2a94455a92fb81478910fbe2f9d430d8 236423.pdf c81008e54b9157725dc67699a6fc4264eb033a9c 236423.pdf a14ec872997a84b2d81cf694f9f06dcac958f2349d49b302b6f0ae795c355d76 236423.pdf Title: The Histone Variant MacroH2A1 Regulates Key Genes for Myogenic Cell Fusion in a Splice-Isoform Dependent Manner Subject: MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present, it is not clear how macroH2As affect gene regulation to exert these functions. We have parted from the initial observation that loss of total macroH2A1 led to a change in the morphology of murine myotubes differentiated ex vivo. The fusion of myoblasts to myotubes is a key process in embryonic myogenesis and highly relevant for muscle regeneration after acute or chronic injury. We have focused on this physiological process, to investigate the functions of the two splice isoforms of macroH2A1. Individual perturbation of the two isoforms in myotubes forming in vitro from myogenic C2C12 cells showed an opposing phenotype, with macroH2A1.1 enhancing, and macroH2A1.2 reducing, fusion. Differential regulation of a subset of fusion-related genes encoding components of the extracellular matrix and cell surface receptors for adhesion correlated with these phenotypes. We describe, for the first time, splice isoform-specific phenotypes for the histone variant macroH2A1 in a physiologic process and provide evidence for a novel underlying molecular mechanism of gene regulation. Keywords: histone variants; myogenic differentiation; myotubes; cell fusion; macroH2A; PARP1; gene regulation; ADP ribose Author: Sarah Hurtado-Bagès, Melanija Posavec Marjanovic, Vanesa Valero, Roberto Malinverni, David Corujo, Philippe Bouvet, Anne-Claire Lavigne, Kerstin Bystricky and Marcus Buschbeck Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Apr 30 03:20:03 2020 CEST ModDate: Thu Apr 30 03:20:03 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2019871 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AYZKMC+URWPalladioL-Ital Type 1 Custom yes yes no 117 0 LHOIGH+URWPalladioL-Bold Type 1 Custom yes yes no 118 0 WYEKQU+VnURWPalladioL-Bold Type 1 Custom yes yes no 119 0 CUHHHZ+URWPalladioL-Roma Type 1 Custom yes yes 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TrueType WinAnsi no no no 308 0 TXCYQG+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 344 0 XLDRPT+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 345 0 JVEQGA+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 346 0 TimesNewRomanPSMT TrueType WinAnsi no no no 347 0 TXCYQG+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 391 0 XLDRPT+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 392 0 JVEQGA+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 393 0 TimesNewRomanPSMT TrueType WinAnsi no no no 394 0 TXCYQG+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 423 0 XLDRPT+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 424 0 JVEQGA+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 425 0 TimesNewRomanPSMT TrueType WinAnsi no no no 426 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-10 02:18:39 CET RepresentationInformation: 236423.