76520e64625497295f3c90edc45b6883 236296.pdf e7f62ba815ae745850a6d1c084e4bdfb137c04c6 236296.pdf 85b213e36a4d4f2b824a6afd494f608767de9d0653976c04b918cd94cb75781b 236296.pdf Title: Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients Subject: Blood Cancer Journal, doi:10.1038/s41408-020-0283-8 Keywords: Author: Alejandro Medina Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Feb 5 16:58:11 2020 CET ModDate: Thu Feb 6 12:20:23 2020 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 881474 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JNNFAA+AdvOT0d9ab1db.I Type 1C WinAnsi yes yes no 123 0 JNNEPP+AdvOT07517017+fb Type 1C Custom yes yes yes 124 0 JNNCNL+AdvOT07517017 Type 1C WinAnsi yes yes no 71 0 JNNCCJ+AdvOT46dcae81 Type 1C WinAnsi yes yes no 106 0 JNNCDK+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 107 0 JNNFBB+AdvOT07517017+22 Type 1C Custom yes yes yes 204 0 JNNCDL+AdvMyriad_R Type 1C WinAnsi yes yes no 490 0 JNNFBC+AdvTTab7e17fd+22 Type 1C Custom yes yes no 96 0 MyriadPro-Regular Type 1C WinAnsi yes no no 491 0 JNNCMK+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 65 0 JNNCNK+AdvOT46dcae81+fb Type 1C Custom yes yes yes 130 0 JNNFCE+AdvOTa9103878+fb Type 1C Custom yes yes yes 68 0 JNNFDF+AdvOTf0bf83d5.I Type 1C WinAnsi yes yes no 69 0 JNNFBD+AdvTTab7e17fd Type 1C WinAnsi yes yes no 70 0 JNNFCD+AdvOTa9103878 Type 1C WinAnsi yes yes no 72 0 JNNFLF+AdvAGaramond-R Type 1C WinAnsi yes yes no 73 0 JNNFJE+AdvOTce3d9a73 Type 1C WinAnsi yes yes no 75 0 JNNFKE+AdvOT07517017+20 Type 1C WinAnsi yes yes no 132 0 JNNFPG+AdvTT7b515deb Type 1C WinAnsi yes yes no 64 0 JNNFPH+AdvOTa9103878+03 Type 1C Custom yes yes yes 66 0 JNNFPI+AdvTTe692faf0+21 Type 1C WinAnsi yes yes no 67 0 JNNFNF+AdvOTa9103878+20 Type 1C WinAnsi yes yes no 74 0 JNNGCH+AdvOTa9103878+22 Type 1C Custom yes yes yes 97 0 JNNGFH+AdvOT56309c18.I Type 1C WinAnsi yes yes no 108 0 JNNGFI+AdvOT07517017+03 Type 1C Custom yes yes yes 109 0 JNNLPH+AdvOTce3d9a73+fb Type 1C Custom yes yes yes 125 0 JNNMCH+AdvOT65f8a23b.I+03 Type 1C Custom yes yes yes 131 0 JNNMEH+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 159 0 JNOPCE+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 205 0 JNOPMB+AdvOTce3d9a73+20 Type 1C WinAnsi yes yes no 272 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-05 02:24:50 CET RepresentationInformation: 236296.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-04 08:45:31 CET Size: 881474 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR4' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR16' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR19' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR20' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR21' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR22' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR23' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR24' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR25' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR26' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR27' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR30' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR33' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR29' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR32' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR12' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR13' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR34' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR35' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR36' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR11' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR31' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR37' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR38' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR39' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR40' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR41' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR42' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR43' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR44' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR45' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR47' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR50' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR51' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR17' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR18' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR52' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR14' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR15' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR53' cannot be found Offset: 509603 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR54' cannot be found Offset: 509603 MIMEtype: application/pdf PDFMetadata: Objects: 595 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Sample collection and IGH sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Immunophenotypic characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Sequence analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: CDR3 clustering analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Clinical characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Detection of clonal VDJH gene rearrangements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Gene repertoire Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: IGHV genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: IGHD and IGHJ genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Somatic hypermutation rates and IGH composition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: CDR3 amino acid composition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Clustering analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Impact