifang Niu Cindy Bell Sergi Beltran Christopher Benz Andrew Berchuck Anke K. Bergmann Erik N. Bergstrom Benjamin P. Berman Daniel M. Berney Stephan H. Bernhart Rameen Beroukhim Mario Berrios Samantha Bersani Johanna Bertl Miguel Betancourt Vinayak Bhandari Shriram G. Bhosle Andrew V. Biankin Matthias Bieg Darell Bigner Hans Binder Ewan Birney Michael Birrer Nidhan K. Biswas Bodil Bjerkehagen Tom Bodenheimer Lori Boice Giada Bonizzato Johann S. De Bono Arnoud Boot Moiz S. Bootwalla Ake Borg Arndt Borkhardt Keith A. Boroevich Ivan Borozan Christoph Borst Marcus Bosenberg Mattia Bosio Jacqueline Boultwood Guillaume Bourque Paul C. Boutros G. Steven Bova David T. Bowen Reanne Bowlby David D. L. Bowtell Sandrine Boyault Rich Boyce Jeffrey Boyd Alvis Brazma Paul Brennan Daniel S. Brewer Arie B. Brinkman Robert G. Bristow Russell R. Broaddus Jane E. Brock Malcolm Brock Annegien Broeks Angela N. Brooks Denise Brooks Benedikt Brors Søren Brunak Timothy J. C. Bruxner Alicia L. Bruzos Alex Buchanan Ivo Buchhalter Christiane Buchholz Susan Bullman Hazel Burke Birgit Burkhardt Kathleen H. Burns John Busanovich Carlos D. Bustamante Adam P. Butler Atul J. Butte Niall J. Byrne Anne-Lise Børresen-Dale Samantha J. Caesar-Johnson Andy Cafferkey Declan Cahill Claudia Calabrese Carlos Caldas Fabien Calvo Niedzica Camacho Peter J. Campbell Elias Campo Cinzia Cantù Shaolong Cao Thomas E. Carey Joana Carlevaro-Fita Rebecca Carlsen Ivana Cataldo Mario Cazzola Jonathan Cebon Robert Cerfolio Dianne E. Chadwick Dimple Chakravarty Don Chalmers Calvin Wing Yiu Chan Kin Chan Michelle Chan-Seng-Yue Vishal S. Chandan David K. Chang Stephen J. Chanock Lorraine A. Chantrill Aurélien Chateigner Nilanjan Chatterjee Kazuaki Chayama Hsiao-Wei Chen Jieming Chen Ken Chen Yiwen Chen Zhaohong Chen Andrew D. Cherniack Jeremy Chien Yoke-Eng Chiew Suet-Feung Chin Juok Cho Sunghoon Cho Jung Kyoon Choi Wan Choi Christine Chomienne Zechen Chong Su Pin Choo Angela Chou Angelika N. Christ Elizabeth L. Christie Eric Chuah Carrie Cibulskis Kristian Cibulskis Sara Cingarlini Peter Clapham Alexander Claviez Sean Cleary Nicole Cloonan Marek Cmero Colin C. Collins Ashton A. Connor Susanna L. Cooke Colin S. Cooper Leslie Cope Vincenzo Corbo Matthew G. Cordes Stephen M. Cordner Isidro Cortés-Ciriano Kyle Covington Prue A. Cowin Brian Craft David Craft Chad J. Creighton Yupeng Cun Erin Curley Ioana Cutcutache Karolina Czajka Bogdan Czerniak Rebecca A. Dagg Ludmila Danilova Maria Vittoria Davi Natalie R. Davidson Helen Davies Ian J. Davis Brandi N. Davis-Dusenbery Kevin J. Dawson Francisco M. De La Vega Ricardo De Paoli-Iseppi Timothy Defreitas Angelo P. Dei Tos Olivier Delaneau John A. Demchok Jonas Demeulemeester German M. Demidov Deniz Demircioğlu Nening M. Dennis Robert E. Denroche Stefan C. Dentro Nikita Desai Vikram Deshpande Amit G. Deshwar Christine Desmedt Jordi Deu-Pons Noreen Dhalla Neesha C. Dhani Priyanka Dhingra Rajiv Dhir Anthony DiBiase Klev Diamanti Li Ding Shuai Ding Huy Q. Dinh Luc Dirix HarshaVardhan Doddapaneni Nilgun Donmez Michelle T. Dow Ronny Drapkin Oliver Drechsel Ruben M. Drews Serge Serge Tim Dudderidge Ana Dueso-Barroso Andrew J. Dunford Michael Dunn Lewis Jonathan Dursi Fraser R. Duthie Ken Dutton-Regester Jenna Eagles Douglas F. Easton Stuart Edmonds Paul A. Edwards Sandra E. Edwards Rosalind A. Eeles Anna Ehinger Juergen Eils Roland Eils Adel El-Naggar Matthew Eldridge Kyle Ellrott Serap Erkek Georgia Escaramis Shadrielle M. G. Espiritu Xavier Estivill Dariush Etemadmoghadam Jorunn E. Eyfjord Bishoy M. Faltas Daiming Fan Yu Fan William C. Faquin Claudiu Farcas Matteo Fassan Aquila Fatima Francesco Favero Nodirjon Fayzullaev Ina Felau Sian Fereday Martin L. Ferguson Vincent Ferretti Lars Feuerbach Matthew A. Field J. Lynn Fink Gaetano Finocchiaro Cyril Fisher Matthew W. Fittall Anna Fitzgerald Rebecca C. Fitzgerald Adrienne M. Flanagan Neil E. Fleshner Paul Flicek John A. Foekens Kwun M. Fong Nuno A. Fonseca Christopher S. Foster Natalie S. Fox Michael Fraser Scott Frazer Milana Frenkel-Morgenstern William Friedman Joan Frigola Catrina C. Fronick Akihiro Fujimoto Masashi Fujita Masashi Fukayama Lucinda A. Fulton Robert S. Fulton Mayuko Furuta P. Andrew Futreal Anja Füllgrabe Stacey B. Gabriel Steven Gallinger Carlo Gambacorti-Passerini Jianjiong Gao Shengjie Gao Levi Garraway Øystein Garred