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Title:          Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis
Subject:        Scientific Reports, https://doi.org/10.1038/s41598-020-76206-y
Author:         Marta Isidro-Hernández 
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     Item: 
      Title: Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis
      Children: 
       Item: 
        Title: RESULTS
        Children: 
         Item: 
          Title: Pax5+- mice developing B-ALL show enhanced expression of the proinflammatory cytokine IL-6. 
         Item: 
          Title: Pax5 controls IL-6 expression in B-cells. 
         Item: 
          Title: Impairment of IL-6 signaling in Pax5+- mice delays natural infection-driven B-ALL development. 
         Item: 
          Title: Pax5 mutant B-ALL is not sensitive to IL-6 inhibition in transplant-based mouse models. 
         Item: 
          Title: IL-6 inhibition therapeutically targets Pax5-dependent B-ALL in vivo. 
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Proleukemic inflammatory environment in Pax5-mutant B-cell leukemogenesis. 
         Item: 
          Title: IL-6 signaling as a target for Pax5-mutant B-ALL therapy. 
       Item: 
        Title: Material and methods
        Children: 
         Item: 
          Title: Mouse model for natural infection-driven leukemia. 
         Item: 
          Title: Flow cytometry and cell sorting. 
         Item: 
          Title: Real- time PCR quantification (Q-PCR) of mIL-6, mBcl6 and mBlnk. 
         Item: 
          Title: Histology. 
         Item: 
          Title: Quantification of cytokine levels in serum. 
         Item: 
          Title: Anti-IL-6R treatment. 
         Item: 
          Title: ProB cell culture. 
         Item: 
          Title: Transplantation. 
         Item: 
          Title: V(D)J recombination. 
         Item: 
          Title: Microarray data analysis. 
         Item: 
          Title: Enrichment analysis. 
         Item: 
          Title: Mouse exome library preparation and NGS. 
         Item: 
          Title: Data analysis. 
         Item: 
          Title: Statistical analysis. 
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
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                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
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                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>Starting page</pdfaProperty:description>
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                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
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                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
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                           <pdfaProperty:name>Trapped</pdfaProperty:name>
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                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
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                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
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                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
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                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
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                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
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                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
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