23ab2f36784990eef6f7de5c22f67ce4 236578.pdf c4867a91c89fd1934f99477ab916856267572868 236578.pdf 2460ce79f2d3bdddca1dcd014f049b7d0736c239460474a854b50189cd49c19e 236578.pdf Title: Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors Subject: miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Keywords: breast cancer, hsa-miR-155-5p, homologous recombination, PARP-1 inhibitors, Olaparib Author: Paola Parrella Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Aug 11 03:33:46 2020 CEST ModDate: Tue Aug 11 05:17:23 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1500062 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LMYSRI+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 37 0 CIISRV+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 42 0 UCRDSB+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 55 0 NTVIVY+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 57 0 KTPSST+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 63 0 OKJSTA+MTSY Type 1C Custom yes yes yes 71 0 JZDOKL+MinionPro-It Type 1C Custom yes yes no 93 0 YPDFMG+MinionPro-Bold Type 1C Custom yes yes no 99 0 UTHPYI+MinionPro-Regular Type 1C Custom yes yes no 79 0 CVJJBP+RMTMI Type 1C Custom yes yes yes 108 0 SNTULK+MTGU Type 1C Custom yes yes no 111 0 QASLBY+MTGUB Type 1C Custom yes yes no 203 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2021-02-12 02:19:22 CET RepresentationInformation: 236578.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-02-11 08:27:47 CET Size: 1500062 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 390 FreeObjects: 19 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inh椀戀椀琀漀爀猩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㈹‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㔯䅣瑩潮⽇潔漯偲敶′㠠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Clinicopathological Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Cell Lines, Culture Conditions, and Reagents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: RNA Isolation and Quantitative Reverse Transcription Polymerase Chain Reaction (RT-qPCR) Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Statistical and Bioinformatics Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Determination of Short-Term Olaparib IC50 (IC5072 h) by PrestoBlueTM Viability Reagent Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: In vitro Transient Transfection of miR-155-5p Mimic/Inhibitor and Olaparib Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Western Blotting Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Surrogate Molecular Classification of the CSS Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: miR-155-5p Expression Is Associated With Unfavorable Prognostic Indicators in Both CSS Cohort and TCGA-BRCA Dataset Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: miR-155-5p May Indirectly Affect Cell Response to PARP-1 Inhibitor Olaparib Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Alterations of C/EBPβ Isoforms Abundance May Mediate the Growth Inhibitory Effect of miR-155-5p Coupled With Olaparib Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Info: Title: Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors Author: Paola Parrella Subject: miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Keywords: breast cancer, hsa-miR-155-5p, homologous recombination, PARP-1 inhibitors, Olaparib Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Tue Aug 11 04:03:46 CEST 2020 ModDate: Tue Aug 11 05:47:23 CEST 2020 ID: 0x1e8a61d02f9aba8cd8b826748982a370, 0x80da4b76621d9d459b543d80c3061385 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 789 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 710 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 787 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1400 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1254 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: YPDFMG+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: YPDFMG+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 860, 714 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LMYSRI+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: LMYSRI+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -9, -214, 848, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UCRDSB+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 135 FontDescriptor: FontName: UCRDSB+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OKJSTA+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: OKJSTA+MTSY Flags: Symbolic FontBBox: 0, -133, 724, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NTVIVY+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 243 FontDescriptor: FontName: NTVIVY+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CIISRV+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 150 FontDescriptor: FontName: CIISRV+HelveticaNeueLTStd-Lt Flags: Serif, Symbolic FontBBox: -13, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: QASLBY+MTGUB FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: QASLBY+MTGUB Flags: Symbolic FontBBox: 0, -201, 460, 699 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CVJJBP+RMTMI FontSubset: true FirstChar: 49 LastChar: 62 FontDescriptor: FontName: CVJJBP+RMTMI Flags: Symbolic FontBBox: 0, 0, 735, 657 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JZDOKL+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 169 FontDescriptor: FontName: JZDOKL+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 903, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTPSST+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 135 FontDescriptor: FontName: KTPSST+HelveticaNeueLTStd-MdIt Flags: Nonsymbolic FontBBox: -49, -205, 891, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: UTHPYI+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: UTHPYI+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SNTULK+MTGU FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: SNTULK+MTGU Flags: Symbolic FontBBox: 0, -196, 607, 683 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2020-08-11T07:03:46+05:30 LaTeX with hyperref package + hypdvips 2020-08-11T08:47:23+05:30 2020-08-11T08:47:23+05:30 application/pdf miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Paola Parrella Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors breast cancer hsa-miR-155-5p homologous recombination PARP-1 inhibitors Olaparib breast cancer, hsa-miR-155-5p, homologous recombination, PARP-1 inhibitors, Olaparib dvips + MiKTeX GPL Ghostscript 9.0 uuid:99862a65-3182-4f53-8fa9-fd79b532240c uuid:99d2dc85-93c0-49a7-a0e6-79a2dd13d8d9 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 140, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 468, 728, 510, 736 Annotation: Subtype: Link Rect: 510, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 457, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 109, 38 Annotation: Subtype: Link Rect: 112, 30, 172, 38 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 527, 160, 537 Annotation: Subtype: Link Rect: 78, 389, 160, 397 Annotation: Subtype: Link Rect: 79, 68, 160, 75 Annotation: Subtype: Link Rect: 176, 511, 551, 601 Annotation: Subtype: Link Rect: 176, 489, 246, 497 Annotation: Subtype: Link Rect: 254, 489, 328, 497 Annotation: Subtype: Link Rect: 176, 467, 243, 476 Annotation: Subtype: Link Rect: 251, 467, 307, 476 Annotation: Subtype: Link Rect: 390, 467, 455, 476 Annotation: Subtype: Link Rect: 176, 455, 265, 465 Annotation: Subtype: Link Rect: 273, 456, 344, 465 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 279, 676, 285, 687 Destination: External Annotation: Subtype: Link Rect: 198, 584, 204, 596 Destination: External Annotation: Subtype: Link Rect: 181, 470, 187, 481 Destination: External Annotation: Subtype: Link Rect: 190, 470, 197, 481 Destination: External Annotation: Subtype: Link Rect: 125, 424, 132, 435 Destination: External Annotation: Subtype: Link Rect: 265, 332, 271, 344 Destination: External Annotation: Subtype: Link Rect: 274, 332, 285, 344 Destination: External Annotation: Subtype: Link Rect: 83, 286, 94, 298 Destination: External Annotation: Subtype: Link Rect: 97, 286, 108, 298 Destination: External Annotation: Subtype: Link Rect: 182, 241, 193, 252 Destination: External Annotation: Subtype: Link Rect: 197, 241, 208, 252 Destination: External Annotation: Subtype: Link Rect: 211, 241, 222, 252 Destination: External Annotation: Subtype: Link Rect: 437, 502, 448, 513 Destination: External Annotation: Subtype: Link Rect: 512, 124, 524, 135 Destination: External Annotation: Subtype: Link Rect: 381, 101, 392, 113 Destination: External Annotation: Subtype: Link Rect: 304, 76, 391, 87 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 47, 504, 58, 515 Destination: External Annotation: Subtype: Link Rect: 87, 216, 98, 228 Destination: External Annotation: Subtype: Link Rect: 244, 79, 255, 90 Destination: External Annotation: Subtype: Link Rect: 304, 190, 418, 202 Annotation: Subtype: Link Rect: 304, 156, 412, 167 Annotation: Subtype: Link Rect: 462, 99, 549, 109 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 530, 342, 536, 353 Destination: External Annotation: Subtype: Link Rect: 539, 342, 546, 353 Destination: External Annotation: Subtype: Link Rect: 419, 330, 425, 342 Destination: External Annotation: Subtype: Link Rect: 431, 330, 437, 342 Destination: External Annotation: Subtype: Link Rect: 