Erik Garrison Dale W. Garsed Nils Gehlenborg Josep L. l. Gelpi Joshy George Daniela S. Gerhard Clarissa Gerhauser Jeffrey E. Gershenwald Mark B. Gerstein Moritz Gerstung Gad Getz Mohammed Ghori Ronald Ghossein Nasra H. Giama Richard A. Gibbs Anthony J. Gill Pelvender Gill Dilip D. Giri Dominik Glodzik Vincent J. Gnanapragasam Maria Elisabeth Goebler Mary J. Goldman Carmen Gomez Santiago Gonzalez Abel Gonzalez-Perez Dmitry A. Gordenin James Gossage Kunihito Gotoh Ramaswamy Govindan Dorthe Grabau Janet S. Graham Robert C. Grant Anthony R. Green Eric Green Liliana Greger Nicola Grehan Sonia Grimaldi Sean M. Grimmond Robert L. Grossman Adam Grundhoff Gunes Gundem Qianyun Guo Manaswi Gupta Shailja Gupta Ivo G. Gut Marta Gut Jonathan Göke Gavin Ha Andrea Haake David Haan Siegfried Haas Kerstin Haase James E. Haber Nina Habermann Faraz Hach Syed Haider Natsuko Hama Freddie C. Hamdy Anne Hamilton Mark P. Hamilton Leng Han George B. Hanna Martin Hansmann Nicholas J. Haradhvala Olivier Harismendy Ivon Harliwong Arif O. Harmanci Eoghan Harrington Takanori Hasegawa David Haussler Steve Hawkins Shinya Hayami Shuto Hayashi D. Neil Hayes Stephen J. Hayes Nicholas K. Hayward Steven Hazell Yao He Allison P. Heath Simon C. Heath David Hedley Apurva M. Hegde David I. Heiman Michael C. Heinold Zachary Heins Lawrence E. Heisler Eva Hellstrom-Lindberg Mohamed Helmy Seong Gu Heo Austin J. Hepperla José María Heredia-Genestar Carl Herrmann Peter Hersey Julian M. Hess Holmfridur Hilmarsdottir Jonathan Hinton Satoshi Hirano Nobuyoshi Hiraoka Katherine A. Hoadley Asger Hobolth Ermin Hodzic Jessica I. Hoell Steve Hoffmann Oliver Hofmann Andrea Holbrook Aliaksei Z. Holik Michael A. Hollingsworth Oliver Holmes Robert A. Holt Chen Hong Eun Pyo Hong Jongwhi H. Hong Gerrit K. Hooijer Henrik Hornshøj Fumie Hosoda Yong Hou Volker Hovestadt William Howat Alan P. Hoyle Ralph H. Hruban Jianhong Hu Taobo Hu Xing Hua Kuan-lin Huang Mei Huang Mi Ni Huang Vincent Huang Yi Huang Wolfgang Huber Thomas J. Hudson Michael Hummel Jillian A. Hung David Huntsman Ted R. Hupp Jason Huse Matthew R. Huska Barbara Hutter Carolyn M. Hutter Daniel Hübschmann Christine A. Iacobuzio-Donahue Charles David Imbusch Marcin Imielinski Seiya Imoto William B. Isaacs Keren Isaev Shumpei Ishikawa Murat Iskar S. M. Ashiqul Islam Michael Ittmann Sinisa Ivkovic Jose M. G. Izarzugaza Jocelyne Jacquemier Valerie Jakrot Nigel B. Jamieson Gun Ho Jang Se Jin Jang Joy C. Jayaseelan Reyka Jayasinghe Stuart R. Jefferys Karine Jegalian Jennifer L. Jennings Seung-Hyup Jeon Lara Jerman Yuan Ji Wei Jiao Peter A. Johansson Amber L. Johns Jeremy Johns Rory Johnson Todd A. Johnson Clemency Jolly Yann Joly Jon G. Jonasson Corbin D. Jones David R. Jones David T. W. Jones Nic Jones Steven J. M. Jones Jos Jonkers Young Seok Ju Hartmut Juhl Jongsun Jung Malene Juul Randi Istrup Juul Sissel Juul Natalie Jäger Rolf Kabbe Andre Kahles Abdullah Kahraman Vera B. Kaiser Hojabr Kakavand Sangeetha Kalimuthu Christof von Kalle Koo Jeong Kang Katalin Karaszi Beth Karlan Rosa Karlić Dennis Karsch Katayoon Kasaian Karin S. Kassahn Hitoshi Katai Mamoru Kato Hiroto Katoh Yoshiiku Kawakami Jonathan D. Kay Stephen H. Kazakoff Marat D. Kazanov Maria Keays Electron Kebebew Richard F. Kefford Manolis Kellis James G. Kench Catherine J. Kennedy Jules N. A. Kerssemakers David Khoo Vincent Khoo Narong Khuntikeo Ekta Khurana Helena Kilpinen Hark Kyun Kim Hyung-Lae Kim Hyung-Yong Kim Hyunghwan Kim Jaegil Kim Jihoon Kim Jong K. Kim Youngwook Kim Tari A. King Wolfram Klapper Kortine Kleinheinz Leszek J. Klimczak Stian Knappskog Michael Kneba Bartha M. Knoppers Youngil Koh Jan Komorowski Daisuke Komura Mitsuhiro Komura Gu Kong Marcel Kool Jan O. Korbel Viktoriya Korchina Andrey Korshunov Michael Koscher Roelof Koster Zsofia Kote-Jarai Antonios Koures Milena Kovacevic Barbara Kremeyer Helene Kretzmer Markus Kreuz Savitri Krishnamurthy Dieter Kube Kiran Kumar Pardeep Kumar Sushant Kumar Yogesh Kumar Ritika Kundra Kirsten Kübler Ralf Küppers Jesper Lagergren Phillip H. Lai Peter W. Laird Sunil R. Lakhani Christopher M. Lalansingh Emilie Lalonde Fabien C. Lamaze Adam Lambert Eric Lander Pablo Landgraf Luca Landoni Anita Langerød Andrés Lanzós Denis Larsimont Erik Larsson Mark Lathrop Loretta M. S. Lau Chris Lawerenz Rita T. Lawlor Michael S. Lawrence Alexander J. Lazar Xuan Le Darlene