54dfa09f081c8aea03d74c133d3688d9  jouenzinh_a2020m9v35n1p1727-1735.pdf
67adf98b84cf550bdd6786a4b15c91767f1d4559  jouenzinh_a2020m9v35n1p1727-1735.pdf
0ba8171210d2b9a840808e775f9b19099445eb502e28f73ca4d3d1543a28843d  jouenzinh_a2020m9v35n1p1727-1735.pdf

Title:          Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment
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        Title: Materials and Methods
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          Title: Pharmacophore modelling and virtual screening
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          Title: Chemistry
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           Item: 
            Title: General procedure for the synthesis of pyridinyl-triazole derivatives 5-11
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             Item: 
              Title: 3-(Phenethylthio)-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-amine (6)
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             Item: 
              Title: 3-((4-Fluorobenzyl)thio)-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-amine (7)
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             Item: 
              Title: 3-((3-Fluorobenzyl)thio)-5-(pyridin-4-yl)-4H-1,2,4-triazol 4-amine (8)
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             Item: 
              Title: 3-((4-Methylbenzyl)thio)-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-amine (9)
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             Item: 
              Title: 3-((3-Methylbenzyl)thio)-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-amine (10)
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             Item: 
              Title: 3-((4-Chlorobenzyl)thio)-5-(pyridin-4-yl)-4H-1,2,4-triazol 4-amine (11)
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          Title: 2.3. Alpha synuclein aggregation and inhibition in vitro assays
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          Title: Docking studies
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        Title: Results and discussion
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          Title: Pharmacophore model generation, virtual screening and preliminary biological assay
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          Title: Design and synthesis of new small molecules as derivatives of compound 3
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          Title: Screening of the activity of the new derivatives 5 11
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          Title: Docking studies
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        Title: Conclusion
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        Title: Disclosure statement
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