aa8e445b2b52576704195edf60140904 antioxidants_a2020v9n12p1249.pdf 350445d5bc46dce773a6fca6c76aca37169a8838 antioxidants_a2020v9n12p1249.pdf 4686e62eb1e2a0d2ef964aa00ee27a1025649516bf876efb51ee5a67c4e608e4 antioxidants_a2020v9n12p1249.pdf Title: The Antinociceptive, Antioxidant and Anti-Inflammatory Effects of 5-Fluoro-2-Oxindole during Inflammatory Pain Subject: Recent studies demonstrate that 5-fluoro-2-oxindole inhibits neuropathic pain but the antinociceptive actions of this drug and its effects on the plasticity, oxidative and inflammatory changes induced by peripheral inflammation as well as on the effects and expression of -opioid receptors (MOR) have not been evaluated. In C57BL/6 male mice with inflammatory pain provoked by the subplantar administration of complete Freund’s adjuvant (CFA), we evaluated: (1) the antinociceptive actions of 5-fluoro-2-oxindole and its reversion with the HO-1 inhibitor, tin protoporphyrin IX (SnPP); (2) the effects of 5-fluoro-2-oxindole in the protein levels of mitogen-activated protein kinase (MAPK), Nrf2, NADPH quinone oxidoreductase1 (NQO1), heme oxygenase 1 (HO-1), oxidative stress marker (4-hydroxy-2-nonenal; 4-HNE), inducible nitric oxide synthase (NOS2), microglial markers (CD11b/c and IBA-1), and MOR in the spinal cord and/or paw of animals with inflammatory pain; (3) the antinociceptive effects of morphine in 5-fluoro-2-oxindole pre-treated animals. Treatment with 5 and 10 mg/kg of 5-fluoro-2-oxindole inhibited the allodynia and hyperalgesia induced by CFA in a different, time-dependent manner. These effects were reversed by SnPP. Treatment with 5-fluoro-2-oxindole increased the expression of NQO1, HO-1 and MOR and inhibited the CFA-induced upregulation of phosphorylated MAPK, 4-HNE, NOS2, CD11b/c and IBA-1 in spinal cords and/or paws. The local effects of morphine were improved with 5-fluoro-2-oxindole. This work reveals that 5-fluoro-2-oxindole inhibits the plasticity, oxidative and inflammatory responses provoked by peripheral inflammation and potentiates the antinociceptive effects of morphine. Thus, treatment with 5-fluoro-2-oxindole alone and/or combined with morphine are two remarkable new procedures for chronic inflammatory pain management. Keywords: analgesia; inflammation; morphine; opioids; oxidative stress; oxindole; pain Author: Alejandro Redondo, Gabriela Riego and Olga Pol Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Dec 9 06:56:57 2020 CET ModDate: Wed Dec 9 06:56:57 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3802041 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WHRJNP+URWPalladioL-Ital Type 1 Custom yes yes no 111 0 SUMYAL+URWPalladioL-Bold Type 1 Custom yes yes no 112 0 LZDGTK+Rpxb Type 1 Builtin yes yes no 113 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 114 0 RIKPUK+URWPalladioL-Roma Type 1 Custom yes yes no 115 0 MWHIBA+VnURWPalladioL Type 1 Custom yes yes no 116 0 FATHTC+Rpxr Type 1 Builtin yes yes no 117 0 IIQMFP+Pxsy Type 1 Builtin yes 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ABENPB+PalatinoLinotype TrueType WinAnsi yes yes no 458 0 ABEOCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 459 0 ABEOCE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 460 0 ABENPB+PalatinoLinotype TrueType WinAnsi yes yes no 549 0 ABEOCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 550 0 ABEOCE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 551 0 ABEPAP+TimesNewRoman CID TrueType Identity-H yes yes yes 552 0 ABFGCG+Arial CID TrueType Identity-H yes yes yes 571 0 ABENPB+PalatinoLinotype TrueType WinAnsi yes yes no 572 0 ABEOCC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 573 0 ABEOCE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 574 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 660 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-01-16 05:44:42 CET RepresentationInformation: antioxidants_a2020v9n12p1249.