Lee Donghoon Lee Eunjung Alice Lee Hee Jin Lee Jake June-Koo Lee Jeong-Yeon Lee Juhee Lee Ming Ta Michael Lee Henry Lee-Six Kjong-Van Lehmann Hans Lehrach Dido Lenze Conrad R. Leonard Daniel A. Leongamornlert Ignaty Leshchiner Louis Letourneau Ivica Letunic Douglas A. Levine Lora Lewis Tim Ley Chang Li Constance H. Li Haiyan Irene Li Jun Li Lin Li Shantao Li Siliang Li Xiaobo Li Xiaotong Li Xinyue Li Yilong Li Han Liang Sheng-Ben Liang Peter Lichter Pei Lin Ziao Lin W. M. Linehan Ole Christian Lingjærde Dongbing Liu Eric Minwei Liu Fei-Fei Liu Fenglin Liu Jia Liu Xingmin Liu Julie Livingstone Dimitri Livitz Naomi Livni Lucas Lochovsky Markus Loeffler Georgina V. Long Armando Lopez-Guillermo Shaoke Lou David N. Louis Laurence B. Lovat Yiling Lu Yong-Jie Lu Youyong Lu Claudio Luchini Ilinca Lungu Xuemei Luo Hayley J. Luxton Andy G. Lynch Lisa Lype Cristina López Carlos López-Otín Eric Z. Ma Yussanne Ma Gaetan MacGrogan Shona MacRae Geoff Macintyre Tobias Madsen Kazuhiro Maejima Andrea Mafficini Dennis T. Maglinte Arindam Maitra Partha P. Majumder Luca Malcovati Salem Malikic Giuseppe Malleo Graham J. Mann Luisa Mantovani-Löffler Kathleen Marchal Giovanni Marchegiani Elaine R. Mardis Adam A. Margolin Maximillian G. Marin Florian Markowetz Julia Markowski Jeffrey Marks Tomas Marques-Bonet Marco A. Marra Luke Marsden John W. M. Martens Sancha Martin Jose I. Martin-Subero Iñigo Martincorena Alexander Martinez-Fundichely Yosef E. Maruvka R. Jay Mashl Charlie E. Massie Thomas J. Matthew Lucy Matthews Erik Mayer Simon Mayes Michael Mayo Faridah Mbabaali Karen McCune Ultan McDermott Patrick D. McGillivray Michael D. McLellan John D. McPherson John R. McPherson Treasa A. McPherson Samuel R. Meier Alice Meng Shaowu Meng Andrew Menzies Neil D. Merrett Sue Merson Matthew Meyerson William U. Meyerson Piotr A. Mieczkowski George L. Mihaiescu Sanja Mijalkovic Ana Mijalkovic Mijalkovic-Lazic Tom Mikkelsen Michele Milella Linda Mileshkin Christopher A. Miller David K. Miller Jessica K. Miller Gordon B. Mills Ana Milovanovic Sarah Minner Marco Miotto Gisela Mir Arnau Lisa Mirabello Chris Mitchell Thomas J. Mitchell Satoru Miyano Naoki Miyoshi Shinichi Mizuno Fruzsina Molnár-Gábor Malcolm J. Moore Richard A. Moore Sandro Morganella Quaid D. Morris Carl Morrison Lisle E. Mose Catherine D. Moser Ferran Muiños Loris Mularoni Andrew J. Mungall Karen Mungall Elizabeth A. Musgrove Ville Mustonen David Mutch Francesc Muyas Donna M. Muzny Alfonso Muñoz Jerome Myers Ola Myklebost Peter Möller Genta Nagae Adnan M. Nagrial Hardeep K. Nahal-Bose Hitoshi Nakagama Hidewaki Nakagawa Hiromi Nakamura Toru Nakamura Kaoru Nakano Tannistha Nandi Jyoti Nangalia Mia Nastic Arcadi Navarro Fabio C. P. Navarro David E. Neal Gerd Nettekoven Felicity Newell Steven J. Newhouse Yulia Newton Alvin Wei Tian Ng Anthony Ng Jonathan Nicholson David Nicol Yongzhan Nie G. Petur Nielsen Morten Muhlig Nielsen Serena Nik-Zainal Michael S. Noble Katia Nones Paul A. Northcott Faiyaz Notta Brian D. O’Connor Peter O’Donnell Maria O’Donovan Sarah O’Meara Brian Patrick O’Neill J. Robert O’Neill David Ocana Angelica Ochoa Layla Oesper Christopher Ogden Hideki Ohdan Kazuhiro Ohi Lucila Ohno-Machado Karin A. Oien Akinyemi I. Ojesina Hidenori Ojima Takuji Okusaka Larsson Omberg Choon Kiat Ong Stephan Ossowski German Ott B. F. Francis Ouellette Christine P’ng Marta Paczkowska Salvatore Paiella Chawalit Pairojkul Marina Pajic Qiang Pan-Hammarström Elli Papaemmanuil Irene Papatheodorou Nagarajan Paramasivam Ji Wan Park Joong-Won Park Keunchil Park Kiejung Park Peter J. Park Joel S. Parker Simon L. Parsons Harvey Pass Danielle Pasternack Alessandro Pastore Ann-Marie Patch Iris Pauporté Antonio Pea John V. Pearson Chandra Sekhar Pedamallu Jakob Skou Pedersen Paolo Pederzoli Martin Peifer Nathan A. Pennell Charles M. Perou Marc D. Perry Gloria M. Petersen Myron Peto Nicholas Petrelli Robert Petryszak Stefan M. Pfister Mark Phillips Oriol Pich Hilda A. Pickett Todd D. Pihl Nischalan Pillay Sarah Pinder Mark Pinese Andreia V. Pinho Esa Pitkänen Xavier Pivot Elena Piñeiro-Yáñez Laura Planko Christoph Plass Paz Polak Tirso Pons Irinel Popescu Olga Potapova Aparna Prasad Shaun R. Preston Manuel Prinz Antonia L. Pritchard Stephenie D. Prokopec Elena Provenzano Xose S. Puente Sonia Puig Montserrat Puiggròs Sergio Pulido-Tamayo Gulietta M. Pupo