cd50700185d15611434bf0e16a68b1e4 236434.pdf 47db4e362cf88d24101545a38f9f764f1f16d018 236434.pdf 560354b0f36c06e85268a0162955a7951e8634487f7db20a4391555f76f7d90f 236434.pdf Title: Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword Subject: Cellular senescence was first described as a physiological tumor cell suppressor mechanism that leads to cell growth arrest with production of the senescence-associated secretory phenotype known as SASP. The main role of SASP in physiological conditions is to attract immune cells to clear senescent cells avoiding tumor development. However, senescence can be damage-associated and, depending on the nature of these stimuli, additional types of senescence have been described. In the context of cancer, damage-associated senescence has been described as a consequence of chemotherapy treatments that were initially thought of as a tumor suppressor mechanism. However, in certain contexts, senescence after chemotherapy can promote cancer progression, especially when immune cells become senescent and cannot clear senescent tumor cells. Moreover, aging itself leads to continuous inflammaging and immunosenescence which are responsible for rewiring immune cells to become defective in their functionality. Here, we define different types of senescence, pathways that activate them, and functions of SASP in these events. Additionally, we describe the role of senescence in cancer and its treatments, including how aging and chemotherapy contribute to senescence in tumor cells, before focusing on immune cell senescence and its role in cancer. Finally, we discuss potential therapeutic interventions to reverse cell senescence. Keywords: senescence; SASP; senescence surveillance; inflammaging; immunotherapy Author: Anthony M. Battram, Mireia Bachiller and Beatriz Martín-Antonio Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Jun 18 16:15:37 2020 CEST ModDate: Thu Jun 18 16:15:37 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 31 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1080866 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DBSGWM+URWPalladioL-Ital Type 1 Custom yes yes no 130 0 OFBCJT+URWPalladioL-Bold Type 1 Custom yes yes no 131 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 132 0 JQOJYZ+URWPalladioL-Roma Type 1 Custom yes yes no 133 0 MHAHCD+Rpxr Type 1 Builtin yes yes no 134 0 IYUNIU+VnURWPalladioL Type 1 Custom yes yes no 135 0 JNLIIF+Rpxi Type 1 Builtin yes yes no 136 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 141 0 IRWHZX+TimesNewRomanPSMT Type 1C 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いづてどのどのでぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮㄩ‾㸊⡜㌷㙜㌷㝜〰うひはねぜ〴ぜ〰くぬつぜ〴ぜ〰ぴはぜ〴ぜ〰ぎづぷぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴぜ〴ぜ〰ぃはのっづばぴびぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㈩‾㸊⡜㌷㙜㌷㝜〰こづのづびっづのっづぜ〴ぜ〰あどはねちひにづひびぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰こぁこぐぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㌩‾㸊⡜㌷㙜㌷㝜〰ぅばどでづのづぴどっびぜ〴ぜ〰どのぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㐩‾㸊⡜㌷㙜㌷㝜〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰ぴとちぴぜ〴ぜ〰ぃはのぴひどぢふぴづぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㔩‾㸊⡜㌷㙜㌷㝜〰ぃはのぴひどぢふぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちでどのでぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰こふひぶづどぬぬちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Children: Item: Title: うひはねぜ〴ぜ〰くぬつぜ〴ぜ〰ぴはぜ〴ぜ〰ぎづぷぜ〴ぜ〰ちのつぜ〴ぜ〰いどててづひづのぴぜ〴ぜ〰ぃはのっづばぴびぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㈩‾㸊⡜㌷㙜㌷㝜〰こづのづびっづのっづぜ〴ぜ〰あどはねちひにづひびぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰こぁこぐぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㌩‾㸊⡜㌷㙜㌷㝜〰ぅばどでづのづぴどっびぜ〴ぜ〰どのぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㐩‾㸊⡜㌷㙜㌷㝜〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰ぴとちぴぜ〴ぜ〰ぃはのぴひどぢふぴづぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㔩‾㸊⡜㌷㙜㌷㝜〰ぃはのぴひどぢふぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちでどのでぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰こふひぶづどぬぬちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: こづのづびっづのっづぜ〴ぜ〰あどはねちひにづひびぜ〴ぜ〰ちのつぜ〴ぜ〰ぴとづぜ〴ぜ〰こぁこぐぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㌩‾㸊⡜㌷㙜㌷㝜〰ぅばどでづのづぴどっびぜ〴ぜ〰どのぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㐩‾㸊⡜㌷㙜㌷㝜〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰ぴとちぴぜ〴ぜ〰ぃはのぴひどぢふぴづぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㔩‾㸊⡜㌷㙜㌷㝜〰ぃはのぴひどぢふぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちでどのでぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰こふひぶづどぬぬちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぅばどでづのづぴどっびぜ〴ぜ〰どのぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㐩‾㸊⡜㌷㙜㌷㝜〰こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰ぴとちぴぜ〴ぜ〰ぃはのぴひどぢふぴづぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㔩‾㸊⡜㌷㙜㌷㝜〰ぃはのぴひどぢふぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちでどのでぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰こふひぶづどぬぬちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: こどでのちぬどのでぜ〴ぜ〰ぐちぴとぷちべびぜ〴ぜ〰ぴとちぴぜ〴ぜ〰ぃはのぴひどぢふぴづぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㔩‾㸊⡜㌷㙜㌷㝜〰ぃはのぴひどぢふぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちでどのでぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰こふひぶづどぬぬちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: ぃはのぴひどぢふぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぉのてぬちねねちでどのでぜ〴ぜ〰ぴはぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰こふひぶづどぬぬちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: こづのづびっづのっづぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰あづてはひづぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴ〺ぜ〴ぜ〰ぁでづ〭げづぬちぴづつぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぃとづねはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: あづてはひづぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴ〺ぜ〴ぜ〰ぁでづ〭げづぬちぴづつぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰ちのつぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぃとづねはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぃとづねはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁてぴづひぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ごひづちぴねづのぴぜ〴ぜ〰ぷどぴとぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こづのづびっづのっづぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰げづびばはのびづぜ〴ぜ〰ぴはぜ〴ぜ〰うどでとぴぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ごぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰あぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ごぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰あぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: あぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちっひはばとちでづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㔩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: くぴとづひぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃぬどのどっちぬぜ〴ぜ〰げづぬづぶちのっづぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのっづぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのはぴとづひちばべ〺ぜ〴ぜ〰ぁぜ〴ぜ〰あちぬちのっづぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰ぉのつふっぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぉのつふっぴどはのぜ〴ぜ〰はひぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃぬづちひちのっづぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのぴぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぢべぜ〴ぜ〰ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰ごぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぴづのぴどちぬぜ〴ぜ〰さびづぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴ぜ〰ちのつぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げづぴふのどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ごふねはひぜ〴ぜ〰きどっひはづのぶどひはのねづのぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭きづつどちぴづつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃぬづちひちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: ぉのつふっぴどはのぜ〴ぜ〰はひぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃぬづちひちのっづぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのぴぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぢべぜ〴ぜ〰ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰ごぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぴづのぴどちぬぜ〴ぜ〰さびづぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴ぜ〰ちのつぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げづぴふのどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ごふねはひぜ〴ぜ〰きどっひはづのぶどひはのねづのぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭きづつどちぴづつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃぬづちひちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃぬづちひちのっづぜ〴ぜ〰はてぜ〴ぜ〰こづのづびっづのぴぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰ぢべぜ〴ぜ〰ぎかぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰ごぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぴづのぴどちぬぜ〴ぜ〰さびづぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴ぜ〰ちのつぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げづぴふのどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ごふねはひぜ〴ぜ〰きどっひはづのぶどひはのねづのぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭きづつどちぴづつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃぬづちひちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰ごぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぐはぴづのぴどちぬぜ〴ぜ〰さびづぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴ぜ〰ちのつぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げづぴふのどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ごふねはひぜ〴ぜ〰きどっひはづのぶどひはのねづのぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭きづつどちぴづつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃぬづちひちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぐはぴづのぴどちぬぜ〴ぜ〰さびづぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬびぜ〴ぜ〰どのぜ〴ぜ〰ぉねねふのはぴとづひちばべぜ〴ぜ〰ちのつぜ〴ぜ〰げづぶづひびちぬぜ〴ぜ〰はてぜ〴ぜ〰あぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰こづのづびっづのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㔩‾㸊⡜㌷㙜㌷㝜〰げづぴふのどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ごふねはひぜ〴ぜ〰きどっひはづのぶどひはのねづのぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭きづつどちぴづつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃぬづちひちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづぴふのどのでぜ〴ぜ〰ぴとづぜ〴ぜ〰ごふねはひぜ〴ぜ〰きどっひはづのぶどひはのねづのぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐひはねはぴづぜ〴ぜ〰きちっひはばとちでづ〭きづつどちぴづつぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬぜ〴ぜ〰ぃぬづちひちのっづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: DBSGWM+URWPalladioL-Ital FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: 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