fd0d80ad95b1f13d5cd9904865b61ea6 236307.pdf 7980fdebd53a4f796f30626f5e76303a991e1c66 236307.pdf c2d80142c15a1e5c2302f1d642e551d7284a5c71d8d9470c9d65c70480f5fb33 236307.pdf Title: Understanding the Relevance of DNA Methylation Changes in Immune Differentiation and Disease Subject: Immune cells are one of the most complex and diverse systems in the human organism. Such diversity implies an intricate network of different cell types and interactions that are dependently interconnected. The processes by which different cell types differentiate from progenitors, mature, and finally exert their function requires an orchestrated succession of molecular processes that determine cell phenotype and function. The acquisition of these phenotypes is highly dependent on the establishment of unique epigenetic profiles that confer identity and function on the various types of effector cells. These epigenetic mechanisms integrate microenvironmental cues into the genome to establish specific transcriptional programs. Epigenetic modifications bridge environment and genome regulation and play a role in human diseases by their ability to modulate physiological programs through external stimuli. DNA methylation is one of the most ubiquitous, stable, and widely studied epigenetic modifications. Recent technological advances have facilitated the generation of a vast amount of genome-wide DNA methylation data, providing profound insights into the roles of DNA methylation in health and disease. This review considers the relevance of DNA methylation to immune system cellular development and function, as well as the participation of DNA methylation defects in immune-mediated pathologies, illustrated by selected paradigmatic diseases. Keywords: epigenetics; DNA methylation; immune system; B cells; T cells; NK cells; innate lymphoid cells; monocytes; granulocytes; rheumatoid arthritis; systemic lupus erythematosus; cryopyrin-associated periodic fever syndrome; Familial Mediterranean Fever; primary immunodeficiencies; innate immune deficiencies Author: Carlos de la Calle-Fabregat, Octavio Morante-Palacios and Esteban Ballestar Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat Jan 18 09:34:36 2020 CET ModDate: Sat Jan 18 09:34:36 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1396894 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OQBFJS+URWPalladioL-Ital Type 1 Custom yes yes no 101 0 NMTQFC+URWPalladioL-Bold Type 1 Custom yes yes no 102 0 WOZBHT+Rpxb 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ごぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぉののちぴづぜ〴ぜ〰がべねばとはどつぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きはのはっべぴづびぜ〴ぜ〰ちのつぜ〴ぜ〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇひちのふぬはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉののちぴづぜ〴ぜ〰がべねばとはどつぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きはのはっべぴづびぜ〴ぜ〰ちのつぜ〴ぜ〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇひちのふぬはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きはのはっべぴづびぜ〴ぜ〰ちのつぜ〴ぜ〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇひちのふぬはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぇひちのふぬはっべぴづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いぎぁぜ〴ぜ〰きづぴとべぬちぴどはのぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのづ〭きづつどちぴづつぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰いぎぁぜ〴ぜ〰きづぴとべぬちぴどはのぜ〴ぜ〰いづてづっぴびぜ〴ぜ〰どのぜ〴ぜ〰ぃはのつどぴどはのびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぶづひちっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰こべびぴづねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸱ Children: Item: Title: いぎぁぜ〴ぜ〰きづぴとべぬちぴどはのぜ〴ぜ〰いづてづっぴびぜ〴ぜ〰どのぜ〴ぜ〰ぃはのつどぴどはのびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰くぶづひちっぴどぶちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰こべびぴづねぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸱ Children: Item: Title: ぁふぴはどねねふのづぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸲ Item: Title: 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