383, 216, 390, 227 Destination: External Annotation: Subtype: Link Rect: 509, 158, 515, 170 Destination: External Annotation: Subtype: Link Rect: 454, 133, 551, 144 Annotation: Subtype: Link Rect: 304, 122, 530, 133 Annotation: Subtype: Link Rect: 440, 99, 527, 110 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 56, 497, 143, 508 Destination: External Annotation: Subtype: Link Rect: 47, 371, 134, 382 Destination: External Annotation: Subtype: Link Rect: 439, 614, 480, 625 Destination: External Annotation: Subtype: Link Rect: 444, 511, 484, 522 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 176, 620, 187, 631 Destination: External Annotation: Subtype: Link Rect: 83, 527, 113, 536 Destination: External Annotation: Subtype: Link Rect: 458, 695, 546, 705 Destination: External Annotation: Subtype: Link Rect: 448, 672, 535, 682 Destination: External Annotation: Subtype: Link Rect: 343, 660, 384, 671 Destination: External Annotation: Subtype: Link Rect: 451, 546, 492, 556 Destination: External Annotation: Subtype: Link Rect: 349, 488, 390, 499 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 167, 157, 208, 167 Destination: External Annotation: Subtype: Link Rect: 447, 159, 458, 171 Destination: External Annotation: Subtype: Link Rect: 404, 125, 415, 136 Destination: External Annotation: Subtype: Link Rect: 418, 125, 429, 136 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 107, 649, 149, 659 Destination: External Annotation: Subtype: Link Rect: 77, 628, 88, 640 Destination: External Annotation: Subtype: Link Rect: 91, 628, 102, 640 Destination: External Annotation: Subtype: Link Rect: 206, 546, 246, 556 Destination: External Annotation: Subtype: Link Rect: 372, 591, 428, 602 Destination: External Annotation: Subtype: Link Rect: 419, 569, 461, 579 Destination: External Annotation: Subtype: Link Rect: 492, 511, 549, 522 Destination: External Annotation: Subtype: Link Rect: 304, 500, 395, 511 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 174, 657, 185, 669 Destination: External Annotation: Subtype: Link Rect: 220, 554, 231, 566 Destination: External Annotation: Subtype: Link Rect: 99, 506, 155, 517 Destination: External Annotation: Subtype: Link Rect: 504, 706, 546, 716 Destination: External Annotation: Subtype: Link Rect: 425, 614, 466, 625 Destination: External Annotation: Subtype: Link Rect: 525, 542, 532, 554 Destination: External Annotation: Subtype: Link Rect: 534, 542, 546, 554 Destination: External Annotation: Subtype: Link Rect: 436, 508, 443, 519 Destination: External Annotation: Subtype: Link Rect: 446, 508, 457, 519 Destination: External Annotation: Subtype: Link Rect: 389, 451, 400, 462 Destination: External Annotation: Subtype: Link Rect: 403, 451, 414, 462 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 43, 488, 150, 500 Destination: External Annotation: Subtype: Link Rect: 253, 319, 264, 330 Destination: External Annotation: Subtype: Link Rect: 178, 273, 189, 284 Destination: External Annotation: Subtype: Link Rect: 148, 239, 160, 250 Destination: External Annotation: Subtype: Link Rect: 162, 239, 174, 250 Destination: External Annotation: Subtype: Link Rect: 170, 204, 181, 216 Destination: External Annotation: Subtype: Link Rect: 242, 181, 253, 193 Destination: External Annotation: Subtype: Link Rect: 256, 181, 267, 193 Destination: External Annotation: Subtype: Link Rect: 143, 124, 154, 135 Destination: External Annotation: Subtype: Link Rect: 170, 101, 181, 113 Destination: External Annotation: Subtype: Link Rect: 80, 67, 91, 78 Destination: External Annotation: Subtype: Link Rect: 95, 67, 106, 78 Destination: External Annotation: Subtype: Link Rect: 534, 697, 546, 708 Destination: External Annotation: Subtype: Link Rect: 354, 662, 366, 674 Destination: External Annotation: Subtype: Link Rect: 338, 651, 349, 662 Destination: External Annotation: Subtype: Link Rect: 433, 628, 444, 640 Destination: External Annotation: Subtype: Link Rect: 448, 628, 459, 640 Destination: External Annotation: Subtype: Link Rect: 438, 605, 449, 617 Destination: External Annotation: Subtype: Link Rect: 454, 605, 465, 617 Destination: External Annotation: Subtype: Link Rect: 430, 582, 441, 594 Destination: External Annotation: Subtype: Link Rect: 485, 536, 496, 548 Destination: External Annotation: Subtype: Link Rect: 432, 502, 443, 514 Destination: External Annotation: Subtype: Link Rect: 447, 502, 458, 514 Destination: External Annotation: Subtype: Link Rect: 470, 456, 481, 468 Destination: External Annotation: Subtype: Link Rect: 488, 456, 499, 468 Destination: External Annotation: Subtype: Link Rect: 537, 422, 548, 433 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 133, 685, 144, 