Colin A. Purdie Michael C. Quinn Raquel Rabionet Janet S. Rader Bernhard Radlwimmer Petar Radovic Benjamin Raeder Keiran M. Raine Manasa Ramakrishna Kamna Ramakrishnan Suresh Ramalingam Benjamin J. Raphael W. Kimryn Rathmell Tobias Rausch Guido Reifenberger Jüri Reimand Jorge Reis-Filho Victor Reuter Iker Reyes-Salazar Matthew A. Reyna Sheila M. Reynolds Esther Rheinbay Yasser Riazalhosseini Andrea L. Richardson Julia Richter Matthew Ringel Markus Ringnér Yasushi Rino Karsten Rippe Jeffrey Roach Lewis R. Roberts Nicola D. Roberts Steven A. Roberts A. Gordon Robertson Alan J. Robertson Javier Bartolomé Rodriguez Bernardo Rodriguez-Martin F. Germán Rodríguez-González Michael H. A. Roehrl Marius Rohde Hirofumi Rokutan Gilles Romieu Ilse Rooman Tom Roques Daniel Rosebrock Mara Rosenberg Philip C. Rosenstiel Andreas Rosenwald Edward W. Rowe Romina Royo Steven G. Rozen Yulia Rubanova Mark A. Rubin Carlota Rubio-Perez Vasilisa A. Rudneva Borislav C. Rusev Andrea Ruzzenente Gunnar Rätsch Radhakrishnan Sabarinathan Veronica Y. Sabelnykova Sara Sadeghi S. Cenk Sahinalp Natalie Saini Mihoko Saito-Adachi Gordon Saksena Adriana Salcedo Roberto Salgado Leonidas Salichos Richard Sallari Charles Saller Roberto Salvia Michelle Sam Jaswinder S. Samra Francisco Sanchez-Vega Chris Sander Grant Sanders Rajiv Sarin Iman Sarrafi Aya Sasaki-Oku Torill Sauer Guido Sauter Robyn P. M. Saw Maria Scardoni Christopher J. Scarlett Aldo Scarpa Ghislaine Scelo Dirk Schadendorf Jacqueline E. Schein Markus B. Schilhabel Matthias Schlesner Thorsten Schlomm Heather K. Schmidt Sarah-Jane Schramm Stefan Schreiber Nikolaus Schultz Steven E. Schumacher Roland F. Schwarz Richard A. Scolyer David Scott Ralph Scully Raja Seethala Ayellet V. Segre Iris Selander Colin A. Semple Yasin Senbabaoglu Subhajit Sengupta Elisabetta Sereni Stefano Serra Dennis C. Sgroi Mark Shackleton Nimish C. Shah Sagedeh Shahabi Catherine A. Shang Ping Shang Ofer Shapira Troy Shelton Ciyue Shen Hui Shen Rebecca Shepherd Ruian Shi Yan Shi Yu-Jia Shiah Tatsuhiro Shibata Juliann Shih Eigo Shimizu Kiyo Shimizu Seung Jun Shin Yuichi Shiraishi Tal Shmaya Ilya Shmulevich Solomon I. Shorser Charles Short Raunak Shrestha Suyash S. Shringarpure Craig Shriver Shimin Shuai Nikos Sidiropoulos Reiner Siebert Anieta M. Sieuwerts Lina Sieverling Sabina Signoretti Katarzyna O. Sikora Michele Simbolo Ronald Simon Janae V. Simons Jared T. Simpson Peter T. Simpson Samuel Singer Nasa Sinnott-Armstrong Payal Sipahimalani Tara J. Skelly Marcel Smid Jaclyn Smith Karen Smith-McCune Nicholas D. Socci Heidi J. Sofia Matthew G. Soloway Lei Song Anil K. Sood Sharmila Sothi Christos Sotiriou Cameron M. Soulette Paul N. Span Paul T. Spellman Nicola Sperandio Andrew J. Spillane Oliver Spiro Jonathan Spring Johan Staaf Peter F. Stadler Peter Staib Stefan G. Stark Lucy Stebbings Ólafur Andri Stefánsson Oliver Stegle Lincoln D. Stein Alasdair Stenhouse Chip Stewart Stephan Stilgenbauer Miranda D. Stobbe Michael R. Stratton Jonathan R. Stretch Adam J. Struck Joshua M. Stuart Henk G. Stunnenberg Hong Su Xiaoping Su Ren X. Sun Stephanie Sungalee Hana Susak Akihiro Suzuki Fred Sweep Monika Szczepanowski Holger Sültmann Takashi Yugawa Angela Tam David Tamborero Benita Kiat Tee Tan Donghui Tan Patrick Tan Hiroko Tanaka Hirokazu Taniguchi Tomas J. Tanskanen Maxime Tarabichi Roy Tarnuzzer Patrick Tarpey Morgan L. Taschuk Kenji Tatsuno Simon Tavaré Darrin F. Taylor Amaro Taylor-Weiner Jon W. Teague Bin Tean Teh Varsha Tembe Javier Temes Kevin Thai Sarah P. Thayer Nina Thiessen Gilles Thomas Sarah Thomas Alan Thompson Alastair M. Thompson John F. Thompson R. Houston Thompson Heather Thorne Leigh B. Thorne Adrian Thorogood Grace Tiao Nebojsa Tijanic Lee E. Timms Roberto Tirabosco Marta Tojo Stefania Tommasi Christopher W. Toon Umut H. Toprak David Torrents Giampaolo Tortora Jörg Tost Yasushi Totoki David Townend Nadia Traficante Isabelle Treilleux Jean-Rémi Trotta Lorenz H. P. Trümper Ming Tsao Tatsuhiko Tsunoda Jose M. C. Tubio Olga Tucker Richard Turkington Daniel J. Turner Andrew Tutt Masaki Ueno Naoto T. Ueno Christopher Umbricht Husen M. Umer Timothy J. Underwood Lara Urban Tomoko Urushidate Tetsuo Ushiku Liis Uusküla-Reimand Alfonso Valencia David J. Van Den Berg Steven Van Laere Peter Van Loo Erwin G. Van Meir Gert G. Van den Eynden Theodorus Van der Kwast Naveen