of molecular variables on clinical outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: Transplant-ineligible patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Transplant-eligible patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients Author: Alejandro Medina Subject: Blood Cancer Journal, doi:10.1038/s41408-020-0283-8 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Feb 05 17:28:11 CET 2020 ModDate: Thu Feb 06 12:20:23 CET 2020 ID: 0x03d515137a3f343df544aa3f44a688df, 0xdddb55eb90e9c6e9f264fa26c3ed904a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1300 ImageHeight: 1400 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1950 ImageHeight: 819 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1950 ImageHeight: 821 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: JNNFPG+AdvTT7b515deb FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: JNNFPG+AdvTT7b515deb Flags: Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNCMK+AdvOT3b30f6db.B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JNNCMK+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNCNK+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNNCNK+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNFPH+AdvOTa9103878+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JNNFPH+AdvOTa9103878+03 Flags: Symbolic FontBBox: -135, -250, 906, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNFPI+AdvTTe692faf0+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: JNNFPI+AdvTTe692faf0+21 Flags: Nonsymbolic FontBBox: 0, -229, 1614, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNMCH+AdvOT65f8a23b.I+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNNMCH+AdvOT65f8a23b.I+03 Flags: Symbolic FontBBox: -72, -208, 760, 802 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNFCE+AdvOTa9103878+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JNNFCE+AdvOTa9103878+fb Flags: Symbolic FontBBox: 0, -10, 812, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNFKE+AdvOT07517017+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JNNFKE+AdvOT07517017+20 Flags: Nonsymbolic FontBBox: 0, -208, 1041, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFDF+AdvOTf0bf83d5.I FontSubset: true FirstChar: 41 LastChar: 117 FontDescriptor: FontName: JNNFDF+AdvOTf0bf83d5.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFBD+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: JNNFBD+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNCNL+AdvOT07517017 FontSubset: true FirstChar: 37 LastChar: 250 FontDescriptor: FontName: JNNCNL+AdvOT07517017 Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFCD+AdvOTa9103878 FontSubset: true FirstChar: 37 LastChar: 225 FontDescriptor: FontName: JNNFCD+AdvOTa9103878 Flags: Serif, Nonsymbolic FontBBox: -20, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFLF+AdvAGaramond-R FontSubset: true FirstChar: 35 LastChar: 95 FontDescriptor: FontName: JNNFLF+AdvAGaramond-R Flags: Nonsymbolic FontBBox: -177, -260, 1093, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFNF+AdvOTa9103878+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: JNNFNF+AdvOTa9103878+20 Flags: Nonsymbolic FontBBox: -166, -218, 968, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFJE+AdvOTce3d9a73 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: JNNFJE+AdvOTce3d9a73 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNFBB+AdvOT07517017+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNNFBB+AdvOT07517017+22 Flags: Symbolic FontBBox: 0, -135, 666, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNOPCE+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNOPCE+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNOPMB+AdvOTce3d9a73+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: JNOPMB+AdvOTce3d9a73+20 Flags: Nonsymbolic FontBBox: -156, -197, 1197, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNMEH+AdvOT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNNMEH+AdvOT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNFBC+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: JNNFBC+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: JNNGCH+AdvOTa9103878+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JNNGCH+AdvOTa9103878+22 Flags: Symbolic FontBBox: -166, -166, 718, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNCCJ+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: JNNCCJ+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNCDL+AdvMyriad_R FontSubset: true FirstChar: 35 LastChar: 95 FontDescriptor: FontName: JNNCDL+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNCDK+AdvOT65f8a23b.I FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: JNNCDK+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNGFH+AdvOT56309c18.I FontSubset: true FirstChar: 45 LastChar: 116 FontDescriptor: FontName: JNNGFH+AdvOT56309c18.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNGFI+AdvOT07517017+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNNGFI+AdvOT07517017+03 Flags: Symbolic FontBBox: -20, -197, 708, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNFAA+AdvOT0d9ab1db.I FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: JNNFAA+AdvOT0d9ab1db.