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-06 08:30:35 CET Size: 2019871 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 7 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉびはぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐひどねちひべぜ〴ぜ〰きべはぢぬちびぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぐぬちびねどつび〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづぴひはぶどひちぬぜ〴ぜ〰ぉのてづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどぢはつどづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはてぬふはひづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉねちでづぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぃづぬぬぜ〴ぜ〰ぃふぬぴふひづぜ〴ぜ〰ちのつぜ〴ぜ〰ぉびはぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぐひどねちひべぜ〴ぜ〰きべはぢぬちびぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぐぬちびねどつび〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづぴひはぶどひちぬぜ〴ぜ〰ぉのてづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどぢはつどづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはてぬふはひづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉねちでづぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぐぬちびねどつび〬ぜ〴ぜ〰ごひちのびてづっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづぴひはぶどひちぬぜ〴ぜ〰ぉのてづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁのぴどぢはつどづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはてぬふはひづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉねちでづぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁのぴどぢはつどづびぜ〴ぜ〰ちのつぜ〴ぜ〰ぉねねふのはてぬふはひづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぉねちでづぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぉねちでづぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぇづのづぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃとひはねちぴどのぜ〴ぜ〰どねねふのはばひづっどばどぴちぴどはの〬ぜ〴ぜ〰こづぱふづのっどのでぜ〴ぜ〰ちのつぜ〴ぜ〰いちぴちぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰がはびびぜ〴ぜ〰はてぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰げづつふっづびぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃちばちっどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぐひどねちひべぜ〴ぜ〰きべはぢぬちびぴびぜ〴ぜ〰ぴはぜ〴ぜ〰うふびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰えちぶづぜ〴ぜ〰ちのぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はのぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰うふびどはのぜ〲㑜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰ぐひはねはぴづびぜ〴ぜ〰ちのつぜ〴ぜ〰きちっひはえ〲ぁ〱〮〲ぜ〴ぜ〰げづつふっづびぜ〴ぜ〰ぉぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰うふのっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰ぃはひひづぬちぴづびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぴとづぜ〴ぜ〰いどててづひづのぴどちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ちぜ〴ぜ〰こふぢびづぴぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰きちぴひどへぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰かのはっにつはぷのぜ〴ぜ〰はてぜ〴ぜ〰ぐぁげぐ〱ぜ〴ぜ〰えちびぜ〴ぜ〰がどぴぴぬづぜ〴ぜ〰ぉねばちっぴぜ〴ぜ〰はのぜ〴ぜ〰うふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰あづっはねづびぜ〴ぜ〰ぅのひどっとづつぜ〴ぜ〰はのぜ〴ぜ〰うふびどはの〭げづぬづぶちのぴぜ〴ぜ〰ぇづのづびぜ〴ぜ〰いふひどのでぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: がはびびぜ〴ぜ〰はてぜ〴ぜ〰ごはぴちぬぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰げづつふっづびぜ〴ぜ〰ぴとづぜ〴ぜ〰ぃちばちっどぴべぜ〴ぜ〰はてぜ〴ぜ〰ぐひどねちひべぜ〴ぜ〰きべはぢぬちびぴびぜ〴ぜ〰ぴはぜ〴ぜ〰うふびづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰えちぶづぜ〴ぜ〰ちのぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はのぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰うふびどはのぜ〲㑜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰ぐひはねはぴづびぜ〴ぜ〰ちのつぜ〴ぜ〰きちっひはえ〲ぁ〱〮〲ぜ〴ぜ〰げづつふっづびぜ〴ぜ〰ぉぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰うふのっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰ぃはひひづぬちぴづびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぴとづぜ〴ぜ〰いどててづひづのぴどちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ちぜ〴ぜ〰こふぢびづぴぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰きちぴひどへぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰かのはっにつはぷのぜ〴ぜ〰はてぜ〴ぜ〰ぐぁげぐ〱ぜ〴ぜ〰えちびぜ〴ぜ〰がどぴぴぬづぜ〴ぜ〰ぉねばちっぴぜ〴ぜ〰はのぜ〴ぜ〰うふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰あづっはねづびぜ〴ぜ〰ぅのひどっとづつぜ〴ぜ〰はのぜ〴ぜ〰うふびどはの〭げづぬづぶちのぴぜ〴ぜ〰ぇづのづびぜ〴ぜ〰いふひどのでぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰えちぶづぜ〴ぜ〰ちのぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰ぅててづっぴぜ〴ぜ〰はのぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰うふびどはのぜ〲㑜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰ぐひはねはぴづびぜ〴ぜ〰ちのつぜ〴ぜ〰きちっひはえ〲ぁ〱〮〲ぜ〴ぜ〰げづつふっづびぜ〴ぜ〰ぉぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰うふのっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰ぃはひひづぬちぴづびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぴとづぜ〴ぜ〰いどててづひづのぴどちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ちぜ〴ぜ〰こふぢびづぴぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰きちぴひどへぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰かのはっにつはぷのぜ〴ぜ〰はてぜ〴ぜ〰ぐぁげぐ〱ぜ〴ぜ〰えちびぜ〴ぜ〰がどぴぴぬづぜ〴ぜ〰ぉねばちっぴぜ〴ぜ〰はのぜ〴ぜ〰うふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰あづっはねづびぜ〴ぜ〰ぅのひどっとづつぜ〴ぜ〰はのぜ〴ぜ〰うふびどはの〭げづぬづぶちのぴぜ〴ぜ〰ぇづのづびぜ〴ぜ〰いふひどのでぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ごとづぜ〴ぜ〰くばばはびどのでぜ〴ぜ〰うふのっぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰ぃはひひづぬちぴづびぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぴとづぜ〴ぜ〰いどててづひづのぴどちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ちぜ〴ぜ〰こふぢびづぴぜ〴ぜ〰はてぜ〴ぜ〰ぇづのづびぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぴはぜ〴ぜ〰ぅへぴひちっづぬぬふぬちひぜ〴ぜ〰きちぴひどへぜ〴ぜ〰ちのつぜ〴ぜ〰ぁつとづびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰かのはっにつはぷのぜ〴ぜ〰はてぜ〴ぜ〰ぐぁげぐ〱ぜ〴ぜ〰えちびぜ〴ぜ〰がどぴぴぬづぜ〴ぜ〰ぉねばちっぴぜ〴ぜ〰はのぜ〴ぜ〰うふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰あづっはねづびぜ〴ぜ〰ぅのひどっとづつぜ〴ぜ〰はのぜ〴ぜ〰うふびどはの〭げづぬづぶちのぴぜ〴ぜ〰ぇづのづびぜ〴ぜ〰いふひどのでぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: かのはっにつはぷのぜ〴ぜ〰はてぜ〴ぜ〰ぐぁげぐ〱ぜ〴ぜ〰えちびぜ〴ぜ〰がどぴぴぬづぜ〴ぜ〰ぉねばちっぴぜ〴ぜ〰はのぜ〴ぜ〰うふびどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ぅへばひづびびどはのぜ〴ぜ〰はてぜ〴ぜ〰げづぬちぴづつぜ〴ぜ〰ぇづのづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰あづっはねづびぜ〴ぜ〰ぅのひどっとづつぜ〴ぜ〰はのぜ〴ぜ〰うふびどはの〭げづぬづぶちのぴぜ〴ぜ〰ぇづのづびぜ〴ぜ〰いふひどのでぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちっひはえ〲ぁ〱〮〱ぜ〴ぜ〰あづっはねづびぜ〴ぜ〰ぅのひどっとづつぜ〴ぜ〰はのぜ〴ぜ〰うふびどはの〭げづぬづぶちのぴぜ〴ぜ〰ぇづのづびぜ〴ぜ〰いふひどのでぜ〴ぜ〰いどててづひづのぴどちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰えはぷぜ〴ぜ〰ぃちのぜ〴ぜ〰こばぬどっづぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰はてぜ〴ぜ〰えどびぴはのづぜ〴ぜ〰ざちひどちのぴぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰ぇづのづぜ〴ぜ〰ごひちのびっひどばぴどはの〿ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰げづぬづぶちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぉつづのぴどてどづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰てはひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰うふびどはの〿ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: えはぷぜ〴ぜ〰ぃちのぜ〴ぜ〰こばぬどっづぜ〴ぜ〰ぉびはてはひねびぜ〴ぜ〰はてぜ〴ぜ〰えどびぴはのづぜ〴ぜ〰ざちひどちのぴぜ〴ぜ〰きちっひはえ〲ぁ〱ぜ〴ぜ〰ぁててづっぴぜ〴ぜ〰ぇづのづぜ〴ぜ〰ごひちのびっひどばぴどはの〿ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰げづぬづぶちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぉつづのぴどてどづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰てはひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰うふびどはの〿ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ごとづぜ〴ぜ〰げづぬづぶちのっづぜ〴ぜ〰はてぜ〴ぜ〰ぉつづのぴどてどづつぜ〴ぜ〰ぇづのづびぜ〴ぜ〰てはひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰うふびどはの〿ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⹁⸩‾㸊⠩਼㰠⽓ 䝯呯 䐠⡴慢汥⹣慰瑩潮⸸ Item: Title: Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: GBLQZB+Rpxi FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: GBLQZB+Rpxi Flags: Symbolic FontBBox: -162, -280, 856, 733 FontFile: true Font: BaseFont: AYZKMC+URWPalladioL-Ital FontSubset: true FirstChar: 2 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