Vasudev Miguel Vazquez Ravikiran Vedururu Umadevi Veluvolu Shankar Vembu Lieven P. C. Verbeke Peter Vermeulen Clare Verrill Alain Viari David Vicente Caterina Vicentini K. Vijay Raghavan Juris Viksna Ricardo E. Vilain Izar Villasante Anne Vincent-Salomon Tapio Visakorpi Douglas Voet Paresh Vyas Ignacio Vázquez-García Nick M. Waddell Nicola Waddell Claes Wadelius Lina Wadi Rabea Wagener Jeremiah A. Wala Jian Wang Jiayin Wang Linghua Wang Qi Wang Wenyi Wang Yumeng Wang Zhining Wang Paul M. Waring Hans-Jörg Warnatz Jonathan Warrell Anne Y. Warren Sebastian M. Waszak David C. Wedge Dieter Weichenhan Paul Weinberger John N. Weinstein Joachim Weischenfeldt Daniel J. Weisenberger Ian Welch Michael C. Wendl Johannes Werner Justin P. Whalley David A. Wheeler Hayley C. Whitaker Dennis Wigle Matthew D. Wilkerson Ashley Williams James S. Wilmott Gavin W. Wilson Julie M. Wilson Richard K. Wilson Boris Winterhoff Jeffrey A. Wintersinger Maciej Wiznerowicz Stephan Wolf Bernice H. Wong Tina Wong Winghing Wong Youngchoon Woo Scott Wood Bradly G. Wouters Adam J. Wright Derek W. Wright Mark H. Wright Chin-Lee Wu Dai-Ying Wu Guanming Wu Jianmin Wu Kui Wu Yang Wu Zhenggang Wu Liu Xi Tian Xia Qian Xiang Xiao Xiao Rui Xing Heng Xiong Qinying Xu Yanxun Xu Hong Xue Shinichi Yachida Sergei Yakneen Rui Yamaguchi Takafumi N. Yamaguchi Masakazu Yamamoto Shogo Yamamoto Hiroki Yamaue Fan Yang Huanming Yang Jean Y. Yang Liming Yang Lixing Yang Shanlin Yang Tsun-Po Yang Yang Yang Xiaotong Yao Marie-Laure Yaspo Lucy Yates Christina Yau Chen Ye Kai Ye Venkata D. Yellapantula Christopher J. Yoon Sung-Soo Yoon Fouad Yousif Jun Yu Kaixian Yu Willie Yu Yingyan Yu Ke Yuan Yuan Yuan Denis Yuen Takashi Yugawa Christina K. Yung Olga Zaikova Jorge Zamora Marc Zapatka Jean C. Zenklusen Thorsten Zenz Nikolajs Zeps Cheng-Zhong Zhang Fan Zhang Hailei Zhang Hongwei Zhang Hongxin Zhang Jiashan Zhang Jing Zhang Junjun Zhang Xiuqing Zhang Xuanping Zhang Yan Zhang Zemin Zhang Zhongming Zhao Liangtao Zheng Xiuqing Zheng Wanding Zhou Yong Zhou Bin Zhu Hongtu Zhu Jingchun Zhu Shida Zhu Lihua Zou Xueqing Zou Anna deFazio Nicholas van As Carolien H. M. van Deurzen Marc J. van de Vijver L. van’t Veer Christian von Mering Springer US Nature Communications, doi:10.1038/s41467-020-18151-y 10.1038/s41467-020-18151-y http://dx.doi.org/10.1038/s41467-020-18151-y journal Nature Communications © 2020, The Author(s) 2041-1723 10.1038/s41467-020-18151-y springer.com springerlink.com 2010-04-23 True 10.1038/s41467-020-18151-y springer.com springerlink.com Springer 2020-09-15T12:12:16+02:00 2020-09-11T22:05:25+05:30 2020-09-15T12:12:16+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:699a8236-4803-4196-a119-a49162603a3d uuid:80715133-06dd-4d91-8586-2820e4c30163 default 1 converted uuid:9d181d72-4fc2-478c-85e1-0460721cf6ea converted to PDF/A-2b pdfToolbox 2020-09-11T22:07:05+05:30 2 B Matthew H. Bailey http://orcid.org/0000-0003-4526-9727 Lewis Jonathan Dursi http://orcid.org/0000-0002-4697-798X Liang-Bo Wang http://orcid.org/0000-0001-6977-9348 Guanlan Dong http://orcid.org/0000-0002-4747-6036 Amila Weerasinghe http://orcid.org/0000-0003-3568-5823 Shantao Li http://orcid.org/0000-0002-5440-2780 Gordon Saksena http://orcid.org/0000-0001-6630-7935 Kyle Ellrott http://orcid.org/0000-0002-6573-5900 David A. Wheeler http://orcid.org/0000-0002-9056-6299 Gad Getz http://orcid.org/0000-0002-0936-0753 Mark B. Gerstein http://orcid.org/0000-0002-9746-3719 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 473, 640, 475, 671 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 473, 643, 508, 674 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 640, 551, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 640, 551, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 128, 539, 129, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 128, 539, 129, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 539, 138, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 127, 539, 138, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 539, 141, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 377, 539, 378, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 377, 539, 378, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 386, 539, 387, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 376, 539, 387, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 