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JNNEPP+AdvOT07517017+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JNNEPP+AdvOT07517017+fb Flags: Symbolic FontBBox: 0, 0, 677, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JNNLPH+AdvOTce3d9a73+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JNNLPH+AdvOTce3d9a73+fb Flags: Symbolic FontBBox: 0, 0, 791, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41408-020-0283-8 Molecular profiling of immunoglobulin heavy-chain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients Alejandro Medina Cristina Jiménez M. Eugenia Sarasquete Marcos González M. Carmen Chillón Ana Balanzategui Isabel Prieto-Conde María García-Álvarez Noemí Puig Verónica González-Calle Miguel Alcoceba Isabel Cuenca Santiago Barrio Fernando Escalante Norma C. Gutiérrez Mercedes Gironella Miguel T. Hernández Anna Sureda Albert Oriol Joan Bladé Juan-José Lahuerta Jesús F. San Miguel María-Victoria Mateos Joaquín Martínez-López María-José Calasanz Ramón García-Sanz Springer US Blood Cancer Journal, doi:10.1038/s41408-020-0283-8 10.1038/s41408-020-0283-8 http://dx.doi.org/10.1038/s41408-020-0283-8 journal Blood Cancer Journal © 2020, The Author(s) 2044-5385 10.1038/s41408-020-0283-8 springer.com springerlink.com 2010-04-23 True 10.1038/s41408-020-0283-8 springer.com springerlink.com Springer 2020-02-06T12:20:23+01:00 2020-02-05T21:28:11+05:30 2020-02-06T12:20:23+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) VoR uuid:907877e4-aa51-4d14-9790-9cfe8cd7b995 uuid:3dd18411-c510-4f93-bba1-1248d16ab78a default 1 converted uuid:19618372-a4b3-4e18-ac85-769d4c35adee converted to PDF/A-2b pdfToolbox 2020-02-05T21:28:51+05:30 2 B Alejandro Medina http://orcid.org/0000-0001-5609-2969 Isabel Prieto-Conde http://orcid.org/0000-0002-2510-8355 Miguel Alcoceba http://orcid.org/0000-0002-3819-4846 María-Victoria Mateos http://orcid.org/0000-0003-2390-1218 María-José Calasanz http://orcid.org/0000-0002-0374-3008 Ramón García-Sanz http://orcid.org/0000-0003-4120-2787 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text internal Mirrors crossmark:DOI doi Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Copyright copyright Text external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. issn Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url Text http://springernature.com/ns/xmpExtensions/2.0/ sn Springer Nature ORCID Schema external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. authorInfo Bag AuthorInformation Specifies the types of author information: name and ORCID of an author. http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author AuthorInformation Gives the name of an author. name Text Gives the ORCID of an author. orcid URI http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 130, 577, 131, 588 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 130, 577, 131, 588 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 140, 577, 141, 588 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 131, 577, 140, 588 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 139, 577, 140, 588 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 217, 563, 218, 574 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 217, 563, 218, 574 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 227, 563, 228, 574 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 218, 563, 227, 574 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 563, 227, 574 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 549, 126, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 549, 126, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 549, 136, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 126, 549, 135, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 134, 549, 135, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 145, 522, 146, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 145, 522, 146, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 154, 522, 155, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 146, 522, 154, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 153, 522, 154, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 522, 352, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 522, 352, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 361, 522, 362, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 352, 522, 361, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 360, 522, 361, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 466, 522, 467, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 466, 522, 467, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 522, 477, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 467, 522, 476, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 475, 522, 476, 532 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 194, 230, 204 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 468, 230, 472, 240 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 454, 218, 457, 228 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 369, 182, 373, 192 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 393, 146, 397, 156 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 269, 59, 385, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 182, 155, 278, 163 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 86, 684, 89, 694 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 172, 648, 175, 658 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 84, 601, 88, 610 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 74, 553, 77, 562 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 82, 553, 89, 562 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 243, 517, 250, 527 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 493, 243, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 260, 445, 267, 455 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 198, 397, 205, 407 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 209, 397, 217, 407 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 129, 110, 136, 120 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 144, 106, 204, 116 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 81, 98, 87, 108 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 98, 94, 154, 104 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 283, 98, 290, 108 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 59, 82, 115, 92 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 