a908faaa1e8550d97aa453006a0c323e antibiotics_a2020v9n12p872.pdf 5468e6a50da556053281db4a7e4eb2b208924050 antibiotics_a2020v9n12p872.pdf ffd13de0a5bdcf0395b34c604b3af0f3136d9c36a5de515085663191b7831bf5 antibiotics_a2020v9n12p872.pdf Title: Do Prosthetic Joint Infections Worsen the Functional Ambulatory Outcome of Patients with Joint Replacements? A Retrospective Matched Cohort Study Subject: Objectives: To assess the effect on the functional ambulatory outcome of postoperative joint infection (PJI) cured at the first treatment attempt versus not developing PJI in patients with hip and knee prostheses. Methods: In a single-hospital retrospectively matched cohort study, each patient with PJI between 2007 and 2016 was matched on age, sex, type of prosthesis and year of implantation with two other patients with uninfected arthroplasties. The definition of a PJI cure included infection eradication, no further surgical procedures, no PJI-related mortality and no suppressive antibiotics. Functional ambulatory status evaluated one year after the last surgery was classified into four simple categories: able to walk without assistance, able to walk with one crutch, able to walk with two crutches, and unable to walk. Patients with total hip arthroplasties (THAs), total knee arthroplasties (TKAs) and partial hip arthroplasties (PHAs) were analysed separately. Results: A total of 109 PJI patients (38 TKA, 41 THA, 30 PHA) and 218 non-PJI patients were included. In a model adjusted for clinically relevant variables, PJI was associated with a higher risk of needing an assistive device for ambulation (vs. walking without aid) among THA (adjusted odds ratio (OR) 3.10, 95% confidence interval (95% CI) 1.26–7.57; p = 0.014) and TKA patients (OR 5.40, 95% CI 2.12–13.67; p < 0.001), and with requiring two crutches to walk or being unable to walk (vs. walking unaided or with one crutch) among PHA patients (OR 3.05, 95% CI 1.01–9.20; p = 0.047). Conclusions: Ambulatory outcome in patients with hip and knee prostheses with postoperative PJI is worse than in patients who do not have PJI. Keywords: prosthetic joint infection; arthroplasty infection; prosthetic joint infection functional outcome; prosthetic joint infection ambulatory outcome Author: Isabel Mur, Marcos Jordán, Alba Rivera, Virginia Pomar, José Carlos González, Joaquín López-Contreras, Xavier Crusi, Ferran Navarro, Mercè Gurguí and Natividad Benito Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Dec 15 09:24:04 2020 CET ModDate: Tue Dec 15 09:27:19 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 548951 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XYDCIJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 FDPKDP+VnURWPalladioL Type 1 Custom yes yes no 15 0 VPZKXM+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 FRMWZL+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 FELCXG+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 32 0 YYFPCJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 41 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 63 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 67 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 71 0 TGMEOR+Rpcxr Type 1 Builtin yes yes no 84 0 WHTNAF+Pxsy Type 1 Builtin yes yes no 91 0 NAOUCR+Rpxb Type 1 Builtin yes yes no 95 0 RJFLWA+t1xtt Type 1 Builtin yes yes no 99 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 103 0 KEGFHN+PalatinoLinotype TrueType WinAnsi yes yes no 123 0 KEGFNM+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 126 0 KEGFOO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 129 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-01-23 02:55:43 CET RepresentationInformation: antibiotics_a2020v9n12p872.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-01-08 12:43:54 CET Size: 548951 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 306 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Setting and Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Study Patients and Controls Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Definitions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Ambulatory Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Characteristics of Patients with Prosthetic Joint Infection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Patients with Infected versus Uninfected Hip and Knee Arthroplasties Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Functional Ambulatory Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Info: Title: Do Prosthetic Joint Infections Worsen the Functional Ambulatory Outcome of Patients with Joint Replacements? A Retrospective Matched Cohort Study Author: Isabel Mur, Marcos Jordán, Alba Rivera, Virginia Pomar, José Carlos González, Joaquín López-Contreras, Xavier Crusi, Ferran Navarro, Mercè Gurguí and Natividad Benito Subject: Objectives: To assess the effect on the functional ambulatory outcome of postoperative joint infection (PJI) cured at the first treatment attempt versus not developing PJI in patients with hip and knee prostheses. Methods: In a single-hospital retrospectively matched cohort study, each patient with PJI between 2007 and 2016 was matched on age, sex, type of prosthesis and year of implantation with two other patients with uninfected arthroplasties. The definition of a PJI cure included infection eradication, no further surgical procedures, no PJI-related mortality and no suppressive antibiotics. Functional ambulatory status evaluated one year after the last surgery was classified into four simple categories: able to walk without assistance, able to walk with one crutch, able to walk with two crutches, and unable to walk. Patients with total hip arthroplasties (THAs), total knee arthroplasties (TKAs) and partial hip arthroplasties (PHAs) were analysed separately. Results: A total of 109 PJI patients (38 TKA, 41 THA, 30 PHA) and 218 non-PJI patients were included. In a model adjusted for clinically relevant variables, PJI was associated with a higher risk of needing an assistive device for ambulation (vs. walking without aid) among THA (adjusted odds ratio (OR) 3.10, 95% confidence interval (95% CI) 1.26 7.57; p = 0.014) and TKA patients (OR 5.40, 95% CI 2.12 13.67; p < 0.001), and with requiring two crutches to walk or being unable to walk (vs. walking unaided or with one crutch) among PHA patients (OR 3.05, 95% CI 1.01 9.20; p = 0.047). Conclusions: Ambulatory outcome in patients with hip and knee prostheses with postoperative PJI is worse than in patients who do not have PJI. Keywords: prosthetic joint infection; arthroplasty infection; prosthetic joint infection functional outcome; prosthetic joint infection ambulatory outcome Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Dec 15 09:24:04 CET 2020 ModDate: Tue Dec 15 09:27:19 CET 2020 ID: 0x0b69ed59551236d66720655a022ef64b, 0x0b69ed59551236d66720655a022ef64b Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: OFLXAT+Rpxr FontSubset: true FirstChar: 11 LastChar: 62 FontDescriptor: FontName: OFLXAT+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: VPZKXM+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: VPZKXM+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RJFLWA+t1xtt FontSubset: true FirstChar: 111 LastChar: 111 FontDescriptor: FontName: RJFLWA+t1xtt Flags: Symbolic FontBBox: -5, -183, 1501, 822 FontFile: true 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