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-01-11 11:01:30 CET Size: 3802041 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぁのどねちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづっとちのどっちぬぜ〴ぜ〰ぁぬぬはつべのどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづひねちぬぜ〴ぜ〰えべばづひちぬでづびどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぁのどねちぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづっとちのどっちぬぜ〴ぜ〰ぁぬぬはつべのどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづひねちぬぜ〴ぜ〰えべばづひちぬでづびどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉのつふっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづっとちのどっちぬぜ〴ぜ〰ぁぬぬはつべのどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづひねちぬぜ〴ぜ〰えべばづひちぬでづびどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きづっとちのどっちぬぜ〴ぜ〰ぁぬぬはつべのどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ごとづひねちぬぜ〴ぜ〰えべばづひちぬでづびどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ごとづひねちぬぜ〴ぜ〰えべばづひちぬでづびどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: しづびぴづひのぜ〴ぜ〰あぬはぴぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅへばづひどねづのぴちぬぜ〴ぜ〰ぐひはっづつふひづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㜩‾㸊⡜㌷㙜㌷㝜〰いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いひふでびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㠩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰げづぶづひびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁのぴどのはっどっづぴばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぷどぴとぜ〴ぜ〰このぐぐぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰きぁぐかぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰きどっづぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁのぴどはへどつちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐひはぴどづのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰〴〭えぎぅ〬ぜ〴ぜ〰ぎくこ〲〬ぜ〴ぜ〰ぃい〱〱ぢ〯っ〬ぜ〴ぜ〰ぉあぁ〭〱ぜ〴ぜ〰ちのつぜ〴ぜ〰きくげぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつ〯はひぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ごとづぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰げづぶづひびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁのぴどのはっどっづぴばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぷどぴとぜ〴ぜ〰このぐぐぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰きぁぐかぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰きどっづぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁのぴどはへどつちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐひはぴどづのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰〴〭えぎぅ〬ぜ〴ぜ〰ぎくこ〲〬ぜ〴ぜ〰ぃい〱〱ぢ〯っ〬ぜ〴ぜ〰ぉあぁ〭〱ぜ〴ぜ〰ちのつぜ〴ぜ〰きくげぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつ〯はひぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: げづぶづひびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぁのぴどのはっどっづぴばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぷどぴとぜ〴ぜ〰このぐぐぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰きぁぐかぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰きどっづぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁのぴどはへどつちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐひはぴどづのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰〴〭えぎぅ〬ぜ〴ぜ〰ぎくこ〲〬ぜ〴ぜ〰ぃい〱〱ぢ〯っ〬ぜ〴ぜ〰ぉあぁ〭〱ぜ〴ぜ〰ちのつぜ〴ぜ〰きくげぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつ〯はひぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰きぁぐかぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰きどっづぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰ぐちどのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁのぴどはへどつちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐひはぴどづのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰〴〭えぎぅ〬ぜ〴ぜ〰ぎくこ〲〬ぜ〴ぜ〰ぃい〱〱ぢ〯っ〬ぜ〴ぜ〰ぉあぁ〭〱ぜ〴ぜ〰ちのつぜ〴ぜ〰きくげぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつ〯はひぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰ぁのぴどはへどつちのぴぜ〴ぜ〰ぐひはぴづどのびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐひはぴどづのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰〴〭えぎぅ〬ぜ〴ぜ〰ぎくこ〲〬ぜ〴ぜ〰ぃい〱〱ぢ〯っ〬ぜ〴ぜ〰ぉあぁ〭〱ぜ〴ぜ〰ちのつぜ〴ぜ〰きくげぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつ〯はひぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅててづっぴぜ〴ぜ〰はてぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐひはぴどづのぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰はてぜ〴ぜ〰〴〭えぎぅ〬ぜ〴ぜ〰ぎくこ〲〬ぜ〴ぜ〰ぃい〱〱ぢ〯っ〬ぜ〴ぜ〰ぉあぁ〭〱ぜ〴ぜ〰ちのつぜ〴ぜ〰きくげぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こばどのちぬぜ〴ぜ〰ぃはひつびぜ〴ぜ〰ちのつ〯はひぜ〴ぜ〰ぐちぷびぜ〴ぜ〰はてぜ〴ぜ〰ぁのどねちぬびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぐづひどばとづひちぬぜ〴ぜ〰ぉのてぬちねねちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㘩‾㸊⡜㌷㙜㌷㝜〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰〵〭うぬふはひは〭〲〭くへどのつはぬづぜ〴ぜ〰ぐはぴづのっどぴづびぜ〴ぜ〰ぴとづぜ〴ぜ〰がはっちぬぜ〴ぜ〰ぁのぴどのはっどっづばぴどぶづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰はてぜ〴ぜ〰きはひばとどのづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: SUMYAL+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: SUMYAL+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LZDGTK+Rpxb FontSubset: true FirstChar: 11 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