220, 86, 226, 96 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 232, 82, 288, 92 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 137, 74, 143, 84 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 151, 70, 207, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 98, 62, 105, 72 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 112, 58, 168, 68 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 283, 62, 290, 72 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 692, 367, 702 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 406, 636, 413, 646 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 504, 589, 512, 598 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 446, 409, 453, 419 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 91, 517, 98, 527 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 255, 469, 262, 479 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 272, 206, 279, 216 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 281, 206, 288, 216 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 180, 170, 187, 180 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 222, 134, 229, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 231, 134, 238, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 451, 477, 456, 486 Flags: Print AppearanceDictionary: true Destination: 98 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 231, 82, 236, 92 Flags: Print AppearanceDictionary: true Destination: 114 Annotation: Subtype: Link Rect: 430, 118, 435, 128 Flags: Print AppearanceDictionary: true Destination: 126 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 202, 290, 209, 299 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 211, 290, 218, 299 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 280, 692, 285, 702 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 240, 620, 244, 630 Flags: Print AppearanceDictionary: true Destination: 114 Annotation: Subtype: Link Rect: 120, 62, 123, 72 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 128, 62, 135, 72 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 324, 309, 328, 319 Flags: Print AppearanceDictionary: true Destination: 164 Annotation: Subtype: Link Rect: 506, 297, 511, 307 Flags: Print AppearanceDictionary: true Destination: 164 Annotation: Subtype: Link Rect: 440, 285, 445, 295 Flags: Print AppearanceDictionary: true Destination: 164 Annotation: Subtype: Link Rect: 386, 249, 391, 259 Flags: Print AppearanceDictionary: true Destination: 164 Annotation: Subtype: Link Rect: 336, 202, 341, 211 Flags: Print AppearanceDictionary: true Destination: 170 Thumb: true Page: Label: 8 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 74, 74, 81, 84 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 83, 74, 90, 84 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 92, 74, 99, 84 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 327, 314, 334, 323 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 339, 314, 346, 323 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 492, 254, 500, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 501, 254, 509, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 514, 206, 518, 216 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 520, 206, 527, 216 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 529, 206, 536, 216 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 182, 409, 192 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 432, 170, 439, 180 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 334, 158, 341, 168 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 377, 134, 385, 144 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 386, 134, 394, 144 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 171, 624, 178, 634 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 264, 589, 271, 598 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 273, 589, 280, 598 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 233, 541, 237, 550 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 225, 433, 232, 443 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 76, 397, 83, 407 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 397, 95, 407 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 248, 373, 255, 383 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 84, 349, 91, 359 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 93, 349, 100, 359 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 101, 349, 108, 359 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 235, 302, 242, 311 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 283, 302, 290, 311 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 153, 134, 160, 144 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 335, 648, 342, 658 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 344, 648, 351, 658 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 428, 565, 431, 574 Flags: Print AppearanceDictionary: true Destination: 262 Annotation: Subtype: Link Rect: 433, 565, 440, 574 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 565, 449, 574 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 330, 409, 337, 419 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 290, 408, 299 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 410, 290, 418, 299 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 419, 290, 427, 299 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 429, 290, 436, 299 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 233, 173, 279, 181 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 164, 137, 172 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 12 Thumb: true Checksum: caad3864 Type: CRC32 Checksum: 76520e64625497295f3c90edc45b6883 Type: MD5 Checksum: e7f62ba815ae745850a6d1c084e4bdfb137c04c6 Type: SHA-1