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Introduction Destination: 1 Children: Item: Title: 1.1. Unmet needs in RRMM Destination: 1 Item: Title: 1.2. Therapies with new MOAs for RRMM Destination: 1 Item: Title: 1.3. Emerging agents Destination: 1 Item: Title: 2. Melflufen Destination: 1 Children: Item: Title: 2.1. Mechanism of action Destination: 1 Item: Title: 2.2. Overview of clinical trials Destination: 1 Children: Item: Title: 2.2.1. O-12-M1 Destination: 1 Item: Title: 2.2.2. HORIZON Destination: 1 Item: Title: 2.2.3. ANCHOR Destination: 1 Item: Title: 2.3. Safety and tolerability Destination: 1 Item: Title: 2.4. Regulatory status Destination: 1 Item: Title: 3. Conclusions Destination: 1 Item: Title: 4. 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Schjesvold Joachim Gullbo Paul G. Richardson Taylor & Francis Expert Opinion on Investigational Drugs, 2020. doi:10.1080/13543784.2020.1808884 Melflufen melphalan flufenamide relapsed/refractory multiple myeloma Journal Expert Opinion on Investigational Drugs © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 1354-3784 1744-7658 29 10 1069 1078 10.1080/13543784.2020.1808884 https://doi.org/10.1080/13543784.2020.1808884 VoR 2020-10-14T21:53:22+05:30 Arbortext Advanced Print Publisher 11.0.3433/W Unicode 2021-02-10T23:31:52-08:00 2021-02-10T23:31:52-08:00 Melflufen; melphalan flufenamide; relapsed/refractory multiple myeloma iText 4.2.0 by 1T3XT uuid:a821a9e2-8d54-42b4-abf5-b50980ad4753 uuid:2a1fca3d-2888-4a9d-9bd9-9495e08fc13d 2020-09-29truewww.tandfonline.com10.1080/13543784.2020.1808884www.tandfonline.comtrue2020-09-2910.1080/13543784.2020.1808884 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 157, 42, 477, 51 Annotation: Subtype: Link Rect: 283, 688, 435, 696 Annotation: Subtype: Link Rect: 303, 481, 453, 490 Annotation: Subtype: Link Rect: 202, 461, 427, 471 Annotation: Subtype: Link Rect: 106, 319, 124, 328 Annotation: Subtype: Link Rect: 131, 319, 286, 328 Annotation: Subtype: Link Rect: 106, 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