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ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 1174829 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found Offset: 1174829 MIMEtype: application/pdf PDFMetadata: Objects: 511 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: PBMC isolation and cryopreservation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: PBMC isolation and activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Single-cell RNA sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Single-cell ATAC sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Primary processing and demultiplexing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Quality control and normalization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Cell type annotation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Variance analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Differential expression analysis (DEA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Gene Ontology (GO) enrichment analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Integration of the sampling signatures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Prediction of sampling time-biased cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Computational correction sampling time signature Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: k-nearest-neighbor batch-effect test (kBET) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Smart-seq2 validation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: ATAC-seq data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Review history Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Peer review information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Authors’ information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Info: Title: Sampling time-dependent artifacts in single-cell genomics studies Author: Ramon Massoni-Badosa Subject: Genome Biology, 2020, doi:10.1186/s13059-020-02032-0 Keywords: Single-cell,Biobank,RNA sequencing,Peripheral blood mononuclear cells,PBMC,Chronic lymphocytic leukemia,CLL,Sampling,Cryopreservation,Benchmarking Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun May 10 04:25:57 CEST 2020 ModDate: Mon May 11 10:31:36 CEST 2020 ID: 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iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13059-020-02032-0 Genome Biology Genome Biology, 2020, doi:10.1186/s13059-020-02032-0 Single-cell Biobank RNA sequencing Peripheral blood mononuclear cells PBMC Chronic lymphocytic leukemia CLL Sampling Cryopreservation Benchmarking Sampling time-dependent artifacts in single-cell genomics studies Ramon Massoni-Badosa Giovanni Iacono Catia Moutinho Marta Kulis Núria Palau Domenica Marchese Javier Rodríguez-Ubreva Esteban Ballestar Gustavo Rodriguez-Esteban Sara Marsal Marta Aymerich Dolors Colomer Elias Campo Antonio Julià José Ignacio Martín-Subero Holger Heyn 2020-05-11T10:31:36+02:00 2020-05-11T10:31:36+02:00 2020-05-10T10:25:57+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:b7af44dc-eeed-4d3d-b09a-b452fe44617d uuid:889f5ff4-bb9a-4948-95a3-85cb1c647651 default 1 converted uuid:b7af44dc-eeed-4d3d-b09a-b452fe44617d converted to PDF/A-2b pdfToolbox 2020-05-11T07:20:49+08:00 2 B 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