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Flags: Nonsymbolic FontBBox: -20, -197, 1000, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGCNCN+AdvOTb65e897d.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: CGCNCN+AdvOTb65e897d.B+20 Flags: Nonsymbolic FontBBox: -125, -177, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGCIPP+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 231 FontDescriptor: FontName: CGCIPP+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGCJMK+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: CGCJMK+HelveticaNeueLTStd-Bd Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGCJAA+AdvOT95952aae.I FontSubset: true FirstChar: 44 LastChar: 230 FontDescriptor: FontName: CGCJAA+AdvOT95952aae.I Flags: Nonsymbolic FontBBox: -135, -197, 979, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGCJBA+AdvOT039b385c FontSubset: true FirstChar: 47 LastChar: 121 FontDescriptor: FontName: CGCJBA+AdvOT039b385c Flags: Nonsymbolic FontBBox: -20, -197, 1093, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: CGCJGI+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: CGCJGI+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.chest.2020.01.048 Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects Ruyang Zhang PhD Chao Chen BS Xuesi Dong MS Sipeng Shen PhD Linjing Lai MS Jieyu He MS Dongfang You BS Lijuan Lin MS Ying Zhu BS Hui Huang BS Jiajin Chen BS Liangmin Wei BS Xin Chen BS Yi Li PhD Yichen Guo PhD Weiwei Duan PhD Liya Liu PhD Li Su BS Andrea Shafer MPH Thomas Fleischer PhD Maria Moksnes Bjaanæs PhD Anna Karlsson PhD Maria Planck PhD Rui Wang PhD Johan Staaf PhD Åslaug Helland PhD Manel Esteller PhD Yongyue Wei PhD Feng Chen PhD David C. Christiani MD FCCP early stage interaction multiomics non-small cell lung cancer prognostic score CHEST, 158 (2020) 808-819. doi:10.1016/j.chest.2020.01.048 Elsevier Inc journal CHEST © 2020 The Authors. 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