387, 539, 389, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 477, 539, 478, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 477, 539, 478, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 539, 487, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 477, 539, 487, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 487, 539, 490, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 109, 523, 110, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 109, 523, 110, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 118, 523, 119, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 108, 523, 119, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 119, 523, 121, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 523, 312, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 523, 312, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 320, 523, 321, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 310, 523, 321, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 321, 523, 324, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 387, 523, 388, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 387, 523, 388, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 396, 523, 397, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 386, 523, 397, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 397, 523, 400, 534 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 459, 507, 460, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 459, 507, 460, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 467, 507, 468, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 458, 507, 468, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 468, 507, 471, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 507, 532, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 507, 532, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 540, 507, 541, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 531, 507, 541, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 541, 507, 544, 518 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 491, 238, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 237, 491, 238, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 246, 491, 247, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 236, 491, 247, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 491, 249, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 316, 491, 317, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 316, 491, 317, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 325, 491, 326, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 315, 491, 326, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 326, 491, 329, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 121, 475, 122, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 121, 475, 122, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 130, 475, 131, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 475, 131, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 131, 475, 134, 486 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 272, 43, 349, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 354, 43, 408, 51 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 129, 631, 132, 639 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 170, 631, 174, 639 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 204, 631, 208, 639 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 245, 631, 249, 639 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 280, 631, 284, 639 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 285, 631, 289, 639 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 88, 621, 92, 629 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 157, 621, 161, 629 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 269, 600, 273, 608 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 119, 527, 127, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 380, 226, 388 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 182, 349, 190, 357 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 307, 234, 315 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 86, 286, 94, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 282, 255, 289, 262 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 92, 