697 Destination: External Annotation: Subtype: Link Rect: 70, 479, 82, 491 Destination: External Annotation: Subtype: Link Rect: 256, 479, 267, 491 Destination: External Annotation: Subtype: Link Rect: 47, 422, 58, 433 Destination: External Annotation: Subtype: Link Rect: 61, 422, 72, 433 Destination: External Annotation: Subtype: Link Rect: 47, 339, 102, 350 Destination: External Annotation: Subtype: Link Rect: 143, 305, 184, 315 Destination: External Annotation: Subtype: Link Rect: 171, 147, 182, 158 Destination: External Annotation: Subtype: Link Rect: 145, 124, 156, 135 Destination: External Annotation: Subtype: Link Rect: 411, 502, 423, 514 Destination: External Annotation: Subtype: Link Rect: 511, 468, 523, 479 Destination: External Annotation: Subtype: Link Rect: 407, 388, 418, 399 Destination: External Annotation: Subtype: Link Rect: 330, 174, 429, 184 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 552, 661, 303, 686 Annotation: Subtype: Link Rect: 85, 328, 145, 335 Annotation: Subtype: Link Rect: 70, 279, 147, 289 Annotation: Subtype: Link Rect: 81, 252, 137, 260 Annotation: Subtype: Link Rect: 81, 213, 160, 222 Annotation: Subtype: Link Rect: 104, 186, 157, 194 Annotation: Subtype: Link Rect: 97, 158, 186, 165 Annotation: Subtype: Link Rect: 77, 129, 162, 137 Annotation: Subtype: Link Rect: 129, 92, 225, 99 Annotation: Subtype: Link Rect: 429, 365, 511, 373 Annotation: Subtype: Link Rect: 341, 327, 421, 335 Annotation: Subtype: Link Rect: 552, 289, 316, 308 Annotation: Subtype: Link Rect: 368, 252, 441, 260 Annotation: Subtype: Link Rect: 390, 224, 493, 231 Annotation: Subtype: Link Rect: 355, 185, 439, 194 Annotation: Subtype: Link Rect: 446, 158, 526, 165 Annotation: Subtype: Link Rect: 346, 129, 422, 137 Annotation: Subtype: Link Rect: 436, 99, 523, 108 Annotation: Subtype: Link Rect: 338, 71, 393, 80 Annotation: Subtype: Link Rect: 43, 28, 109, 37 Annotation: Subtype: Link Rect: 112, 28, 172, 36 Annotation: Subtype: Link Rect: 432, 28, 551, 37 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 179, 688, 236, 697 Annotation: Subtype: Link Rect: 158, 651, 225, 659 Annotation: Subtype: Link Rect: 108, 613, 193, 621 Annotation: Subtype: Link Rect: 100, 583, 193, 593 Annotation: Subtype: Link Rect: 112, 546, 191, 555 Annotation: Subtype: Link Rect: 81, 508, 138, 517 Annotation: Subtype: Link Rect: 177, 479, 256, 488 Annotation: Subtype: Link Rect: 81, 442, 160, 450 Annotation: Subtype: Link Rect: 204, 413, 273, 422 Annotation: Subtype: Link Rect: 108, 367, 198, 375 Annotation: Subtype: Link Rect: 115, 319, 197, 327 Annotation: Subtype: Link Rect: 77, 282, 181, 289 Annotation: Subtype: Link Rect: 97, 243, 155, 252 Annotation: Subtype: Link Rect: 146, 216, 200, 223 Annotation: Subtype: Link Rect: 129, 168, 228, 176 Annotation: Subtype: Link Rect: 176, 139, 254, 148 Annotation: Subtype: Link Rect: 81, 93, 158, 101 Annotation: Subtype: Link Rect: 465, 699, 532, 706 Annotation: Subtype: Link Rect: 341, 669, 466, 678 Annotation: Subtype: Link Rect: 341, 640, 433, 649 Annotation: Subtype: Link Rect: 440, 613, 506, 621 Annotation: Subtype: Link Rect: 345, 575, 426, 583 Annotation: Subtype: Link Rect: 552, 526, 316, 546 Annotation: Subtype: Link Rect: 552, 469, 316, 490 Annotation: Subtype: Link Rect: 341, 423, 440, 432 Annotation: Subtype: Link Rect: 341, 405, 404, 413 Annotation: Subtype: Link Rect: 350, 377, 440, 384 Annotation: Subtype: Link Rect: 357, 337, 409, 346 Annotation: Subtype: Link Rect: 361, 299, 426, 309 Annotation: Subtype: Link Rect: 375, 263, 460, 271 Annotation: Subtype: Link Rect: 357, 225, 446, 233 Annotation: Subtype: Link Rect: 341, 176, 398, 185 Annotation: Subtype: Link Rect: 341, 139, 430, 148 Annotation: Subtype: Link Rect: 450, 110, 533, 119 Annotation: Subtype: Link Rect: 347, 72, 504, 82 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 201, 687, 279, 696 Annotation: Subtype: Link Rect: 108, 659, 188, 668 Annotation: Subtype: Link Rect: 108, 621, 182, 630 Annotation: Subtype: Link Rect: 104, 576, 186, 583 Annotation: Subtype: Link Rect: 126, 498, 183, 507 Annotation: Subtype: Link Rect: 357, 689, 436, 696 Annotation: Subtype: Link Rect: 415, 661, 469, 668 Annotation: Subtype: Link Rect: 381, 623, 467, 630 Annotation: Subtype: Link Rect: 324, 537, 351, 544 Annotation: Subtype: Link Rect: 352, 537, 384, 544 Annotation: Subtype: Link Rect: 385, 537, 420, 545 Annotation: Subtype: Link Rect: 421, 537, 444, 544 Annotation: Subtype: Link Rect: 445, 536, 474, 545 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 432, 29, 551, 38 Checksum: b61c06ce Type: CRC32 Checksum: 23ab2f36784990eef6f7de5c22f67ce4 Type: MD5 Checksum: c4867a91c89fd1934f99477ab916856267572868 Type: SHA-1