3a1f91cd8140be437d346709524cf64f frobiobio_a2020m10v8p588947.pdf 7cb4aecbad0d71394c131e00144c0ed325e35b8f frobiobio_a2020m10v8p588947.pdf fdf3c32d0e0773ab2cbaa8653e5411eb4bce413789cf49bc09e322add8035dc3 frobiobio_a2020m10v8p588947.pdf Title: Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm Subject: Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Keywords: α-synuclein, protein aggregation, amyloid inhibitor, Parkinson's disease, synucleinopathies, small molecules Author: Salvador Ventura Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Wed Oct 14 08:59:07 2020 CEST ModDate: Wed Oct 14 13:02:41 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2562588 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MPQWOJ+MinionPro-Regular Type 1 Custom yes yes no 30 0 DNVDUM+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 31 0 XGGZEP+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 32 0 CKSQVL+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 37 0 VZNXET+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 38 0 VFIYVZ+RBLMI Type 1 Builtin yes yes no 39 0 WXGRYX+MTGUB Type 1 Builtin yes yes no 40 0 ZYLESW+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 41 0 QHWLRN+MTGU Type 1 Builtin yes yes no 42 0 PRJQZH+MinionPro-It Type 1 Custom yes yes no 125 0 WUZKBU+MinionPro-Bold Type 1 Custom yes yes no 129 0 XMPBKK+MTSYN Type 1 Builtin yes yes no 136 0 BSIVVH+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 250 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-12-17 06:03:35 CET RepresentationInformation: frobiobio_a2020m10v8p588947.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-12-16 16:33:39 CET Size: 2562588 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 834 FreeObjects: 3 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Protein Expression and Purification Item: Title: In vitro Aggregation of α-Syn Item: Title: Light-Scattering Item: Title: Transmission Electron Microscopy (TEM) Item: Title: Protein Misfolding Cyclic Amplification (PMCA) Item: Title: Proteinase K Digestion Item: Title: Nuclear Magnetic Resonance (NMR) Item: Title: Caenorhabditis Elegans Assays Children: Item: Title: Maintenance Item: Title: Strains Item: Title: ZPDm Administration Item: Title: Aggregate Quantification Item: Title: Microscopy and Imaging Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: ZPDm Inhibits α-Synuclein Aggregation in vitro Item: Title: ZPDm Prevents α-Syn Aggregation in Protein Misfolding Cyclic Amplification Assays Item: Title: ZPDm Exhibits Amyloid Disaggregation Activity in vitro Item: Title: ZPDm Decreases the Formation of α-Syn Aggregates in a C. elegans Model of PD Item: Title: Discussion Item: Title: Data Availability Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Inhibition of α-Synuclein Aggregation and Mature Fibril Disassembling With a Minimalistic Compound, ZPDm Author: Salvador Ventura Subject: Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. 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620 Annotation: Subtype: Link Rect: 341, 574, 435, 583 Annotation: Subtype: Link Rect: 431, 498, 457, 508 Annotation: Subtype: Link Rect: 458, 498, 490, 508 Annotation: Subtype: Link Rect: 491, 498, 527, 508 Annotation: Subtype: Link Rect: 528, 498, 551, 508 Annotation: Subtype: Link Rect: 302, 489, 329, 498 Annotation: Subtype: Link Rect: 43, 29, 183, 38 Annotation: Subtype: Link Rect: 187, 29, 247, 38 Annotation: Subtype: Link Rect: 424, 29, 551, 38 Checksum: 2af04104 Type: CRC32 Checksum: 3a1f91cd8140be437d346709524cf64f Type: MD5 Checksum: 7cb4aecbad0d71394c131e00144c0ed325e35b8f Type: SHA-1