223, 99, 231 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 103, 223, 111, 231 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 151, 223, 158, 231 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 162, 223, 169, 231 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 64, 182, 71, 189 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 408, 691, 413, 700 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 476, 670, 481, 679 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 322, 516, 329, 524 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 351, 513, 355, 522 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 350, 241, 487, 250 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 526, 182, 533, 189 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 454, 53, 459, 62 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 142, 137, 146, 147 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 281, 43, 285, 52 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 512, 158, 517, 168 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 324, 63, 328, 73 Flags: Print AppearanceDictionary: true Destination: 113 Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 65, 210, 70, 219 Flags: Print AppearanceDictionary: true Destination: 113 Annotation: Subtype: Link Rect: 162, 129, 166, 137 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 63, 74, 68, 83 Flags: Print AppearanceDictionary: true Destination: 113 Annotation: Subtype: Link Rect: 156, 53, 161, 62 Flags: Print AppearanceDictionary: true Destination: 113 Annotation: Subtype: Link Rect: 325, 346, 331, 352 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 181, 468, 184, 475 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 172, 391, 176, 400 Flags: Print AppearanceDictionary: true Destination: 152 Annotation: Subtype: Link Rect: 132, 328, 137, 338 Flags: Print AppearanceDictionary: true Destination: 152 Annotation: Subtype: Link Rect: 250, 95, 255, 104 Flags: Print AppearanceDictionary: true Destination: 152 Annotation: Subtype: Link Rect: 396, 628, 401, 638 Flags: Print AppearanceDictionary: true Destination: 164 Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 544, 255, 551, 263 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 123, 161, 131, 168 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 132, 161, 140, 168 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 104, 140, 111, 147 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 70, 129, 77, 137 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 170, 95, 174, 104 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 63, 63, 68, 73 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 490, 224, 497, 232 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 234, 345, 238, 353 Flags: Print AppearanceDictionary: true Destination: 113 Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 462, 43, 466, 53 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 283, 492, 287, 501 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 204, 460, 209, 470 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 147, 453, 154, 461 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 63, 387, 68, 397 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 130, 387, 134, 397 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 262, 387, 267, 397 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 107, 314, 112, 323 Flags: Print AppearanceDictionary: true Destination: 195 Annotation: Subtype: Link Rect: 191, 307, 199, 314 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 200, 307, 208, 314 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 245, 286, 252, 293 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 95, 178, 99, 187 Flags: Print AppearanceDictionary: true Destination: 247 Annotation: Subtype: Link Rect: 269, 139, 276, 147 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 444, 684, 451, 691 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 473, 108, 551, 115 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 99, 423, 107 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 411, 70, 414, 77 Flags: Print AppearanceDictionary: true Destination: 83 Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 547, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 544, 166, 551, 172 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 449, 155, 456, 162 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 236, 723, 291, 730 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 714, 167, 722 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 232, 539, 238, 545 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 75, 476, 81, 482 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 339, 649, 343, 656 Flags: Print AppearanceDictionary: true Destination: 113 Annotation: Subtype: Link Rect: 449, 543, 455, 549 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 349, 470, 352, 476 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 500, 304, 506, 310 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 83, 643, 89, 649 Flags: Print AppearanceDictionary: true Destination: 359 Annotation: Subtype: Link Rect: 221, 322, 288, 329 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 43, 313, 146, 321 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 70, 209, 76, 215 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 546, 668, 551, 674 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 390, 657, 494, 664 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 517, 648, 551, 655 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 639, 361, 646 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 450, 605, 546, 612 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 596, 358, 603 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 421, 587, 475, 594 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 316, 552, 512, 559 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 353, 544, 486, 550 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 381, 535, 542, 542 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 526, 342, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 502, 526, 544, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 517, 466, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 524, 517, 544, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 509, 419, 516 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 509, 547, 516 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 500, 377, 507 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 500, 541, 507 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 491, 336, 498 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 411, 491, 544, 498 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 482, 546, 489 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 395, 474, 496, 481 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 465, 460, 472 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 375, 456, 511, 463 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 495, 408, 549, 415 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 399, 404, 406 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 464, 329, 545, 336 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 321, 344, 328 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 511, 627, 544, 634 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 318, 618, 423, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 463, 361, 551, 367 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 352, 338, 359 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 457, 291, 546, 298 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 472, 155, 551, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 303, 146, 346, 153 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 19 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 20 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 21 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 22 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 23 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 24 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 25 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 26 Annotations: Annotation: Subtype: Link Rect: 436, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 27 Annotations: Annotation: Subtype: Link Rect: 369, 23, 485, 30 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 543, 23, 551, 30 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 5dd558c6 Type: CRC32 Checksum: 01c1866c03bc3653d83e43a5dd63d733 Type: MD5 Checksum: d311e621f807904cd15880e89f29ee188785fa99 Type: SHA-1